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    AMPK
    May 1, 2019
    FOXO3
    July 27, 2019

    SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[8]

    Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.[6]

    Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[9]Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15]

    In mammals, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein.[16] SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells and embryonic and neonatal tissues. This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction.[17] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15]

    Human aging is characterized by a chronic, low-grade inflammation level[18] and NF-κB is the main transcriptional regulator of genes related to inflammation.[19] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[20][21]

    Increased expression of SIRT1 protein extended both the mean and maximal lifespan of mice.[53] In these mice health was also improved as well as bone and muscle mass. Another SIRT1 activator (SRT1720) also extended lifespan and improved the health of mice.[54]

    A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human

    Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.

    LONGEVITY FORMULA:
    ✅AMPK
    ✅Autophagy
    ✅SIRT1
    ✅Insulin Sensitivity
    XmTOR
    XOxidative Stress
    XInflammation

    • ✅=Activate, INCREASE, ENHANCE
    • X=Turn Down, Neutralize, Inhibit

     

    This is EXACTLY what the blends and fasting achieves. 

    1000 Scientific Studies

    1. A novel pathway regulates memory and plasticity via SIRT1 and miR-134
    2. Metabolic adaptations through the PGC‐1α and SIRT1 pathways
    3. Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
    4. SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
    5. How does SIRT1 affect metabolism, senescence and cancer?
    6. SIRT1 and energy metabolism
    7. Regulation of SIRT1 in cellular functions: Role of polyphenols
    8. SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
    9. Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
    10. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
    11. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
    12. Mammalian SIRT1 Represses Forkhead Transcription Factors
    13. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
    14. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
    15. miR-34a repression of SIRT1 regulates apoptosis
    16. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
    17. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    18. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
    19. Mechanism of Human SIRT1 Activation by Resveratrol
    20. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
    21. Calorie restriction, SIRT1 and metabolism: understanding longevity
    22. Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
    23. SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
    24. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    25. Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
    26. Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
    27. Sirt1 protects against high-fat diet-induced metabolic damage
    28. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
    29. Increase in Activity During Calorie Restriction Requires Sirt1
    30. DBC1 is a negative regulator of SIRT1
    31. SIRT1 transgenic mice show phenotypes resembling calorie restriction
    32. Tissue-specific regulation of SIRT1 by calorie restriction
    33. SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
    34. The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
    35. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
    36. SIRT1 and other sirtuins in metabolism
    37. Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
    38. A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
    39. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
    40. PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    41. SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
    42. AMPK and SIRT1: a long-standing partnership?
    43. SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
    44. Caloric restriction, SIRT1 and longevity
    45. Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
    46. Negative regulation of the deacetylase SIRT1 by DBC1
    47. SIRT1 controls endothelial angiogenic functions during vascular growth
    48. SIRT1 and insulin resistance
    49. Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
    50. SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
    51. The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
    52. Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
    53. SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase
    54. MiR-34, SIRT1, and p53: The feedback loop
    55. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
    56. PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
    57. Phosphorylation Regulates SIRT1 Function
    58. Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
    59. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
    60. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
    61. SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
    62. Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
    63. SIRT1 Regulates HIV Transcription via Tat Deacetylation
    64. SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
    65. Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
    66. Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
    67. Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
    68. Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
    69. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
    70. SIRT1 and endocrine signaling
    71. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    72. SirT1 Regulates Adipose Tissue Inflammation
    73. The interaction between FOXO and SIRT1: tipping the balance towards survival
    74. Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
    75. SIRT1: recent lessons from mouse models
    76. SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
    77. Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
    78. SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
    79. Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
    80. SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
    81. SIRT1 promotes DNA repair activity and deacetylation of Ku70
    82. SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
    83. Sirt1 contributes critically to the redox-dependent fate of neural progenitors
    84. Sirt1 modulates premature senescence-like phenotype in human endothelial cells
    85. STAT3 inhibition of gluconeogenesis is downregulated by SirT1
    86. RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
    87. Shear stress, SIRT1, and vascular homeostasis
    88. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
    89. The ups and downs of SIRT1
    90. Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
    91. The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
    92. Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
    93. SIRT1 in Neurodevelopment and Brain Senescence
    94. SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
    95. Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
    96. Function of the SIRT1 protein deacetylase in cancer
    97. SIRT1 and SIRT2: emerging targets in neurodegeneration
    98. Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
    99. SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
    100. JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
    101. Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1
    102. Protective roles of SIRT1 in atherosclerosis
    103. SIRT1: Regulation of longevity via autophagy
    104. Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival
    105. Cytoplasm‐localized SIRT1 enhances apoptosis
    106. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
    107. Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
    108. Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
    109. Hormonal Control of Androgen Receptor Function through SIRT1
    110. SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 POSSIBLE ROLE IN AMP-ACTIVATED PROTEIN KINASE ACTIVATION
    111. Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
    112. SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein
    113. SIRT1 and p53, effect on cancer, senescence and beyond
    114. SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
    115. Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
    116. Small molecule SIRT1 activators for the treatment of aging and age-related diseases
    117. SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex
    118. Exercise Training Promotes SIRT1 Activity in Aged Rats
    119. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
    120. Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
    121. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
    122. SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
    123. SIRT1 regulation of apoptosis of human chondrocytes
    124. Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
    125. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
    126. Progressive loss of SIRT1 with cell cycle withdrawal
    127. MicroRNA regulation of SIRT1
    128. SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
    129. Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
    130. Biochemical effects of SIRT1 activators
    131. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
    132. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
    133. Mammalian Sirt1: insights on its biological functions
    134. Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
    135. Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
    136. Sirt1 activation protects the mouse renal medulla from oxidative injury
    137. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
    138. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
    139. Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
    140. Deacetylation of cortactin by SIRT1 promotes cell migration
    141. SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
    142. Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
    143. Metabolic benefits from Sirt1 and Sirt1 activators
    144. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    145. SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
    146. Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
    147. Negative regulation of inflammation by SIRT1
    148. Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
    149. Protective Role of SIRT1 in Diabetic Vascular Dysfunction
    150. SIRT1 and neuronal diseases
    151. A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
    152. SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
    153. JNK2-dependent regulation of SIRT1 protein stability
    154. SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
    155. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
    156. Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications
    157. Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
    158. Emerging roles of SIRT1 in vascular endothelial homeostasis
    159. PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
    160. Activation of Sirt1 Decreases Adipocyte Formation During Osteoblast Differentiation of Mesenchymal Stem Cells
    161. Redox regulation of SIRT1 in inflammation and cellular senescence
    162. SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
    163. SIRT1 contributes to telomere maintenance and augments global homologous recombination
    164. Metformin suppresses hepatic gluconeogenesis through inductionof SIRT1 and GCN5
    165. Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
    166. Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib
    167. Sirt1: a metabolic master switch that modulates lifespan
    168. Dietary activators of Sirt1
    169. SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
    170. Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
    171. sirt1-null mice develop an autoimmune-like condition
    172. SIRT1: Tumor promoter or tumor suppressor?
    173. SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1
    174. FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
    175. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
    176. SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis
    177. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
    178. Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
    179. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
    180. Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
    181. Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
    182. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
    183. Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
    184. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
    185. Sirtuin 1 (SIRT1): The Misunderstood HDAC
    186. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
    187. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
    188. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
    189. Janus-faced role of SIRT1 in tumorigenesis
    190. SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
    191. High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
    192. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
    193. DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
    194. SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation
    195. Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
    196. A Review of Sirt1 and Sirt1 Modulators in Cardiovascular and Metabolic Diseases
    197. SIRT1-mediated acute cardioprotection
    198. Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
    199. SIRT1: roles in aging and cancer
    200. The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
    201. Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
    202. SIRT1 Is a Circadian Deacetylase for Core Clock Components
    203. Regulation of SIRT1 protein levels by nutrient availability
    204. SIRT1 deacetylates APE1 and regulates cellular base excision repair
    205. MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
    206. Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation
    207. Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
    208. Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
    209. Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
    210. Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure
    211. Sirt1 and the Mitochondria
    212. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
    213. High glucose downregulates endothelial progenitor cell number via SIRT1
    214. Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
    215. NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
    216. SIRT1, metabolism and cancer
    217. FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
    218. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    219. SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
    220. Resveratrol inhibits insulin responses in a SirT1-independent pathway
    221. SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
    222. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
    223. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
    224. SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer
    225. SIRT1 Promotes Differentiation of Normal Human Keratinocytes
    226. Sirt1 activation by resveratrol is substrate sequence-selective
    227. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
    228. A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
    229. Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
    230. miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells
    231. SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
    232. Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
    233. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
    234. Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
    235. The Roles of SIRT1 in Cancer
    236. The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
    237. Sirt1 increases skeletal muscle precursor cell proliferation
    238. Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
    239. NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
    240. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    241. SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
    242. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1
    243. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
    244. SIRT1 stimulation by polyphenols is affected by their stability and metabolism
    245. Control of Multidrug Resistance Gene mdr1 and Cancer Resistance to Chemotherapy by the Longevity Gene sirt1
    246. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
    247. Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
    248. Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
    249. Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells
    250. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
    251. MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
    252. The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation
    253. Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
    254. Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase
    255. SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
    256. The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
    257. MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
    258. Cellular Regulation of SIRT1
    259. SIRT1: Regulator of p53 Deacetylation
    260. SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
    261. SIRT1 Shows No Substrate Specificity in Vitro
    262. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
    263. Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
    264. The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
    265. SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
    266. SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
    267. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
    268. SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
    269. AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
    270. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
    271. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
    272. SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
    273. Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function
    274. The ways and means that fine tune Sirt1 activity
    275. SIRT1 and insulin resistance
    276. Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
    277. Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
    278. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
    279. SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60
    280. The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
    281. Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
    282. Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
    283. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
    284. SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents
    285. Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage
    286. Inhibition of transcriptional activity of c-JUN by SIRT1
    287. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
    288. Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS
    289. Role of SIRT1 in homologous recombination
    290. Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
    291. Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
    292. Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
    293. Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
    294. CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
    295. Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation
    296. Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
    297. SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma
    298. Structural and Functional Analysis of Human SIRT1
    299. SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
    300. Induction of apoptosis by inhibition of sirtuin SIRT1 expression
    301. SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
    302. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
    303. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
    304. Resveratrol and novel potent activators of Sirt1: effects on aging and age-related diseases
    305. SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis
    306. SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?
    307. Sirt1 protects the heart from aging and stress
    308. Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
    309. miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
    310. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons
    311. SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
    312. Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
    313. SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress
    314. Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
    315. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    316. Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
    317. Targeting cardiovascular disease with novel SIRT1 pathways
    318. Peptide Switch Is Essential for Sirt1 Deacetylase Activity
    319. The anti-aging, metabolism potential of SIRT1.
    320. SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
    321. A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
    322. Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
    323. Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
    324. Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways
    325. Controlling SIRT1 expression by microRNAs in health and metabolic disease
    326. Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
    327. Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors
    328. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
    329. High-intensity interval training increases SIRT1 activity in human skeletal muscle
    330. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
    331. Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
    332. Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
    333. The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
    334. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
    335. SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
    336. SIRT1: new avenues of discovery for disorders of oxidative
    337. Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
    338. Neurogenesis directed by Sirt1
    339. Sirt1 Involvement in rd10 Mouse Retinal Degeneration
    340. SIRT1 metabolic actions: Integrating recent advances from mouse models
    341. SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
    342. Expression and role of SIRT1 in hepatocellular carcinoma
    343. SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
    344. Regulation of SIRT1 activity by genotoxic stress
    345. Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
    346. SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
    347. Association of SIRT1 gene variation with visceral obesity
    348. Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
    349. SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
    350. Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
    351. Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
    352. TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
    353. SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
    354. The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
    355. Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
    356. Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF‐β/Smad3 Pathway
    357. Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase
    358. MicroRNA‐146b promotes adipogenesis by suppressing the SIRT1‐FOXO1 cascade
    359. The role of SIRT1 in ocular aging
    360. Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1
    361. Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
    362. Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer
    363. USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development
    364. Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
    365. Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
    366. Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation
    367. MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation
    368. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression
    369. SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
    370. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
    371. SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
    372. MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
    373. The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
    374. Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD
    375. SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
    376. Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
    377. Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
    378. H2O2 Accelerates Cellular Senescence by Accumulation of Acetylated p53 via Decrease in the Function of SIRT1 by NAD+ Depletion
    379. Nicotinamide-induced Mitophagy
      EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
    380. Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
    381. Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets
    382. SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
    383. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    384. Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway
    385. Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation
    386. Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
    387. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
    388. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
    389. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
    390. SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology
    391. Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway
    392. MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
    393. SirT1 fails to affect p53‐mediated biological functions
    394. The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
    395. SIRT1 deacetylates RORγt and enhances Th17 cell generation
    396. Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
    397. The controversial links among calorie restriction, SIRT1, and resveratrol
    398. SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer
    399. Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain
    400. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
    401. mIGF‐1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
    402. SIRT1 stabilizes PML promoting its sumoylation
    403. PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
    404. Agrp Neurons Mediate Sirt1‘s Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
    405. SIRT1, STEM CELLS, AGING, AND STEM CELL AGING
    406. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
    407. Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
    408. Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice
    409. Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
    410. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke
    411. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
    412. SIRT1 is required for long-term growth of human mesenchymal stem cells
    413. Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
    414. Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
    415. Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
    416. Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
    417. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
    418. The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
    419. ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse
    420. Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
    421. Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
    422. Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
    423. Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
    424. Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
    425. Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
    426. Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2†
    427. SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    428. Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
    429. SIRT1 Is a Novel Regulator of Key Pathways of Human Labor
    430. Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
    431. SIRT1 in cardiovascular aging
    432. SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
    433. SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
    434. SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
    435. SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
    436. Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway
    437. The physiological roles of Sirt1 in skeletal muscle
    438. Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
    439. Balance between SIRT1 and DBC1 expression is lost in breast cancer
    440. SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
    441. CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
    442. Human SIRT1: A potential biomarker for tumorigenesis?
    443. Regulation of SIRT1 by MicroRNAs
    444. SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
    445. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
    446. Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism
    447. A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
    448. PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
    449. Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
    450. C/EBPα regulates SIRT1 expression during adipogenesis
    451. Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
    452. Comparative and pharmacophore model for deacetylase SIRT1
    453. Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor
    454. SIRT1 gene is associated with major depressive disorder in the Japanese population
    455. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
    456. The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
    457. SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
    458. Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
    459. Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver
    460. Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
    461. SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
    462. SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
    463. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
    464. Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
    465. Sirt1: Def-eating senescence?
    466. Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise
    467. A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis
    468. Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
    469. Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
    470. Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection
    471. A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
    472. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    473. Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems
    474. Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
    475. SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
    476. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
    477. Roles of FoxO1 and Sirt1 in the central regulation of food intake
    478. Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
    479. Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
    480. Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
    481. SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
    482. SIRT1 in the brain—connections with aging-associated disorders and lifespan
    483. Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
    484. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
    485. Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
    486. SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
    487. Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
    488. Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
    489. Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation
    490. Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
    491. BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
    492. Brain Activation of SIRT1: Role in Neuropathology
    493. SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
    494. MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
    495. Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1
    496. Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
    497. SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
    498. Function of SIRT1 in physiology
    499. Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
    500. SIRT1 Regulates Dendritic Development in Hippocampal Neurons
    501. Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
    502. SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
    503. SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
    504. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
    505. Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
    506. LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells
    507. Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
    508. Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes
    509. Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
    510. Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1–3 mRNA Expression in Human Visceral Adipocytes
    511. Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
    512. Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
    513. Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
    514. Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
    515. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
    516. Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
    517. Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
    518. Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
    519. SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
    520. SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
    521. Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex
    522. Age-associated decrease of SIRT1 expression in rat hippocampus: Prevention by late onset caloric restriction
    523. SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
    524. SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
    525. Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
    526. Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
    527. Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
    528. Towards elucidating the role of SirT1 in osteoarthritis.
    529. Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
    530. Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
    531. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
    532. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
    533. SirT1 in muscle physiology and disease: lessons from mouse models
    534. Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
    535. Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance
    536. Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
    537. Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
    538. The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO
    539. Deacetylation by SIRT1 Reprograms Inflammation and Cancer
    540. Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar
    541. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice
    542. Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
    543. Metabolic actions of hypothalamic SIRT1
    544. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
    545. SIRT1 and NAD as regulators of ageing
    546. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
    547. The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
    548. Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
    549. Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
    550. SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
    551. SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
    552. SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
    553. SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
    554. Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
    555. Impact of Sirt1 on mammalian aging
    556. The role of SirT1 in muscle mitochondrial turnover
    557. SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis
    558. AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
    559. P53 and Sirt1: Routes of metabolism and genome stability
    560. SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
    561. Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells
    562. SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
    563. Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
    564. Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
    565. Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
    566. SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60
    567. The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock
    568. Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation
    569. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor pathway
    570. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
    571. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
    572. SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory
    573. mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
    574. Downregulation of Sirt1 as aging change in advanced heart failure
    575. SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
    576. Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
    577. SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
    578. Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway
    579. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
    580. SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
    581. SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
    582. Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
    583. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
    584. Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
    585. SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
    586. Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity
    587. Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
    588. Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
    589. The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
    590. Emerging Roles of SIRT1 in Cancer Drug Resistance
    591. Multifaceted Modulation of SIRT1 in Cancer and Inflammation
    592. Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes
    593. Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation
    594. SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity
    595. Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis
    596. SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
    597. Sirt1 restrains lung inflammasome activation in a murine model of sepsis
    598. SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis
    599. Silencing Insulin Resistance through SIRT1
    600. Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
    601. Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
    602. The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis
    603. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
    604. Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
    605. Sirt1-deficient mice exhibit an altered cartilage phenotype
    606. miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
    607. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
    608. SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
    609. α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
    610. Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1
    611. SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
    612. Translating cell survival and cell longevity into treatment strategies with SIRT1
    613. Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
    614. Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
    615. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
    616. SIRT1: A novel target to prevent atherosclerosis
    617. Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
    618. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
    619. ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
    620. SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    621. Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
    622. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
    623. SIRT1 — a metabolic sensor that controls blood vessel growth
    624. Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
    625. ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
    626. SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
    627. Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
    628. SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
    629. Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
    630. Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
    631. Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor‐induced neurite outgrowth in PC12 cells
    632. Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
    633. Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1
    634. Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation
    635. Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
    636. SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
    637. SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
    638. The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
    639. Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
    640. Sirt1 in cerebral ischemia
    641. SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
    642. FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
    643. A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
    644. Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells
    645. Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy
    646. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
    647. Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
    648. Physiological and Pathophysiological Functions of SIRT1
    649. Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
    650. Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
    651. Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
    652. SIRT1: Role in cardiovascular biology
    653. SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
    654. SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
    655. Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
    656. Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
    657. Resveratrol activates SIRT1 in a Lamin A-dependent manner
    658. Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
    659. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
    660. Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
    661. A Potential Treatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators
    662. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
    663. Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
    664. Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
    665. Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
    666. Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
    667. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition
    668. SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    669. Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity
    670. SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
    671. The role of SIRT1 in tumorigenesis
    672. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
    673. Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
    674. Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein
    675. Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
    676. The role of SIRT1 in diabetic kidney disease
    677. Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
    678. Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
    679. SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
    680. Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells
    681. Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
    682. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
    683. SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
    684. SIRT1 in metabolic syndrome: Where to target matters
    685. SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
    686. Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
    687. Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
    688. CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
    689. BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
    690. SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
    691. Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
    692. Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
    693. Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression
    694. Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
    695. Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase
    696. SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
    697. p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
    698. Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
    699. SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
    700. Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
    701. SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
    702. SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways
    703. Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
    704. Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
    705. SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
    706. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
    707. Interference between PARPs and SIRT1: a novel approach to healthy ageing?
    708. Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
    709. MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
    710. Fructose induces gluconeogenesis and lipogenesis through aSIRT1-dependent mechanism
    711. NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
    712. SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
    713. Identification, stability and expression of Sirt1 antisense long non-coding RNA
    714. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
    715. A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
    716. SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
    717. miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in human fibrosarcoma cells
    718. SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
    719. Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis
    720. SIRT1 associates with eIF2-alpha and regulates the cellular stress response
    721. Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
    722. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
    723. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
    724. Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
    725. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
    726. The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
    727. The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
    728. Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
    729. FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
    730. Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
    731. The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling
    732. FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide
    733. SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
    734. Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
    735. MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
    736. SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
    737. SIRT1 and Caloric Restriction: An Insight Into Possible Trade-Offs Between Robustness and Frailty
    738. Induction of Sirt1 by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response
    739. Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
    740. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
    741. SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
    742. Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
    743. PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
    744. Cross-talk between SIRT1 and p66Shc in vascular diseases
    745. Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
    746. Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
    747. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
    748. SirT1 brings stemness closer to cancer and aging
    749. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
    750. Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
    751. SirT1 brings stemness closer to cancer and aging
    752. SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
    753. SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
    754. High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
    755. Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors
    756. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells
    757. Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
    758. Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1
    759. Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
    760. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
    761. Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
    762. PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
    763. Critical Reviews™ in Eukaryotic Gene Expression
    764. Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells
    765. NO Targets SIRT1
    766. SIRT1 Directly Regulates SOX2 to Maintain Self‐Renewal and Multipotency in Bone Marrow‐Derived Mesenchymal Stem Cells
    767. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
    768. Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
    769. SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons
    770. SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression
    771. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
    772. SIRT1 modulation of adipogenesis and adipose function
    773. Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in Humans
    774. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation
    775. The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response
    776. Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling
    777. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway
    778. Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
    779. Resveratrol is neuroprotective because it is not a direct activator of Sirt1—A hypothesis
    780. SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
    781. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells
    782. Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
    783. Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
    784. Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
    785. Tat-SIRT1 Tango
    786. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
    787. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
    788. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
    789. High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
    790. Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
    791. Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
    792. Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
    793. SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
    794. Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
    795. Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
    796. SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
    797. SIRT1 Modulates Aggregation and Toxicity through Deacetylation of the Androgen Receptor in Cell Models of SBMA
    798. SIRT1 links CIITA deacetylation to MHC II activation
    799. Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy
    800. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms
    801. Dietary Resveratrol Prevents Development of High-Grade Prostatic Intraepithelial Neoplastic Lesions: Involvement of SIRT1/S6K Axis
    802. Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression
    803. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
    804. Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
    805. Transcriptional Corepressor SMILE Recruits SIRT1 to Inhibit Nuclear Receptor Estrogen Receptor-related Receptor γ Transactivation
    806. Sirtuin-1 (SIRT1) Is Required for Promoting Chondrogenic Differentiation of Mesenchymal Stem Cells
    807. Interactions between DBC1 and SIRT1 arederegulated in breast cancer cells
    808. SIRT1 Protects Against Oxidative Stress‐Induced Endothelial Progenitor Cells Apoptosis by Inhibiting FOXO3a via FOXO3a Ubiquitination and Degradation
    809. Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
    810. AROuSing SIRT1: Identification of a Novel Endogenous SIRT1 Activator
    811. Activation of SIRT1 by Resveratrol Represses Transcription of the Gene for the Cytosolic Form of Phosphoenolpyruvate Carboxykinase (GTP) by Deacetylating Hepatic Nuclear Factor 4α
    812. Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol
    813. SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation
    814. NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
    815. SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
    816. Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
    817. SIRT1 Is Downregulated in Gastric Cancer and Leads to G1-phase Arrest via NF-κB/Cyclin D1 Signaling
    818. Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
    819. Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
    820. SIRT1 signaling as potential modulator of skeletal muscle diseases
    821. Hydrogen sulfide prevents H2O2-induced senescence in huma