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    Codonopsis
    April 16, 2019
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    April 16, 2019

    Icariin

    Icariin is a type of flavonoid which is found in Epimedium plants but more commonly found in Horny Goat Weed and can grow in China as well as smaller areas within Asia.


    This medicine is known within the Chinese Medicinal family greatly for it's ability to increase male sexual functions as well as increasing the libido. Icariin also contains functions of being an antioxidant, an anti-inflammatory, promoting health with bones, neuroprotection and anti tumor.

    This is a well known Aphrodisiac so, if you want to spice up your life a bit look into this herb and use it as a supplement.

    Benefits of Icariin

    Increase Libido - PDE5 was isolated from the human platelet and PDE4 from the rat liver tissue using the FPLC system (Pharmacia, Milton Keynes, UK) and the Mono Q column. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [(3)H]-cGMP/[(3)H]-cAMP. Papaverine served as the control drug.

    Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of Erectile Dysfunction.

    (Article)

    Antioxidant - The objective in this work is to determine the antioxidant capacity and effectiveness of icariin (2-(4‘-methoxylphenyl)-3-rhamnosido-5-hydroxyl-7-glucosido-8-(3‘-methyl-2-butylenyl)-4-chromanone), the major component in herba epimedii being used widely in traditional Chinese medicine for the treatment of artherosclerosis and neuropathy, in which 2,2‘-azobis(2-amidinopropane) dihydrochloride (AAPH)-induced peroxidation of linoleic acid (LH) in sodium dodecyl sulfate (SDS) acts as the experimental system.

    By the view of kinetics, icariin is an antioxidant with much higher effectiveness. In addition, the antioxidant capacities of icariin used together with other antioxidants have been determined and the results indicate that the n of icariin decreases markedly while the n values of Trolox and TOH increase, even if the n of icariin is a negative value in the presence of VC-12.

    These findings implicate that the evaluation of antioxidant activity should not only focus on an n value, a thermodynamic possibility, but kinh and the charge property of the micelle should be also taken into account. To some extent, the latter factors are more important than the thermodynamic possibility.

    (Article)

    Anti-Cancer - The aims of the present study were to determine the estrogenic activities of icariin (ICA) and its derivatives and their structure–estrogenic activity relationship. Therefore, icaritin (ICT) and desmethylicaritin (DICT) were derived from ICA. The estrogenic activities of ICA, ICT and DICT were examined by cell proliferation and progestogen receptor mRNA expression of estrogen-receptor-positive MCF-7 cells.

    Cell proliferation induced by ICT and DICT was completely antagonized by ICI182,780. ICT and DICT increased progestogen receptor (PR) at mRNA levels at 48 h after treatment, although the effects were not as prominent as 17β">-estradiol (E2).

    These phenomena were not observed with ICA. Results demonstrate that ICT and DICT (nonconjugated forms) possess estrogen-like activity; however, ICA appears to have no estrogenicity in the MCF-7 cell line model in vitro.

    (Article)

    Boosts Nitric Oxide- Icariin, a flavonoid isolated from Epimedii herba, is considered to be the major therapeutical constituent of E. herba. The aim of this study was to investigate the possible protective effects and to clarify the mechanism of icariin on endothelial cells in vitro. Incubation of human umbilical vein endothelial cells (HUVEC) derived EA. hy926 cells with icariin(0.1, 1, 10 μmol l− 1) from 6 h to 72 h, then the production of NO was measured to evaluate the protective effects of icariin. RT-PCR was employed to confirm the mRNA expression of endothelial nitric oxide synthase (eNOS).

    Western blotting was used to evaluate the protein expression of eNOS. NO production was enhanced in a time- and concentration-dependent manner (P < 0.05), which was well matched with the expression of eNOS mRNA (up to 2.4-fold) and protein (up to 2.5-fold) after long-term incubation with icariin in endothelial cells (P < 0.05). Moreover, activated NF-κB was increased in EA. hy926 cells incubated with icariin for 24 h, in association with an increase in the expression of eNOS gene. In addition to its long-term effects on eNOS expression, icariin also enhanced the production of bioactive NO in the short-term (after a 5 min incubation, P < 0.05). In concert with other effects, the protective effects of icariin on endothelial cells may contribute to the cardiovascular protective effects.

    (Article)

    Anti-Inflammatory - Icariin is the major active constituent of Epimedii Herba. This recent study showed that icariin displayed anti-inflammatory potential. One novel derivate of icariin is 3,5,7-Trihydroxy-4′-methoxy-8-(3-hydroxy-3-methylbutyl)-flavone (ICT). Little is known about ICT’s pharmacological activities.

    In this study, the anti-inflammatory properties of ICT were evaluated. Murine RAW264.7 cells and C57BL/6J mice stimulated by lipopolysaccharide (LPS) was used as in vitro and in vivo inflammatory model, respectively.

    This data showed that ICT (1–100 μg/mL) significantly inhibited LPS-induced tumor necrosis factor-α (TNF-α), nitric oxide (NO), prostaglandin E2 (PGE2) production in vitro.

    Furthermore, this data suggested that ICT reduced NO and PGE2 levels by inhibiting inducible NO synthase and cyclooxygenase-2 protein expression. It is the first time that the anti-inflammatory effects of ICT have been evaluated.

    (Article)

    Osteoporosis - Icariin is the major active ingredient in Herba epimedii which is a commonly used Chinese herbal medicine for the treatment of osteoporosis.

    The present study aims to evaluate the osteoprotective effect of Icariin in glucocorticoid-induced osteoporosis in vivo and investigate the effect of Icariin on glucocorticoid-induced osteocyte apoptosis in vitro. A total of 48 female Sprague–Dawley rats were used.

    Icariin significantly increased bone-alkaline phosphatase (bone formation marker) and reduced carboxy-terminal collagen cross links (bone resorption marker). In vitro studies demonstrated that Icariin significantly prevented GC-induced apoptosis in osteocytes by activating ERK signaling via estrogen receptor.

    Results suggest that Icariin might exert osteoprotective effect by maintaining osteocyte viability, thereby, regulating bone remodeling. Furthermore, our study provides preclinical evidence for the efficacy of Icariin for management of Glucocorticoid-induced osteoporosis.

    (Article)

    Apoptosis - In the present study the neuroprotective effects of icariin, an active natural ingredient from the Chinese plant Epimedium sagittatum maxim against corticosterone-induced apoptosis were examined in primary cultured rat hippocampal neuronal cells.

    Pre-treatment of neuronal cells with icariin suppressed corticosterone-induced cytotoxicity in a dose-dependent manner.

    The present results suggest that the protective effects of icariin on apoptosis in hippocampal neuronal cells are potentially mediated through blockade of p38 MAPK phosphorylation.

    (Article)

    Neurogenesis- In conclusion, the present study demonstrates that ICA is capable of promoting the growth and proliferation of NSCs, which is related to the ICA-mediated modulation on the regulation of cell cycle genes cyclin D1 and p21. These results suggest a potential of ICA as an alternative treatment of AD disease.

    (Article)

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    1. A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin
    2. A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast …
    3. A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis
    4. A natural flavonoid glucoside, icariin, regulates Th17 and alleviates rheumatoid arthritis in a murine model
    5. A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin
    6. A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide
    7. A novel approach to utilize icariin as icariin-derived ecm on small intestinal submucosa scaffold for bone repair
    8. A novel icariin type flavonoid from Epimedium pseudowushanense
    9. A sensitive and specific indirect competitive enzyme‑linked immunosorbent assay for the detection of icariin
    10. A simultaneous determination of ferulic acid and icariin in the Li’ankang tablet by HPLC
    11. A study on PLGA sustained release icariin/titanium dioxide nanotube composite coating
    12. A Traditional Chinese Medicine–icariin-Enhances the Effectiveness of Bone Morphogenetic Protein 2
    13. AB045. Therapeutic potential of icariin in combination with PDE5 inhibitor on penile atrophy and erectile dysfunction in a rat model of post-prostatectomy
    14. AB117. Efficacy and mechanism of combination therapy using icariin and daily sildenafil citrate for the treatment of erectile dysfunction in a rat model of bilateral …
    15. Absorption and metabolism of icariin in different osteoporosis rat models
    16. Absorption and metabolism of icariin in the in situ singlepass perfused rat intestinal model
    17. Absorption and utilisation of epimedin C and icariin from Epimedii herba, and the regulatory mechanism via the BMP2/Runx2 signalling pathway
    18. Absorption kinetics of icariin solid lipid nanoparticles in rat’s intestines
    19. Absorption mechanism of icariin across Caco-2 monolayer model
    20. Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells
    21. Activation of Nrf2 signaling by icariin protects against 6‐OHDA‐induced neurotoxicity
    22. Adsorption and Purification of Total Flavonoids and icariin on Herba Epimedii. by Macroprous Resin [J]
    23. Advances in neuroharmacological effects and molecular mechanisms of icariin
    24. Advances in study on icariin extraction, separation, and its anti-tumor mechanism.
    25. Amelioration of icariin for the epididymis impairment induced by streptozocin (STZ) in rats
    26. An Experimental Study of Effects of icariin on Increasing Smad4 mRNA Level in Osteoblast Cells of OVX Rats
    27. An experimental study on the use of icariin for improving thickness of thin endometrium
    28. An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis
    29. An open-label pilot study of icariin for co-morbid bipolar and alcohol use disorder
    30. An outline for the pharmacological effect of icariin in the nervous system
    31. Analysis of biliary excretion of icariin in rats
    32. Analysis of genes expression profiles of icariin in treating osteoporosis of ovariectomized rats
    33. Analysis of icariin and epimedin C in cigarette and its smoke particulate matter by LC/ESI/MS.
    34. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro
    35. Analysis of Uncertainty for Determination of the icariin in Bushen Oral Liquid by HPLC [J]
    36. Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats
    37. Anti-apoptotic effect of icariin on renal tubular epithelial cell in SHR
    38. Antibacterial and osteoinductive properties of icariin-metronidazole/calcium phosphate cement sustained release system
    39. Anti-cancer mechanism of the flavonoid icariin (ICA) and its derivative ICT on the tumor microenvironment (46.41)
    40. Anti-cancer properties of the naturally occurring aphrodisiacs: icariin and its derivatives
    41. Antidepressant effects of icariin in prenatally stressed offsprings
    42. Antidepressant-like activity of icariin mediated by group I mGluRs in prenatally stressed offspring
    43. Antidepressant-like effect of icariin and its possible mechanism in mice
    44. icariin-from-epimedium-brevicornum.html” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?hl=en&q=http://www.biomedres.info/biomedical-research/antifatigue-properties-of-icariin-from-epimedium-brevicornum.html&source=gmail&ust=1579280816297000&usg=AFQjCNG-B2X8Co32qhm3hNQjSg4NgK9wCQ”>Anti-fatigue properties of icariin from Epimedium brevicornum
    45. Anti-fatigue Properties of icariin Isolated from Epimedium Brevicornum Maxim in Mice
    46. Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing dba/2j mice
    47. Anti-Left ventricular remodeling effects of icariin in SHR by decreasing MMP-9 levels
    48. Anti-myeloma effects of icariin are mediated through the attenuation of jak/stat3-dependent signaling cascade
    49. Antiosteoporotic activity of icariin in ovariectomized rats
    50. Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway
    51. Antioxidant effects of icariin and icariside Ⅱ in vitro [J]
    52. Antioxidative protective effect of icariin on the FeSO4/H2O2-damaged human sperm based on confocal raman micro-spectroscopy
    53. Anti-proliferative and cytoskeleton-disruptive effects of icariin on HepG2 cells
    54. Anti-proliferative efficacy of icariin on HepG2 hepatoma and its possible mechanism of action
    55. Application of icariin in the preparation of drugs for the treatment of low-androgen infertility in epididymis
    56. Application of near infrared spectroscopy for the rapid determination of epimedin A, B, C and icariin in Epimedium
    57. Application of uniform design for preparation of icariin solid lipid nanoparticles
    58. Arsenic trioxide and icariin show synergistic anti-leukemic activity
    59. Assay of icariin, psoralen and isopsoralenin in Xianling Gubao Dripping Pill by RP-HPLC [J]
    60. Atomic Force Microscopic Study on icariin Induced Osteogenic Differentiation of Human Umbilical Cord Mesenchymal Stem Cells [J]
    61. Attenuation of LPS-induced inflammation by ICT, a derivate of icariin, via inhibition of the CD14/TLR4 signaling pathway in human monocytes
    62. Autologous Freeze-Dried, Platelet-Rich Plasma Carrying icariin Enhances Bone-Tendon Healing in a Rabbit Model
    63. Bioactive glass based scaffolds coated with gelatin for the sustained release of icariin
    64. Bioactive molecule icariin inhibited proliferation while enhanced apoptosis and autophagy of rat airway smooth muscle cells in vitro
    65. Bioactive Study on Mixtures of Epimedin C and icariin Monomers with Invariant Molarity to Zebrafish Osteoporosis Model
    66. BMP-2 and icariin synergistically promote p38MAPK-mediated cardiomyocyte differentiation of mesenchymal stem cells via enhanced NOX4-driven ROS generation
    67. Bone mass improved effect of icariin for postmenopausal osteoporosis in ovariectomy-induced rats: a meta-analysis and systematic review
    68. Bone-targeting drug delivery system of biomineral-binding liposomes loaded with icariin enhances the treatment for osteoporosis
    69. Cartilage tissue engineering via icariin and adipose-derived stem cells in fibrin scaffold
    70. Cathepsin K inhibitor, icariin, increases the healing potential and biomechanical properties of femoral neck in a mice fractured model
    71. Change of CD4+ CD25+ Foxp3+ treg cells and foxp3 expression in a mouse model of asthma and the effects of icariin.
    72. Change of icariin content in five Epimedium species by heating process
    73. Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins
    74. Characterization and Dissolution Studies of icariin-β-cyclodextrin (β-CD) Inclusion Complex
    75. Characterization of Icarrin and icariin-2-Hydroxypropyl-beta-Cyclodextrin Inclusion Complex-Loading Poly (L-Lactic Acid) Scaffolds
    76. China Ginger Root Powder-Pure natural epimedium brevicornum extract pe/epimedium sagittatum extract icariin 20%-Ningbo J&S Botanics
    77. Chondroprotective effects and multi-target mechanisms of icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model
    78. Clinical Comparative Study of icariin Complex Versus Lidocaine for Treatment of Primary Premature Ejaculation [J]
    79. Colon targeted oral drug delivery system based on alginate-chitosan microspheres loaded with icariin in the treatment of ulcerative colitis
    80. Combination of icariin and bone morphogenetic protein 2: A potential osteogeniccompound for bone tissue engineering
    81. Combination of icariin and oleanolic acid attenuates in vivo and in vitro glucocorticoid resistance through protecting dexamethasone-induced glucocorticoid …
    82. Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction
    83. Combination treatment of icariin and L-DOPA against 6-OHDA-lesioned dopamine neurotoxicity
    84. Comparative effects of er-xian decoction, epimedium herbs, and icariin with estrogen on bone and reproductive tissue in ovariectomized rats
    85. Comparative effects of hispidulin, genistein, and icariin with estrogen on bone tissue in ovariectomized rats
    86. Comparative pharmacokinetics of icariin in plasma after oral administration of Er-Xian decoction or pure icariin in rats
    87. Comparative pharmacokinetics study of icariin and icariside II in rats
    88. Comparative proteomic and metabolomic analysis reveal the antiosteoporotic molecular mechanism of icariin from Epimedium brevicornu maxim
    89. Comparative studies on protective effects on reproduction of icariin and the substance extracted from the semen cuscutae in rats with partial androgen deficiency
    90. Comparative study on effect of icariin and genistein on proliferation and mineralization of osteoblasts in vitro
    91. Comparative study on effect of icariin and genistein on proliferation and mineralization of osteoblasts in vitro [J]
    92. Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II
    93. Comparison between HPLC and HPTLC densitometry for the determination of icariin from Epimedium koreanum extracts
    94. Comparison between icariin and genistein in osteogenic activity of marrow stromal cells
    95. Comparison of the pharmacokinetic characteristics of icariin and icarisideⅡafter administration of icariin monomer and Epimedium flavonoids in Wistar rats [J]
    96. Comparison on the Content of icariin in Kanggu Zengsheng Pills on Sale [J]
    97. Comparison research with icariin and genistein by anti-inflammatory reaction and angiogenesis pathway to inhibit bone loss on ovariectomized rats
    98. Compound of icariin, astragalus, and puerarin mitigates iron overload in the cerebral cortex of Alzheimer’s disease mice
    99. Conjugated icariin promotes tissue-engineered cartilage formation in hyaluronic acid/collagen hydrogel
    100. Construction of a novel catalysis system for clean and efficient preparation of Baohuoside I from icariin based on biphase enzymatic hydrolysis
    101. Construction of a small-caliber tissue-engineered blood vessel using icariin-loaded β-cyclodextrin sulfate for in situ anticoagulation and endothelialization
    102. Content Comparison of icariin between Herba Epimedii and Dispensing Granules [J]
    103. Content Determination of icariin in Yishenkang Granules by RP-HPLC [J]
    104. Controlled delivery of icariin on small intestine submucosa for bone tissue engineering
    105. Controlled release in vitro of icariin from gelatin/hyaluronic acid composite microspheres
    106. Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and …
    107. Correction: icariin and icaritin recover UVB-induced photoaging by stimulating Nrf2/ARE and reducing AP-1 and NF-κB signaling pathways: a comparative study on …
    108. Cytotoxic effects of Coptis chinensis and Epimedium sagittatum extracts and their major constituents (berberine, coptisine and icariin) on hepatoma and leukaemia …
    109. Design and Synthesis of icariin Analogues as a PDE-5 inhibitors
    110. Design, preparation, surface recognition properties, and characteristics of icariin molecularly imprinted polymers
    111. Detemination of icariin in the Zhonghuadalishen by HPLC [J]
    112. Detennination of icariin in Bushenqiangshen Capsules by HPLC Method
    113. Determination of Content of icariin in Xianrong Gejie Oral by HPLC [J]
    114. Determination of dioscin and icariin in Chuanlong Guci Tablet by HPLC [J]
    115. Determination of Dissolution Amount of icariin in Different Particle Sizes of Epimedium by HPLC [J]
    116. Determination of epimedin C and icariin in Herba Epimedii by HPLC
    117. Determination of epimedin C and icariin in Xianling Guobao Capsules by RP-HPLC [J]
    118. Determination of equilibrium solubility of icariin and its apparent oil/water partition coefficient
    119. Determination of geographical origin and icariin content of Herba Epimedii using near infrared spectroscopy and chemometrics
    120. Determination of icariin and adenosine in Cordyceps Vigorine Tablet by HPLC
    121. Determination of icariin and Levamisole Hydrochloride in Wan Ru Kang Sample by Ion-pair Chromatography
    122. Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin
    123. Determination of icariin and Paeonol in Nan Bao Capsules by RP-HPLC
    124. Determination of icariin and stilbene glycoside in anshenbunaoye by HPLC [J]
    125. Determination of icariin and tanshinone IIA in Jiliu Huaxiao Granules by HPLC.
    126. Determination of icariin by HPLC [J]
    127. Determination of icariin Concentration in a tablet by HPLC
    128. Determination of icariin content in gengnianling capsule by HPLC [J]
    129. Determination of icariin Content in Gengnianshu Tables by HPLC
    130. Determination of icariin Content in Ruhexiao Capsule by HPLC
    131. Determination of icariin Content in Shenrongqiangshen Capsule by HPLC [J]
    132. Determination of icariin content in Yishen granules by HPLC [J]
    133. Determination of icariin contents in Bushen Nuanyang granules by HPLC
    134. Determination of icariin Contents in Different Plant Parts of Epimedium Plants in Guizhou by HPLC [J]
    135. Determination of icariin Contents in Epimedium brevicornum Maxim. with Substitute Reference Substance [J]
    136. Determination of icariin Contents in Jianrumei Oral Liquid by HPLC
    137. Determination of icariin Contents in Nanbao Capsules by HPLC [J]
    138. Determination of icariin Contents in Qianlieshu Granule by HPLC
    139. Determination of icariin Epimedium from Different Haital in China by HPLC [J]
    140. Determination of icariin from Wantong Jingu Tablets by HPLC
    141. Determination of icariin in Ancient Han Health-Keeping Extract by HPLC
    142. Determination of icariin in Bikang capsules by HPLC
    143. Determination of icariin in Bushen Capsule [J]
    144. Determination of icariin in Bushen Fangchuan Film-coaling Tablets by HPLC
    145. Determination of icariin in Bushen Huoxue Tablets by HPLC
    146. Determination of icariin in Bushen Qiangshen Tablets by HPLC
    147. Determination of icariin in Bushen Qiangshen Tablets by RP-HPLC [J]
    148. Determination of icariin in bushenqiangshen capsule in high-performance liquid chromatography with fluorescence detection by precolumn chelation with aluminum
    149. Determination of icariin in Bushenqiangshen Capsules by RP-HPLC
    150. Determination of icariin in Bushenyishou Capsules by High Performance Liquid Chromatography
    151. Determination of icariin in Bushenyishou Capsules by HPLC [J]
    152. Determination of icariin in Butianling tablets by HPLC [J]
    153. Determination of icariin in Chuan Long Gu Ci Tablets by HPLC
    154. Determination of icariin in Chuankezhi Injection by HPLC [J]
    155. Determination of icariin in Chuanlong Guci Pian by HPLC.
    156. Determination of icariin in compound Erxiancao capsule by HPLC
    157. Determination of icariin in Compound Sanqi Mingmu Capsules by HPLC
    158. Determination of icariin in Cortex Eucommia Zhuanggu Capsules by RP-HPLC
    159. Determination of icariin in Cuyun Guanzhuye by HPLC [J]
    160. Determination of icariin in Erxianzengjing mixture by HPLC
    161. Determination of icariin in Fuguigutong Capsule by HPLC
    162. Determination of icariin in Funingkang Soft Capsule by HPLC
    163. Determination of icariin in Geng Nian San Hao Capsule by HPLC
    164. Determination of icariin in Gengshu’an Granules by RP-HPLC
    165. Determination of icariin in Guilubushen capsules by HPLC
    166. Determination of icariin in Guilubushen Pills by HPLC [J]
    167. Determination of icariin in Gukangbao Granules (Sugar Free) by RP-HPLC
    168. Determination of icariin in gushukang granula by HPLC
    169. Determination of icariin in Gusongbao Effervescent Tablets by HPLC
    170. Determination of icariin in Haimabaji Capsules by HPLC
    171. Determination of icariin in Hanshui Capsule by HPLC
    172. Determination of icariin in health food by SPE-HPLC
    173. Determination of icariin in Herba Epimedium by reversed-phase high performance liquid chromatography [J]
    174. Determination of icariin in HuiChun Capsules by RP-HPLC [J]
    175. Determination of icariin in Huobu Capsule by HPLC
    176. Determination of icariin in Jianbu Guanjie Capsule by HPLC [J]
    177. Determination of icariin in Jiangu Capsules by RP-HPLC
    178. Determination of icariin in Jiawei Wu-Zi-Yan-Zong Pill by HPLC
    179. Determination of icariin in JieXinTong Capsules by RP-HPLC [J]
    180. Determination of icariin in Jiexintong tablets by HPLC [J]
    181. Determination of icariin in Kanggu Zengsheng Pills by HPLC [J]
    182. Determination of icariin in Kanggu Zengsheng tablet by HPLC
    183. Determination of icariin in Kangguzengsheng Pills by HPLC
    184. Determination of icariin in Kanggu-Zengsheng tablet by HPLC [J]
    185. Determination of icariin in Kangguzengsheng Tablets by HPLC
    186. Determination of icariin in Kangguzengsheng Tablets by HPLC [J]
    187. Determination of icariin in Laonian Kechuan Tablets by HPLC [J]
    188. Determination of icariin in Laoniankechuan tablets by HPLC [J]
    189. Determination of icariin in Luweibian Wine by RP-HPLC [J]
    190. Determination of icariin in Naogongyang Granule by RP-HPLC
    191. Determination of icariin in Naoyiyuan capsules
    192. Determination of icariin in Qianlie Huichun Concentrated Pills by HPLC [J]
    193. Determination of icariin in Qianlie Shule Granules by HPLC [J]
    194. Determination of icariin in Qianliekang Capsule by Reversed Phase High-Performance Liquid Chromatography
    195. Determination of icariin in Qianliekangshu Capsule by HPLC [J]
    196. Determination of icariin in Qianlieshule Capsule by HPLC
    197. Determination of icariin in Qiyang Capsules by HPLC
    198. Determination of icariin in Qizierxian capsule by High performance Liquid Chromatography [J]
    199. Determination of icariin in rat plasma by reverse‐phase high‐performance liquid chromatography after oral administration of a lipid‐based suspension of Epimedium …
    200. Determination of icariin in rat plasma in different time by improved RP-HPLC after oral administration of epimedium compound preparation
    201. Determination of icariin in Ruhe Sanjie Capsules by HPLC
    202. Determination of icariin in Rujiling Tablets by HPLC
    203. Determination of icariin in Ruzengning Capsule by Solid Phase Extraction/Quantitative Nuclear Magnetic Resonance Spectroscopy
    204. Determination of icariin in Ruzenning Tablets by Column Chromatography-HPLC [J]
    205. Determination of icariin in sanitarian food by HPLC [J]
    206. Determination of icariin in sanziqiangshen capsule by HPLC [J]
    207. Determination of icariin in Shengbaiyin by RP-HPLC [J]
    208. Determination of icariin in Shenglixiong Capsule by RP-HPLC
    209. Determination of icariin in Shenjiang Suoyang Yiqi Tables by HPLC [J]
    210. Determination of icariin in Shenqi Anshen Capsule by HPLC [J]
    211. Determination of icariin in Shenxiongjing oral liquid by TLC
    212. Determination of icariin in Shuxin Tablets by HPLC
    213. Determination of icariin in supercritical fluid extracts of epimedium by RP-HPLC
    214. Determination of icariin in Tenghuang Jiangu granules by HPLC [J]
    215. Determination of icariin in the Anshenbunaoye by HPLC [J]
    216. Determination of icariin in Tian’e bushen oral liquid by HPLC
    217. Determination of icariin in Wujia Baozhen product by HPLC
    218. Determination of icariin in Xianlingubao Tablets by HPLC [J]
    219. Determination of icariin in Xianyang Xiongfeng Capsule by HPLC
    220. Determination of icariin in Yangguang Capsule by HPLC combined with Solid-phase Extraction [J]
    221. Determination of icariin in Yangqiang Baoshen Pills by Column Chromatography-HPLC [J]
    222. Determination of icariin in Yanzong Yuzi Capsules by HPLC [J]
    223. Determination of icariin in Yihechun Capsules by HPLC [J]
    224. Determination of icariin in Yijing Pill by HPLC [J]
    225. Determination of icariin in Yinyangsu capsules by HPLC [J]
    226. Determination of icariin in Yishen Gao by High Performance Liquid Chromatography
    227. Determination of icariin in Yishen Kanggu tablets by RP-HPLC
    228. Determination of icariin in Yishenjiangu Capsule by HPLC
    229. Determination of icariin in Yishenling Capsules by HPLC [J]
    230. Determination of icariin using HPLC with chemiluminescence detection
    231. Determination of icariin, hesperidin and paeoniflorin in Bufei Yishen Granules by HPLC [J]
    232. Determination of plasma aglycon of icariin in Beagle dogs by liquid chromatography-tandem mass spectrometry [J]
    233. Determination of Plasma Protein Binding Rates of icariin by Ultrafiltration Coupled with HPLC
    234. Determination of psoralen, isopsoralen, icariin and baohuoside I in Shengrong Yanling Pill by HPLC elution method.
    235. Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells
    236. Determination of the Content of icariin in Shengjing Capsule by HPLC [J]
    237. Determination of the Content of icariin in Tongbizhitong Granules by HPLC [J]
    238. Determination of the Contents of icariin in Gushen Pills with HPLC
    239. Determination of the pKa value of icariin and its content in the Chinese herb medicine epimedium grandiflorum morr. by capillary electrophoresis
    240. Determination of the solubility, dissolution enthalpy and entropy of icariin in water, ethanol, and methanol
    241. Determination of Total Flavonoids and icariin in Yulin Mixture
    242. Determination the Content of icariin in Fufangxuanju Capsule by HPLC [J]
    243. Determination the Content of icariin in Gengnianling Capsule by HPLC
    244. Determination the Content of icariin in Qianliehuichun Capsules by HPLC [J]
    245. Determination the content of icariin in Yigu Capsules by HPLC
    246. Determination the content of icariin in Yinyangsuo Granules by HPLC
    247. Determine the structure of phosphorylated modification of icariin and its antiviral activity against duck hepatitis virus A
    248. Determinnation on the contents of icariin in Kanggu-zengsheng tablets by HPLC
    249. Development and Validation of a LC–ESI–MS Assay for Determination of icariin in Rat Plasma after Administration of Herba Epimedii
    250. Development and validation of a TLC-densitometric method for the simultaneous quantitation of icariin and l-arginine from commercial formulations
    251. Development and validation of nonaqueous capillary electrophoresis method for simultaneous estimation of icariin, icariside II, and epimedin K in Epimedium leaves
    252. Development effect of icariin on the structure and function of mouse main organs
    253. Development of a One-Step Lateral Flow Immunoassay for Rapid Detection of icariin
    254. Development of an injectable thiolated icariin functionalized collagen/hyaluronic hydrogel to promote cartilage formation in vitro and in vivo
    255. Development of Fluorescence-Linked Immunosorbent Assay for icariin
    256. Different molecular targets of icariin on bMSCs in CORT and OVX-rats
    257. Drug-drug interactions potential of icariin and its intestinal metabolites via inhibition of intestinal UDP-glucuronosyltransferases
    258. Dual-delivery of vancomycin and icariin from an injectable calcium phosphate cement-release system for controlling infection and improving bone healing
    259. Dynamic content changes of active constituent icariin in Er-xian decoctum detected by HPLC method
    260. ED 16. Effects of icariin and IcarisideⅡon eNOS expression and NOS activity in porcine aorta endothelial cell
    261. ED 17. Effects of icariin on improving erectile function in Streptozotocin-induced diabetic rats
    262. Effect and mechanism of icariin on myocardial ischemia-reperfusion injury model in diabetes rats
    263. Effect of chinese traditional herb Epimedium grandiflorum C.Morren and its extract icariin on osteoarthritis via suppressing NF-B pathway
    264. Effect of Clarificant Chitosan on the Content of icariin in the Refined Liquid
    265. Effect of different fatty acids on icariin in vivo and in vitro system solution
    266. Effect of Hyperin and icariin on steroid hormone secretion in rat ovarian granulosa cells
    267. Effect of icariin and its metabolites on the production of cytokines by THP-1 cells.
    268. Effect of icariin in combination with daily sildenafil on penile atrophy and erectile dysfunction in a rat model of bilateral cavernous nerves injury
    269. Effect of icariin in Increasing Apoptosis of Cervical Cancer TC-1 Cells
    270. Effect of icariin on ability to prevent endothelial dysfunction in hypercholesterolemia rabbit
    271. Effect of icariin on allogeneic skin transplantation in mice [J]
    272. Effect of icariin on apoptosis and expression of Fas, Fas ligand, B cell lymphoma, and Bcl-2-associated X protein in CD4+ T lymphocytes from patients with …
    273. Effect of icariin on apoptosis in hippocampal neurons cultured in high glucose
    274. Effect of icariin on apoptosis of spermatogenic cells in alcohol-treated testis of mice
    275. Effect of icariin on bone destruction and serum RANKL/OPG levels in type II collagen-induced arthritis rats
    276. Effect of icariin on bone formation during distraction osteogenesis in the rabbit mandible
    277. Effect of icariin on cell proliferation and the expression of bone resorption/formation-related markers in human periodontal ligament cells
    278. Effect of icariin on Con A-induced BRL-3A cell injury in vitro
    279. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum
    280. Effect of icariin on cyclic GMP levels and on the mRNA expression of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in penile cavernosum.
    281. Effect of icariin on engineered 3d-printed porous scaffolds for cartilage repair
    282. Effect of icariin on fracture healing in an ovariectomized rat model of osteoporosis
    283. Effect of icariin on Glucocorticoid Receptor Expression in Kidney Yang—deficiency Cells
    284. Effect of icariin on hypoxia induced vascular endothelial cells injury
    285. Effect of icariin on hypoxia/reoxygenation injury in neonatal rat cardiomyocytes
    286. EFFECT OF icariin ON INFLAMMATORY RESPONSE AND LEARNING AND MEMORY ABILITIES IN MICE WITH ALZHEIMER’S DISEASE
    287. Effect of icariin on intermediate and advanced activation of murine T lymphocytes in vitro
    288. Effect of icariin on Intimal Proliferation and Apoptosis of Vascular Smooth Muscle Cell after Vascular Injury in Rats [J]
    289. Effect of icariin on learning and memory abilities and activity of cholinergic system of senescence-accelerated mice SAMP10
    290. Effect of icariin on OPG/RANKL Gene and Protein Expression Influence of Mus Musculus Osteolysis Model [J]
    291. Effect of icariin on Osteoarthritis Fibroblast-Like Synoviocytes: An In Vitro Study
    292. Effect of icariin on osteoblastic differentiation gene expression of human periodontal ligament cells
    293. Effect of icariin on osteoclastic bone resorption and the mechanism
    294. Effect of icariin on Osteogenic Differentiation and Adipogenic Differentiation of Rat Bone Marrow Stromal Stem Cells
    295. Effect of icariin on proliferation and apoptosis of hepatocellular carcinoma SMMC-7721 cells
    296. Effect of icariin on Rats Femur Tissue in vitro [J]
    297. Effect of icariin on serum bone turnover markers expressions and histology changes in mouse osteoarthritis model
    298. Effect of icariin on the chondrogenesis of human adipose derived stem cells on poly (lactic-co-glycolic) acid/fibrin composite scaffold
    299. Effect of icariin on the Expression of GATA-4 by Bone Marrow Mesenchymal Stem Cells [J]
    300. Effect of icariin on the Expression of Matrix Metalloprotease-2 after Vascular Injury in Rats
    301. Effect of icariin on the expression of MMP-9 and CK mRNA in mouse osteoclasts.
    302. Effect of icariin on the expression of receptor activator nuclear factor-κB ligand and osteoprotegerin of human periodontal ligament cells
    303. Effect of icariin on the expression of transforming growth factor-beta 1 and bone morphogenetic protein-2 in the process of mesenchymal stem cells differentiation into …
    304. Effect of icariin on the mRNA and protein expression of NOS isoform in corpus cavernosum of castrated rats
    305. Effect of icariin on the mRNA expressions of Cbfalpha1, BMP2, BMP4 in rat osteoblasts
    306. Effect of icariin on the osteoarthritic knee of rabbits in the early stage
    307. Effect of icariin on the proteomic expression profile of bone microvascular endothelial cells of human femoral head against steroids-induced lesion
    308. Effect of icariin on the vasodilation function of renal artery in diabetic nephropathy rats
    309. Effect of icariin on tibial dyschondroplasia incidence and tibial characteristics by regulating P2RX7 in chickens
    310. Effect of icariin on UDP-glucuronosyltransferases in mouse liver
    311. Effect of icariin, diosgenin and genistein on proliferation and differentiation of newborn rat skull cells in vitro
    312. Effect of icariin/attapulgite/collagen type Ⅰ/polycaprolactone composite scaffold in repair of rabbit tibia defect
    313. Effect of oral administration of icariin on periodontitis associated alveolar bone resorption in an osteoporosis mouse model
    314. Effect of Solid State Fermentation of Herba Epimedii with Spergillus Niger on the Content of icariin and Assay
    315. Effect of the Compatibility of Panax notoginseng Saponinsn and icariin on Proliferation of Osteoblasts Cultured by High Glucose
    316. Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin
    317. Effect of β-sitosterol and icariin on porcine spermatozoa capacitation in vitro.
    318. Effect on the content of icariin in Gubi Granules by the radiation of~(60) cobalt-γ ray
    319. Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption
    320. Effects and mechanisms of icariin on atherosclerosis
    321. Effects of dietary supplementation with icariin on growth performance, antioxidant capacity and non-specific immunity of Chinese mitten crab (Eriocheir sinensis)
    322. Effects of Different Extraction Methods on Total Flavonoids and icariin Contents of Herba Epimedii
    323. Effects of different processed products on the main ingredient of epimedin C and icariin of Epimedium wushanense
    324. Effects of different processed products on the main ingredient of epimedin C and icariin of Epimedium wushanense.
    325. Effects of EPCs Preconditioned by Syn-transplanting BMSc and icariin on AMI Rat’s Heart Function [J]
    326. Effects of Epimedin C and icariin on uterus of ovariectomized mice
    327. Effects of icariin (ICA) on Proliferation of Gastric Cancer Cell Line SGC-7901 [J]
    328. Effects of icariin and genistein on peak bone mass in rats
    329. Effects of icariin and icariside II on eNOS expression and NOS activity in porcine aorta endothelial cells
    330. Effects of icariin and icarisideⅡon eNOS expression and NOS activity in porcine aorta endothelial cells [J]
    331. Effects of icariin and nimodipine on behavioral changes in mice with transient cerebral ischemia/reperfusion
    332. Effects of icariin combined with Panax notoginseng saponins on ischemia reperfusion‐induced cognitive impairments related with oxidative stress and CA1 of …
    333. Effects of icariin combined with Panax notoginseng saponins on vascular dementia model rats and anti lipid peroxidation in brain [J]
    334. Effects of icariin in Isoproterenol induced Cardiotoxicity in Wistar Rats
    335. Effects of icariin of experimental IgA nephropathy in rats
    336. Effects of icariin on activation and proliferation of murine T lymphocytes in vitro [J]
    337. Effects of icariin on acute lung injury in mice induced by activation of the complement alternative pathway
    338. Effects of icariin on asthma mouse model are associated with regulation of prostaglandin D2 level
    339. Effects of icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice
    340. Effects of icariin on autophagy and exosome production of bone microvascular endothelial cells
    341. Effects of icariin on Bcl-2 and Bax protein expressions and eosinophils apoptosis in bronchial asthmatic mice
    342. Effects of icariin on BDNF and TrkB of rats with focal cerebral ischemia-reperfusion injury
    343. Effects of icariin on beta-amyloid and neurotrophic factors in brain of mitochondrial deficiency model rats
    344. Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities
    345. Effects of icariin on Cyclic GMP and Cyclic AMP Levels in the Rabbit Corpus Cavernosum in vitro
    346. Effects of icariin on cytokine-induced ankylosing spondylitis with fibroblastic osteogenesis and its molecular mechanism
    347. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats
    348. Effects of icariin on expression of BDNF and TrkB mRNA in natural aging rat hippocampus [J]
    349. Effects of icariin on expression of glucose regulated protein 78 in vascular smooth muscle cell induced by homocysteine
    350. Effects of icariin on expression of OPN mRNA and type I collegen in rat osteoblastsin vitro
    351. Effects of icariin on expression of the estrogen receptor beta mRNA of boneand different hypothalamic nuclei in ovariectomy rats [J]
    352. Effects of icariin on expression of transforming growth factor β_1 and type Ⅳ collagen in diabetic rat testis
    353. Effects of icariin on human bone marrow stromal stem cells differentiate and proliferate in vitro
    354. Effects of icariin on hypothalamic-pituitary-adrenal axis action and cytokine levels in stressed Sprague-Dawley rats
    355. Effects of icariin on IL-17-associated RANKL of Type Ⅱ Collagen-induced Arthritis in Mice [J]
    356. Effects of icariin on improving erectile function in streptozotocin‐induced diabetic rats
    357. Effects of icariin on inducing osteoclast formation and bone resorption in mouse bone marrow culture
    358. Effects of icariin on inflammation model stimulated by lipopolysaccharide in vitro and in vivo
    359. Effects of icariin on insulin resistance via the activation of AMPK pathway in C2C12 mouse muscle cells
    360. Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat
    361. Effects of icariin on liver microsomal cytochrome P450 in rats with different ages
    362. Effects of icariin on long noncoding RNA and mRNA expression profile in the aortas of apoE-deficient mice
    363. Effects of icariin on orthodontic tooth movement in rats
    364. Effects of icariin on osteogenic differentiation of bone marrow stromal cells in beagle canine
    365. Effects of icariin on osteogenic differentiation of rat bone marrow mesenchymal stem cells [J]
    366. Effects of icariin on ovarian development in neonatal rats.
    367. Effects of icariin on ovarian function in d-galactose-induced aging mice
    368. Effects of icariin on ovariectomized osteoporotic rats
    369. Effects of icariin on partial vasoactive substances in monocrotaline-induced pulmonary arterial hypertension rat model
    370. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
    371. Effects of icariin on physiological properties of isolated small intestinal smooth muscle from the rabbit
    372. Effects of icariin on Proliferation and Differentiation of Osteoblasts from Chicken Embryo
    373. Effects of icariin on proliferation of vascular smooth muscle cell induced by ox-LDL via impacting MAPK signaling pathway
    374. Effects of icariin on reproductive functions in male rats
    375. Effects of icariin on the alkline phosphatase activity of human periodontal ligament cells inhibited by lipopolysaccharide
    376. Effects of icariin on the development of ovary and uterus in sexually matured female rats [J]
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