“5′ AMP-activated protein kinase or AMPK or 5′ adenosine monophosphate-activated protein kinase is an enzyme (EC 2.7.11.31) that plays a role in cellular energy homeostasis, largely to activate glucose and fatty acid uptake and oxidation when cellular energy is low. It belongs to a highly conserved eukaryoticprotein family and its orthologues are SNF1 and SnRK1 in yeast and plants, respectively. It consists of three proteins (subunits) that together make a functional enzyme, conserved from yeast to humans. It is expressed in a number of tissues, including the liver, brain, and skeletal muscle. In response to binding AMP and ADP, the net effect of AMPK activation is stimulation of hepatic fatty acid oxidation, ketogenesis, stimulation of skeletal muscle fatty acid oxidation and glucose uptake, inhibition of cholesterol synthesis, lipogenesis, and triglyceride synthesis, inhibition of adipocyte lipogenesis, activation of adipocyte lipolysis, and modulation of insulin secretion by pancreatic beta-cells.^[1]”

1. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
2. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
3. AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
4. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
5. AMPK: a nutrient and energy sensor that maintains energy5 homeostasis
6. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
7. The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
8. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
9. AMPK and PPARδ Agonists Are Exercise Mimetics
10. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
11. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
12. The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
13. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK– and COX-2–dependent mechanisms
14. AMPK in Health and Disease
15. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
16. AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
17. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
18. AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice
19. AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
20. The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
21. Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia
22. SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
23. Structure of mammalian AMPK and its regulation by ADP
24. Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
25. Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks
26. AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen
27. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
28. AMPK: a key regulator of energy balance in the single cell and the whole organism
29. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
30. Metabolism of inflammation limited by AMPK and pseudo-starvation
31. Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
32. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
33. Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
34. An AMPK-FOXO Pathway Mediates Longevity Induced by a Novel Method of Dietary Restriction in C. elegans
35. AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase
36. Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
37. Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
38. Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation
39. Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
40. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
41. Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity*
42. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
43. AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARα and PGC-1
44. The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
45. AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
46. The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
47. AMPK, insulin resistance, and the metabolic syndrome
48. AMPK: A Key Sensor of Fuel and Energy Status in Skeletal Muscle
49. AMPK: a metabolic gauge regulating whole-body energy homeostasis
50. AMPK, the metabolic syndrome and cancer
51. AMP-Activated Protein Kinase (AMPK) Is Activated in Muscle of Subjects With Type 2 Diabetes During Exercise
52. AMPK and cell proliferation – AMPK as a therapeutic target for atherosclerosis and cancer
53. Ca2+ and AMPK Both Mediate Stimulation of Glucose Transport by Muscle Contractions
54. AMPK and SIRT1: a long-standing partnership?
55. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
56. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
57. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
58. The Association of AMPK with ULK1 Regulates Autophagy
59. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation
60. AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
61. Physiological role of AMP-acivated proein kinase (AMPK): insights from knockout mouse models
62. SNF1/AMPK pathways in yeast
63. Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans
64. Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
65. 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments
66. Important role fo the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
67. Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
68. A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
69. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise
70. The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor
71. Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway
72. AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
73. Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy
74. MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells
75. Effect of AMPK activation on muscle glucose metabolism in conscious rats
76. TAK1 activates AMPK‐dependent cytoprotective autophagy in TRAIL‐treated epithelial cells
77. Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle
78. AMP-activated Protein Kinase (AMPK) Signaling in Endothelial Cells Is Essential for Angiogenesis in Response to Hypoxic Stress*
79. New roles for the LKB1→AMPK pathway
80. Acute Metformin Therapy Confers Cardioprotection Against Myocardial Infarction Via AMPK-eNOS–Mediated Signaling
81. Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype
82. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
83. SREBP-1c, regulated by the insulin and AMPK signaling pathways, plays a role in nonalcoholic fatty liver disease
84. Roles of 5′-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis
85. Effects of α-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
86. Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway
87. Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes
88. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
89. AMPK alterations in cardiac physiology and pathology: enemy or ally?
90. Berberine suppresses proinflammatory responses through AMPK activation in macrophages
91. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
92. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR
93. AMPK: positive and negative regulation, and its role in whole-body energy homeostasis
94. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
95. Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
96. AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise
97. SNF1/AMPK/SnRK1 kinases, global regulators at the heart of energy control?
98. Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
99. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)
100. AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer
101. AMPK and the biochemistry of exercise: implications for human health and disease
102. AMPK-Mediated AS160 Phosphorylation in Skeletal Muscle Is Dependent on AMPK Catalytic and Regulatory Subunits
103. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
104. Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1
105. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
106. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio
107. β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)
108. AMPK as a mediator of hormonal signalling
109. Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
110. AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs
111. AMPK as a metabolic tumor suppressor: control of metabolism and cell growth
112. Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK
113. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
114. AMPK Mediates Autophagy during Myocardial Ischemia In Vivo
115. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK
116. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
117. AMPK inhibits fatty acid-induced increases in NF-κB transactivation in cultured human umbilical vein endothelial cells
118. Structural basis of AMPK regulation by small molecule activators
119. Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
120. AMPK in the brain: its roles in energy balance and neuroprotection
121. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
122. Phosphorylation-activity relationships of AMPK and acetyl-CoA carboxylase in muscle
123. Metformin Amplifies Chemotherapy-Induced AMPK Activation and Antitumoral Growth
124. Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop
125. AMPK inhibition in health and disease
126. Hypoxia Triggers AMPK Activation through Reactive Oxygen Species-Mediated Activation of Calcium Release-Activated Calcium Channels
127. α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle
128. Stimulation of muscle cell glucose uptake by resveratrol through sirtuins and AMPK
129. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury
130. AMPK—Sensing Energy while Talking to Other Signaling Pathways
131. AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1
132. Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-κB Pathway
133. Expanding role of AMPK in endocrinology
134. Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle
135. Identification of Phosphorylation Sites in AMP-activated Protein Kinase (AMPK) for Upstream AMPK Kinases and Study of Their Roles by Site-directed Mutagenesis*
136. AMPK activation: a therapeutic target for type 2 diabetes?
137. AMPK and Raptor: Matching Cell Growth to Energy Supply
138. AMPK: Lessons from transgenic and knockout animals
139. LKB1 and AMPK and the cancer-metabolism link – ten years after
140. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise
141. GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK
142. Exercise Increases Nuclear AMPK α2 in Human Skeletal Muscle
143. LKB1 and AMPK maintain epithelial cell polarity under energetic stress
144. Targeting the AMPK pathway for the treatment of Type 2 diabetes
145. Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
146. Control of AMPK-related kinases by USP9X and atypical Lys29/Lys33-linked polyubiquitin chains
147. Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
148. A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss
149. Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation
150. Chutes and Ladders: the search for protein kinases that act on AMPK
151. AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes
152. AMPK and transcriptional regulation.
153. Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+
154. The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo
155. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
156. Rosiglitazone Reduces Glucose-Induced Oxidative Stress Mediated by NAD(P)H Oxidase via AMPK-Dependent Mechanism
157. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
158. Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways
159. AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes
160. Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells
161. Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR‐γ signal pathways
162. Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle
163. Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site
164. The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
165. Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR
166. Dissociation of Bcl-2–Beclin1 Complex by Activated AMPK Enhances Cardiac Autophagy and Protects Against Cardiomyocyte Apoptosis in Diabetes
167. Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells
168. Stimulation of AMP-Activated Protein Kinase (AMPK) Is Associated with Enhancement of Glut1-Mediated Glucose Transport
169. AMPK: A Contextual Oncogene or Tumor Suppressor?
170. AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy
171. Therapeutic metformin/AMPK activation promotes the angiogenic phenotype in the ERα negative MDA-MB-435 breast cancer model
172. Deregulated MYC expression induces dependence upon AMPK-related kinase 5
173. Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle
174. The AMP-activated protein kinase (AMPK) and cancer: Many faces of a metabolic regulator
175. Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells
176. Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte
177. Targeting AMPK: A new therapeutic opportunity in breast cancer
178. AMPK and autophagy get connected
179. An energetic tale of AMPK–independent effects of metformin
180. AMP-activated protein kinase (AMPK) control of fatty acid and glucose metabolism in the ischemic heart
181. Ionizing Radiation Activates AMP-Activated Kinase (AMPK): A Target for Radiosensitization of Human Cancer Cells
182. AMPK‐mediated autophagy inhibits apoptosis in cisplatin‐treated tumour cells
183. Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells
184. Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner
185. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes
186. Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
187. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
188. Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators
189. Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1- and -R2-Mediated AMPK Activation
190. Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
191. Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
192. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
193. AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1
194. In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis
195. The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation
196. The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice
197. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
198. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK
199. AMPK– and p62/SQSTM1-dependent autophagy mediate Resveratrol-induced cell death in chronic myelogenous leukemia
200. Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
201. Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by AMPK activation
202. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
203. Metformin inhibits TNF-α-induced IκB kinase phosphorylation, IκB-α degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation
204. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
205. The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic β-Cells
206. Ilex paraguariensis extract ameliorates obesity induced by high-fat diet: Potential role of AMPK in the visceral adipose tissue
207. Sirtuin 1–Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
208. Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid–Induced Increase in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
209. AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels
210. Alpha‐lipoic acid decreases hepatic lipogenesis through adenosine monophosphate‐activated protein kinase (AMPK)‐dependent and AMPK‐independent pathways
211. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer’s disease and other tauopathies
212. AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes
213. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPK-FOXO3 pathway
214. Calorie Restriction: Is AMPK a Key Sensor and Effector?
215. The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism
216. LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism
217. Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase
218. Neither LKB1 Nor AMPK Are the Direct Targets of Metformin
219. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1
220. The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
221. Matched work high-intensity interval and continuous running induce similar increases in PGC-1α mRNA, AMPK, p38, and p53 phosphorylation in human skeletal muscle
222. Metformin activates a duodenal AMPK–dependent pathway to lower hepatic glucose production in rats
223. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells
224. p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin’s Effect on Food Intake
225. AMPK modulates Hippo pathway activity to regulate energy homeostasis
226. Etoposide Induces ATM-Dependent Mitochondrial Biogenesis through AMPK Activation
227. Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK
228. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
229. Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons
230. Regulation and function of AMPK in physiology and diseases
231. Resveratrol enhances GLUT‐4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
232. Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation
233. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
234. LKB1 and AMPK in cell polarity and division
235. Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
236. AMPK functions as an adenylate charge-regulated protein kinase
237. Metformin increases the PGC-1α protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo
238. Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
239. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation
240. Regulation of the autophagy initiating kinase ULK1by nutrients: Roles of mTORC1 and AMPK
241. Ischemic preconditioning activates AMPK in a PKC-dependent manner and induces GLUT4 up-regulation in the late phase of cardioprotection
242. AMPK at the Nexus of Energetics and Aging
243. Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK–eNOS Pathway
244. The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells
245. β-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling
246. Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice
247. AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
248. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway
249. Histological evaluation of AMPK signalling in primary breast cancer
250. AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet
251. Nitric oxide increases GLUT4 expression and regulates AMPK signaling in skeletal muscle
252. Resveratrol Induces Apoptosis in Chemoresistant Cancer Cells via Modulation of AMPK Signaling Pathway
253. Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation
254. The AMPK⁄SNF1⁄SnRK1 fuel gauge and energy regulator:structure, function and regulation
255. Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes
256. AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm
257. 20(S)-Ginsenoside Rg3 Enhances Glucose-Stimulated Insulin Secretion and Activates AMPK
258. Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes
259. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer
260. Fenofibrate regulates retinal endothelial cell survival through the AMPK signal transduction pathway
261. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
262. Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK
263. Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
264. AMPK: guardian of metabolism and mitochondrial homeostasis
265. The AMPK-FoxO3A axis as a target for cancer treatment
266. AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
267. PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. signalling: protein kinases in glucose homeostasis
268. AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
269. Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma
270. AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis
271. Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein
272. Redox implications of AMPK-mediated signal transduction beyond energetic clues
273. AMPK-independent induction of autophagy by cytosolic Ca2+ increase
274. Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling
275. AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance
276. Therapeutics by Cytotoxic Metabolite Accumulation: Pemetrexed Causes ZMP Accumulation, AMPK Activation, and Mammalian Target of Rapamycin Inhibition
277. Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity
278. Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner
279. Caffeine-induced Ca2+ release increases AMPK-dependent glucose uptake in rodent soleus muscle
280. Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression
281. Downregulation of AMPK Accompanies Leucine- and Glucose-Induced Increases in Protein Synthesis and Insulin Resistance in Rat Skeletal Muscle
282. AMPK-mediated increase in myocardial long-chain fatty acid uptake critically depends on sarcolemmal CD36
283. The regulation and function of mammalian AMPK‐related kinases
284. Dissociation of AMPK activity and ACCβ phosphorylation in human muscle during prolonged exercise
285. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling
286. Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
287. A small molecule AMPK activator protects the heart against ischemia–reperfusion injury
288. Metformin inhibitsP-glycoprotein expression via the NF-kB pathway andCRE transcriptional activitythrough AMPK activation
289. AMPK activation attenuates S6K1, 4E-BP1, and eEF2 signaling responses to high-frequency electrically stimulated skeletal muscle contractions
290. Involvement of AMPK Signaling Cascade in Capsaicin‐Induced Apoptosis of HT‐29 Colon Cancer Cells
291. AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure
292. The AMPK Inhibitor Compound C Is a Potent AMPK-Independent Antiglioma Agent
293. Nitric oxide and AMPK cooperatively regulate PGC‐1α in skeletal muscle cells
294. Osteogenesis and angiogenesis induced by porous β-CaSiO3/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways
295. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2–mediated suppression of mTORC1
296. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
297. Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells
298. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
299. AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure
300. High molecular weight adiponectin activates AMPK and suppresses cytokine‐induced NF‐κB activation in vascular endothelial cells
301. Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK
302. 5-Aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK
303. Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
304. C1q/TNF-Related Proteins, A Family of Novel Adipokines, Induce Vascular Relaxation Through the Adiponectin Receptor-1/AMPK/eNOS/Nitric Oxide Signaling Pathway
305. AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner
306. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain
307. AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3
308. AMPKα1: A glucose sensor that controls CD8 T‐cell memory
309. Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression
310. Short‐term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen
311. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53
312. Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis
313. AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
314. The role of LKB1 and AMPK in cellular responses to stress and damage
315. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats
316. Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
317. AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons
318. Functional analysis of Peutz–Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity
319. AMPK activators: mechanisms of action and physiological activities
320. LKB1-AMPK signaling in muscle from obese insulin-resistant Zucker rats and effects of training
321. SIRT1 and AMPK in regulating mammalian senescence: A critical reviewand a working model
322. Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways
323. Nuclear translocation of AMPK-α1 potentiates striatal neurodegeneration in Huntington’s disease
324. Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
325. Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet‐treated rat adrenal1
326. AMPK
327. Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells
328. The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels
329. Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
330. AMPK‐independent pathways regulate skeletal muscle fatty acid oxidation
331. Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation
332. Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells
333. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK
334. Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism
335. Glioma‐Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK
336. Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP
337. Diminished overload-induced hypertrophy in aged fast-twitch skeletal muscle is associated with AMPK hyperphosphorylation
338. AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B
339. Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus
340. Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
341. AMP-activated protein kinase (AMPK) beyond metabolism
342. LKB1 is required for adiponectin-mediated modulation of AMPK–S6K axis and inhibition of migration and invasion of breast cancer cells
343. Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival
344. Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy
345. Regulation of interplay between autophagy and apoptosis in the diabetic heart
346. Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways
347. Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanism
348. EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
349. Cross-Talk between AMPK and mTOR in Regulating Energy Balance
350. Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction
351. AMPK → ULK1 → Autophagy
352. Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition
353. The PPARβ/δ Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1α-Lipin 1-PPARα Pathway Leading to Increased Fatty Acid Oxidation
354. SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
355. AS160 phosphorylation is associated with activation of α2β2γ1- but not α2β2γ3-AMPK trimeric complex in skeletal muscle during exercise in humans
356. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner
357. Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
358. IGF-1 phosphorylates AMPK-α subunit in ATM-dependent and LKB1-independent manner
359. Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart
360. Targeting AMPK for cancer prevention and treatment
361. Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK
362. Inhibition of AMPK Catabolic Action by GSK3
363. Effects of Metformin on Bovine Granulosa Cells Steroidogenesis: Possible Involvement of Adenosine 5′ Monophosphate-Activated Protein Kinase (AMPK)
364. Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
365. Metformin inhibits inflammatory response via AMPK–PTEN pathway in vascular smooth muscle cells
366. AMP as a Low-Energy Charge Signal Autonomously Initiates Assembly of AXIN-AMPK-LKB1 Complex for AMPK Activation
367. LKB1/AMPK/mTOR signaling pathway in hematological malignancies: From metabolism to cancer cell biology
368. Metabolic adaptations to fasting and chronic caloric restriction in heart, muscle, and liver do not include changes in AMPK activity
369. AICAR, an AMPK Activator, Has Protective Effects on Alcohol‐Induced Fatty Liver in Rats
370. Adenosine Nucleotide Biosynthesis and AMPK Regulate Adult Life Span and Mediate the Longevity Benefit of Caloric Restriction in Flies
371. The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
372. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
373. Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells
374. Troglitazone causes acute mitochondrial membrane depolarisation and an AMPK-mediated increase in glucose phosphorylation in muscle cells
375. AMPK activation increases uncoupling protein-3 expressionand mitochondrial enzyme activities in rat muscle withoutfibre type transitions
376. Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
377. CTRP9 Protein Protects against Myocardial Injury following Ischemia-Reperfusion through AMP-activated Protein Kinase (AMPK)-dependent Mechanism
378. Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells
379. AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
380. Chronic AMPK activation evokes the slow, oxidative myogenic program and triggers beneficial adaptations in mdx mouse skeletal muscle
381. Increased ∝
     2 Subunit–Associated AMPK Activity and PRKAG2Cardiomyopathy
382. A Fluorescent Reporter of AMPK Activity and Cellular Energy Stress
383. New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo
384. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases
385. AMPK-dependent Repression of Hepatic Gluconeogenesis via Disruption of CREB·CRTC2 Complex by Orphan Nuclear Receptor Small Heterodimer Partner
386. CaM Kinase Kinase β-Mediated Activation of the Growth Regulatory Kinase AMPK Is Required for Androgen-Dependent Migration of Prostate Cancer Cells
387. Identification and characterization of AMPK γ3 mutations in the pig
388. AMPK signalling in health and disease
389. Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury
390. Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells
391. Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity
392. Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma
393. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway
394. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
395. Fenofibrate activates AMPK and increases eNOS phosphorylation in HUVEC
396. Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress
397. AICAR potentiates ROS production induced by chronic high glucose: Roles of AMPK in pancreatic β-cell apoptosis
398. Cannabinoid Receptor Stimulation Impairs Mitochondrial Biogenesis in Mouse White Adipose Tissue, Muscle, and Liver
399. AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets
400. Berberine reduces ischemia/reperfusion-induced myocardial apoptosis via activating AMPK and PI3K–Akt signaling in diabetic rats
401. trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease
402. Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
403. An Ezrin/Calpain/PI3K/AMPK/eNOSs1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production
404. Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
405. Oxidative stress induces GLUT4 translocation by activation of PI3‐K/Akt and dual AMPK kinase in cardiac myocytes
406. AMPK regulation of mouse oocyte meiotic resumption in vitro
407. AMPK-Mediated Inhibition of mTOR Kinase Is Circumvented during Immediate-Early Times of Human Cytomegalovirus Infection
408. Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle
409. Adiponectin activation of AMPK disrupts leptin‐mediated hepatic fibrosis via suppressors of cytokine signaling (SOCS‐3)
410. AMPK-mediated regulation of transcription in skeletal muscle
411. Small Molecule Drug A-769662 and AMP Synergistically Activate Naive AMPK Independent of Upstream Kinase Signaling
412. Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations
413. Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance
414. Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts
415. Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells
416. Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK
417. Hypoxia Leads to Na,K-ATPase Downregulation via Ca2+ Release-Activated Ca2+ Channels and AMPK Activation
418. Androgens regulate prostate cancer cell growth via an AMPK-PGC-1α-mediated metabolic switch
419. AMPK exerts dual regulatory effects on the PI3K pathway
420. Effect of exercise intensity and hypoxia on skeletal muscle AMPK signaling and substrate metabolism in humans
421. AMPK‐dependent hormonal regulation of whole‐body energy metabolism
422. The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2
423. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress
424. CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells
425. Regulation of hepatic metabolism by AMPK
426. Enhancing AMPK activation during ischemia protects the diabetic heart against reperfusion injury
427. The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis
428. Role of AMPK activation in oxidative cell damage: Implications for alcohol-induced liver disease
429. Time course changes in signaling pathways and protein synthesis in C2C12 myotubes following AMPK activation by AICAR
430. AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt–MDM2–Foxo3a Signaling Axis
431. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells
432. Differential effects of AMPK agonists on cell growth and metabolism
433. AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes
434. AMPK: energy sensor and survival mechanism in the ischemic heart
435. Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
436. Cross-talk between Two Essential Nutrient-sensitive Enzymes
     O-GlcNAc TRANSFERASE (OGT) AND AMP-ACTIVATED PROTEIN KINASE (AMPK)
437. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
438. Structural Insight into AMPK Regulation: ADP Comes into Play
439. Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms
440. MicroRNA-451 Exacerbates Lipotoxicity in Cardiac Myocytes and High-Fat Diet-Induced Cardiac Hypertrophy in Mice Through Suppression of the LKB1/AMPK Pathway
441. The role of ATM in response to metformin treatment and activation of AMPK
442. Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism
443. Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
444. Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells
445. Regulatory Effect of the AMPK–COX‐2 Signaling Pathway in Curcumin‐Induced Apoptosis in HT‐29 Colon Cancer Cells
446. A Redox-Dependent Mechanism for Regulation of AMPK Activation by Thioredoxin1 during Energy Starvation
447. Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator
448. Compound C inhibits hypoxic activation of HIF‐1 independent of AMPK
449. Compound K, Intestinal Metabolite of Ginsenoside, Attenuates Hepatic Lipid Accumulation via AMPK Activation in Human Hepatoma Cells
450. Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells
451. Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies
452. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells
453. The metabolic “switch” AMPK regulates cardiac heparin-releasable lipoprotein lipase
454. Quercetin suppresses HeLa cell viability via AMPK‐induced HSP70 and EGFR down‐regulation
455. Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
456. Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms
457. AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity
458. MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer
459. PK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells
460. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer
461. Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR‐induced AMPK Activation
462. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
463. AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy
464. Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
465. Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis
466. The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation
467. AMPK and p53 help cells through lean times
468. Cinnamaldehyde Prevents Adipocyte Differentiation and Adipogenesis via Regulation of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) and AMP-Activated Protein Kinase (AMPK) Pathways
469. Berberine inhibits platelet-derived growth factor-induced growth and migration partly through an AMPK-dependent pathway in vascular smooth muscle cells
470. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
471. Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia
472. Adiponectin inhibits induction of TNF‐α/RANKL‐stimulated NFATc1 via the AMPK signaling
473. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo
474. Activation of AMPK inhibits inflammation in MRL/lpr mouse mesangial cells
475. Insulin resistance due to nutrient excess
476. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells
477. vFeedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans
478. Adiponectin-mediated stimulation of AMP-activated protein kinase (AMPK) in pancreatic beta cells
479. Hypothalamic AMPK: a canonical regulator of whole-body energy balance
480. Requirement for distinct vesicle-associated membrane proteins in insulin– and AMP-activated protein kinase (AMPK)-induced translocation of GLUT4 and CD36 in cultured cardiomyocytes
481. Metformin suppresses glucose-6-phosphatase expression by a complex I inhibition and AMPK activation-independent mechanism
482. Thrombin and histamine stimulate endothelial nitric‐oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K‐Akt
483. Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?
484. AMPK-mediated GSK3β inhibition by isoliquiritigenin contributes to protecting mitochondria against iron-catalyzed oxidative stress
485. Glucose-induced repression of PPARα gene expression in pancreatic β-cells involves PP2A activation and AMPK inactivation
486. Citrus junos Tanaka Peel Extract Exerts Antidiabetic Effects via AMPK and PPAR-
     both In Vitro and In Vivo in Mice Fed a High-Fat Diet
487. Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling
488. Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1
489. Upregulation of AMPK during cold exposure occurs via distinct mechanisms in brown and white adipose tissue of the mouse
490. Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells
491. Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK
492. Carnosol, a Dietary Diterpene, Displays Growth Inhibitory Effects in Human Prostate Cancer PC3 Cells Leading to G2-Phase Cell Cycle Arrest and Targets the 5′-AMP-Activated Protein Kinase (AMPK) Pathway
493. Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons
494. Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade
495. Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart
496. The antidiabetic effect of ginsenoside Rb2 via activation of AMPK
497. Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response
498. Intensified exercise training does not alter AMPK signaling in human skeletal muscle
499. The DPP-4 inhibitor sitagliptin attenuates the progress of atherosclerosis in apolipoprotein-E-knockout mice via AMPK– and MAPK-dependent mechanisms
500. Resistin induces insulin resistance by both AMPK-dependent and AMPK-independent mechanisms in HepG2 cells
501. The LKB1-AMPK Pathway—Friend or Foe in Cancer?
502. Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation
503. Conserved regulatory elements in AMPK
504. The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells
505. Activation of AMP-activated protein kinase (AMPK) mediates plumbagin-induced apoptosis and growth inhibition in cultured human colon cancer cells
506. Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension
507. Antagonistic control of muscle cell size by AMPK and mTORC
508. Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
509. Treatment of nonalcoholic fatty liver disease: role of AMPK
510. The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
511. SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
512. Structure of a CBS-domain pair from the regulatory [gamma]1 subunit of human AMPK in complex with AMP and ZMP
513. AMPK and vasculoprotection
514. ACa2+–calmodulin–eEF2K–eEF2 signalling cascade,but not AMPK, contributes to the suppression of skeletalmuscle protein synthesis during contractions
515. Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
516. Structural basis of AMPK regulation by adenine nucleotides and glycogen
517. Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury
518. mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat
519. Low Concentrations of Metformin Suppress Glucose Production in Hepatocytes through AMP-activated Protein Kinase (AMPK)
520. AMPK Regulates Circadian Rhythms in a Tissue– and Isoform-Specific Manner
521. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic miceModification des niveaux d’adiponectine, de ses récepteurs et de l’activité AMPK dans les tissus de souris diabétiques
522. Curcumin Induces Autophagy via Activating the AMPK Signaling Pathway in Lung Adenocarcinoma Cells
523. Mangiferin Decreases Plasma Free Fatty Acids through Promoting Its Catabolism in Liver by Activation of AMPK
524. Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
525. AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast
526. Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress
527. Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK
528. Phosphorylation of BRAF by AMPK Impairs BRAF-KSR1 Association and Cell Proliferation
529. Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy
530. Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK
531. A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism
532. AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress
533. AMPK: Sensing Glucose as well as Cellular Energy Status
534. Differentiated mTOR but not AMPK signaling after strength vs endurance exercise in training‐accustomed individuals
535. AMPK α1 Activation Is Required for Stimulation of Glucose Uptake by Twitch Contraction, but Not by H2O2, in Mouse Skeletal Muscle
536. Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas
537. Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson’s disease
538. AMPK: A cellular metabolic and redox sensor. A minireview
539. Repurposing of Metformin and Aspirin by Targeting AMPK-mTOR and Inflammation for Pancreatic Cancer Prevention and Treatment
540. Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
541. Mechanism of AMPK Suppression of LXR-dependent Srebp-1c Transcription
542. Regulation of the renal-specific Na+–K+–2Cl− co-transporter NKCC2 by AMP-activated protein kinase (AMPK)
543. Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation
544. Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway
545. Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways
546. Adiponectin Inhibits Lipopolysaccharide-Induced Adventitial Fibroblast Migration and Transition to Myofibroblasts via AdipoR1-AMPK-iNOS Pathway
547. Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain
548. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
549. Targeting AMPK for cardiac protection: Opportunities and challenges
550. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
551. Prolonged AMPK Activation Increases the Expression of Fatty Acid Transporters in Cardiac Myocytes and Perfused Hearts
552. AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
553. Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK
554. Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism
555. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle
556. Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)
557. Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases
558. Astragalus polysaccharides alleviates glucose toxicity and restores glucose homeostasis in diabetic states via activation of AMPK
559. Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: Interference of AMPK/PGC-1α pathway
560. Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway
561. Mechanistic Insight into Control of CFTR by AMPK
562. AMPK Structure and Regulation from Three Angles
563. 20(S)-Ginsenoside Rg3-induced apoptosis in HT-29 colon cancer cells is associated with AMPK signaling pathway
564. Adiponectin modulates carnitine palmitoyltransferase-1 through AMPK signaling cascade in rat cardiomyocytes
565. AMPK: Evidence for an energy-sensing cytokinetic tumor suppressor
566. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction
567. AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
568. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia
569. AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease
570. Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways
571. Geminivirus Infection Up-Regulates the Expression of Two Arabidopsis Protein Kinases Related to Yeast SNF1- and Mammalian AMPK-Activating Kinases
572. Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity
573. Sulforaphane attenuates obesity by inhibiting adipogenesis and activating the AMPK pathway in obese mice
574. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
575. Curcumin decreases renal triglyceride accumulation through AMPK–SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats
576. SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK
577. Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis
578. Betulinic acid alleviates non-alcoholic fatty liver by inhibiting SREBP1 activity via the AMPK–mTOR–SREBP signaling pathway
579. An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential
580. Transitory Activation of AMPK at Reperfusion Protects the Ischaemic-Reperfused Rat Myocardium Against Infarction
581. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
582. Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase
583. Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice
584. Methyl succinate antagonises biguanide-inducedAMPK-activation and death of pancreaticb-cellsthrough restoration of mitochondrial electrontransfer
585. Expanding roles for AMPK in skeletal muscle plasticity
586. CTRP1 Protein Enhances Fatty Acid Oxidation via AMP-activated Protein Kinase (AMPK) Activation and Acetyl-CoA Carboxylase (ACC) Inhibition
587. LKB1 and AMPK and the regulation of skeletal muscle metabolism
588. Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
589. The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway
590. Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet
591. Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser
592. A-769662 activates AMPK β1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle
593. AMPK in cardiovascular health and disease
594. Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db mice
595. Characterization of the CaMKKβ–AMPK signaling complex
596. Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems
597. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
598. Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells
599. AMPK Activation by Oncogenesis Is Required to Maintain Cancer Cell Proliferation in Astrocytic Tumors
600. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect
601. Antileukemic effects of AMPK activators on BCR-ABL–expressing cells
602. Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice
603. AMPK at the crossroads of circadian clocks and metabolism
604. AMPK regulates basal skeletal muscle capillarization andVEGF expression, but is not necessary for the angiogenicresponse to exercise
605. Oxytocin stimulates glucose uptake in skeletal muscle cells through the calcium–CaMKK–AMPK pathway
606. Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
607. AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice
608. AMPK and Akt Determine Apoptotic Cell Death following Perturbations of One-Carbon Metabolism by Regulating ER Stress in Acute Lymphoblastic Leukemia
609. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
610. AMPK as a Therapeutic Target for Treating Metabolic Diseases
611. AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
612. Resveratrol enhances prostate cancer cell response to ionizing radiation. Modulation of the AMPK, Akt and mTOR pathways
613. SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
614. Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK
615. Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats
616. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
617. Suppression of AMPK Activation via S485 Phosphorylation by IGF-I during Hyperglycemia Is Mediated by AKT Activation in Vascular Smooth Muscle Cells
618. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
619. Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK
620. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation
621. Type 2 Diabetes Is Associated with Altered NF-κB DNA Binding Activity, JNK Phosphorylation, and AMPK Phosphorylation in Skeletal Muscle after LPS
622. AMPK activation enhances PPARα activity to inhibit cardiac hypertrophy via ERK1/2 MAPK signaling pathway
623. AMPK-mediated autophagy is a survival mechanism in androgen-dependent prostate cancer cells subjected to androgen deprivation and hypoxia
624. AMPK activation is fiber type specific in human skeletal muscle: effects of exercise and short-term exercise training
625. Control of glycogen synthase through ADIPOR1-AMPK pathway in renal distal tubules of normal and diabetic rats
626. Structure and Dimerization of the Kinase Domain from Yeast Snf1, a Member of the Snf1/AMPK Protein Family
627. Cytokine Regulation of AMPK signalling.
628. Activation of AMP-activated protein kinase (AMPK) provides a metabolic barrier to reprogramming somatic cells into stem cells
629. Role of AMPK in pancreatic beta cell function
630. Regulation of caspase-6 and FLIP by the AMPK family member ARK5
631. Genistein selectively potentiates arsenic trioxide‐induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species‐inducible protein kinases (p38‐MAPK, AMPK)
632. AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1
633. AMP-activated kinase (AMPK)-generated signals in malignant melanoma cell growth and survival
634. Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism
635. AMP-activated protein kinase kinase: detection with