AMPK
May 1, 2019
FOXO3
July 27, 2019
The anti-aging effects of SIRT1 activation include:
– Protection against oxidative stress
– Regulation of age-related diseases
– Increased stress resistance
– Potential lifespan elongation
– Involvement in the metabolic response to calorie restriction
– Extension of lifespan in various organisms
– Resistance to oxidative stress and cardiovascular health
– Cellular protection and regulation of gene expression
– Support for vascular and metabolic health
– Impact on age-related diseases and longevity
– Correlation with age, cholesterol levels, and eNOS expression
– Potential compensatory mechanism against oxidative stress
– Induction of antioxidants and contribution to longevity through gene-environment interactions.
SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[8]
Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.[6] Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[9]Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] In mammals, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein.[16] SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells and embryonic and neonatal tissues. This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction.[17] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] Human aging is characterized by a chronic, low-grade inflammation level[18] and NF-κB is the main transcriptional regulator of genes related to inflammation.[19] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[20][21] Increased expression of SIRT1 protein extended both the mean and maximal lifespan of mice.[53] In these mice health was also improved as well as bone and muscle mass. Another SIRT1 activator (SRT1720) also extended lifespan and improved the health of mice.[54]
Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study, we analyzed the SIRT1 gene polymorphisms (rs7895833 A>G, rs7069102 C>G and rs2273773 C>T) and its relation with levels of SIRT1, eNOS, PON-1, cholesterol, TAS, TOS, and OSI to demonstrate the association between genetic variation in SIRT1 and phenotype at different ages in humans. We observed a significant increase in the SIRT1 level in older people and found a significant positive correlation between SIRT1 level and age in the overall studied population. The oldest people carrying AG genotypes for rs7895833 have the highest SIRT1 level suggesting an association between rs7895833 SNP and lifespan longevity. Older people have lower PON-1 levels than those of adults and children which may explain the high levels of SIRT1 protein as a compensatory mechanism for oxidative stress in the elderly. The eNOS protein level was significantly decreased in older people as compared to adults. There was no significant difference in the eNOS level between older people and children. The current study is the first to demonstrate age-related changes in SIRT1 levels in humans and it is important for a much better molecular understanding of the role of the longevity gene SIRT1 and its protein product in aging. It is also the first study presenting the association between SIRT1 expression in older people and rs7895833 in SIRT1 gene.
LONGEVITY FORMULA: ✅AMPK ✅Autophagy ✅SIRT1 ✅Insulin Sensitivity XmTOR XOxidative Stress XInflammation
- ✅=Activate, INCREASE, ENHANCE
- X=Turn Down, Neutralize, Inhibit
This is EXACTLY what the blends and fasting achieves. 1000 Scientific Studies
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- Metabolic adaptations through the PGC‐1α and SIRT1 pathways
- Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice
- SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice
- How does SIRT1 affect metabolism, senescence and cancer?
- SIRT1 and energy metabolism
- Regulation of SIRT1 in cellular functions: Role of polyphenols
- SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
- SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging
- Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
- Mammalian SIRT1 Represses Forkhead Transcription Factors
- Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- miR-34a repression of SIRT1 regulates apoptosis
- Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
- Mechanism of Human SIRT1 Activation by Resveratrol
- Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
- Calorie restriction, SIRT1 and metabolism: understanding longevity
- Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
- SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1
- Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
- Sirt1 protects against high-fat diet-induced metabolic damage
- Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
- Increase in Activity During Calorie Restriction Requires Sirt1
- DBC1 is a negative regulator of SIRT1
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
- Tissue-specific regulation of SIRT1 by calorie restriction
- SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
- The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control
- Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
- SIRT1 and other sirtuins in metabolism
- Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1
- A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1
- AMPK and SIRT1: a long-standing partnership?
- SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
- Caloric restriction, SIRT1 and longevity
- Phosphorylation of HuR by Chk2 Regulates SIRT1 Expression
- Negative regulation of the deacetylase SIRT1 by DBC1
- SIRT1 controls endothelial angiogenic functions during vascular growth
- SIRT1 and insulin resistance
- Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
- SIRT1 Improves Insulin Sensitivity under Insulin-Resistant Conditions by Repressing PTP1B
- The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
- Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin
- SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase
- MiR-34, SIRT1, and p53: The feedback loop
- SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
- PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
- Phosphorylation Regulates SIRT1 Function
- Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
- Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
- SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
- Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses
- SIRT1 Regulates HIV Transcription via Tat Deacetylation
- SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
- Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1
- Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
- Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle
- Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1
- SIRT1 and endocrine signaling
- Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
- SirT1 Regulates Adipose Tissue Inflammation
- The interaction between FOXO and SIRT1: tipping the balance towards survival
- Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
- SIRT1: recent lessons from mouse models
- SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
- Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
- Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
- SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
- SIRT1 promotes DNA repair activity and deacetylation of Ku70
- SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
- Sirt1 contributes critically to the redox-dependent fate of neural progenitors
- Sirt1 modulates premature senescence-like phenotype in human endothelial cells
- STAT3 inhibition of gluconeogenesis is downregulated by SirT1
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- Shear stress, SIRT1, and vascular homeostasis
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
- The ups and downs of SIRT1
- Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
- The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer
- Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
- SIRT1 in Neurodevelopment and Brain Senescence
- SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
- Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets
- Function of the SIRT1 protein deacetylase in cancer
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
- SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity
- JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
- Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1
- Protective roles of SIRT1 in atherosclerosis
- SIRT1: Regulation of longevity via autophagy
- Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and Survival
- Cytoplasm‐localized SIRT1 enhances apoptosis
- SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
- Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability
- Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction
- Hormonal Control of Androgen Receptor Function through SIRT1
- SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1 POSSIBLE ROLE IN AMP-ACTIVATED PROTEIN KINASE ACTIVATION
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
- SIRT1 Regulates the Function of the Nijmegen Breakage Syndrome Protein
- SIRT1 and p53, effect on cancer, senescence and beyond
- SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism
- Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex
- Exercise Training Promotes SIRT1 Activity in Aged Rats
- SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
- Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
- SIRT Inhibitors Induce Cell Death and p53 Acetylation through Targeting Both SIRT1 and SIRT2
- SIRT1 regulation of apoptosis of human chondrocytes
- Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
- SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
- Progressive loss of SIRT1 with cell cycle withdrawal
- MicroRNA regulation of SIRT1
- SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
- Adiponectin Secretion Is Regulated by SIRT1 and the Endoplasmic Reticulum Oxidoreductase Ero1-Lα
- Biochemical effects of SIRT1 activators
- Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
- Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
- Mammalian Sirt1: insights on its biological functions
- Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
- Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
- Sirt1 activation protects the mouse renal medulla from oxidative injury
- Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
- Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- Deacetylation of cortactin by SIRT1 promotes cell migration
- SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
- Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands
- Metabolic benefits from Sirt1 and Sirt1 activators
- Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
- SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
- Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
- Negative regulation of inflammation by SIRT1
- Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway
- Protective Role of SIRT1 in Diabetic Vascular Dysfunction
- SIRT1 and neuronal diseases
- A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
- SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
- JNK2-dependent regulation of SIRT1 protein stability
- SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications
- Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress
- Emerging roles of SIRT1 in vascular endothelial homeostasis
- PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
- Activation of Sirt1 Decreases Adipocyte Formation During Osteoblast Differentiation of Mesenchymal Stem Cells
- Redox regulation of SIRT1 in inflammation and cellular senescence
- SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA
- SIRT1 contributes to telomere maintenance and augments global homologous recombination
- Metformin suppresses hepatic gluconeogenesis through inductionof SIRT1 and GCN5
- Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction
- Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib
- Sirt1: a metabolic master switch that modulates lifespan
- Dietary activators of Sirt1
- SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
- Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
- sirt1-null mice develop an autoimmune-like condition
- SIRT1: Tumor promoter or tumor suppressor?
- SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1
- FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression
- A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
- SIRT1 Activation Confers Neuroprotection in Experimental Optic Neuritis
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
- Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- Expression of DBC1 and SIRT1 Is Associated with Poor Prognosis of Gastric Carcinoma
- Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System
- SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
- Overexpression of SIRT1 Protects Pancreatic β-Cells Against Cytokine Toxicity by Suppressing the Nuclear Factor-κB Signaling Pathway
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
- Sirtuin 1 (SIRT1): The Misunderstood HDAC
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
- Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
- Janus-faced role of SIRT1 in tumorigenesis
- SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
- High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
- DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
- SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation
- Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
- A Review of Sirt1 and Sirt1 Modulators in Cardiovascular and Metabolic Diseases
- SIRT1-mediated acute cardioprotection
- Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
- SIRT1: roles in aging and cancer
- The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet
- Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
- SIRT1 Is a Circadian Deacetylase for Core Clock Components
- Regulation of SIRT1 protein levels by nutrient availability
- SIRT1 deacetylates APE1 and regulates cellular base excision repair
- MicroRNA 132 Regulates Nutritional Stress-Induced Chemokine Production through Repression of SirT1
- Resveratrol Protects Human Endothelium from H2O2-Induced Oxidative Stress and Senescence via SirT1 Activation
- Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
- Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
- Activation of Sirt1 by Resveratrol Inhibits TNF-α Induced Inflammation in Fibroblasts
- Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure
- Sirt1 and the Mitochondria
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- High glucose downregulates endothelial progenitor cell number via SIRT1
- Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
- NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin Tolerance
- SIRT1, metabolism and cancer
- FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- SIRT1 Promotes Cell Survival under Stress by Deacetylation-Dependent Deactivation of Poly(ADP-Ribose) Polymerase 1
- Resveratrol inhibits insulin responses in a SirT1-independent pathway
- SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
- miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
- SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
- SirT1 Is an Inhibitor of Proliferation and Tumor Formation in Colon Cancer
- SIRT1 Promotes Differentiation of Normal Human Keratinocytes
- Sirt1 activation by resveratrol is substrate sequence-selective
- Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
- Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
- miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells
- SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
- Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
- SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress
- Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
- The Roles of SIRT1 in Cancer
- The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
- Sirt1 increases skeletal muscle precursor cell proliferation
- Double Strand Breaks Can Initiate Gene Silencing and SIRT1-Dependent Onset of DNA Methylation in an Exogenous Promoter CpG Island
- NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
- SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages
- MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
- SIRT1 stimulation by polyphenols is affected by their stability and metabolism
- Control of Multidrug Resistance Gene mdr1 and Cancer Resistance to Chemotherapy by the Longevity Gene sirt1
- SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
- Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
- Cilostazol Inhibits Oxidative Stress–Induced Premature Senescence Via Upregulation of Sirt1 in Human Endothelial Cells
- Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
- MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
- The Direct Involvement of SirT1 in Insulin-induced Insulin Receptor Substrate-2 Tyrosine Phosphorylation
- Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
- Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase
- SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
- The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+
- MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
- Cellular Regulation of SIRT1
- SIRT1: Regulator of p53 Deacetylation
- SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
- SIRT1 Shows No Substrate Specificity in Vitro
- A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
- The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy
- SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
- SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions
- MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
- Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
- Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function
- The ways and means that fine tune Sirt1 activity
- SIRT1 and insulin resistance
- Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
- Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
- Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
- SIRT1 Regulates Autoacetylation and Histone Acetyltransferase Activity of TIP60
- The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells
- Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes
- Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection
- SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents
- Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage
- Inhibition of transcriptional activity of c-JUN by SIRT1
- SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
- Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS
- Role of SIRT1 in homologous recombination
- Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
- Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
- Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
- Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
- Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation
- Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
- SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma
- Structural and Functional Analysis of Human SIRT1
- SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
- Induction of apoptosis by inhibition of sirtuin SIRT1 expression
- SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
- SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
- Resveratrol and novel potent activators of Sirt1: effects on aging and age-related diseases
- SIRT1/eNOS Axis as a Potential Target against Vascular Senescence, Dysfunction and Atherosclerosis
- SIRT1 longevity factor suppresses NF‐κB ‐driven immune responses: regulation of aging via NF‐κB acetylation?
- Sirt1 protects the heart from aging and stress
- Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
- miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
- Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons
- SIRT1 Activates MAO-A in the Brain to Mediate Anxiety and Exploratory Drive
- Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
- SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress
- Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
- SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
- Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
- Targeting cardiovascular disease with novel SIRT1 pathways
- Peptide Switch Is Essential for Sirt1 Deacetylase Activity
- The anti-aging, metabolism potential of SIRT1.
- SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
- A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
- Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
- Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation
- Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways
- Controlling SIRT1 expression by microRNAs in health and metabolic disease
- Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation
- Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors
- Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
- High-intensity interval training increases SIRT1 activity in human skeletal muscle
- Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
- Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway
- Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
- The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance
- SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
- SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
- SIRT1: new avenues of discovery for disorders of oxidative
- Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21
- Neurogenesis directed by Sirt1
- Sirt1 Involvement in rd10 Mouse Retinal Degeneration
- SIRT1 metabolic actions: Integrating recent advances from mouse models
- SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis
- Expression and role of SIRT1 in hepatocellular carcinoma
- SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
- Regulation of SIRT1 activity by genotoxic stress
- Sirt1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
- SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model
- Association of SIRT1 gene variation with visceral obesity
- Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
- SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity
- Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
- TIMP3 Is Reduced in Atherosclerotic Plaques From Subjects With Type 2 Diabetes and Increased by SirT1
- SIRT1 Acts as a Modulator of Neointima Formation Following Vascular Injury in Mice
- The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
- Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
- Sirt1 Activation Ameliorates Renal Fibrosis by Inhibiting the TGF‐β/Smad3 Pathway
- Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase
- MicroRNA‐146b promotes adipogenesis by suppressing the SIRT1‐FOXO1 cascade
- The role of SIRT1 in ocular aging
- Chromatin remodeling, metabolism and circadian clocks: The interplay of CLOCK and SIRT1
- Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
- Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer
- USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development
- Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
- Negative Regulation of STAT3 Protein-mediated Cellular Respiration by SIRT1 Protein
- Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation
- MST1 Promotes Apoptosis through Regulating Sirt1-dependent p53 Deacetylation
- Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression
- SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
- SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
- SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity
- MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1
- The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
- Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: Implication in pathogenesis of COPD
- SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus
- Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria
- Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
- H2O2 Accelerates Cellular Senescence by Accumulation of Acetylated p53 via Decrease in the Function of SIRT1 by NAD+ Depletion
- Nicotinamide-induced Mitophagy EVENT MEDIATED BY HIGH NAD+/NADH RATIO AND SIRT1 PROTEIN ACTIVATION
- Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
- Overexpression of SIRT1 Protein in Neurons Protects against Experimental Autoimmune Encephalomyelitis through Activation of Multiple SIRT1 Targets
- SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis
- miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
- Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway
- Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS generation
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
- Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
- SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
- Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
- SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology
- Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1–FOXO1 signaling pathway
- MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
- SirT1 fails to affect p53‐mediated biological functions
- The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
- The controversial links among calorie restriction, SIRT1, and resveratrol
- SIRT1 Is Essential for Oncogenic Signaling by Estrogen/Estrogen Receptor α in Breast Cancer
- Sirt1 Mediates Hyperbaric Oxygen Preconditioning-Induced Ischemic Tolerance in Rat Brain
- Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
- mIGF‐1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart
- SIRT1 stabilizes PML promoting its sumoylation
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- Agrp Neurons Mediate Sirt1‘s Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
- SIRT1, STEM CELLS, AGING, AND STEM CELL AGING
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
- Exendin-4 Improves Steatohepatitis by Increasing Sirt1 Expression in High-Fat Diet-Induced Obese C57BL/6J Mice
- Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
- Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α Expression in experimental stroke
- Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
- Identification of a SIRT1 Mutation in a Family with Type 1 Diabetes
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
- Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
- The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
- ΔNp63&alpha Overexpression Induces Downregulation of Sirt1 and an Accelerated Aging Phenotype in the Mouse
- Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women
- Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice
- Activation of Sirt1 Decreases Adipocyte Formation during Osteoblast Differentiation of Mesenchymal Stem Cells
- Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
- Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
- Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
- Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2†
- SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
- Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
- SIRT1 Is a Novel Regulator of Key Pathways of Human Labor
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- SIRT1 in cardiovascular aging
- SirT1 Regulation of Antioxidant Genes Is Dependent on the Formation of a FoxO3a/PGC-1α Complex
- SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
- SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
- SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
- Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway
- The physiological roles of Sirt1 in skeletal muscle
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and Sirt1
- Balance between SIRT1 and DBC1 expression is lost in breast cancer
- SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
- CK2 Is the Regulator of SIRT1 Substrate-Binding Affinity, Deacetylase Activity and Cellular Response to DNA-Damage
- Human SIRT1: A potential biomarker for tumorigenesis?
- Regulation of SIRT1 by MicroRNAs
- SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
- Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
- Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism
- A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
- PPARα-Sirt1 Complex Mediates Cardiac Hypertrophy and Failure through Suppression of the ERR Transcriptional Pathway
- Involvement of the Histone Deacetylase SIRT1 in Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF)-interacting Protein 2-mediated Transcriptional Repression
- C/EBPα regulates SIRT1 expression during adipogenesis
- Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network
- Comparative and pharmacophore model for deacetylase SIRT1
- Stimulation of Sirt1-Regulated FoxO Protein Function by the Ligand-Bound Vitamin D Receptor
- SIRT1 gene is associated with major depressive disorder in the Japanese population
- The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
- The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
- SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
- Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
- Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver
- Sirt1 deacetylates c-Myc and promotes c-Myc/Max association
- SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
- SIRT1 Inhibition Alleviates Gene Silencing in Fragile X Mental Retardation Syndrome
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
- Sirt1: Def-eating senescence?
- Sirtuin 1 (SIRT1) Deacetylase Activity Is Not Required for Mitochondrial Biogenesis or Peroxisome Proliferator-activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation following Endurance Exercise
- A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis
- Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
- Stabilization of Suv39H1 by SirT1 Is Part of Oxidative Stress Response and Ensures Genome Protection
- A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
- Distribution Analysis of Deacetylase SIRT1 in Rodent and Human Nervous Systems
- Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
- Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
- Roles of FoxO1 and Sirt1 in the central regulation of food intake
- Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear Sirt1
- Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
- Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
- SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: Implications for vascular aging
- SIRT1 in the brain—connections with aging-associated disorders and lifespan
- Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
- Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
- Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
- SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
- Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
- Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity
- Proatherogenic Abnormalities of Lipid Metabolism in SirT1 Transgenic Mice Are Mediated through Creb Deacetylation
- Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
- BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets
- Brain Activation of SIRT1: Role in Neuropathology
- SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
- MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
- Silibinin Protects Against Isoproterenol-Induced Rat Cardiac Myocyte Injury Through Mitochondrial Pathway After Up-regulation of SIRT1
- Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity
- SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
- Function of SIRT1 in physiology
- Effect of estrogens on bone marrow adipogenesis and Sirt1 in aging C57BL/6J mice
- SIRT1 Regulates Dendritic Development in Hippocampal Neurons
- Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
- SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription
- SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
- LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells
- Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
- Identification of a Domain within Peroxisome Proliferator-Activated Receptor γ Regulating Expression of a Group of Genes Containing Fibroblast Growth Factor 21 That Are Selectively Repressed by SIRT1 in Adipocytes
- Diverse Roles of SIRT1 in Cancer Biology and Lipid Metabolism
- Resveratrol Upregulated SIRT1, FOXO1, and Adiponectin and Downregulated PPARγ1–3 mRNA Expression in Human Visceral Adipocytes
- Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
- Sirt1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
- Metabolic Stress Modulates Alzheimer’s β-Secretase Gene Transcription via SIRT1-PPARγ-PGC-1 in Neurons
- Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
- Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization
- Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
- SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD
- SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
- Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex
- Age-associated decrease of SIRT1 expression in rat hippocampus: Prevention by late onset caloric restriction
- SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth
- SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
- Tumor necrosis factor α–mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes
- Sirt1 Promotes Axonogenesis by Deacetylation of Akt and Inactivation of GSK3
- Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
- Towards elucidating the role of SirT1 in osteoarthritis.
- Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
- Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis
- Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
- Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
- SirT1 in muscle physiology and disease: lessons from mouse models
- Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
- Expression of SIRT1 in Gastric Cardiac Cancer and Its Clinicopathologic Significance
- Resveratrol Protects HUVECs from Oxidized-LDL Induced Oxidative Damage by Autophagy Upregulation via the AMPK/SIRT1 Pathway
- Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
- The Evolutionarily Conserved Longevity Determinants HCF-1 and SIR-2.1/SIRT1 Collaborate to Regulate DAF-16/FOXO
- Deacetylation by SIRT1 Reprograms Inflammation and Cancer
- Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar
- SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice
- Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases
- Metabolic actions of hypothalamic SIRT1
- SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
- SIRT1 and NAD as regulators of ageing
- Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
- The role of Sirt1: At the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
- Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network
- Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
- SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
- SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability
- SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
- SIRT1 Takes a Backseat to AMPK in the Regulation of Insulin Sensitivity by Resveratrol
- Protection by EGb 761 against β-amyloid-induced neurotoxicity: Involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
- Impact of Sirt1 on mammalian aging
- The role of SirT1 in muscle mitochondrial turnover
- SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis
- AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation
- P53 and Sirt1: Routes of metabolism and genome stability
- SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
- Aberrant Cytoplasm Localization and Protein Stability of SIRT1 is Regulated by PI3K/IGF-1R Signaling in Human Cancer Cells
- SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
- Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
- Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
- Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy
- SIRT1 Negatively Regulates the Activities, Functions, and Protein Levels of hMOF and TIP60
- The Time of Metabolism: NAD+, SIRT1, and the Circadian Clock
- Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation
- SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor pathway
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
- SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
- SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory
- mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
- Downregulation of Sirt1 as aging change in advanced heart failure
- SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas
- Resveratrol Inhibits the Growth of Gastric Cancer by Inducing G1 Phase Arrest and Senescence in a Sirt1-Dependent Manner
- SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
- Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: Involvement of SIRT1 and TGF-β1 pathway
- The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
- SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
- SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
- Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
- Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment
- Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
- SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
- Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival and Longevity
- Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy
- Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
- The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
- Emerging Roles of SIRT1 in Cancer Drug Resistance
- Multifaceted Modulation of SIRT1 in Cancer and Inflammation
- Relationship between mitochondrial DNA Copy Number and SIRT1 Expression in Porcine Oocytes
- Resveratrol Inhibits Ionising Irradiation-Induced Inflammation in MSCs by Activating SIRT1 and Limiting NLRP-3 Inflammasome Activation
- SIRT1 Contains N- and C-terminal Regions That Potentiate Deacetylase Activity
- Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis
- SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
- Sirt1 restrains lung inflammasome activation in a murine model of sepsis
- SIRT1 – An Anti-Inflammatory Pathway at the Crossroads Between Metabolic Disease and Atherosclerosis
- Silencing Insulin Resistance through SIRT1
- Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
- Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
- The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis
- DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
- Sirt1-deficient mice exhibit an altered cartilage phenotype
- miR-543 promotes gastric cancer cell proliferation by targeting SIRT1
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Resveratrol Improves Cardiac Contractility following Trauma-Hemorrhage by Modulating Sirt1
- SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
- Translating cell survival and cell longevity into treatment strategies with SIRT1
- Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: A role for Sirt1-Mef2 in adult heart
- Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress
- Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
- SIRT1: A novel target to prevent atherosclerosis
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
- ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
- SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
- SIRT1 — a metabolic sensor that controls blood vessel growth
- Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
- ATGL Promotes Autophagy/Lipophagy via SIRT1 to Control Hepatic Lipid Droplet Catabolism
- SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
- Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
- SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer
- Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
- Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
- Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor‐induced neurite outgrowth in PC12 cells
- Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
- Amurensin G, a Potent Natural SIRT1 Inhibitor, Rescues Doxorubicin Responsiveness via Down-Regulation of Multidrug Resistance 1
- Vitamin D Protects Human Endothelial Cells from H2O2 Oxidant Injury Through the Mek/Erk-Sirt1 Axis Activation
- Liver Steatosis and Increased ChREBP Expression in Mice Carrying a Liver Specific SIRT1 Null Mutation under a Normal Feeding Condition
- SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
- SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
- The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions: NAD-Dependent Histone Deacetylase SIRT1 (Sir2α)
- Sirt1 in cerebral ischemia
- SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
- FoxO-dependent and -independent mechanisms mediate SirT1 effects on IGFBP-1 gene expression
- A Dietary Regimen of Caloric Restriction or Pharmacological Activation of SIRT1 to Delay the Onset of Neurodegeneration
- Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4+ T Cells
- Sirt1 hyperexpression in SHR heart related to left ventricular hypertrophy
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- Physiological and Pathophysiological Functions of SIRT1
- Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
- Relationship between Sirt1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
- Radioprotective and Antioxidant Effect of Resveratrol in Hippocampus by Activating Sirt1
- SIRT1: Role in cardiovascular biology
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
- SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
- Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
- Resveratrol activates SIRT1 in a Lamin A-dependent manner
- Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
- Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
- Resveratrol Induces Vascular Smooth Muscle Cell Differentiation through Stimulation of SirT1 and AMPK
- A Potential Treatment of Non-Alcoholic Fatty Liver Disease with SIRT1 Activators
- The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
- Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
- Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
- Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
- Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
- Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition
- SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
- Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity
- SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells
- The role of SIRT1 in tumorigenesis
- SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
- Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
- Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein
- Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
- The role of SIRT1 in diabetic kidney disease
- Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
- Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of Sirt1 and Ku70
- SIRT1 Suppresses the Senescence-Associated Secretory Phenotype through Epigenetic Gene Regulation
- Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells
- Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation
- Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
- SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
- SIRT1 in metabolic syndrome: Where to target matters
- SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
- Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
- CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
- BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
- SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
- Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer
- Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
- Shear stress regulates endothelial cell autophagy via redox regulation and Sirt1 expression
- Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
- Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase
- SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
- p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic Mechanisms
- Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
- SIRT1 Mediates the Effect of GLP-1 Receptor Agonist Exenatide on Ameliorating Hepatic Steatosis
- Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats
- SIRT1 and AMPK Mediate Hypoxia-Induced Resistance of Non–Small Cell Lung Cancers to Cisplatin and Doxorubicin
- SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways
- Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
- Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
- SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
- Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
- Interference between PARPs and SIRT1: a novel approach to healthy ageing?
- Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
- MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function
- Fructose induces gluconeogenesis and lipogenesis through aSIRT1-dependent mechanism
- NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
- SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells
- Identification, stability and expression of Sirt1 antisense long non-coding RNA
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- A Pilot Randomized, Placebo Controlled, Double Blind Phase I Trial of the Novel SIRT1 Activator SRT2104 in Elderly Volunteers
- SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
- miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in human fibrosarcoma cells
- SIRT1 Limits the Function and Fate of Myeloid-Derived Suppressor Cells in Tumors by Orchestrating HIF-1α–Dependent Glycolysis
- Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis
- SIRT1 associates with eIF2-alpha and regulates the cellular stress response
- Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
- SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
- Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
- Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
- Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
- The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition
- The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
- Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes
- The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling
- FoxO1 and SIRT1 Regulate β-Cell Responses to Nitric Oxide
- SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
- Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
- SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
- SIRT1 and Caloric Restriction: An Insight Into Possible Trade-Offs Between Robustness and Frailty
- Induction of Sirt1 by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response
- Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
- Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
- SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
- Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
- PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
- Cross-talk between SIRT1 and p66Shc in vascular diseases
- Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
- Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
- Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
- SirT1 brings stemness closer to cancer and aging
- SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
- Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1
- SirT1 brings stemness closer to cancer and aging
- SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
- SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
- High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
- Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors
- Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells
- Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
- Testosterone Deficiency Accelerates Neuronal and Vascular Aging of SAMP8 Mice: Protective Role of eNOS and SIRT1
- Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
- Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits
- PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
- Critical Reviews™ in Eukaryotic Gene Expression
- Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells
- NO Targets SIRT1
- SIRT1 Directly Regulates SOX2 to Maintain Self‐Renewal and Multipotency in Bone Marrow‐Derived Mesenchymal Stem Cells
- Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
- Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
- SIRT1 Regulation of Wakefulness and Senescence-Like Phenotype in Wake Neurons
- SIRT1 Positively Regulates Breast Cancer Associated Human Aromatase (CYP19A1) Expression
- PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
- SIRT1 modulation of adipogenesis and adipose function
- Changes in SIRT1 Expression and Its Downstream Pathways in Age-Related Cataract in Humans
- The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation
- The SIRT1 Modulators AROS and DBC1 Regulate HSF1 Activity and the Heat Shock Response
- Curcumin pretreatment attenuates inflammation and mitochondrial dysfunction in experimental stroke: The possible role of Sirt1 signaling
- Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- Resveratrol is neuroprotective because it is not a direct activator of Sirt1—A hypothesis
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
- Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model
- Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
- Expression of SIRT1 and DBC1 Is Associated with Poor Prognosis of Soft Tissue Sarcomas
- Tat-SIRT1 Tango
- Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
- Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
- SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
- High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
- Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
- Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
- Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene
- Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
- Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues
- SIRT1 and insulin resistance
- The ups and downs of SIRT1
- SIRT1: recent lessons from mouse models
- Phosphorylation of HuR by Chk2 regulates SIRT1 expression
- Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
- Phosphorylation regulates SIRT1 function
- Protective roles of SIRT1 in atherosclerosis
- Mammalian SIRT1: insights on its biological functions
- SIRT1 regulates aging and resistance to oxidative stress in the heart
- Mechanism of human SIRT1 activation by resveratrol
- JNK1 phosphorylates SIRT1 and promotes its enzymatic activity
- Regulation of SIRT1 in cellular functions: role of polyphenols
- Metabolic benefits from SIRT1 and SIRT1 activators
- A review of SIRT1 and SIRT1 modulators in cardiovascular and metabolic diseases
- SIRT1 is significantly elevated in mouse and human prostate cancer
- AMPK and SIRT1: a long-standing partnership?
- How does SIRT1 affect metabolism, senescence and cancer?
- Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
- SIRT1 and endocrine signaling
- DBC1 is a negative regulator of SIRT1
- SIRT1 and neuronal diseases
- SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
- Tissue-specific regulation of SIRT1 by calorie restriction
- Shear stress, SIRT1, and vascular homeostasis
- JNK2-dependent regulation of SIRT1 protein stability
- SIRT1 regulates adipose tissue inflammation
- The critical role of the class III histone deacetylase SIRT1 in cancer
- SIRT1 controls endothelial angiogenic functions during vascular growth
- Function of the SIRT1 protein deacetylase in cancer
- SIRT1: roles in aging and cancer
- Cellular regulation of SIRT1
- A role for the NAD-dependent deacetylase SIRT1 in the regulation of autophagy
- Increase in activity during calorie restriction requires SIRT1
- Regulation of SIRT1 protein levels by nutrient availability
- A novel pathway regulates memory and plasticity via SIRT1 and miR-134
- SIRT1 is essential for normal cognitive function and synaptic plasticity
- Biochemical effects of SIRT1 activators
- Progressive loss of SIRT1 with cell cycle withdrawal
- Emerging roles of SIRT1 in vascular endothelial homeostasis
- SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
- Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
- SIRT1, is it a tumor promoter or tumor suppressor?
- Metabolic adaptations through the PGC-1α and SIRT1 pathways
- Resveratrol is not a direct activator of SIRT1 enzyme activity
- Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
- SIRT1 and p53, effect on cancer, senescence and beyond
- SIRT1 protects against high-fat diet-induced metabolic damage
- SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease
- Cytoplasm‐localized SIRT1 enhances apoptosis
- Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
- SIRT1 regulation of apoptosis of human chondrocytes
- Caloric restriction, SIRT1 and longevity
- Protective role of SIRT1 in diabetic vascular dysfunction
- Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
- Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
- SIRT1 is a novel regulator of key pathways of human labor
- Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
- Expression and role of SIRT1 in hepatocellular carcinoma
- Brain SIRT1: anatomical distribution and regulation by energy availability
- Calorie restriction, SIRT1 and metabolism: understanding longevity
- Mammalian SIRT1 represses forkhead transcription factors
- Hormonal control of androgen receptor function through SIRT1
- SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- SIRT1 transgenic mice show phenotypes resembling calorie restriction
- SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
- SIRT1 shows no substrate specificity in vitro
- SIRT1 regulates energy metabolism and response to caloric restriction in mice
- SIRT1 modulation as a novel approach to the treatment of diseases of aging
- SIRT1 is an inhibitor of proliferation and tumor formation in colon cancer
- SIRT1 gain of function increases energy efficiency and prevents diabetes in mice
- Dietary activators of SIRT1
- miR-34a repression of SIRT1 regulates apoptosis
- SIRT1-null mice develop an autoimmune-like condition
- SIRT1: regulation of longevity via autophagy
- SIRT1 negatively regulates the mammalian target of rapamycin
- The interaction between FOXO and SIRT1: tipping the balance towards survival
- STAT3 inhibition of gluconeogenesis is downregulated by SIRT1
- SIRT1 stimulation by polyphenols is affected by their stability and metabolism
- Negative regulation of the deacetylase SIRT1 by DBC1
- SIRT1 improves healthy ageing and protects from metabolic syndrome-associated cancer
- SIRT1 modulates premature senescence-like phenotype in human endothelial cells
- Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
- SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
- Exercise training promotes SIRT1 activity in aged rats
- SIRT1 regulates the function of the Nijmegen breakage syndrome protein
- Interactions between E2F1 and SIRT1 regulate apoptotic response to DNA damage
- A c-Myc–SIRT1 feedback loop regulates cell growth and transformation
- The physiological roles of SIRT1 in skeletal muscle
- SIRT1 acts as a modulator of neointima formation following vascular injury in mice
- FoxO1 mediates an autofeedback loop regulating SIRT1 expression
- SIRT1 deacetylates and positively regulates the nuclear receptor LXR
- Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
- Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
- Stabilization of Suv39H1 by SIRT1 is part of oxidative stress response and ensures genome protection
- SIRT1-mediated acute cardioprotection
- Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
- SIRT1 regulates circadian clock gene expression through PER2 deacetylation
- SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes
- Role of SIRT1 in homologous recombination
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease
- Inhibition of transcriptional activity of c-JUN by SIRT1
- Age‐associated loss of SIRT1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific SIRT1‐overexpressing (BESTO) mice
- Hypothalamic SIRT1 regulates food intake in a rodent model system
- Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress
- SIRT1 genetic variation is related to BMI and risk of obesity
- Modulation of SIRT1 expression in different neurodegenerative models and human pathologies
- Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
- SIRT1: a metabolic master switch that modulates lifespan
- miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
- SIRT1 contributes critically to the redox-dependent fate of neural progenitors
- A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells
- SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
- Expression and prognostic significance of SIRT1 in ovarian epithelial tumours
- SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
- The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
- A protein deacetylase SIRT1 is a negative regulator of metalloproteinase‐9
- SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- Controlling SIRT1 expression by microRNAs in health and metabolic disease
- Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
- The anti-aging, metabolism potential of SIRT1.
- PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
- SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
- SIRT1 activation protects the mouse renal medulla from oxidative injury
- SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR♦
- SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Function of SIRT1 in physiology
- SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis
- Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
- SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
- SIRT1 increases skeletal muscle precursor cell proliferation
- SIRT1 promotes DNA repair activity and deacetylation of Ku70
- Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
- Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
- SIRT1 regulates HIV transcription via Tat deacetylation
- DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
- SIRT1 protects the heart from aging and stress
- SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
- SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis
- SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress
- Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
- Human SIRT1 interacts with histone H1 and promotes formation of facultative heterochromatin
- Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells
- Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
- Age related changes in NAD+ metabolism oxidative stress and SIRT1 activity in wistar rats
- The expression of SIRT1 in nonalcoholic fatty liver disease induced by high‐fat diet in rats
- SIRT1 deficiency attenuates spermatogenesis and germ cell function
- SIRT1 in muscle physiology and disease: lessons from mouse models
- SIRT1 involvement in rd10 mouse retinal degeneration
- High-intensity interval training increases SIRT1 activity in human skeletal muscle
- Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
- Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma
- SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
- Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma
- Association of SIRT1 gene variation with visceral obesity
- Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1
- Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
- SIRT1 regulates UV-induced DNA repair through deacetylating XPA
- Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
- Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis
- Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
- Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
- The role of SIRT1 in tumorigenesis
- Low SIRT1 expression, which is upregulated by fasting, in human adipose tissue from obese women
- SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/-mice
- The type III histone deacetylase SIRT1 is essential for maintenance of T cell tolerance in mice
- Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
- Deacetylation of cortactin by SIRT1 promotes cell migration
- SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance
- SIRT1 gene is associated with major depressive disorder in the Japanese population
- SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
- SIRT1 contributes to telomere maintenance and augments global homologous recombination
- Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
- SIRT1 deacetylates APE1 and regulates cellular base excision repair
- Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage
- SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
- Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-Lα
- SIRT1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation
- SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
- SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma
- SIRT1: tumor promoter or tumor suppressor?
- SIRT1 activation confers neuroprotection in experimental optic neuritis
- Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
- Resveratrol regulates human adipocyte number and function in a SIRT1-dependent manner
- SIRT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1
- Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
- The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
- Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
- SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities
- Peptide switch is essential for SIRT1 deacetylase activity
- SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
- Activation of SIRT1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts
- SIRT1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
- Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
- The direct involvement of SIRT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
- Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase
- Physiological and pathophysiological functions of SIRT1
- Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
- SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1, 2 and HMGCS1, 2
- SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Roles of SIRT1 in the acute and restorative phases following induction of inflammation
- SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model
- Expression of SIRT1 in gastric cardiac cancer and its clinicopathologic significance
- SIRT1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
- Modulation of SIRT1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes
- SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2
- The NAD World: a new systemic regulatory network for metabolism and aging—SIRT1, systemic NAD biosynthesis, and their importance
- Balance between SIRT1 and DBC1 expression is lost in breast cancer
- Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
- Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
- Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson’s disease
- Human SIRT1: a potential biomarker for tumorigenesis?
- RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
- Overexpression of SIRT1 protects pancreatic β-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway
- SIRT1 is a circadian deacetylase for core clock components
- SIRT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
- SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance
- SIRT1-dependent regulation of chromatin and transcription: linking NAD+ metabolism and signaling to the control of cellular functions
- SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1: possible role in AMP-activated protein kinase activation
- Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems
- SIRT1 fails to affect p53‐mediated biological functions
- Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
- High glucose downregulates endothelial progenitor cell number via SIRT1
- Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
- SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology
- SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
- Neurogenesis directed by SIRT1
- Lysine deacetylation in ischaemic preconditioning: the role of SIRT1
- miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
- SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
- Regulation of cartilage-specific gene expression in human chondrocytes by SIRT1 and nicotinamide phosphoribosyltransferase
- Control of AIF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
- Kidney-specific overexpression of SIRT1 protects against acute kidney injury by retaining peroxisome function
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
- Resveratrol protects human endothelium from H2O2-induced oxidative stress and senescence via SIRT1 activation
- Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK–SIRT1–PGC-1α pathway
- Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
- Roles of FoxO1 and SIRT1 in the central regulation of food intake
- SIRT1 is a redox‐sensitive deacetylase that is post‐translationally modified by oxidants and carbonyl stress
- Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation
- SIRT1 deacetylates c-Myc and promotes c-Myc/Max association
- Calorie restriction enhances cell adaptation to hypoxia through SIRT1-dependent mitochondrial autophagy in mouse aged kidney
- Translating cell survival and cell longevity into treatment strategies with SIRT1
- Deacetylation of FoxO by SIRT1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
- Macrophage α1 AMP-activated protein kinase (α1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
- The controversial links among calorie restriction, SIRT1, and resveratrol
- Resveratrol inhibits insulin responses in a SIRT1-independent pathway
- SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein α transcriptional complex
- SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly (ADP-ribose) polymerase 1
- The role of SIRT1: at the crossroad between promotion of longevity and protection against Alzheimer’s disease neuropathology
- Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation
- Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
- SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
- SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer
- FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
- Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy
- Role of sirtuin histone deacetylase SIRT1 in prostate cancer: a target for prostate cancer management via its inhibition?
- Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection
- ΔNp63&alpha overexpression induces downregulation of SIRT1 and an accelerated aging phenotype in the mouse
- Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
- Impact of SIRT1 on mammalian aging
- Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
- SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice
- A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development
- Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
- The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD+
- SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis
- PPARα-SIRT1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway
- #VALUE!
- Hepatic SIRT1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
- Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
- SIRT1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras–MAPK signaling in human cancer cells
- Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the SIRT1 pathway
- SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling
- Melatonin, a novel SIRT1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
- The SIRT1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
- SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60
- SIRT1 hyperexpression in SHR heart related to left ventricular hypertrophy
- Cigarette smoke-induced autophagy is regulated by SIRT1–PARP-1-dependent mechanism: implication in pathogenesis of COPD
- Relationship between SIRT1 expression and mitochondrial proteins during conditions of chronic muscle use and disuse
- Regulation of MEF2 by histone deacetylase 4-and SIRT1 deacetylase-mediated lysine modifications
- SIRT1 Gene, Age-Related Diseases, and Mortality: The Leiden 85-Plus Study
- Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype
- Interaction of aging-associated signaling cascades: Inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1
- Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin
- Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
- Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
- SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling
- Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells
- SIRT1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
- PPARβ/δ regulates the human SIRT1 gene transcription via Sp1
- SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol
- SIRT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
- Cilostazol inhibits oxidative stress–induced premature senescence via upregulation of SIRT1 in human endothelial cells
- NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance
- SIRT1 and mir‐9 expression is regulated during glucose‐stimulated insulin secretion in pancreatic β‐islets
- SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts
- SIRT1 Is a Regulator of Bone Mass and a Repressor of Sost Encoding for Sclerostin, a Bone Formation Inhibitor
- Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway
- Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/− Mice: A Role of Lipid Mobilization and Inflammation
- SIRT1 longevity factor suppresses NF‐κB‐driven immune responses: regulation of aging via NF‐κB acetylation?
- Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1–FoxO1 pathway
- SIRT1 takes a backseat to AMPK in the regulation of insulin sensitivity by resveratrol
- SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
- Interference between PARPs and SIRT1: a novel approach to healthy ageing?
- Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle
- Agrp neurons mediate SIRT1‘s action on the melanocortin system and energy balance: roles for SIRT1 in neuronal firing and synaptic plasticity
- Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands
- Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
- Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene SIRT1
- Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor γ coactivator-1α protein expressions in rat skeletal muscle
- Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice
- CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
- Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2
- CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability
- SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53
- Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1α expression in experimental stroke
- Metabolic regulation of SIRT1 transcription via a HIC1: CtBP corepressor complex
- Tumor necrosis factor α–mediated cleavage and inactivation of SIRT1 in human osteoarthritic chondrocytes
- Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SIRT1 expression
- Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1
- Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
- SIRT1: a novel target to prevent atherosclerosis
- SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
- Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy
- Do we age on SIRT1 expression?
- SIRT1—a metabolic sensor that controls blood vessel growth
- Proatherogenic abnormalities of lipid metabolism in SIRT1 transgenic mice are mediated through Creb deacetylation
- Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis
- SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL
- SIRT1, stem cells, aging, and stem cell aging
- Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins
- Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis
- The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation
- Role of p53 in the anti-proliferative effects of SIRT1 inhibition in prostate cancer cells
- C/EBPα regulates SIRT1 expression during adipogenesis
- The SIRT1 activator resveratrol protects SK‐N‐BE cells from oxidative stress and against toxicity caused by α‐synuclein or amyloid‐β (1‐42) peptide
- Activation of SIRT1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
- SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53
- A role for SIRT1 in the hypoxic response
- Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation
- SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts
- Inhibition of SIRT1 deacetylase suppresses estrogen receptor signaling
- Role of NAD‐dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin‐induced cell death in vertebrate cells
- SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
- Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients
- SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
- Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin‐like growth factor receptor …
- Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis
- Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway
- SIRT1 plays an important role in mediating greater functionality of human ES/iPS-derived vascular endothelial cells
- Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
- H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion
- SIRT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
- Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes
- Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type‐2 diabetes
- Nutrient-dependent regulation of PGC-1α’s acetylation state and metabolic function through the enzymatic activities of SIRT1/GCN5
- SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells
- Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase
- SIRT1 associates with eIF2-alpha and regulates the cellular stress response
- SIRT1 transcription is decreased in visceral adipose tissue of morbidly obese patients with severe hepatic steatosis
- SIRT1 confers protection against UVB‐ and H2O2‐induced cell death via modulation of p53 and JNK in cultured skin keratinocytes
- Comparative and pharmacophore model for deacetylase SIRT1
- Mediobasal hypothalamic SIRT1 is essential for resveratrol’s effects on insulin action in rats
- SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription
- Induction of hypothalamic SIRT1 leads to cessation of feeding via agouti-related peptide
- SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
- Changes in SIRT1 expression and its downstream pathways in age-related cataract in humans
- SIRT1 stabilizes PML promoting its sumoylation
- Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells
- The LXXLL motif of murine forkhead transcription factor FoxO1 mediates SIRT1-dependent transcriptional activity
- Effect of estrogens on bone marrow adipogenesis and SIRT1 in aging C57BL/6J mice
- Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
- Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti‐aging and metabolic effects of sirtuins
- SIRT1 variants are associated with aging in a healthy Han Chinese population
- Stimulation of SIRT1-regulated FoxO protein function by the ligand-bound vitamin D receptor
- The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
- The time of metabolism: NAD+, SIRT1, and the circadian clock
- SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α …
- The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis
- Silencing insulin resistance through SIRT1
- Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-κB pathways and inhibition of intracellular ROS/RNS …
- PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
- Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells
- SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA
- SIRT1 inhibits angiotensin II-induced vascular smooth muscle cell hypertrophy
- Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via SIRT1–FOXO1 signaling pathway
- Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress
- SIRT1 brings stemness closer to cancer and aging
- Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition
- The histone deacetylase SIRT1 controls male fertility in mice through regulation of hypothalamic-pituitary gonadotropin signaling
- Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β-cells and human islets through a SIRT1-dependent mechanism
- … Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically …
- SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced
- Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1-and HEY2-mediated transcriptional repression
- Early apoptotic vascular signaling is determined by SIRT1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation
- Resveratrol attenuates doxorubicin-induced cardiomyocyte apoptosis in mice through SIRT1-mediated deacetylation of p53
- Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al 2 O 3 ) …
- SIRT1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol
- MST1 promotes apoptosis through regulating SIRT1-dependent p53 deacetylation
- Role of SIRT1 in heat stress-and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cells
- Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats: involvement of SIRT1 and TGF-β1 pathway
- Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide
- Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors
- SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons
- FoxO1 and SIRT1 regulate β-cell responses to nitric oxide
- Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network
- Amurensin G, a potent natural SIRT1 inhibitor, rescues doxorubicin responsiveness via down-regulation of multidrug resistance 1
- Resveratrol is neuroprotective because it is not a direct activator of SIRT1—A hypothesis
- Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1–3 mRNA expression in human visceral adipocytes
- Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of SIRT1 in diabetic Wistar …
- Disruption of a SIRT1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
- Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
- #VALUE!
- p16INK4a Suppression by Glucose Restriction Contributes to Human Cellular Lifespan Extension through SIRT1-Mediated Epigenetic and Genetic …
- Inhibition of SIRT1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells
- Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats
- SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells
- Downregulation of SIRT1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells
- SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians
- SIRT1 modulates high‐mobility group box 1‐induced osteoclastogenic cytokines in human periodontal ligament cells
- Aging and exercise affect the level of protein acetylation and SIRT1 activity in cerebellum of male rats
- SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome
- A functional link between SIRT1 deacetylase and NBS1 in DNA damage response
- SIRT1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor κB-mediated transcription
- Could SIRT1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?
- SIRT1 and caloric restriction: an insight into possible trade-offs between robustness and frailty
- Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells
- Induction of SIRT1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
- SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox
- Distribution of the longevity gene product, SIRT1, in developing mouse organs
- A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression
- Roles of SIRT1 in high glucose-induced endothelial impairment: association with diabetic atherosclerosis
- Activating SIRT1: a new strategy to prevent atherosclerosis?
- Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional …
- Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via SIRT1 expression
- SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase
- SIRT1—a sensor for monitoring self-renewal and aging process in retinal stem cells
- Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor α activity and co-activator synergy
- Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2α)
- Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic …
- Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) …
- Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically‐obese db/db …
- SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183
- SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
- Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC‐1α by PRMT1 and SIRT1
- FoxO-dependent and-independent mechanisms mediate SIRT1 effects on IGFBP-1 gene expression
- A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells
- Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
- Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1
- Genetic study between SIRT1, PPARD, PGC-1 α genes and Alzheimer’s disease
- SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age‐related neoplasms
- SIRT1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint exercise: influence of glucose ingestion
- Akt/FOXO3a/SIRT1-Mediated Cardioprotection by n-Tyrosol against Ischemic Stress in Rat in Vivo Model of Myocardial Infarction: Switching Gears toward Survival …
- Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation
- Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by SIRT1 and FoxO1
- Proteomic analyses of SIRT1-mediated cisplatin resistance in OSCC cell line
- AROuSing SIRT1: identification of a novel endogenous SIRT1 activator
- SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
- Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation
- Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates β-catenin signaling and NFκB-specific transcription activity leading to MDR1 and Bcl-xL gene …
- Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function
- Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1‐independent sensitization to TRAIL‐induced apoptosis
- SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications
- Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin-and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile
- SIRT1 links CIITA deacetylation to MHC II activation
- Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
- Resveratrol with antioxidant activity inhibits matrix metalloproteinase via modulation of SIRT1 in human fibrosarcoma cells
- Overexpression of SIRT1 in mouse forebrain impairs lipid/glucose metabolism and motor function
- Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
- SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a
- SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kγ activity through deacetylation of specific lysine residues in mammals
- SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention–the TULIP Study
- The type III histone deacetylase SIRT1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation
- Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1
- Dual role of Zn2+ in maintaining structural integrity and suppressing deacetylase activity of SIRT1
- Resveratrol prevents antibody-induced apoptotic death of retinal cells through upregulation of SIRT1 and Ku70
- NO targets SIRT1: a novel signaling network in endothelial senescence
- Low-frequency electroacupuncture improves insulin sensitivity in obese diabetic mice through activation of SIRT1/PGC-1 in skeletal muscle
- SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
- Delivery of Oct4 and SIRT1 with cationic polyurethanes-short branch PEI to aged retinal pigment epithelium
- SIRT1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX
- Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis
- PARP-2 regulates SIRT1 expression and whole-body energy expenditure
- Involvement of the p65/RelA subunit of NF-κB in TNF-α-induced SIRT1 expression in vascular smooth muscle cells
- Effects of resveratrol on NO secretion stimulated by insulin and its dependence on SIRT1 in high glucose cultured endothelial cells
- BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression
- Interactions between DBC1 and SIRT1 are deregulated in breast cancer cells
- SIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity
- SIRT1 and SIRT5 activity expression and behavioral responses to calorie restriction
- Aberrant expression pattern of histone acetylation modifiers and mitigation of lupus by SIRT1-siRNA in MRL/lpr mice
- Acute and long-term nutrient-led modifications of gene expression: potential role of SIRT1 as a central co-ordinator of short and longer-term programming of tissue …
- Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic …
- SIRT1: a guardian at the gates of adipose tissue inflammation
- Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor γ transactivation
- Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells
- Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1
- The role of SIRT1 in renal rejuvenation and resistance to stress
- Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
- Tat-SIRT1 tango
- Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
- Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells
- Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX
- Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
- Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index
- A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide
- Upregulation of SIRT1 deacetylase in phenylephrine-treated cardiomyoblasts
- Serum withdrawal up‐regulates human SIRT1 gene expression in a p53‐dependent manner
- Hexosamines stimulate apoptosis by altering SIRT1 action and levels in rodent pancreatic β-cells.
- Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML
- Nicotinamide phosphoribosyltransferase is essential for interleukin-1β-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal …
- Ambient glucose levels qualify the potency of insulin myogenic actions by regulating SIRT1 and FoxO3a in C2C12 myocytes
- Limited role of SIRT1 in cancer protection by dietary restriction
- Zyxin is a novel interacting partner for SIRT1
- Influence of aging and hemorrhage injury on SIRT1 expression: possible role of myc-SIRT1 regulation in mitochondrial function
- From heterochromatin islands to the NAD World: a hierarchical view of aging through the functions of mammalian SIRT1 and systemic NAD biosynthesis
- Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the α-myosin heavy chain expression
- Is SIRT1 a miracle bullet for longevity?
- Nε-Modified lysine containing inhibitors for SIRT1 and SIRT2
- … receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1
- Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice
- Does hypothalamic SIRT1 regulate aging?
- Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
- Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin’s protection against UV-induced A375-S2 cell apoptosis
- WldS enhances insulin transcription and secretion via a SIRT1-dependent pathway and improves glucose homeostasis
- Metabolic signals regulate SIRT1 expression
- Old drug acquires new target: metformin and SIRT1
- Resveratrol induces SIRT1-and energy–stress-independent inhibition of tumor cell regrowth after low-dose platinum treatment
- MiR-34, SIRT1, and p53: the feedback loop
- Food restriction improves glucose and lipid metabolism through SIRT1 expression: a study using a new rat model with obesity and severe hypertension
- Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?
- Calorie restriction and obesity under the regulation of SIRT1
- Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SIRT1 activity
- Resveratrol (trans‐3, 5, 4′‐trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF‐κB
- SIRT1 performs a balancing act on the tight-rope toward longevity
- p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence
- SIRT1 deficiency attenuates MPP+-induced apoptosis in dopaminergic cells
- Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca 2+ and AMPK/SIRT1
- SIRT1 protein levels in cancer: Tuning SIRT1 to the needs of a cancer cell
- Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation
- Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1
- Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis
- CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes
- Regulatory role of SIRT1 on the gene expression of fatty acid‐binding protein 3 in cultured porcine adipocytes
- Effects of caloric restriction on SIRT1 expression and apoptosis of islet beta cells in type 2 diabetic rats
- Restriction of advanced glycation end products improves insulin resistance in human type 2 diabetes: potential role of AGER1 and SIRT1
- Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity
- MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating SIRT1
- Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1
- Design, synthesis, enzyme inhibition, and tumor cell growth inhibition of 2-anilinobenzamide derivatives as SIRT1 inhibitors
- Is systemic activation of SIRT1 beneficial for ageing-associated metabolic disorders?
- TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SIRT1
- Poly (ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction
- Red wine decreases asymmetric dimethylarginine via SIRT1 induction in human endothelial cells
- Anticancer Effects of 15d-Prostaglandin-J2 in Wild-Type and Doxorubicin-Resistant Ovarian Cancer Cells: Novel Actions on SIRT1 and HDAC
- Pharmacophore mapping and virtual screening for SIRT1 activators
- Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
- Sirtuin 1 (SIRT1) the misunderstood HDAC
- Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
- Substrate specificity of SIRT1-catalyzed lysine Nε-deacetylation reaction probed with the side chain modified Nε-acetyl-lysine analogs
- Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats
- Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers
- … peroxisome proliferator-activated receptor γ regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in …
- MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SIRT1
- Increased expression of miR-34a and miR-93 in rat liver during aging, and their impact on the expression of Mgst1 and SIRT1
- A nutrient‐sensitive interaction between SIRT1 and HNF‐1α regulates Crp expression
- High dose of dietary resveratrol enhances insulin sensitivity in healthy rats but does not lead to metabolite concentrations effective for SIRT1 expression
- Dual targeting of the antagonistic pathways mediated by SIRT1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Determinants of serum-induced SIRT1 expression in older men: the CHAMP study
- Roles of SIRT1 and phosphoinositide 3-OH kinase/protein kinase C pathways in evodiamine-induced human melanoma A375-S2 cell death
- Anti-aging protein SIRT1: A role in cervical cancer?
- SIRT1 deacetylase activity and the maintenance of protein homeostasis in response to stress: an overview
- Dysregulation of Myeloid‐specific Transcription Factors in Congenital Neutropenia: Rescue by NAMPT/NAD+/SIRT1
- SIRT1 inhibitory diterpenoids from the Vietnamese medicinal plant Croton tonkinensis
- Impact of 6-mo caloric restriction on myocardial ischemic tolerance: possible involvement of nitric oxide-dependent increase in nuclear SIRT1
- The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO
- Comparative deacetylase activity of wild type and mutants of SIRT1
- Discovery of oxazolo [4, 5-b] pyridines and related heterocyclic analogs as novel SIRT1 activators
- SIRT1, notch and stem cell” age asymmetry”
- Glucagon-like peptide 1 inhibits the sirtuin deacetylase SIRT1 to stimulate pancreatic β-cell mass expansion
- PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity
- Protection by EGb 761 against β-amyloid-induced neurotoxicity: involvement of NF-κB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation
- Resveratrol inhibited Tat-induced HIV-1 LTR transactivation via NAD+-dependent SIRT1 activity
- Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
- Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors
- Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology
- A novel role of SIRT1 in sildenafil induced cardioprotection in mice
- p53-, SIRT1-, and PARP-1-independent downregulation of p21WAF1 expression in nicotinamide-treated cells
- Decreased SIRT1 expression and LKB1 phosphorylation occur with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase
- Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats
- Silencing metabolic disorders by novel SIRT1 activators
- WldS Reduces Paraquat-Induced Cytotoxicity via SIRT1 in Non-Neuronal Cells by Attenuating the Depletion of NAD
- Ethanol extracts of black pepper or turmeric down-regulated SIRT1 protein expression in Daudi culture cells
- High fat diet increases and the polyphenol, S17834, decreases acetylation of the SIRT1-dependent lysine-382 on p53 and apoptotic signaling in …
- Effects of resveratrol on pig primary preadipocytes proliferation, differentiation and transcription expression of SIRT1 gene
- SIRT1 promotes DNA damage repair and cellular survival
- Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
- Negative regulation of stress‐induced matrix metalloproteinase‐9 by SIRT1 in skin tissue
- Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1α in mice in vivo
- A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of SIRT1 in the metabolic regulation of caspase-2
- Functional interplay between Parp-1 and SIRT1 in genome integrity and chromatin-based processes
- Correction: Corrigendum: SIRT1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
- Intra-arterial targeted islet-specific expression of SIRT1 protects β cells from streptozotocin-induced apoptosis in mice
- Poly (ADP‐ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes
- SIRT1 as a key regulator orchestrating the response to caloric restriction
- Isolation of megastigmane sesquiterpenes from the silkworm (Bombyx mori L.) droppings and their promotion activity on HO-1 and SIRT1
- SIRT1 Activation Mediates Sildenafil-Induced Cardioprotection Against Ischemia/Reperfusion Injury in Mice
- Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1
- … acid B protects beta-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2–HO-1 and SIRT1
- SIRT1 as a new therapeutic target in metabolic and age-related diseases
- EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1
- Real-time fluorescence imaging of SIRT1 cytosolic translocation under the treatment of growth factor deprivation
- SIRT1, p53 and mitotic chromosomes
- High-affinity Na+-dependent dicarboxylate cotransporter promotes cellular senescence by inhibiting SIRT1
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- Bone and calcium update; diagnosis and therapy of bone metabolism disease update. Regulatory Mechanism of Mammalian Sirtuin SIRT1 in Vascular calcification …
- Effects of 2-deoxyglucose and dehydroepiandrosterone on intracellular NAD+ level, SIRT1 activity and replicative lifespan of human Hs68 cells
- No significant association between SIRT1 gene and methamphetamine‐induced psychosis in the Japanese population
- Myocardial SIRT1 expression following endurance and resistance exercise training in young and old rats
- SIRT1 and neurodegenerative diseases
- Targeting SIRT1-a multitasker
- Genetic and expression analysis of the SIRT1 gene in gastric cancers
- Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in …
- Resveratrol (trans-3, 5, 4′-trihydroxystilbene) induces SIRT1 and down-regulates NF-κB activation to abrogate DSS-induced colitis
- Identification of single nucleotide polymorphisms of SCD and SIRT1 and evaluation of their genetic diversities in chickens
- Not miR-ly aging: SIRT1 boosts memory via a microRNA-dependent mechanism
- Inhibition of SIRT1 increases EZH2 protein level and enhances the repression of EZH2 on target gene expression
- Effect of SIRT1 gene on cardiac function and life
- SIRT1 enhances survival of human osteoarthritic chondrocytes by repressing PTP1B and activating the IGF receptor pathway
- Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells
- Nicotinamide, a Recognized Inhibitor of SIRT1, Promotes Expansion in Ex Vivo Cultures of Short and Long-Term Repopulating Cells.
- SIRT1 inhibits IL-1β mRNA transcription in lipopolysaccharide tolerant THP-1 cells
- Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1
- SIRT1 increases satellite cell cycle progression
- 3D-QSAR of SIRT1 activators targeting against diet-induced metabolic syndrome
- Research progression of deacetylase (SIRT1)
- Disruption of Igfbp1 fails to rescue the phenotype of SIRT1−/− mice
- iNOS inactivates SIRT1, a key regulator of stress resistance and metabolism, by S-Nitrosylation
- Abstract SY11-03: SIRT1 transgenic and cancer models
- Effects of resveratrol on SIRT1 expression, eNOS activity and NO secretion of hyperlipid cultured HUVEC
- SIRT1: a novel adipocyte and myocyte regulatory factor
- Toward productive aging: SIRT1, systemic NAD biosynthesis, and the NAD world
- Expression of SIRT1 in primary human uveal melanoma
- Involvement of SIRT1 in mouse myocardial hypertrophy induced by isorenin [J]
- Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- SIRT1 regulates bone mass in vivo through regulation of osteoblast and osteoclast differentiation
- The antioxidative role of SIRT1/PGC-1α pathway in Parkinson disease
- SIRT1 activators promote p65 deacetylation and suppress TNFa stimulated NF‐kB activation
- Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SIRT1-independent pathway in LβT2 gonadotrope cells
- Overexpression of SIRT1, a Longevity Gene-Encoded Protein, and Induction of Apoptosis by Its Inhibition In Adult T-Cell Leukemia Cells
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- SIRT1 expression in adult acute leukemia and its clinical significance [J]
- Overexpression of the Sirtuin SIRT1 Increases Insulin Sensitivity in Aging Mice.
- Development of Fluorescent Quantitative PCR Assay for Porcine SIRT1 Gene
- Nox4 regulates cellular survival by modulating FoxO3a activity and SIRT1 expression
- Neuroprotective mechanisms of SIRT1
- Mechanism of SIRT1 acting on tumor formation
- SIRT1, a Stress-responsive Deacetylase is Required for Development of Compensatory Cardiac Hypertrophy
- The race to control aging and diseases: Sir2/SIRT1 against Ras, TOR and Akt/S6K
- SIRT1 overexpression modifies cardiac energy metabolism
- SIRT1 activator SRT1720 suppresses inflammatory reaction in OVA-induced asthma model mouse
- SIRT1 is not required for exercise‐induced mitochondrial biogenesis, but maintains basal organelle content and function
- Both the Activity and Stability of the Transcriptional Repressor PLZF Are Modified by the Class III Histone Deacetylase SIRT1.
- Long-Term Calorie Restriction increases SIRT1 expression and Inhibits Vascular Senescence in Mice
- Reduced SIRT1 leads to increased Th2 cytokine expression via hyper-acetylation of GATA3
- SIRT1 and adult stem cell senescence
- Mechanism of regulating deacetylase SIRT1 expression and activity.
- SIRT1 Deficiency Suppresses the Maintenance of Hematopoietic Stem Cell Pool.
- SIRT1, a Longevity Gene Encoded Protein, Regulates Apoptosis of Adult T-Cell Leukemia Cells and Its Inhibition by Sirtinol Induces Apoptosis.
- The Longevity Factor SIRT1 Protects Heart from Ischemia/Reperfusion Stress
- SIRT1 and Ku70 expression in acute leukemia and its clinical significance
- SIRT1 regulates human vascular smooth muscle cell Lifespan
- Upregulation of SIRT1 protects lens epithelial cells in oxidative conditions and cataract formation in humans
- Role of SIRT1 in Proliferation and Self-Renewal of Mouse Embryonic Stem Cells.
- SIRT1 controls endothelial angiogenic functions during vascular growth and maturation
- SIRT1 diminishes atherogenesis by suppressing NF-kB signaling-mediated pro-inflammatory events
- Role of SIRT1 histone deacetylase in melanoma: A target for melanoma management via its inhibition
- Abstract# 4441: c-Myc/SIRT1 feedback loop: A novel regulation of c-Myc induced cellular transformation
- SIRT1 overexpression in pancreatic adenocarcinomas correlates with shortened patient survival and small molecule inhibition as well as target knockdown of SIRT1 …
- Caloric restriction and SIRT1 modulate APP metabolism in vitro and in vivo
- Nuclear shuttling of SIRT1 is associated with caloric restriction-induced cardioprotection
- In silico evidence supports a role for DNA methylation in SIRT1-mediated effects of dietary restriction
- Regulation of translation and transcription by SIRT1: Potential novel mechanisms for regulating stress response and aging
- Treatment with the SIRT1 activator SRT1720 reduces large elastic artery stiffness, superoxide production and inflammation in old mice
- SIRT1 Activators Attenuate Retinal Ganglion Cell Loss During Acute Optic Neuritis
- BDNF-deficiency downregulates SIRT1 and upregulates SIRT2 expression in aging mouse retina
- Chronic treatment with SIRT1 activator SRT1720 ameliorates age-associated vascular endothelial dysfunction in B6D2F1 mice
- SIRT1 inhibition induces apoptosis in human CML progenitors by enhancing p53 acetylation and activation
- A novel SIRT1 activator SIRT1720 triggers in vitro and in vivo cytotoxicity in multiple myeloma via ATM-dependent mechanism
- SIRT1-Mediated Deacetylation Promotes Akt Membrane Localization and Activation During Development of Cardiac Hypertrophy.
- The Role of SIRT1 in Reproduction.
- SIRT1 Regulates PTEN/Akt/FOXO1 Pathway to Trigger ROS-Induced Apoptosis In Mouse Embryonic Stem Cells.
- Pharmacological inhibition of the stress-related deacetylase SIRT1 enhances eradication of cml stem cells
- SIRT1 modulates foxo-dependent transcription and prevents smooth muscle cell apoptosis in response to oxidative stress
- SIRT1 and Heart Disease [J]
- SIRT1 takes down tumors
- Study on the clinicopathologic significance and expression of SIRT1
- Brain space for SIRT1
- SIRT1 and Tumorigenesis
- Resveratrol, an Activator of Protein Deacetylase SIRT1, Suppresses Oxidative Stress-Induced Cell Death by Upregulating MnSOD Expression through Transactivation …
- SIRT1 keeps escapees quiet
- SIRT1 in transcription regulation
- Significance of SIRT1 expression in breast cancer
- The SIRT1 Activator Resveratrol Suppresses Cardiomyocyte Hypertrophy by Promoting Histone H3 Lys9 Deacetylation and Tri-methylation
- Response to Gomez-Cabrera et al: update on SIRT1 signaling
- SIRT1 and cell migration
- Abstract# 5092: Inhibition of SIRT1 by sirtinol causes p53-independent activation of FoxO1 in human prostate cancer cells.
- Inhibition of FoxO1-SIRT1 Signaling by Sustained Acetylation of PGC-1 Alpha Promotes Angiotensin II-Induced Vascular Senescence
- Expression and significance of SIRT1 in breast cancer with diabetes meilitus
- SIRT1 and neoplasms
- Abstract# 4126: SIRT1 is required for normal prostate gland development and androgen signaling in vivo
- Evidence for a Common Mechanism of SIRT1 Regulation by
- The skinny on SIRT1 regulation
- SIRT1 and neoplasms.
- The regulatory effect of SIRT1 on CⅡTA under hypoxia
- 152. Involvement of Trp53 in SIRT1 function during embryo development
- Identification of DNA Targets for SIRT1 in Human Cells
- Authentic SIRT1 activators? No, for Sirtin
- SIRT1 Gene Eukaryotic Eexpression of SD Rat
- SIRT1 Fluorometric Drug Discovery Kit
- Protective Roles of SIRT1 in Vascular Diseases
- SIRT1 Phosphorylation and Cell Proliferation
- Effect of SIRT1 on insulin secretion in MIN6 cell line and its mechanism
- SIRT1 Rabbit Polyclonal Antibody
- The Correlation of SIRT1 and Skin Senescence
- A potential tumor suppressive role of SIRT1 in Cancer
- Nuclear SIRT1 activity regulates oxidative capacity
- SIRT1 Regulates Notch4 Signaling In Endothelial Cells
- SIRT1 promotes DNA repair activity in response to radiation
- The Regulation of SIRT1 in Endocrine and Metabolism
- Effects of dairy consumption on SIRT1 and metabolic risk in humans
- Inhibition of SIRT1 Catalytic Activity
- SIRT1 promotes differentiation of normal human keratinocytes
- SIRT1, metabolism and calorie restriction
- The role of SIRT1 in restricted energy intake
- Expression and significance of SIRT1 in breast cancer with diabetes mellitus
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- Expression of SIRT1 in Retinoblastoma: A Potential Therapeutic Target
- Cancer Connection: Tumor-fighter throttles life-extending protein SIRT1
- Identification of a novel SIRT1/FEN1 interaction and their regulation by karyopherins
- SIRT1 DIMINISHES ATHEROGENESIS BY SUPPRESSING NF-‐ΚB SIGNALING-‐MEDIATED PRO-‐INFLAMMATORY EVENTS
- The SIRT1 mRNA expression in human intervertebral disc
- SIRT1 Involvement in Mouse and Human Retinal Development and Function
- miR-200a targets SIRT1 for malignant transformation
- The Role of SIRT1 in Resveratrol Toxicity
- Role of SIRT1 in Smooth Muscle Cell Function and Vascular Remodeling
- SIRT1 enhances drug resistance of CML K562 cells
- On the role of TLR2 and SIRT1 in the development of diabetes mellitus
- Effect of SIRT1 on the Transcription of HIV-1 Induced by Tat
- Abstract B46: Essential roles of SIRT1 for BCR‐ABL transformation and genetic mutations
- Effects of CR on H_2O_2-Induced Stress Injury and Expression of SIRT1 in PC12 Cells
- The SIRT1 Inhibitor Tenovin-6 Induces Monocytic Differentiation in APL Cells
- SIRT1 Gene Silencing: A Potential Therapeutic Strategy for Pancreatic Cancer
- Molecular mechanisms of a disease susceptibility variant of SIRT1: Genotoxic stress‐induced, CTCF‐dependent activation of SIRT1 gene expression
- Deficiency Of SIRT1 Enhances Elastase-induced Emphysema In Mice
- SIRT1 ACTIVATION SEEMS TO PROMOTE APOPTOSIS OF HUMAN OSTEOSARCOMA CELLS
- Characterization of the role of SIRT1 and its potential as a chemotherapeutic target in breast cancer
- SIRT1 Regulates the Mouse Gastric Emptying and Intestinal Growth
- Roles of SIRT1 in neuronal oxidative damage and brain function
- Negative Regulation of STAT3-mediated Cellular Respiration by SIRT1
- SIRT1 Inhibits VSMC Proliferation and Migration Underlying Neointima Formation Following Vascular Injury
- Effects of calorie restriction on expression of SIRT1 and SIRT2
- SIRT1 modulates E2/ERα-associated oncogenic signaling in human breast cancer
- The Research Progression of NAD~+, Nampt and SIRT1 [J]
- Phosphorylation of Thr522 activates SIRT1 and is required for DYRK‐mediated cell survival in response to DNA damage
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- Establishment of Stable SIRT1 Gene-Downregulated Hepatocarcinoma Cell Lines by Lentiviral Vector
- Constitutive SIRT1 Overexpression Impairs Mitochondrial Function in Mice
- SIRT1 deacetylation regulates NFAT transcriptional activity
- Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells
- FoxO1 Mediates an Auto-feedback Loop Regulation of SIRT1 Expression
- PPARalpha-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- Effects of silencing SIRT1 gene expression on proliferation and apoptosis of pancreatic cancer cell line PANC1
- SIRT1 Is Critical for Pdx1 Transcription and β‐Cell Formation
- Th lf Si t1 i The role of SIRT1 in restricted energy intake
- Involvement of SIRT1 in ultraviolet radiation mediated damages and transformation of skin keratinocytes
- SIRT1 Regulates Hyperglycemia-Induced Vascular Senescence
- Expressions of SIRT1 as prognostic biomarker on resectable gastric cancer patient
- Expression of SIRT1 during axonal degeneration by NAD.
- Muscle‐Specific Disruption of SIRT1 Reduces Mitochondrial Function and Increases Reactive Oxygen Species Production
- SIRT1 Is Required for Mouse Embroyonic Stem Cell Commitment to Hematopoietic Cell Differentiation.
- Expression of SIRT1 mRNA in abdominal aorta in rats with spontaneous type 2 diabetic mellitus
- Growth factor deprivation induces cytosolic translocation of SIRT1
- SIRT1 Mediates Pressure Overload-Induced Cardiac Hypertrophy and Failure in vivo
- SIRT1-Dependent and-Independent Effects of Resveratrol on Cardiovascular Oxidative Stress
- Nutrient and hormonal control of the protein deacetylase SIRT1
- The Development of Choroidal Neovascular Membranes in Patients With AMD Is a SIRT1-Independent Process
- SIRT1 Activation Affects the Transmission of Photoperiodic Information by Melatonin
- SIRT1 and AMPK: the Seesaw Effect in Regulating Endothelial Sene-scence
- Effect of SIRT1 and telomerase on stem cells
- Histone deacetylase SIRT1 promotes the differentiation of P19CL6 cells into cardiomyocytes
- Research Progress of the Nonalcoholic Fatty Liver Based on the SIRT1 Target Spot
- SIRT1 REGULATES CIGARETTE SMOKE-MEDIATED IMPAIRMENT OF ENDOTHELIAL CELL SIGNALING
- The pro-apoptotic effect of vitamin C on colon cancer cell lines, HCT116 via the regulation of SIRT1 expression (165.11)
- Stress and survival: Possible role of SIRT1 in the diencephalon during fasting
- Role of the longevity gene hSir2 (SIRT1) in cancer resistance to chemotherapy
- SIRT1 Decreases Lox-1 Mediated Foam Cell Formation in Atherogenesis
- Transcriptional control of glucose homeostasis through SIRT1 and PGC-1alpha
- HIGH LEVELS OF E-SELECTIN ARE ASSOCIATED WITH A REDUCTION OF SIRT1 EXPRESSION IN LYMPHOMONOCYTES FROM SUBJECTS WITH METABOLIC …
- SIRT1 Overexpression Modulates Cardiac Metabolic Genes Expression and Induces Dilated Cardiomyopathy
- Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
- Resveratrol upregulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- Overexpression of SIRT1 and induction of apoptosis by its inhibition in adult T-cell leukemia cells
- Investigation on SIRT1 in Peripheral Blood Mononuclear Cell (PBMC) and Relationship with Pathogenesis of Psoriasis
- Primary study on the association of expression between SIRT1 and FOXO1 in B cells of islet in rat.
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- Regulation of the NAD+‐dependent histone deacetylase SIRT1 in conditions of muscle use and disuse
- Regulation of SIRT1 protein in cancer metabolism and ribosome biogenesis
- Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction
- Characterization and investigation of seven SIRT proteins in human cell aging: down-regulation of SIRT1 extends cellular lifespan
- Role of SIRT1 and Sirt6 Expression in the Pathophysiology of the rd10 Mouse Retinal Degeneration
- Alcohol consumption and Western style diet alter colonic SIRT1 gene expression during aging
- SIRT1 is expressed in prostatic adenocarcinomas and increases tumor cell invasion when overexpressed in DU145 cells
- SIRT1 Stabilizes PML promoting its Sumoylation
- Transcription Regulator SIRT1 Protects Choroidal Endothelial Cells from Oxidative Stress
- Effects of resveratrol on cardiomyocyte apoptosis induced by anoxia and the expression of SIRT1
- Modulation of Angiogenesis and Postnatal Vascular Growth by the NAD-Dependent Histone Deacetylase SIRT1
- SIRT1 Activation Restores Cardioprotection in the Aged Heart Against Ischemia/Reperfusion Injury
- PPARalpha-SIRT1 Complex Downregulates Mitochondrial Gene Expression Through Suppression of the ERR Response Element in the Heart Under Pressure …
- Selenoprotein S Suppression Enhances the Late Stage Differentiation of Proerythrocytes Via SIRT1
- The Longevity Factor SIRT1 Exacerbates LV Dysfunction and Energy Depletion in Response to Pressure Overload
- SIRT1 represses MMP13 expression in human articular chondrocytes.
- The role of TNFα in circadian rhythmic responses and regulation of metabolic regulator SIRT1 in liver
- Effects of CR on H2O2-induced stress injury and expression of SIRT1 in PC12 cells.
- Aging and vascular endothelial cell senescence: potential role of SIRT1 in development of inflammation and dysfunction
- Abstract P233: PPARα-SIRT1 Complex Mediates Metabolic Adaptation in Response to Starvation in the Heart
- NAD-Dependent Histone Deacetylase, SIRT1, Plays Essential Roles in the Maintenance of Hematopoietic Stem Cells.
- Impaired Nucleocytoplasmic Shuttling of SIRT1 in the Senescent Heart in Response to Ischemic Stress
- SIRT1 promotes N-Myc oncogenesis stabilizing N-Myc protein
- SIRT1 ACTIVATES CELL PROLIFERATION ACTIVITY OF HUMAN INTERVERTEBRAL DISC BOTH IN LOW NUTRITIONAL AND CHEMICAL HYPOXIC CONDITIONS …
- SIRT1 blocks apoptosis in human chondrocytes via activation of the IGF-1 Receptor/Akt pathway
- Uncoupling Insulin: SIRT1 boosts insulin release by blocking mitochondrial protein
- The Role of SIRT1 Activation of AMP-Activated Protein Kinase in the Effect of Polyphenols on Lipid Metabolism in HepG2 Cells Exposed to High Glucose.
- SIRT1 deficiency compromises mouse embryonic stem cell differentiation, and embryonic and adult hematopoiesis in the mouse
- Impaired Nucleocytoplasmic Shuttling and Activity of SIRT1 in Response to Ischemic Stress in the Senescent Heart
- Identification of novel mechanisms regulating the NAD+-dependent deacetylase SIRT1
- The SIRT1 activator resveratrol inhibits the mTOR-p70/S6K pathway
- GENETIC VARIANTS IN THE SIRT1 GENE MAY AFFECT DIABETES RISK IN INTERACTION WITH PRENATAL EXPOSURE TO FAMINE: 7E. 01
- p63 overexpression induces downregulation of SIRT1 and accelerated aging phenotypes in the mouse
- Oral SIRT1 Activators Are Neuroprotective for Retinal Ganglion Cells in Experimental Optic Neuritis
- Increased Nuclear Translocation of SIRT1 and MnSOD Up-regulation in Failing Hearts: A Novel Mechanism of the Cardiomyocyte Death Suppression
- AMPKα2 deletion leads to marked alterations in SIRT1 activity, CPT1 expression and basal FA muscle metabolism in high‐fat‐fed mice
- The protective effect of resveratrol on myocardial ischemia-reperfusion injury by SIRT1-p53 pathway in rats
- SIRT1 Activator 3 Potently Induces Apoptosis in Multiple Myeloma Cell Lines and in Primary Human Multiple Myeloma Cells.
- Construction and identification of eukaryotic plasmid expression vectors encoding the short hairpin RNA targeting human SIRT1
- Resveratrol and Other SIRT1 Activators Exert Similar Neuroprotective Effects in Experimental Optic Neuritis
- The NAD-dependent protein deacetylase SIRT1 regulates POMC transcription and ACTH synthesis
- Sirtuin histone deacetylases SIRT1 and SIRT2 as novel targets for the management of prostate cancer
- Interactions between SIRT1 and AP1 reveal a mechanistic insight into the growth promoting properties of alumina…
- The effect of resveratrol intervention on the expression of SIRT1 in the atrial tissues in pigs with chronic atrial fibrillation induced by right atrial tachypacing
- Effect of High Fat and High Energy Diet on Expression of SIRT1/FOXO1 in White Fat Tissue of Young Rats
- Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its
- The NAD-dependent protein deacetylase SIRT1 is present in the human anterior pituitary gland where it plays a role in GH transcription
- AMP-Activated Protein Kinase Activity Is Altered by Changes in Redox State in HepG2 Cells by a SIRT1-Dependent Mechanism.
- Identification of cofactor network, including SIRT1 and SRC-3, which converges on energy expenditure through PGC-1α
- SIRT1 Limits Endothelial Notch Signaling During Blood Vessel Growth Through NICD Deacetylation
- Effects of SIRT1 inhibition by lentivirus-mediated shRNA vector on apoptosis of porcine preadipocytes.
- A targeted knockdown of sirtuin histone deacetylase SIRT1 imparts significant growth inhibitory effects in human prostate cancer cells.
- SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity Swami R. Narala, Richard C. Allsopp† …
- SIRT1 activator SRT1720 promotes tumor cell migration and lung metastasis in mouse models of breast cancer
- The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
- p22phox-Based Nox4 Regulates Cellular Survival by Modulating FOXO3A Activity and SIRT1 Expression
- Expression of senescence-associated miR-34c and SIRT1 in premature senescence of human skin fibroblasts induced by ultraviolet B
- Regulatory Role of Resveratrol on SIRT1-mediated Metabolic Syndrome and Significance of SIRT Family Proteins for Prevention and Treatment of Metabolic …
- Role of the SIRT1 Deacetylase in Survival and Imatinib Resistance of CML CD34+ Progenitors.
- Activation of the Longevity Factor, SIRT1 Deacetylase Blocks the Phenylephrine-induced Cardiomyocyte Hypertrophy
- Effects of SIRT1 Hyper-expression Induced by Calorie Restriction on Life Span of β Cells and Insulin Secretion
- Atorvastatin Affects Expression of SIRT1 via Microrna-34a in Circulating Their Progenitor Cells Get Pirated From be with Coronary Artery Disease
- SIRT1 Mediated Deacetylation of Foxo1 Is Involved in Starvation Induced Autophagy in the Heart
- Signal-Responsive Repression of Notch1 Signaling by the SIRT1 Deacetylase Regulates Sprouting Angiogenesis
- Dual role of SIRT1 as a regulator of retinal development and a therapeutic target in age-related macular degeneration
- SIRT1 signalling promotes lipopolysaccharide-induced TNF-a expression in cardiomyocytes
- Endothelial Biology/Homeostasis: The Roles of AMPK and SIRT1 in eNOS Phosphorylation and Deacetylation
- Erratum to “SIRT1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol”[Exp. Mol. Path. 85 (2008) 155–159]
- Fetal Hepatic SIRT1, a Histone H3 Deacetylase, Is Decreased in a Nonhuman Primate Model of Maternal Obesity.
- Treatment with a SIRT1 Activator Resveratrol Prevents Cardiomyopathy in Dystrophin-Deficient Mice
- Cisplatin induces SIRT1 in association with histone deacetylation and increased Werner syndrome protein in the kidney
- Activation of SIRT1, a Longevity Gene, Prevents the Development of Diabetic Vasculopathy by Inhibiting Endothelial Senescence
- Expression and function of SIRT1, Sirt4, and glutamate dehydrogenase 1 within the central nervous system
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+ / SIRT1 Mediated Deacetylation of p53 in Myeloid Cells.
- Activation of a Protein Deacetylase, SIRT1, by Resveratrol Suppresses Progression of Heart Failure and Improves Survival by Up-Regulation of Mn-SOD
- Melatonin, a novel SIRT1 inhibitor, imparts anti-proliferative effects against PCa in vitro in cell culture and in vivo in transgenic adenocarcinoma of mouse prostate …
- SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kγgamma Activity through Deacetylation of Specific Lysine Residues in Mammals
- Enhanced cell viability and decreased expression of a senescence marker exhibited in SIRT1-induced human skin cells Claude dal Farra, PhD, Vincience, Sophia …
- Nicotinamide Phosphoribosyltransferase (Nampt) Induces NAD+/SIRT1 Mediated Deacetylation of FOXO3a in Myeloid Cells.
- Activation of a Class-III Histone Deacetylase, SIRT1, Prevents the Oxidative-stress Mediated Cell-death by Suppressing the Activity of Poly (ADP) Ribose Polymerase …
- Long-Term Treatment with the SIRT1 Activator Resveratrol Ameliorates Cardiomyopathy in Dystrophin-Deficient Mice
- Control of Notch Signaling by Reversible Acetylation Through the Antagonistic Activities of p300/PCAF and SIRT1 in Endothelial Cells
- Activation of SIRT1 Suppresses Hypertrophic Response of Cardiomyocytes by Inhibition of H3K9 Acetylation via Proteasome-mediated p300 Degradation.
- Modulation of the longevity proteins FOXO3a and SIRT1 by chorionic gonadotropin prevents hepatocellular injury during acute liver inflammation
- Down‐regulation of MnSOD via SIRT1/FoxO3a complex increase oxidative stress with cardiac overexpression of Type 5 Adenylyl Cyclase
- Novel SIRT1 Agonists, SRT501 and SRT2183, Induce Expression of DNA Repair Genes and Apoptosis of Ph− Acute Lymphoblastic Leukemia Cells Alone and in …
- Increased SIRT1 following repetitive hypoxic preconditioning: A mechanism for mediating long-term tolerance (LTT) to focal stroke in adult mouse brain
- Apo-10′-lycopenoic acid increases both mRNA and protein levels of SIRT1 as well as decreasing the fat accumulation in the livers of ob/ob mice
- Hepatitis B virus X (HBX) Protein Inhibits the Expression of SIRT1 Deacetylase, Leading to Up-regulation of Survivin for the Survival of Hepatocellular Carcinoma Cells
- Nicotinamide activates the p53/miR-34a/SIRT1 tumor suppressor network leading to apoptosis of chronic lymphocytic leukemia cells
- Regulation of WRN Function by Acetylation and SIRT1-Mediated Deacetylation in Response to DNA Damage: A Dissertation
- Resveratrol Induces Cell Growth Arrest and Cell Death of Adult T-Cell Leukemia Cells Via Deacetylation of STAT3 by SIRT1
- … protein kinase α1 silencing provides evidence for a Metformin‐induced decrease in FA uptake and oxidation and increase in glucose uptake and SIRT1 activity in L6 …
- Endothelial Cell Polyploidization Induces an Atherogenic Phenotype and is Prevented by Activating the Nampt-SIRT1 Axis
- 441 INTRAUTERINE GROWTH RETARDATION MODULATES SIRT1 DEACETYLASE, FOXO3 TRANSCRIPTION FACTOR, AND SUPEROXIDE DISMUTASE 2 …
- Acetyltransfer in gene regulation: Structural and biochemical studies of human SIRT1 deacetylase, its FoxO1 substrate, and archaeal PAT acetyltransferase
- Nicotinamide Promotes Apoptosis In Chronic Lymphocytic Leukemia through Activation of the p53/Mir-34a/SIRT1 Tumor Suppressor Network
- Cardiac protective effects of resveratrol and SIRT1 in old rat with emphysema induced by cigarette smoke-expose and lipopolysaccharide instillation: attenuation of …
- Abstract# 183: SIRT1 contributes to tumorigenicity and radioresistance in glioblastoma CD133+ cells
- SIRT1 inhibits transforming growth factor β-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation
- SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via …
- Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)
- 875 RESVERATROL, A POLYPHENOLIC SIRT1 ACTIVATOR, IMPROVES ERECTILE FUNCTION IN STREPTOZOTOCIN INDUCED DIABETIC RATS
- TR-FRET Assay for Sirtuin 1 (SIRT1) Inhibitor Screening
- Co-Upregulation of Peroxisome Proliferator-Activated Receptor-Alpha (PPARalpha) and Silent Information Regulator 1 (SIRT1) Negatively Regulates Cardiac Function …
- Sirtuin 1 (SIRT1) regulates the HSF1-dependent pro-survival mechanism in neurons
- Interplay Between Hypoxia-inducible Factor 1 [alpha] and SIRT1 Protein Deacetylase in Hypoxic Cancer Cells
- 57: Histone deacetylase SIRT1 alterations parallel fetal epigenetic and metabolic reprogramming in response to a maternal high fat (MHF) diet
- Abstract# 3569: Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates\# 946;-Catenin signaling and NF\# 954; B-specific transcription activity leading …
- 032 A REDUCTION IN SIRT1 LEVELS IN OA ARTICULAR CARTILAGE IS ASSOCIATED WITH AN INCREASE IN PTP1B, MMP13 AND CHONDROCYTE APOPTOSIS
- Regulation of the transcription factor GATA-3 within T cells-Involvement of SIRT1, a class III histone deacetylase
- Activation of the AKT Pathway Mediates Upregulation of Hif-1α and SIRT1 via Downregulation of miR-199a and is Neutralized by Beta-adrenergic Stimulation
- Abstract LB-427: Differential effects of resveratrol-induced SIRT1 in prostate cancer: A novel therapeutic target
- Influence of AP endonuclease 1 deacetylation by protein deacetylase SIRT1 on DNA base excision repair
- Microrna-195 Promotes Apoptosis in Cardiomyocytes by Down-Regulating SIRT1
- Influence of Ethnicity in Association of UCP2‐866G/A, PGC1α (Gly 482 Ser) and SIRT1‐1400T/C Polymorphisms in North Indian Punjabi Population Groups
- Abstract LB-185: Oxidative damage targets complexes containing DNA methyltransferases, SIRT1 and polycomb members to promoter CpG islands
- SIRT1 and energy metabolism
- The roles of SIRT1 in cancer
- The ways and means that fine tune SIRT1 activity
- MicroRNA regulation of SIRT1
- Negative regulation of inflammation by SIRT1
- SIRT1 in type 2 diabetes: mechanisms and therapeutic potential
- Neuroprotective role of SIRT1 in mammalian models of Huntington’s disease through activation of multiple SIRT1 targets
- Evidence for a common mechanism of SIRT1 regulation by allosteric activators
- Crosstalk between oxidative stress and SIRT1: impact on the aging process
- The role of SIRT1 in ocular aging
- Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress
- Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
- SIRT1: new avenues of discovery for disorders of oxidative stress
- SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons
- SIRT1, metabolism and cancer
- Identification of a SIRT1 mutation in a family with type 1 diabetes
- Regulation of SIRT1 by microRNAs
- Targeting cardiovascular disease with novel SIRT1 pathways
- SIRT1 and SIRT2: emerging targets in neurodegeneration
- Janus-faced role of SIRT1 in tumorigenesis
- SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging
- Redox regulation of SIRT1 in inflammation and cellular senescence
- SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
- Stress inducibility of SIRT1 and its role in cytoprotection and cancer
- Regulation of SIRT1 activity by genotoxic stress
- Emerging roles of SIRT1 in cancer drug resistance
- Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets
- SIRT1 is required for long-term growth of human mesenchymal stem cells
- Towards elucidating the role of SIRT1 in osteoarthritis.
- Roles of SIRT1 in leukemogenesis
- SIRT1: regulator of p53 deacetylation
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
- SIRT1 in metabolic syndrome: where to target matters
- SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin
- Brown remodeling of white adipose tissue by SIRT1-dependent deacetylation of Pparγ
- Brain activation of SIRT1: role in neuropathology
- SIRT1 activation by resveratrol is substrate sequence-selective
- Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways
- High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
- The effects of SIRT1 on Alzheimer’s disease models
- SIRT1 promotes tumorigenesis and resistance to chemotherapy in hepatocellular carcinoma and its expression predicts poor prognosis
- Deacetylation by SIRT1 reprograms inflammation and cancer
- The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing
- Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex
- SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells
- SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis
- Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib
- SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
- MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression
- Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
- SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
- SIRT1 expression is associated with good prognosis in colorectal cancer
- Metabolic actions of hypothalamic SIRT1
- SIRT1 regulates dendritic development in hippocampal neurons
- SIRT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain
- SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60
- Peripheral blood monocyte SIRT1 expression is reduced in patients with coronary artery disease
- Dilated cardiomyopathy and mitochondrial dysfunction in SIRT1-deficient mice: a role for SIRT1-Mef2 in adult heart
- Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions
- Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress
- The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin‐1β in human chondrocytes
- SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
- SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis
- SIRT1-deficient mice exhibit an altered cartilage phenotype
- SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
- SIRT1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
- Expansion of oligodendrocyte progenitor cells following SIRT1 inactivation in the adult brain
- SIRT1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway
- SIRT1 contains N-and C-terminal regions that potentiate deacetylase activity
- Anti-aging molecule, SIRT1: a novel therapeutic target for diabetic nephropathy
- Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1α complex
- Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity
- Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3
- Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights
- SIRT1 modulates MAPK pathways in ischemic–reperfused cardiomyocytes
- SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
- SIRT1 regulation modulates stroke outcome
- Renal tubular SIRT1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes
- The role of SIRT1 in muscle mitochondrial turnover
- Age-associated decrease of SIRT1 expression in rat hippocampus: prevention by late onset caloric restriction
- A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis
- Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
- SIRT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
- SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency
- SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
- Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
- SIRT1: Def-eating senescence?
- SIRT1 promotes axonogenesis by deacetylation of Akt and inactivation of GSK3
- Regulation of SIRT1 by oxidative stress-responsive miRNAs and a systematic approach to identify its role in the endothelium
- SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis
- SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas
- Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation
- Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SIRT1 mice
- USP22 antagonizes p53 transcriptional activation by deubiquitinating SIRT1 to suppress cell apoptosis and is required for mouse embryonic development
- New synthetic approach to paullones and characterization of their SIRT1 inhibitory activity
- A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration
- A maternal high‐fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates
- SIRT1 is a highly networked protein that mediates the adaptation to chronic physiological stress
- SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury
- SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
- Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1
- SIRT1 signaling as potential modulator of skeletal muscle diseases
- Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity
- Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo
- SIRT1 Polymorphism, Long-Term Survival and Glucose Tolerance in the General Population
- SIRT1 enhances matrix metalloproteinase‐2 expression and tumor cell invasion in prostate cancer cells
- A pilot randomized, placebo controlled, double blind phase I trial of the novel SIRT1 activator SRT2104 in elderly volunteers
- SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging
- High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
- SIRT1 promotes proliferation and inhibits apoptosis of human malignant glioma cell lines
- SIRT1 is a direct coactivator of thyroid hormone receptor β1 with gene-specific actions
- Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation
- SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells
- SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-κB/Cyclin D1 signaling
- Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer
- SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells
- SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human THP-1 cells
- Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria
- SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth
- Adult mice maintained on a high-fat diet exhibit object location memory deficits and reduced hippocampal SIRT1 gene expression
- SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC
- The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury
- A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- SIRT1, a histone deacetylase, regulates prion protein-induced neuronal cell death
- Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action
- SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus
- Neuronal SIRT1 deficiency increases insulin sensitivity in both brain and peripheral tissues
- Genetic analysis of the SIRT1 gene promoter in myocardial infarction
- miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
- Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s disease
- SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
- Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas
- SIRT1 regulates endothelial Notch signaling in lung cancer
- SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway
- Autophagy induced by the class III histone deacetylase SIRT1 prevents prion peptide neurotoxicity
- Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway
- Extranuclear localization of SIRT1 and PGC-1α: an insight into possible roles in diseases associated with mitochondrial dysfunction
- Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of SIRT1
- PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells
- Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice
- Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation
- High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T‐cell leukemia cells
- Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways
- Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
- SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells
- Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of SIRT1
- Leucine supplementation increases SIRT1 expression and prevents mitochondrial dysfunction and metabolic disorders in high-fat diet-induced obese mice
- SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity
- SIRT1 regulates cd40 expression induced by tnf-α via nf-ĸb pathway in endothelial cells
- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
- Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction
- Modulatory effect of resveratrol on SIRT1, SIRT3, SIRT4,PGC1α and NAMPT gene expression profiles in wild-type adult zebrafish liver
- Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and …
- SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice
- The loss of SIRT1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
- Resveratrol‐mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation
- Cross-talk between SIRT1 and p66Shc in vascular diseases
- Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury
- SIRT1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells
- SIRT1 promotes RGC survival and delays loss of function following optic nerve crush
- SIRT1 attenuates palmitate-induced endoplasmic reticulum stress and insulin resistance in HepG2 cells via induction of oxygen-regulated protein 150
- Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription
- SIRT1 expression is associated with good prognosis for head and neck squamous cell carcinoma patients
- Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer
- Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle
- Angiogenic Deficiency and Adipose Tissue Dysfunction Are Associated with Macrophage Malfunction in SIRT1−/− Mice
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells
- Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway
- SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway
- Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation
- Resveratrol inhibits the growth of gastric cancer by inducing G1 phase arrest and senescence in a SIRT1-dependent manner
- Resveratrol activates SIRT1 in a Lamin A-dependent manner
- SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human …
- SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle
- Expression of SIRT1 is associated with lymph node metastasis and poor prognosis in both operable triple-negative and non-triple-negative breast cancer
- Identification of a small molecule activator of SIRT1 gene expression
- SIRT1, p66Shc, and Set7/9 in vascular hyperglycemic memory: bringing all the strands together
- Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high‐fat‐diet feeding
- BCL6 controls neurogenesis through SIRT1-dependent epigenetic repression of selective Notch targets
- SIRT1 silencing confers neuroprotection through IGF‐1 pathway activation
- SIRT1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenanceSIRT1 in adult stem cell homeostasis
- Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine
- Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal SIRT1
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway
- Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
- SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase …
- Hydrogen sulfide prevents H2O2-induced senescence in human umbilical vein endothelial cells through SIRT1 activation
- PPARα and SIRT1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders
- Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells
- Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis
- SIRT1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis
- Impaired cardiac SIRT1 activity by carbonyl stress contributes to aging-related ischemic intolerance
- SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein
- SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling
- Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
- Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes
- Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle
- The full capacity of AICAR to reduce obesity-induced inflammation and insulin resistance requires myeloid SIRT1
- Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase
- Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway
- Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate
- Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
- CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1
- Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear …
- SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells
- Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis
- A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
- SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression
- Resveratrol improves cardiac contractility following trauma-hemorrhage by modulating SIRT1
- Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats
- Decreased vitamin B12 availability induces ER stress through impaired SIRT1-deacetylation of HSF1
- SIRT1 regulates adaptive response of the growth hormone–insulin-like growth factor-I axis under fasting conditions in liver
- Regulation of SIRT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
- SIRT1 is highly expressed in brain metastasis tissues of non-small cell lung cancer (NSCLC) and in positive regulation of NSCLC cell migration
- mIGF‐1/JNK1/SIRT1 signaling confers protection against oxidative stress in the heart
- Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression
- Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
- DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage
- Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1 Protein-mediated Modulation of p300 Protein*[S]
- TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes
- A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells
- SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence
- The role of SIRT1 on angiogenic and odontogenic potential in human dental pulp cells
- SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway
- Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
- The Interactive Effect of SIRT1 Promoter Region Polymorphism on Type 2 Diabetes Susceptibility in the North Indian Population
- Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells
- Terpenylated Coumarins As SIRT1 Activators Isolated from Ailanthus altissima
- Resveratrol induces SIRT1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression
- The PPARδ-mediated inhibition of angiotensin II-induced premature senescence in human endothelial cells is SIRT1-dependent
- Fortifying the link between SIRT1, resveratrol, and mitochondrial function
- SIRT1 prevents atherosclerosis via liver‑X‑receptor and NF‑κB signaling in a U937 cell model
- Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice
- Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice
- Association of SIRT1 expression with shear stress induced endothelial progenitor cell differentiation
- The involvement of SIRT1 and transcription factor NF-κB (p50/p65) in regulation of porcine ovarian cell function
- Enterocyte-Specific Inactivation of SIRT1 Reduces Tumor Load in the APC+/min Mouse Model
- The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response
- Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3, 2′-quinazolines
- Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
- SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β …
- SIRT1 protects against thrombomodulin down-regulation and lung coagulation after particulate matter exposure
- A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes
- Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis
- SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1
- … protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1
- Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in …
- Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway
- SIRT1 as a novel potential treatment target for vascular aging and age-related vascular diseases
- 17‐β Oestradiol prevents cardiovascular dysfunction in post‐menopausal metabolic syndrome by affecting SIRT1/AMPK/H3 acetylation
- SIRT1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway
- Nicotinamide‑mediated inhibition of SIRT1 deacetylase is associated with the viability of cancer cells exposed to antitumor agents and apoptosis
- SIRT1 attenuates diabetic albuminuria
- Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
- … in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 …
- Overexpression of SIRT1 Promotes High Glucose–Attenuated Corneal Epithelial Wound Healing via p53 Regulation of the IGFBP3/IGF-1R/AKT Pathway
- Pharmacological activation of SIRT1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy
- Suppression of ERR targets by a PPARα/SIRT1 complex in the failing heart
- SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells
- SIRT1 regulates radiosensitivity of hepatoma cells differently under normoxic and hypoxic conditions
- Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway
- SIRT1-mediated FoxO1 deacetylation is essential for multidrug resistance-associated protein 2 expression in tamoxifen-resistant breast cancer cells
- Isoflavones derived from soy beans prevent MuRF1-mediated muscle atrophy in C2C12 myotubes through SIRT1 activation
- SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide
- Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1
- The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- Effects of SIRT1 on DNA methylation and expression of genes affected by dietary restriction
- SIRT1 inhibits akt2-mediated porcine adipogenesis potentially by direct protein-protein interaction
- The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel …
- When is SIRT1 activity bad for dying neurons?
- Novel acridinedione derivatives: design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies
- Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair
- IL-15 overexpression promotes endurance, oxidative energy metabolism, and muscle PPARδ, SIRT1, PGC-1α, and PGC-1β expression in male mice
- Identification and characterization of novel indole based small molecules as anticancer agents through SIRT1 inhibition
- Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SIRT1 axis
- Enantioselective Synthesis of Cyclohepta[b]indoles: Gram-Scale Synthesis of (S)-SIRT1-Inhibitor IV
- Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1
- Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway
- Rejuvenating SIRT1 activators
- Visceral adiposity is associated with SIRT1 expression in peripheral blood mononuclear cells: a pilot study
- Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase
- Metabolic energy sensors (AMPK and SIRT1), protein carbonylation and cardiac failure as biomarkers of thermal stress in an intertidal limpet: linking energetic …
- The effects of caloric restriction and a high-fat diet on ovarian lifespan and the expression of SIRT1 and SIRT6 proteins in rats
- c-MYC and SIRT1 locked in a vicious cycle
- SIRT1 interacts with metabolic transcriptional factors in the pancreas of insulin-resistant and calorie-restricted rats
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells
- Hepatic menin recruits SIRT1 to control liver steatosis through histone deacetylation
- SIRT1 deacetylates FOXA2 and is critical for Pdx1 transcription and β-cell formation
- SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells
- SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue
- Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols
- WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1
- The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes
- Carvacrol protects against hepatic steatosis in mice fed a high-fat diet by enhancing SIRT1-AMPK signaling
- SIRT1 Regulation—It Ain’t All NAD
- β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice
- Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by SIRT1 Protein-mediated Deacetylation♦
- Activation of type 2 cannabinoid receptors (CB2R) promotes fatty acid oxidation through the SIRT1/PGC-1α pathway
- Salvianolic acid A preconditioning confers protection against concanavalin A-induced liver injury through SIRT1-mediated repression of p66shc in mice
- Expression of SIRT1 and DBC1 in developing and adult retinas
- Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats
- Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: Their evaluation as inhibitors of SIRT1
- Acetylation status of P53 and the expression of DBC1, SIRT1, and androgen receptor are associated with survival in clear cell renal cell carcinoma patients
- Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins
- Nicotinamide prohibits proliferation and enhances chemosensitivity of pancreatic cancer cells through deregulating SIRT1 and Ras/Akt pathways
- SIRT1 activation protects against autoimmune T cell-driven retinal disease in mice via inhibition of IL-2/Stat5 signaling
- Expression of SIRT1 in choroidal neovascular membranes
- Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro
- Cellular NAD depletion and decline of SIRT1 activity play critical roles in PARP-1-mediated acute epileptic neuronal death in vitro
- Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late …
- Activation of SIRT1 by resveratrol requires lamin A
- Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells
- Association between SIRT1 gene polymorphisms and longevity of populations from Yongfu region of Guangxi
- MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
- SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κ B/STAT3 complex to its promoter in …
- PARP1 inhibition affects pleural mesothelioma cell viability and uncouples AKT/mTOR axis via SIRT1
- Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- Anti-correlation between longevity gene SIRT1 and Notch signaling in ascending aorta biopsies from patients with bicuspid aortic valve disease
- MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS
- Exendin-4 improves steatohepatitis by increasing SIRT1 expression in high-fat diet-induced obese C57BL/6J mice
- DBC1 does not function as a negative regulator of SIRT1 in liver cancer
- SIRT1–Claudin-1 crosstalk regulates renal function
- Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
- PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway
- SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: implications for cell survival after irradiation
- Molecular architecture of the human protein deacetylase SIRT1 and its regulation by AROS and resveratrol
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic …
- Epigallocatechin-3-gallate suppresses 1-methyl-4-phenyl-pyridine-induced oxidative stress in PC12 cells via the SIRT1/PGC-1α signaling pathway
- SIRT1 inhibits the mouse intestinal motility and epithelial proliferation
- … and anti‐inflammatory effects of melatonin in hydrogen peroxide‐stimulated CHON‐001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 …
- Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis
- Vitamin D protects human endothelial cells from H 2 O 2 oxidant injury through the Mek/Erk-SIRT1 axis activation
- The identification of the SIRT1 activator SRT2104 as a clinical candidate
- The brain: A new organ for the metabolic actions of SIRT1
- SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells
- SIRT1 and the clock gene machinery in colorectal cancer
- Hypermethylation of HIC1 promoter and aberrant expression of HIC1/SIRT1 might contribute to the carcinogenesis of pancreatic cancer
- Molecular dissection of the interaction between HIC1 and SIRT1
- Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
- Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats
- … Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 …
- Poor glycaemic control in type 2 diabetes patients reduces endothelial progenitor cell number by influencing SIRT1 signalling via platelet-activating factor …
- Expression of SIRT1 in ocular surface squamous neoplasia
- SIRT1 inhibits resistin expression in aortic stenosis
- Association of Sirtuin 1 (SIRT1) Gene SNPs and Transcript Expression Levels With Severe Obesity
- Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise
- Modeling miRNA regulation in cancer signaling systems: miR-34a regulation of the p53/SIRT1 signaling module
- Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/SIRT1 signaling in mice
- Insulin signal meets SIRT1 at Akt
- SIRT1 confers hypoxia-induced radioresistance via the modulation of c-Myc stabilization on hepatoma cells
- hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SIRT1
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- Regulation of SIRT1 in vascular smooth muscle cells from streptozotocin-diabetic rats
- Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity
- SIRT1, p53, and p38MAPK Are Crucial Regulators of Detrimental Phenotypes of Embryonic Stem Cells with Max Expression Ablation
- Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of SIRT1–eNOS axis
- The time-dependent autophagy protects against apoptosis with possible involvement of SIRT1 protein in multiple myeloma under nutrient depletion
- Activation of AMPK–SIRT1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects
- SIRT1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes
- Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism
- SIRT1 mediates the protective function of Nkx2. 5 during stress in cardiomyocytes
- Metabolic stress modulates Alzheimer’s β-secretase gene transcription via SIRT1-PPARγ-PGC-1 in neurons
- MicroRNA-138 and SIRT1 form a mutual negative feedback loop to regulate mammalian axon regeneration
- Pentamethylquercetin reduces fat deposition via SIRT1-mediated pathways in male obese mice induced by a high fat diet
- The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a SIRT1‐dependent mechanism in mice
- Late-onset running biphasically improves redox balance, energy-and methylglyoxal-related status, as well as SIRT1 expression in mouse hippocampus
- The expression of SIRT1 and DBC1 in laryngeal and hypopharyngeal carcinomas
- An autoregulatory loop reverts the mechanosensitive SIRT1 induction by EGR1 in skeletal muscle cells
- SIRT1 attenuates neointima formation by inhibiting HIF-1α expression in neointimal lesion of a murine wire-injured femoral artery
- MiR-34a is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation through the SIRT1/NFκB pathway
- Three single nucleotide variants of the SIRT1 gene are associated with overweight in a Chinese population: a case control study
- SIRT1 deacetylates SATB1 to facilitate MAR HS2 -MAR ε interaction and promote ε-globin expression
- Diet-induced obesity promotes murine gastric cancer growth through a nampt/SIRT1/c-myc positive feedback loop
- MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1
- Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1 …
- SIRT1 exerts anti-inflammatory effects and promotes steroidogenesis in Leydig cells
- The tumor suppressor protein menin inhibits NF-κB-mediated transactivation through recruitment of SIRT1 in hepatocellular carcinoma
- SIRT1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
- SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis
- The mitochondrial SIRT1–PGC-1α axis in podocyte injury
- SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for …
- Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of SIRT1 and AMPK in rats
- SIRT1 and Connexin40 Mediate the normal shear stress-induced inhibition of the proliferation of endothelial cells co-cultured with vascular smooth muscle cells
- Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway
- Synergistic actions of insulin-sensitive and SIRT1-mediated pathways in the differentiation of mouse embryonic stem cells to osteoblast
- α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase
- Investigation of silent information regulator 1 (SIRT1) agonists from Traditional Chinese Medicine
- Involvement of SIRT1–AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet
- MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1
- Genetic analysis of the SIRT1 gene promoter in ventricular septal defects
- Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1
- SIRT1 activators: the evidence STACks up
- Hypoxanthine-xanthine oxidase down-regulates GLUT1 transcription via SIRT1 resulting in decreased glucose uptake in human placenta
- miR‐520c and miR‐373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF‐κB factor in …
- Omentin-1, a new adipokine, promotes apoptosis through regulating SIRT1-dependent p53 deacetylation in hepatocellular carcinoma cells
- SIRT1 expression and activity are up-regulated in the brain tissue of epileptic patients and rat models
- The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels …
- Active regulator of SIRT1 is required for ribosome biogenesis and function
- Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells
- … -associated TDP-43 interacts with fragile X mental retardation protein (FMRP)/Staufen (STAU1) and regulates SIRT1 expression in neuronal cells
- Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes
- Sirt7 promotes adipogenesis by binding to and inhibiting SIRT1
- Insulin induces neurite outgrowth via SIRT1 in SH-SY5Y cells
- Monacolin K affects lipid metabolism through SIRT1/AMPK pathway in HepG2 cells
- Angiogenic Dysfunction in Bone Marrow‐Derived Early Outgrowth Cells from Diabetic Animals Is Attenuated by SIRT1 Activation
- Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced …
- SIRT1 catalytic activity has little effect on tumor formation and metastases in a mouse model of breast cancer
- Activating transcription factor 4 confers a multidrug resistance phenotype to gastric cancer cells through transactivation of SIRT1 expression
- MiR-217 is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation by down-regulation of SIRT1
- Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation
- Porphyromonas gingivalis lipopolysaccharide regulates interleukin (IL)-17 and IL-23 expression via SIRT1 modulation in human periodontal ligament cells
- Identification of benzofuran-3-yl (phenyl) methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action
- Bisdemethoxycurcumin increases SIRT1 to antagonize t-BHP-induced premature senescence in WI38 fibroblast cells
- Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1
- Genetic variation in SIRT1 affects susceptibility of lung squamous cell carcinomas in former uranium miners from the Colorado plateau
- Effect of breed on the expression of Sirtuins (SIRT1-7) and antioxidant capacity in porcine brain
- Ginkgolide B reduces LOX-1 expression by inhibiting Akt phosphorylation and increasing SIRT1 expression in oxidized LDL-stimulated human umbilical vein …
- Lentivirus-mediated SIRT1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway
- Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells
- Effect of metformin on the expression of SIRT1 and UCP2 in rat liver of type 2 diabetes mellitus and nonalcoholic fatty liver
- Functional Complementation of sir2Δ Yeast Mutation by the Human Orthologous Gene SIRT1
- Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
- Fragmentation studies of SIRT1‐activating drugs and their detection in human plasma for doping control purposes
- Expression of SIRT1 in right auricle tissues and the relationship with oxidative stress in patients with atrial fibrillation
- Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and …
- Inverse Regulation of the Cytosolic Ca2+ Buffer Parvalbumin and Mitochondrial Volume in Muscle Cells via SIRT1/PGC-1α Axis
- SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation
- Novel SIRT1 mutation linked to autoimmune diabetes in humans
- Upregulation of SIRT1 in carbon-tetrachloride–induced acute liver injury
- Hypothalamic SIRT1 and regulation of food intake
- Cardioprotective mIGF-1/SIRT1 signaling induces hypertension, leukocytosis and fear response in mice
- Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene
- MicroRNA-217 promotes angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A
- Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer
- Methods to investigate the role of SIRT1 in endothelial senescence
- Electroconvulsive shock increases SIRT1 immunoreactivity in the mouse hippocampus and hypothalamus
- SIRT1 is a useful biomarker for high-grade dysplasia and carcinoma in Barrett’s esophagus
- Resveratrol-poor red wines modulate SIRT1 in human renal cells
- SRT1720, a SIRT1 activator, aggravates bleomycin-induced lung injury in mice
- Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is SIRT1-independent
- Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS
- SILAC-based quantification of SIRT1-responsive lysine acetylome
- MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1
- Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells
- Dissecting the Roles of the N‐and C‐Flanking Residues of Acetyllysine Substrates for SIRT1 Activity
- RETRACTED ARTICLE: MicroRNA-126 inhibits osteosarcoma cells proliferation by targeting SIRT1
- Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance
- Commentaries on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments …
- MicroRNA-142 reduces monoamine oxidase A expression and activity in neuronal cells by downregulating SIRT1
- Nephroprotective action of sirtuin 1 (SIRT1)
- Indole-3-carbinol directly targets SIRT1 to inhibit adipocyte differentiation
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- Measles virus nucleocapsid protein, a key contributor to Paget’s disease, increases IL-6 expression via down-regulation of FoxO3/SIRT1 signaling
- Mechanism of temozolomide-induced anti-tumor effects on glioblastoma cells in vitro is via ROS-dependent SIRT1 signaling pathway
- GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (SIRT1)
- Mass spectrometric studies on the in vitro generated metabolites of SIRT1 activating drugs for doping control purposes
- Relative quantitative comparison between lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes
- Metformin, metabolic stress, and mitochondria. Focus on “A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein …
- Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation
- Deacetylase SIRT1 and vascular endothelial function
- PARP-2 knockdown protects cardiomyocytes from hypertrophy via activation of SIRT1
- Involvement of SIRT1 in Zn2+, streptozotocin, non-obese diabetic, and cytokine-mediated toxicities of β-cells
- Cloning expression and purification of human truncated SIRT1
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- SIRT1 inhibits p53 but not NF-κB transcriptional activity during differentiation of mouse embryonic stem cells into embryoid bodies
- Yet another role for SIRT1: reduction of α-synuclein aggregation in stressed neurons
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- Last Word on Viewpoint: Does SIRT1 determine exercise-induced skeletal muscle mitochondrial biogenesis: differences between in vitro and in vivo experiments?
- SIRT1 and anxiety
- A multicancer-like syndrome in a dog characterized by p53 and cell cycle-checkpoint kinase 2 (CHK2) mutations and sirtuin gene (SIRT1) down-regulation
- Resveratrol stimulates extracellular matrix synthesis in degenerative nucleus pulposus cells via upregulation of SIRT1
- SIRT1 suppresses activating transcription factor 4 (ATF4) expression in response to proteasome inhibition
- Incretin-stimulated interaction between β-cell Kv1. 5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SIRT1
- Discovery and Characterization of Protein‐Modifying Natural Products by MALDI Mass Spectrometry Reveal Potent SIRT1 and p300 Inhibitors
- SIRT1 negatively regulates the protein stability of HIPK2
- Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo
- Expression and significance of SIRT1 and survivin in endometrial carcinoma
- Effects of exercise training duration on SIRT1 and eNOS expression in rat aortas
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- SRT2379, a small-molecule SIRT1 activator, fails to reduce cytokine release in a human endotoxemia model
- Hepatic SIRT1 and UCP2 expressions in rats with type 2 diabetes mellitus and nonalcoholic fatty liver
- miR-520c and miR-373 target mTOR and SIRT1, activate the Ras/Raf/MEK/Erk pathway and NF-κB, with up-regulation of MMP9 in human fibrosarcoma cells
- The modulation of SIRT1 expression by different types of high fat state in hepatocytes
- AMPK-SIRT1-PGC-1α signaling regulates mitochondrial function in human articular chondrocytes
- Role of SIRT1 in Resistance Exercise‐Induced Changes in Vascular Function
- SIRT1 knockout impairs the differentiation of adipocyte in C57BL/6J mice and its underlying mechanism
- Research progress of SIRT1 and osteoporosis
- Implications of a novel point mutation of SIRT1 in T1DM
- The role of SIRT1 in the activation of innate immune responses during RSV infection (68.6)
- Expressions and clinical significance of SIRT1, P53 and P-gp in gastric carcinoma.
- SIRT1 Activators in Development
- SIRT1‐independent epigenetic effects of resveratrol mediated through the estrogen receptor
- Pancreatic ductal cells acquire mesenchymal characteristics through cell fusion with bone marrow-derived mesenchymal stem cells and SIRT1 attenuates the apoptosis …
- Is a deceptive role of IGF-1 in SIRT1–PARP1 interactions the primary step of postnatal regression of hypertrophic cardiomyopathy in infants of diabetic mothers?
- Role of SIRT1/UCP2 signaling pathway in resveratrol-induced inhibition of oxidative injury in vascular endothelial cells
- Reproductive effects of SIRT1 expression in astrocytes
- Abstract P2-06-02: Pparg deacetylation by SIRT1 determines breast tumor lipid synthesis and growth
- Mammalian target of rapamycin (mTOR) sigaling pathway involved in the inhibition of silence information regulator1 (SIRT1) on fat deposition of mice.
- Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of MnSOD via the SIRT1/FoxO3a pathway
- Mutual inhibition between miR-34a and SIRT1 contributes to regulation of DNA double-strand break repair
- Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism
- Electrochemical Immunosensor Based on AuNPs/PDDA-GO for Detection of SIRT1
- Expression of SIRT1 and P55PIK in Gastric Cancer and Clinical Significance
- SIRT1 deacetylase is essential for hematopoietic stem cell activity
- Metformin modulates hyperglycemia‐induced endothelial dysfunction through SIRT1
- PPARalpha/SIRT1 Complex is Involved in the Deterioration of Fatty Acid Metabolism During the Pathological Development of Heart Failure
- SIRT1 protects cortical neurons from shear stress induced mechanical injury
- GSPE enhance eNOS expression through AMPK/SIRT1–KLF2 pathway and modulate blood pressure in ouabain induced hypertensive rats
- Inhibition of SIRT1 Transcription in Resveratrol-differentiated Medulloblastoma Cells
- Construction of recombinant lentiviral vector of shRNA targeting SIRT1 gene and its effects on the proliferation of breast cancer cell
- SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3.
- The role of melatonin in SIRT1 and p-AMPK regulation in HT-29 cell line
- Inhibition studies of SIRT1
- Leucine modulation of AMPK and mitochondrial biogenesis in C2C12 myotubes is SIRT1 dependent
- Relationship between SIRT1 expression in atrial tissue and atrial fibrosis in patients with atrial fibrillation
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- Research on the Morphological Changes of Ischemic Cell Mediated via SIRT1 Pathway in the Intervention with Xuefu Zhuyu Capsules
- Conjugated linoleic acid (CLA) activates PGC‐1alpha via AMPK and SIRT1 in C2C12 myotubes
- Hepatic deletion of SIRT1 decreases HNF1α/FXR signaling and induces formation of cholesterol gallstones in mice
- Caloric restriction ameliorates myocardial ischemia/reperfusion injury by suppressing complement activation in a SIRT1-dependent manner
- Research on Effect of SIRT1 on Ameliorating Lipid Metabolism Disorder of Type 2 Diabetic Rats after Exercise and Oral Resveratrol [J]
- Ezetimibe Inhibit Hyperacetylation of SREBP-1c in Lipid-Loaded Cells Derived from VSMC Required for SIRT1 [J]
- Tafluprost Protects Human Trabecular Meshwork Cells From Oxidative Stress Through The Activation Of C-myc/SIRT1 Transcription Pathway
- The Role of SIRT1 in Central Nervous System
- Pharmacological Inhibition Of The SIRT1 Deacetylase With The Small Molecule Inhibitor Tenovin-6 Enhances Ablation Of FLT3-ITD+ LSC In Combination With TKI …
- Adiponectin induces autophagic cell death in breast cancer cells through SIRT1 mediated deacetylation of LKB1 leading to ATG1 activation.
- Effects of SIRT1 on material metabolism and influence factors
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- Abstract A37: Beta-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J …
- THU0033 SET7/9 and SIRT1 induce promoter-driven collagen 2ALPHA1 expression in 3D cultured human chodrocytes
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in
- SIRT1 as a Potential Therapeutic Target in Breast Cancer
- Research progress of SIRT1 in suppressing inflammatory response.
- Activation of SIRT1 by an N-terminal Regulatory Domain
- Examination of the reproductive effects of SIRT1 expression in neurons
- The deacetylase SIRT1 is down-regulated in gastric cancer and leads to G1 phase
- Role of SIRT1 in inflammation-associated carcinogenesis
- SIRT1: A novel target for treatment in cardiovascular diseases
- Roles of SIRT1 in tumorigenesis and tumor progression
- Expression of SIRT1 in tissues of patients with gastric carcinoma
- GW24-e2135 SIRT1 significantly influences Old sourced MSCs aging and proliferation
- Deciphering the role of 75kDa SIRT1 fragment in osteoarthritis
- The Role of SIRT1 in Preventing Mitochondrial Dysfunction with Obesity and Aging
- Research advances in SIRT1 regulating microRNA
- SIRT1-mediated suppression of cell death in breast cancer.
- Co-location of SIRT1 and IR in the adult mouse brain
- SIRT1 against breast cancer through downregulating Bcl-2 protein.
- Unravelling New Roles for SIRT1 in Mitochondrial Biollogy
- GW24-e3662 The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Functional complementation of sir2Δ yeast mutation by the human orthologous gene SIRT1
- THE LIPID SECOND MESSENGER PHOSPHATIDYLINOSITOL-5-PHOSPHATE STIMULATES SIRT1 DEACETYLASE ACTIVITY
- Isolation and Characterization of New Sirtuin1 (SIRT1) Activators from Medicinal Plants
- SIRT1 Inactivation Reduces Tumor Growth in Colon Cancer Model
- Role of adipose SIRT1 in regulating systemic energy metabolism
- Constitutive SIRT1 overexpression impairs mitochondria and
- Influence of Mailuoning on SIRT1 expression of brain tissue in Alzheimer′ s disease rat model
- The impact of SIRT1 inhibition on zebrafish morphology and behavior
- Recent Advances of Deacetylase SIRT1 on Apoptosis Regulation
- FLT3-ITD+ AML Stem/Progenitor Cells Demonstrate Increased SIRT1 Expression and Enhanced Sensitivity to SIRT1 Inhibition
- Supression of SIRT1 in angiogenesis of endothelial cells induced by HCMV infection
- Loss of SIRT1 histone deacetylase expression associates with tumour progression in colorectal adenocarcinoma
- PPARdelta-SIRT1 Interaction Protects Endothelial Function in Diabetic Mice
- The neuroprotective effects of SIRT1 on NMDA-induced excitotoxicity
- Red Wine Molecule Makes a Comeback to Activate SIRT1
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- SIRT1 Mediated Mitochondrial Biogenesis for The Protection of RGC-5 Cell During Oxidative Stress
- Leptin-induced SIRT1 expression: a potential linker between obesity and cancer
- Role of SIRT1 in regulation of hepatic gene expression by thyroid hormone
- The Role Of SIRT1 In The Pathogenesis Of Dry Age-related Macular Degeneration
- The Effects of SIRT1 SiRNA on the Bloodfat and Actived Platelets in Insulin Resistance Mice
- SIRT1 enhances Th17 cell generation by deacetylating RORγt (P1163)
- Expression of SIRT1 and p27 during progression of human cervical cancer
- Transgenic Mice Lacking SIRT1 or SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- SIRT1 enhances endothelium‐dependent relaxation through an eNOS‐independent mechanism
- Original article SIRT1-deficient mice exhibit an altered cartilage phenotype
- Immunomodulation and Mechanism of Protein Deacetylase SIRT1
- Screening of SIRT1 activating compounds and their cytotoxicity in prostate cancer cell lines.
- PPARa Activation Inhibits Inflammatory Response in Endothelial Cells via the SIRT1-dependent Signaling Pathway
- Contrasting Effects of Enhanced SIRT1 Activity in Normal and BCR-ABL1-Depedent Haematopoiesis
- Regularity analysis of deacetylase SIRT1 expression in different pig organs and tissues
- Keratinocyte-specific deletion in mice reveals gene dose-dependent function of SIRT1 in tumorigenesis.
- Variant analysis of the Sirtuin [SIRT1] gene in multiple sclerosis
- AMPK-SIRT1 axis: a potential therapeutic target for prostate cancer management.
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes
- SIRT1 silencing confers neuroprotection through IGF-1 pathway activation
- Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF
- Interactions of SIRT1 with Acetyl Substrate, NAD+ or Nicotinamide
- Adipocyte-selective disruption of SIRT1 accelerates high fat diet
- Does resveratrol act independently of SIRT1 to affect genes relevant to ageing?
- Preliminary research of the relationship between coronary artery atherosclerosis and the genetic expression of AMPK and SIRT1
- MicroRNA-29c functions as a tumor suppressor by direct targeting endogenous SIRT1 in hepatocarcinogenesis
- SIRT1 Delays RGC Loss Following Optic Nerve Crush By Reducing Oxidative Stress
- SIRT1 links tumor suppressive NOTCH signaling to p53
- Mechanism of anti-proliferative effects of SIRT1 inhibition in melanoma cells: a proteomics approach.
- Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus
- INHIBITION OF SIRT1 INDUCES APOPTOSIS IN BREAST CANCER STEM CELLS; POSTER PRESENTATION
- The signal pathway of SIRT1 underlying the neuroprotection in NMDA-induced excitotoxicity
- The novel SIRT1 activator srt3025 provides atheroprotection through increased hepatic low-density lipoprotein receptor expression
- Regulation of Skeletal Muscle Insulin Action by SIRT1 and STAT3
- Impact of SIRT1 silencing on DNA damage repair and chemoradiotherapy resistance in human pancreatic cancer
- Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1ᴳ⁹³ᴬ transgenic mice as an in vivo model of amyotrophic …
- Amelioration of Age-Related Vascular Dysfunction with SIRT1 Activation
- Changes of PGC-1α and SIRT1 expression in hippocampus of type 2 diabetes mellitus rats and its significance
- Effects of Endurance Exercise on Hepatic SIRT1 and PGC-1α Protein Expression in Ovariectomized Rats
- Metformin regulates hyperglycemia-induced vascular senescence through SIRT1
- Anti-aging Effects of Simvastatin on ox-LDL Induced Endothelial Cells Via Upregulation of SIRT1
- Strategies of SIRT1 enhancement against frailty in aging and neurodegeneration
- CDK5-MEDIATED HYPERPHOSPHORYLATION CONTRIBUTES TO THE LOSS-OF-SIRT1 FUNCTION DURING THE DEVELOPMENT OF ENDOTHELIAL …
- FRI0036 Epigallocatechin gallate modulates SIRT1 expression in CPP crystal-induced inflammation
- SIRT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1a complex in vascular endothelial cells
- Evaluation of energy requirement in growing Lanyu pigs and the role of hepatic SIRT1 under different caloric levels.
- Neuroprotective Role of Sirtuin (SIRT1) Against Hypoxia in Retinal Ganglion Cells
- GW24-e0624 Impairted cardiac SIRT1 activity by carbonyl stress increase susceptibility of aged hearts to ischaemia reperfusion injury
- Obesity Accelerates Ovarian Follicle Development and Loss through Supressing SIRT1 Signaling in Rats
- The Relation between Resveratrol, SIRT1, mTOR and Autophagy
- SIRT1 Protects Against Lung Endothelial Cell Dysfunction Following Particulate Matter Exposure
- Influence of chidamide on proliferation, apoptosis with expression of Notch1 and SIRT1 in gastric carcinoma cell line SGC-7901
- Eicosapentaenoic acid enhances nitric oxide production through up‐regulating SIRT1 expression in human endothelial cells
- Disruption of SIRT1 in chondrocytes causes accelerated development of osteoarthritis induced by joint instability in the mouse
- SIRT1 acutely modulates glucose sensing of POMC neurons in the hypothalamus
- SIRT1 Regulation of the Heat Shock Response in an HSF1-Dependent Manner and the Impact of Caloric Restriction
- Exploring the Possibility of Changes in SIRT1 Activity in Lipotoxicity-mediated β-cell Dysfunction
- Correction: SIRT1 Regulates Endothelial Notch Signaling in Lung Cancer
- Improvement Of Corneal Staining By A SIRT1 Activator In A Mouse Model Of Dry Eye
- NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells
- MicroRNA-34a regulates diabetes-induced impaired angiogenesis: Role of SIRT1
- Significance and expression of SIRT1 gene in human cervical endplate chondrocyte in vitro degeneration
- Silencing of Pericyte MicroRNA-132 Reduces Renal Fibrosis and Myofibroblast Proliferation and is Associated with Altered SIRT1 and Cox2 Expression
- The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells.
- Expression Of FLT3-ITD Dysregulates The DBC1-SIRT1-p53 Signaling and Promotes Therapy Resistance
- Targeted inhibition of SIRT1 histone deacetylase by small-molecule inhibitor Tenovin-1 imparts significant anti-proliferative effects in human melanoma cells
- Cloning and prokaryotic expression of SIRT1 gene from torafugu Takifugu rubripes.
- The CREB SIRT1 axis mediates Neural Stem Cells modulation by nutrient availability
- Duration-and concentration-dependent induction of SIRT1 on human degenerative endplate chondrocytes by Resveratrol
- Supplementary Figures The NAD+-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status
- The Histone Deacetylase SIRT1 Modulates STAT3 Activity and Prevents De-differentiation and Proliferation of Vascular Smooth Muscle Cells
- Sirtuin1 (SIRT1) regulates HBV transcription and replication by targeting transcription factor AP-1.
- OP0256 SIRT1 Regulates Cigarette Smoke-Induced IL8 Expression and TNFA-Mediated Il6 Release in Rheumatoid Arthritis Synovial Fibroblasts
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- New molecular insights in APE1 binding to nCaRE elements of gene promoters: identification of SIRT1 as novel target gene
- Abolished Daily Expression Patterns of SIRT1, SIRT2, and SIRT5 in Human Chronic Myeloid Leukemia
- SIRT1 is Associated with Age-related Susceptibility to Acute Kidney Injury caused by Ischemia-reperfusion in Mice
- The growth arrest and apoptosis of adult T-cell leukemia cell lines MT2 induced by SIRT1 deacetylases inhibitor.
- Moderate alcohol consumption alters hepatic AdipoR1/SREBP‐1c and SIRT1 activity in rats with pre‐existing NASH
- SIRT1 regulates cigarette smoke-induced production of reactive oxygen species in myocardial mitochondria: Role of resveratrol [J]
- Correlation between estrogen secretion and SIRT1 gene expression levels in porcine ovarian granulosa cells.
- SIRT1 Activators Attenuate RGC Cell Loss By Reducing Oxidative Stress In MHV-A59 Induced Optic Neuritis
- PGE2 cigarette smoke-induced modulates endothelial tissue factor: role of EP1 receptor and SIRT1
- Combined Effect of Flow‐Mediated Shear Stress and Resveratrol on SIRT1/PGC‐1α Pathway in Vascular Endothelial Cells.
- A SUMOylation-dependent pathway regulates SIRT1 transcription and cancer metastasis
- Dimer Conversion of PPARalpha/RXR To PPARalpha/SIRT1 Suppresses Fatty Acid Oxidation Genes
- Abstract A86: SIRT1 regulates Rac1-GTPase activation via the guanine nucleotide exchange factor TIAM1
- SIRT1 antagonizes Stra13 Mediated p53 Acetylation and Senescence
- Overcoming of radiochemoresistance in glioblastoma stem cells via inhibition of lipid catabolism and SIRT1 deacetylase.
- Fullerenol Protects RPE cells from Oxidative-stress Induced Premature Senescence via Activation of SIRT1
- Accelerated Senescence of Cord Blood Endothelial Progenitor Cells From Premature Neonates is Driven by SIRT1 Decreased Expression
- Sirtuin (SIRT1/Sirt2) protect human pluripotent stem cells from DNA damage-induced apoptosis
- AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver
- Age-Associated Reduction of SIRT1 in Vascular Smooth Muscle Accelerates Angiotensin II-Induced Vascular Aging and Abdominal Aortic Aneurysm in Mice
- SIRT1 Activation with SRT1720 Reverses Impaired Endothelium‐Dependent Dilation in Old Mice by Augmenting COX‐2 Mediated Vasodilation
- The Role of SIRT1 in Exercise-and Resveratrol-induced Muscle Mitochondrial Biogenesis
- Inflammation and apoptosis in the synovium of patients with rheumatoid arthritis: the role of SIRT1 and microRNA-34a
- Resveratrol Displays Cardioprotection in Postinfarction Remodeling Through Autophagic Activation Associated With Ampk but not SIRT1 Pathway
- Epigenetic Regulation of p66Shc by SIRT1 Causes Persistent Myocardial Oxidative Stress and Inflammation Despite Optimal Glycemic Control in Diabetes
- Quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain.
- Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic SIRT1
- Inhibition of SIRT1 Sensitizes TRAIL-Resistant MCF-7 Cells by Upregulation of DR5 and Inhibition of c-FLIP
- The stability and bifurcation of modeling micro RNA regulation in signaling networks: miR-34a regulation of the p53/SIRT1 module
- NAMPT/NAD+/SIRT1-Triggered Deacetylation Of Hematopoietic Cell-Specific Lyn-Substrate 1 (HCLS1) In Congenital Neutropenia
- Resveratrol-induced activation of the SIRT1/AMPK axis in human CD4 T cells triggers replicative stress and an ATR-dependent cell cycle arrest
- Abstract LB-133: A novel tumor suppressor role for SIRT1 inhibiting mitophagy in prostate mouse tissue.
- Abstract LB-266: SIRT1 governs GnRH neuron migration and The Kallmann syndrome phenotype.
- H2S and L‐Cysteine Increase the Glucose Utilization via the PIP3 Mediated Insulin Dependent (PI3K/AKT) and the Insulin Independent (SIRT1/AMPK/PPAR gamma) …
- 496 Transgenic Mice Lacking SIRT1 Catalytic Activity Exhibit Greater Susceptibility to Pulmonary Hypertension in Response to Chronic Hypoxia
- Lycopene metabolite, apo‐10′‐lycopenoic acid, inhibits diet‐induced obesity‐promoted liver carcinogenesis via the up‐regulation of SIRT1 signaling and the …
- POLY (ADP‐RIBOSE) POLYMERASE‐2 DEPLETION REDUCES DOXORUBICIN‐INDUCED DAMAGE THROUGH SIRT1 INDUCTION
- Hematopoietic-specific lyn-substrate 1 (HCLS) is deacetylated by NAMPT/NAD+/SIRT1 pathway
- HEMATOPOIETIC-SPECIFIC LYN-SUBSTRATE 1 (HCLS) IS DEACETYLAT-ED BY NAMPT/NAD+/SIRT1 PATHWAY
- Phosphodiesterase-5 (PDE-5) Inhibitor, Tadalafil, Activates NO/SIRT1/PGC-1 Signaling And Attenuates Mitochondrial Dysfunction In Type 2 Diabetic Hearts
- Linking lipids to acetylation novel roles of of PI (5) P and PIP4K in SIRT1 regulation and development
- PHOSPHATIDYLINOSITOL-5-PHOSPHATE 4 KINASE BETA (PIP4Kβ) BINDS TO AND IS DEACETYLATED BY SIRT1
- Resveratrol Inhibits IL-6-induced STAT3 Activation in Human Colon Epithelial Cells: SIRT1 as a Potential Target
- the effects of GLP-1 on SIRT1 and on the related metabolic pathways in vascular endothelial cells: potential effects on vascular injury in diabetic patients
- Effect of crocin-1 on learning, memory, and expression of SIRT1 in hippocampus of rats under acute hypoxia
- Angiogenesis Inhibitor Vasohibin-1 Prevents Paraquat-Induced Lung Injury Via The Induction Of SOD2 And SIRT1
- Linking the pro‐oxidant influences of epigallocatechin gallate (EGCG) to intestinal cholesterol metabolism via alterations in sirtuin 1 (SIRT1) using Caco‐2 cells
- Set7/9 represses SIRT1 to induce collagen type II expression in 3D cultured human chodrocytes
- Identification of Novel Acetylation Sites in Nrf1 (NFE2L1) and Their Regulation by Sirtuin 1 (SIRT1)
- Endothelial Overexpression of LOX-1 Protects From in vivo Arterial Thrombosis and Modulates Oct-1 and SIRT1 Expression
- TP 40 Implication of SIRT1 and its downstream pathways in dystrophic process
- … pancreatic beta cells from cytokine-induced apoptosis by both alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2\2013HO-1 and SIRT1
- Sharp-1 Mediates p53-dependent cellular senescence through antagonism of SIRT1
- Structural and functional analysis of human SIRT1
- SIRT1 and other sirtuins in metabolism
- SIRT1 in cardiovascular aging
- Multifaceted modulation of SIRT1 in cancer and inflammation
- SIRT1 in neurodevelopment and brain senescence
- SIRT1 metabolic actions: integrating recent advances from mouse models
- Small molecule SIRT1 activators for the treatment of aging and age-related diseases
- SIRT1: role in cardiovascular biology
- The role of SIRT1 in cancer: the saga continues
- SIRT1 and NAD as regulators of ageing
- The role of SIRT1 in diabetic kidney disease
- SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases
- SIRT1 in cerebral ischemia
- Diverse roles of SIRT1 in cancer biology and lipid metabolism
- SIRT1 and kidney function
- SIRT1 is decreased during relapses in patients with multiple sclerosis
- The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
- SIRT1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy
- A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human
- Downregulation of SIRT1 as aging change in advanced heart failure
- Crystallographic structure of a small molecule SIRT1 activator-enzyme complex
- High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients
- SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress
- P53 and SIRT1: routes of metabolism and genome stability
- SIRT1 deacetylates RORγt and enhances Th17 cell generation
- Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma
- An exploratory double‐blind, randomized clinical trial with selisistat, a SIRT1 inhibitor, in patients with H untington’s disease
- Epigenetic effects of natural polyphenols: A focus on SIRT1‐mediated mechanisms
- Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21
- SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
- Molecular links between caloric restriction and Sir2/SIRT1 activation
- The N-terminal domain of SIRT1 is a positive regulator of endogenous SIRT1-dependent deacetylation and transcriptional outputs
- NAD+-dependent activation of SIRT1 corrects the phenotype in a mouse model of mitochondrial disease
- SIRT1 restrains lung inflammasome activation in a murine model of sepsis
- SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma
- SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
- SIRT1 in the brain—connections with aging-associated disorders and lifespan
- MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma
- Role of SIRT1 and AMPK in mesenchymal stem cells differentiation
- Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
- Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma
- Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
- Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients
- SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function
- SIRT1 activation ameliorates renal fibrosis by inhibiting the TGF‐β/Smad3 pathway
- Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes
- Disruption of SIRT1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice
- SIRT1 suppresses doxorubicin-induced cardiotoxicity by regulating the oxidative stress and p38MAPK pathways
- The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer
- Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: A mechanism including AMPKα1/SIRT1 [S]
- Adversity in childhood and depression: linked through SIRT1
- SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging
- SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia
- Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis
- SIRT1 protects against myocardial ischemia–reperfusion injury via activating eNOS in diabetic rats
- Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway
- Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut
- Age-related loss of SIRT1 expression results in dysregulated human vascular smooth muscle cell function
- The NAD+-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells
- Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through SIRT1 protein stabilization
- SIRT1 is involved in oncogenic signaling mediated by GPER in breast cancer
- Quercetin is a potent anti‐atherosclerotic compound by activation of SIRT1 signaling under oxLDL stimulation
- A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators
- CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity by SIRT1
- Spinal SIRT1 activation attenuates neuropathic pain in mice
- Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells
- Shear stress regulates endothelial cell autophagy via redox regulation and SIRT1 expression
- Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
- Identification, stability and expression of SIRT1 antisense long non-coding RNA
- A high-fat diet and NAD+ activate SIRT1 to rescue premature aging in cockayne syndrome
- SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
- SIRT1 is required in the male germ cell for differentiation and fecundity in mice
- Relationship between mitochondrial DNA copy number and SIRT1 expression in porcine oocytes
- Role of SIRT1 during the ageing process: relevance to protection of synapses in the brain
- Age-dependent tissue expression patterns of SIRT1 in senescence-accelerated mice
- Expression of SIRT1 and oxidative stress in diabetic dry eye
- SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
- Salvianolic acid B attenuates apoptosis and inflammation via SIRT1 activation in experimental stroke rats
- Effects of exercise and body temperature on eNOS, SIRT1, SIRT3 and Hsp70 expression in rat plantaris muscles (1164.6)
- The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice
- SIRT1-mediated eNAMPT secretion from adipose tissue regulates hypothalamic NAD+ and function in mice
- SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β
- The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome
- Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling
- SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation
- Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1
- NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells
- SIRT1 expression is associated with poor prognosis of lung adenocarcinoma
- SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
- Intercellular interplay between SIRT1 signalling and cell metabolism in immune cell biology
- mTOR, AMPK, and SIRT1: key players in metabolic stress management
- Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver
- Dual role of SIRT1 in UVB-induced skin tumorigenesis
- SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia
- AMPK-dependent phosphorylation of GAPDH triggers SIRT1 activation and is necessary for autophagy upon glucose starvation
- Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice
- SIRT1 protects pig oocyte against in vitro aging
- Radioprotective and antioxidant effect of resveratrol in hippocampus by activating SIRT1
- Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure
- SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264. 7 cells
- New indole–isoxazolone derivatives: Synthesis, characterisation and in vitro SIRT1 inhibition studies
- Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
- SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism
- SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma
- SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer
- Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes
- Resveratrol activates duodenal SIRT1 to reverse insulin resistance in rats through a neuronal network
- NAD+-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1
- SIRT1 suppresses self-renewal of adult hippocampal neural stem cells
- SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells
- Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
- SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells
- Role of SIRT1 in autoimmune demyelination and neurodegeneration
- Association of genetic variants of SIRT1 with type 2 diabetes mellitus
- SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo
- Expression of SIRT1 and SIRT3 varies according to age in mice
- Caloric restriction, resveratrol and melatonin: role of SIRT1 and implications for aging and related-diseases
- Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia
- SIRT1 deletion leads to enhanced inflammation and aggravates endotoxin-induced acute kidney injury
- SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α–dependent glycolysis
- Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1‐BMAL1 pathway
- SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements
- A randomized, placebo-controlled study of SRT2104, a SIRT1 activator, in patients with moderate to severe psoriasis
- … resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and …
- SIRT1 directly regulates SOX2 to maintain self‐renewal and multipotency in bone marrow‐derived mesenchymal stem cells
- The SIRT1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
- Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
- Role of SIRT1 in the growth and regulation of normal hematopoietic and leukemia stem cells
- SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
- SIRT1 in B [a] P-induced lung tumorigenesis
- The deacetylase SIRT1 is an essential regulator of Aire-mediated induction of central immunological tolerance
- SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens
- Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy
- SIRT1 and AMPK mediate hypoxia-induced resistance of non–small cell lung cancers to cisplatin and doxorubicin
- SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells
- SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
- Age-associated weight gain, leptin, and SIRT1: a possible role for hypothalamic SIRT1 in the prevention of weight gain and aging through modulation of leptin …
- SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and …
- DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
- The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy
- SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response
- Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness
- ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signaling
- SIRT1 regulates lamellipodium extension and migration of melanoma cells
- SIRT1 attenuates severe ischemic damage by preserving cerebral blood flow
- Modulation of SIRT1-Foxo1 signaling axis by resveratrol: implications in skeletal muscle aging and insulin resistance
- Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and SIRT1
- Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway
- In vivo RNA interference models of inducible and reversible SIRT1 knockdown in kidney cells
- PRMT1 and PRMT4 regulate oxidative stress-induced retinal pigment epithelial cell damage in SIRT1-dependent and SIRT1-independent manners
- SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer
- A phase II, randomized, placebo‐controlled, double‐blind, multi‐dose study of SRT2104, a SIRT1 activator, in subjects with type 2 diabetes
- Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons
- SIRT1 counteracted the activation of STAT3 and NF-κB to repress the gastric cancer growth
- Accelerated senescence of cord blood endothelial progenitor cells in premature neonates is driven by SIRT1 decreased expression
- Differential roles of SIRT1 in HIF-1α and HIF-2α mediated hypoxic responses
- Sirtuin1 (SIRT1) promotes cortical bone formation by preventing β-catenin sequestration by FoxO transcription factors in osteoblast progenitors
- Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a SIRT1‐independent manner
- SIRT1 promotes proliferation and inhibits the senescence-like phenotype in human melanoma cells
- Fasting protects liver from ischemic injury through SIRT1-mediated downregulation of circulating HMGB1 in mice
- The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis
- Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
- Interferon β protects against lethal endotoxic and septic shock through SIRT1 upregulation
- Resveratrol relieves ischemia‑induced oxidative stress in the hippocampus by activating SIRT1
- SIRT1 protects against oxidative stress‐induced endothelial progenitor cells apoptosis by inhibiting FOXO3a via FOXO3a ubiquitination and degradation
- Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line
- Oxidative stress-induced inhibition of SIRT1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
- Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SIRT1 and AMPK
- The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1
- Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathway
- Correlation and prognostic value of SIRT1 and Notch1 signaling in breast cancer
- Association between the SIRT1 mRNA expression and acute coronary syndrome
- SIRT1 activation rescues doxorubicin-induced loss of functional competence of human cardiac progenitor cells
- Overexpression of SIRT1 induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia
- SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis
- Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic …
- High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression
- NAD+-dependent SIRT1 deactivation has a key role on ischemia–reperfusion-induced apoptosis
- Attenuation of β‐amyloid‐induced tauopathy via activation of CK2α/SIRT1: Targeting for cilostazol
- Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5
- Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating SIRT1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat …
- Simvastatin attenuates TNF‑α‑induced apoptosis in endothelial progenitor cells via the upregulation of SIRT1
- Carbon monoxide protects against hepatic ischemia/reperfusion injury by modulating the miR-34a/SIRT1 pathway
- Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease
- Linking DNA damage, NAD+/SIRT1, and aging
- SIRT1 plays a protective role in intervertebral disc degeneration in a puncture-induced rodent model
- Calorie restriction attenuates cerebral ischemic injury via increasing SIRT1 synthesis in the rat
- Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue …
- Suppression of deacetylase SIRT1 mediates tumor-suppressive NOTCH response and offers a novel treatment option in metastatic Ewing sarcoma
- Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis
- Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/SIRT1/PGC-1α signaling
- Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice
- Modulating effect of SIRT1 activation induced by resveratrol on Foxo1‐associated apoptotic signalling in senescent heart
- Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of SIRT1 and Mn-SOD pathway
- SIRT1 deacetylase is overexpressed in human melanoma and its small molecule inhibition imparts anti-proliferative response via p53 activation
- SIRT1 activating compounds reduce oxidative stress mediated neuronal loss in viral induced CNS demyelinating disease
- Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation
- Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the SIRT1/AMPK and the Nrf2/antioxidant defense pathways in a …
- Metformin induces microRNA-34a to downregulate the SIRT1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress …
- Ligand and structure-based approaches for the identification of SIRT1 activators
- Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis
- FGF21 treatment ameliorates alcoholic fatty liver through activation of AMPK-SIRT1 pathway
- Resveratrol protects against doxorubicin‐induced cardiotoxicity in aged hearts through the SIRT1‐USP7 axis
- Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet
- Ketosis may promote brain macroautophagy by activating SIRT1 and hypoxia-inducible factor-1
- Specific turn-on fluorescent probe with aggregation-induced emission characteristics for SIRT1 modulator screening and living-cell imaging
- SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling
- SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis
- Over-expression of SIRT1 contributes to chemoresistance and indicates poor prognosis in serous epithelial ovarian cancer (EOC)
- Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through SIRT1‐mediated deacetylation
- MicroRNA-34a induces vascular smooth muscle cells senescence by SIRT1 downregulation and promotes the expression of age-associated pro-inflammatory …
- Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes
- Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
- Safety, pharmacokinetics, pharmacogenomics and QT concentration− effect modelling of the SIRT1 inhibitor selisistat in healthy volunteers
- Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype
- Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1
- Resveratrol induced premature senescence is associated with DNA damage mediated SIRT1 and SIRT2 down-regulation
- … -specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
- Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, SIRT1, and KLF4 and decreased tissue factor
- Resveratrol prevents doxorubicin-induced cardiotoxicity in H9c2 cells through the inhibition of endoplasmic reticulum stress and the activation of the SIRT1 …
- … of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1–p53 signaling pathways
- SIRT1 is a tumor promoter in lung adenocarcinoma
- Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
- Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis
- SIRT1 promoter polymorphisms as clinical modifiers on systemic lupus erythematosus
- High glucose induces renal tubular epithelial injury via SIRT1/NF-kappaB/microR-29/Keap1 signal pathway
- SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization
- SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system
- Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
- Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α
- Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats
- Polydatin alleviates small intestine injury during hemorrhagic shock as a SIRT1 activator
- Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway
- Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss
- SIRT1-deficiency causes defective protein quality control
- Korean Red Ginseng attenuates ethanol-induced steatosis and oxidative stress via AMPK/SIRT1 activation
- Novel downstream molecular targets of SIRT1 in melanoma: a quantitative proteomics approach
- Loss of SIRT1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
- Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model
- SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling
- Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1/p300/p53/p21 pathway
- Kaempferol protects cardiomyocytes against anoxia/reoxygenation injury via mitochondrial pathway mediated by SIRT1
- miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
- Minireview: central SIRT1 regulates energy balance via the melanocortin system and alternate pathways
- SIRT1 relays nutritional inputs to the circadian clock through the Sf1 neurons of the ventromedial hypothalamus
- rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1
- The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy
- Pyrroloquinoline quinone increases the expression and activity of SIRT1 and-3 genes in HepG2 cells
- A divergent role of the SIRT1-TopBP1 axis in regulating metabolic checkpoint and DNA damage checkpoint
- SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression
- SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth
- TNF‐α and LPS activate angiogenesis via VEGF and SIRT1 signalling in human dental pulp cells
- Macrophage‐specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP‐9 pathways
- miR-195 regulates SIRT1-mediated changes in diabetic retinopathy
- Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis
- Hypothalamic SIRT1 in aging
- ANG II promotes IGF-IIR expression and cardiomyocyte apoptosis by inhibiting HSF1 via JNK activation and SIRT1 degradation
- Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia
- The SIRT1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE−/− mice through inhibiting vascular inflammatory response
- High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased …
- Reduced SIRT1 expression correlates with enhanced oxidative stress in compensated and decompensated heart failure
- Effect of resveratrol, a SIRT1 activator, on the interactions of the CLOCK/BMAL1 complex
- A TagSNP in SIRT1 Gene Confers Susceptibility to Myocardial Infarction in a Chinese Han Population
- … acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway
- Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease
- Silent information regulator 1 (SIRT1) ameliorates liver fibrosis via promoting activated stellate cell apoptosis and reversion
- SIRT1-mediated deacetylation of CRABPII regulates cellular retinoic acid signaling and modulates embryonic stem cell differentiation
- Resveratrol differentially regulates NAMPT and SIRT1 in hepatocarcinoma cells and primary human hepatocytes
- Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort
- Roles of SIRT1 in granulosa cell apoptosis during the process of follicular atresia in porcine ovary
- Resveratrol enhanced FOXO3 phosphorylation via synergetic activation of SIRT1 and PI3K/Akt signaling to improve the effects of exercise in elderly rat hearts
- SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss
- α-Mangostin regulates hepatic steatosis and obesity through SIRT1-AMPK and PPARγ pathways in high-fat diet-induced obese mice
- Resveratrol inhibition of human keratinocyte proliferation via SIRT1/ARNT/ERK dependent downregulation of aquaporin 3
- Expression of SIRT1 in the ovaries of rats with polycystic ovary syndrome before and after therapeutic intervention with exenatide
- Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc …
- Exercise training enhanced SIRT1 longevity signaling replaces the IGF1 survival pathway to attenuate aging-induced rat heart apoptosis
- SIRT1 functions as an important regulator of estrogen-mediated cardiomyocyte protection in angiotensin II-induced heart hypertrophy
- SIRT1 inhibition by sirtinol aggravates brain edema after experimental subarachnoid hemorrhage
- Loss of SIRT1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria
- Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice
- Acetylation of HDAC1 and degradation of SIRT1 form a positive feedback loop to regulate p53 acetylation during heat-shock stress
- SIRT1 suppresses human T-cell leukemia virus type 1 transcription
- SIRT1 Polymorphisms Associate with Seasonal Weight Variation, Depressive Disorders, and Diastolic Blood Pressure in the General Population
- MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells
- Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1
- SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids
- A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling
- SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes
- The effect of alcohol on SIRT1 expression and function in animal and human models of hepatocellular carcinoma (HCC)
- GABA protects pancreatic beta cells against apoptosis by increasing SIRT1 expression and activity
- Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis
- Protective effects of resveratrol on hepatotoxicity induced by isoniazid and rifampicin via SIRT1 modulation
- AROS has a context-dependent effect on SIRT1
- Inhibition of HMGB1-induced angiogenesis by cilostazol via SIRT1 activation in synovial fibroblasts from rheumatoid arthritis
- … antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of SIRT1-Sirt3-Foxo3-PINK1 …
- SIRT1 attenuates high glucose-induced insulin resistance via reducing mitochondrial dysfunction in skeletal muscle cells
- Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
- Involvement of AMPK/SIRT1 pathway in anti-allodynic effect of troxerutin in CCI-induced neuropathic pain
- Simiao pill ameliorates renal glomerular injury via increasing SIRT1 expression and suppressing NF-κB/NLRP3 inflammasome activation in high fructose-fed rats
- FoxM1 regulates SIRT1 expression in glioma cells
- Changed profile of microRNAs in acute lung injury induced by cardio-pulmonary bypass and its mechanism involved with SIRT1
- Fullerenol protects retinal pigment epithelial cells from oxidative stress–induced premature senescence via activating SIRT1
- … SIRT1 activators SRT2183 and SRT3025 inhibit RANKL-induced osteoclastogenesis in bone marrow-derived macrophages and down-regulate Sirt3 in SIRT1 …
- AGEs-RAGE system down-regulates SIRT1 through the ubiquitin-proteasome pathway to promote FN and TGF-β1 expression in male rat glomerular mesangial cells
- SIRT1-metabolite binding histone macroH2A1. 1 protects hepatocytes against lipid accumulation
- SIRT1 inhibition affects angiogenic properties of human MSCs
- Intestine-specific deletion of SIRT1 in mice impairs DCoH2–HNF-1α–FXR signaling and alters systemic bile acid homeostasis
- Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of SIRT1-mediated apoptosis
- Short‑term calorie restriction activates SIRT1‑4 and‑7 in cardiomyocytes in vivo and in vitro
- Curcumin attenuates hydrogen peroxide-induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells
- Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors
- Pancreas-specific SIRT1-deficiency in mice compromises beta-cell function without development of hyperglycemia
- Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes
- HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA
- SIRT1 inactivation evokes antitumor activities in NSCLC through the tumor suppressor p27
- Isocaloric pair-fed high-carbohydrate diet induced more hepatic steatosis and inflammation than high-fat diet mediated by miR-34a/SIRT1 axis in mice
- Molecular insights into SIRT1 protection against UVB-induced skin fibroblast senescence by suppression of oxidative stress and p53 acetylation
- Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells
- Regulation of cell cycle regulators by SIRT1 contributes to resveratrol-mediated prevention of pulmonary arterial hypertension
- Nutraceutical activators of AMPK/SIRT1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection
- Investigating the role of SIRT1-modulated oxidative stress in relation to benign paroxysmal positional vertigo and Parkinson’s disease
- Humulus japonicus extract exhibits antioxidative and anti‑aging effects via modulation of the AMPK‑SIRT1 pathway
- SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing
- SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling
- KAP1 deacetylation by SIRT1 promotes non-homologous end-joining repair
- SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis
- Histone/protein deacetylase SIRT1 is an anticancer therapeutic target
- New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng
- The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin
- Cilostazol upregulates autophagy via SIRT1 activation: reducing amyloid-β peptide and APP-CTFβ levels in neuronal cells
- SIRT1 gene variants are related to risk of childhood obesity
- Set7/9 Impacts COL2A1 Expression Through Binding and Repression of SIRT1 Histone Deacetylation
- Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction
- Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng
- Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer …
- Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet …
- MicroRNAs and SIRT1: a strategy for stem cell renewal and clinical development?
- Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissues
- The metabolic sensors FXRα, PGC‐1 α, and SIRT1 cooperatively regulate hepatitis B virus transcription
- Novel small-molecule SIRT1 inhibitors induce cell death in adult T-cell leukaemia cells
- Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent SIRT1 upregulation
- Aspirin targets SIRT1 and AMPK to induce senescence of colorectal carcinoma cells
- SIRT1 and FOXO mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch
- SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner
- Aspirin attenuates vinorelbine-induced endothelial inflammation via modulating SIRT1/AMPK axis
- Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by β‐amyloid through activation of SIRT1/Akt1 pathway
- Antagonistic crosstalk between SIRT1, PARP-1, and-2 in the regulation of chronic inflammation associated with aging and metabolic diseases
- Protective effects of icariin‑mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion‑induced acute lung injury
- Calorie restriction inhibits ovarian follicle development and follicle loss through activating SIRT1 signaling in mice
- SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through …
- Fisetin induces SIRT1 expression while inhibiting early adipogenesis in 3T3-L1 cells
- Sensitization of chemo-resistant human chronic myeloid leukemia stem-like cells to Hsp90 inhibitor by SIRT1 inhibition
- Modulation of the AMPK/SIRT1 axis during neuronal infection by herpes simplex virus type 1
- Electroacupuncture upregulates SIRT1-dependent PGC-1α expression in SAMP8 Mice
- Peripheral leukocyte expression of the potential biomarker proteins Bdnf, SIRT1, and Psen1 is not regulated by promoter methylation in Alzheimer’s disease patients
- Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts: potential role of NO/SIRT1/PGC-1α signaling
- Prognostic role of SIRT1 in hepatocellular carcinoma
- Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells
- Palmitate inhibits SIRT1-dependent BMAL1/CLOCK interaction and disrupts circadian gene oscillations in hepatocytes
- Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death
- Higher expression of SIRT1 induced resistance of esophageal squamous cell carcinoma cells to cisplatin
- TNFα regulates SIRT1 cleavage during ocular autoimmune disease
- Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway
- SIRT1 and circadian gene expression in pancreatic ductal adenocarcinoma: effect of starvation
- SIRT1 and Sirt6 mediate beneficial effects of rosiglitazone on hepatic lipid accumulation
- MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of SIRT1
- Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2 pathway
- Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of SIRT1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells
- Activation of PPAR alpha by fenofibrate inhibits apoptosis in vascular adventitial fibroblasts partly through SIRT1-mediated deacetylation of FoxO1
- Chronic pancreatitis and pancreatic cancer demonstrate active epithelial–mesenchymal transition profile, regulated by miR-217-SIRT1 pathway
- Visfatin/Nampt and SIRT1
- Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1
- BET inhibition upregulates SIRT1 and alleviates inflammatory responses
- SIRT1 mediates the effect of the heme oxygenase inducer, cobalt protoporphyrin, on ameliorating liver metabolic damage caused by a high-fat diet
- SIRT1 mediates FOXA2 breakdown by deacetylation in a nutrient-dependent manner
- Homocysteine facilitates LOX-1 activation and endothelial death through the PKCβ and SIRT1/HSF1 mechanism: relevance to human hyperhomocysteinaemia
- Effects of resveratrol in patients with type 2 diabetes mellitus on skeletal muscle SIRT1 expression and energy expenditure
- Mitochondrial complex I deficiency enhances skeletal myogenesis but impairs insulin signaling through SIRT1 inactivation
- Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure
- Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
- Programmed hyperphagia secondary to increased hypothalamic SIRT1
- Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle
- Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance
- Cryptosporidium parvum induces SIRT1 expression in host epithelial cells through downregulating let-7i
- The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells
- Differential SIRT1 expression in hepatocellular carcinomas and cholangiocarcinoma of the liver
- Guignardins A–F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors
- Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo
- Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats
- Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1
- SIRT1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration
- Fentanyl increases colorectal carcinoma cell apoptosis by inhibition of NF-κB in a SIRT1-dependent manner
- Vitamin C protected human retinal pigmented epithelium from oxidant injury depending on regulating SIRT1
- The miR-29b–SIRT1 axis regulates self-renewal of mouse embryonic stem cells in response to reactive oxygen species
- Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge
- CPEB1 modulates differentiation of glioma stem cells via downregulation of HES1 and SIRT1 expression
- Nicotinic acid inhibits vascular inflammation via the SIRT1-dependent signaling pathway
- Structure-based drug design of small molecule SIRT1 modulators to treat cancer and metabolic disorders
- SIRT1 and STAT3 protect retinal pigmented epithelium cells against oxidative stress
- SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes
- SIRT1 gene is associated with cardiovascular disease in the Iranian population
- SIRT1 Overexpression Maintains Cell Phenotype and Function of Endothelial Cells Derived from Induced Pluripotent Stem Cells
- Coumestrol induces mitochondrial biogenesis by activating SIRT1 in cultured skeletal muscle cells
- The comparative study on expression of SIRT1 signal transduction by Xuefuzhuyu capsule
- Globular adiponectin causes tolerance to LPS-induced TNF-α expression via autophagy induction in RAW 264.7 macrophages: involvement of SIRT1/FoxO3A …
- Hydrogen sulfide delays nicotinamide-induced premature senescence via upregulation of SIRT1 in human umbilical vein endothelial cells
- Divalproex sodium enhances the anti-leukemic effects of imatinib in chronic myeloid leukemia cells partly through SIRT1
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/SIRT1/PGC-1α signaling
- Emodin inhibits HMGB1-induced tumor angiogenesis in human osteosarcoma by regulating SIRT1
- Effect of shikonin on multidrug resistance in HepG2: The role of SIRT1
- SIRT1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice
- Licochalcone suppresses LXRα-induced hepatic lipogenic gene expression through AMPK/SIRT1 pathway activation
- Protective effect of saponins extract from Panax japonicus on myocardial infarction: involvement of NF-κB, SIRT1 and mitogen-activated protein kinase signalling …
- Sirtuin 1 (SIRT1) activation mediates sildenafil induced delayed cardioprotection against ischemia-reperfusion injury in mice
- Acetylcholinesterase inhibitors and compounds promoting SIRT1 expression from Curcuma xanthorrhiza
- Correction: SIRT1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
- Butyric acid-induced rat jugular blood cytosolic oxidative stress is associated with SIRT1 decrease
- … ‐3‐glucoside protects human umbilical vein endothelial cells against oxidized low‐density lipoprotein‐induced injury by autophagy upregulation via the AMPK/SIRT1 …
- MicroRNA-204-5p–mediated regulation of SIRT1 contributes to the delay of epithelial cell cycle traversal in diabetic corneas
- … functions as a potent suppressor of oncogene‐induced senescence in prostate cancer via its transcriptional co‐regulation of the CDKN1A (p21WAF1/CIP1) and SIRT1 …
- SIRT1 mediates a primed response to immune challenge after traumatic lung injury
- SIRT1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers
- Cilostazol suppresses β‐amyloid production by activating a disintegrin and metalloproteinase 10 via the upregulation of SIRT1‐coupled retinoic acid receptor‐β
- Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway
- SIRT1 overexpression in skeletal muscle in vivo induces increased insulin sensitivity and enhanced complex I but not complex II–V functions in individual …
- The role of SIRT1 in the pathogenesis of insulin resistance in skeletal muscle
- Silent information regulator 1 (SIRT1) promotes the migration and proliferation of endothelial progenitor cells through the PI3K/Akt/eNOS signaling pathway
- Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
- MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function
- RhNRG-1β protects the myocardium against irradiation-induced damage via the ErbB2-ERK-SIRT1 signaling pathway
- The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest
- Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial …
- A novel role of SIRT1 in gammaherpesvirus latency and replication
- Cooperative action of Cdk1/cyclin B and SIRT1 is required for mitotic repression of rRNA synthesis
- SIRT1 mediates the effects of a short-term high-fat diet on the heart
- Celecoxib Sensitizes Staphylococcus aureus to Antibiotics in Macrophages by Modulating SIRT1
- Silencing angiopoietin‐like protein 4 (ANGPTL4) protects against lipopolysaccharide‐induced acute lung injury via regulating SIRT1/NF‐kB pathway
- Dysregulated miR-34a–SIRT1–acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of …
- Role of SIRT1-mediated mitochondrial and Akt pathways in glioblastoma cell death induced by Cotinus coggygria flavonoid nanoliposomes
- Hepatic SIRT1-dependent gain of function of stearoyl-CoA desaturase-1 conveys dysmetabolic and tumor progression functions
- Endoplasmic reticulum (ER) stress induces sirtuin 1 (SIRT1) expression via the PI3K-Akt-GSK3β signaling pathway and promotes hepatocellular injury
- Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation and mitochondrial dysfunction in the testis
- SIRT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation
- The SIRT1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice
- Reversible acetylation of Lin28 mediated by PCAF and SIRT1
- WRN translocation from nucleolus to nucleoplasm is regulated by SIRT1 and required for DNA repair and the development of chemoresistance
- Visfatin is involved in TNFα-mediated insulin resistance via an NAD+/SIRT1/PTP1B pathway in 3T3-L1 adipocytes
- SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing
- SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells
- SIRT1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice
- SIRT1 synchs satellite cell metabolism with stem cell fate
- Fructose mediated non-alcoholic fatty liver is attenuated by HO-1-SIRT1 module in murine hepatocytes and mice fed a high fructose diet
- Vestibular rehabilitation ameliorates chronic dizziness through the SIRT1 axis
- A novel mutation in SIRT1-AS leading to a decreased risk of HCC
- Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
- Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
- Depletion of sirtuin 1 (SIRT1) leads to epigenetic modifications of telomerase (TERT) gene in hepatocellular carcinoma cells
- Effects of nitric oxide synthase inhibition on fiber-type composition, mitochondrial biogenesis, and SIRT1 expression in rat skeletal muscle
- SIRT1 activation ameliorates aldara-induced psoriasiform phenotype and histology in mice
- Tenovin-6-mediated inhibition of SIRT1/2 induces apoptosis in acute lymphoblastic leukemia (ALL) cells and eliminates ALL stem/progenitor cells
- Potato protein hydrolysate attenuates high fat diet-induced cardiac apoptosis through SIRT1/PGC-1a/Akt signalling
- Functional sequence variants within the SIRT1 gene promoter in indirect inguinal hernia
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells
- AAV8-mediated SIRT1 gene transfer to the liver prevents high carbohydrate diet-induced nonalcoholic fatty liver disease
- Enhancement in efferocytosis of oxidized low‑density lipoprotein-induced apoptotic RAW264. 7 cells through SIRT1-mediated autophagy
- Rhein promotes the expression of SIRT1 in kidney tissues of type 2 diabetic rat
- Gene expression profiling of SIRT1, FoxO1, and PPARγ in backfat tissues and subcutaneous adipocytes of Lilu bulls
- Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer
- Methylation gets into rhythm with NAD+-SIRT1
- Quantitative insights for the design of substrate-based SIRT1 inhibitors
- SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells
- Ubiquitinated sirtuin 1 (SIRT1) function is modulated during DNA damage-induced cell death and survival
- Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis
- Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer
- Stem cell transplantation upregulates SIRT1 and antioxidant expression, ameliorating fatty liver in type 2 diabetic mice
- Regulation of HepG2 cell apoptosis by hepatitis C virus (HCV) core protein via the SIRT1–p53–bax pathway
- Genetic variation in SIRT1 is associated with lipid profiles but not with longevity in Ashkenazi Jews
- 5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-SIRT1 axis
- Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy
- Resveratrol relieves hydrogen peroxide-induced premature senescence associated with SIRT1 in human mesenchymal stem cells
- Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord
- Molecular characterization, expression profiles, and analysis of Qinchuan cattle SIRT1 gene association with meat quality and body measurement traits (Bos taurus)
- Endothelial cell senescence increases traction forces due to age-associated changes in the glycocalyx and SIRT1
- SIRT1 modulates miRNA processing defects in p53-mutated human keratinocytes
- Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, SIRT1, and mitochondrial function
- Ectopic expression of miR-494 inhibited the proliferation, invasion and chemoresistance of pancreatic cancer by regulating SIRT1 and c-Myc
- Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer
- Acetylated 8-oxoguanine DNA glycosylase 1 and its relationship with p300 and SIRT1 in lens epithelium cells from age-related cataract
- Down-regulation of mir-221 and mir-222 restrain prostate cancer cell proliferation and migration that is partly mediated by activation of SIRT1
- SIRT1 interacts with and deacetylates ATP6V1B2 in mature adipocytes
- Central SIRT1 regulates body weight and energy expenditure along with the POMC-derived peptide α-MSH and the processing enzyme CPE production in diet-induced …
- Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs
- Acetylome analysis identifies SIRT1 targets in mRNA-processing and chromatin-remodeling in mouse liver
- Resveratrol Regulates the Quiescence‐Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio
- Scrapie infection in experimental rodents and SMB-S15 cells decreased the brain endogenous levels and activities of SIRT1
- Suppression of RANKL-induced osteoclast differentiation by cilostazol via SIRT1-induced RANK inhibition
- MiR-132 inhibits expression of SIRT1 and induces pro-inflammatory processes of vascular endothelial inflammation through blockade of the SREBP-1c metabolic …
- Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy
- Potent SIRT1 Enzyme-stimulating and Anti-glycation Activities of Polymethoxyflavonoids from Kaempferia parviflora
- Nicotinamide and resveratrol regulate bovine adipogenesis through a SIRT1-dependent mechanism
- Mass spectrometric studies on the in vivo metabolism and excretion of SIRT1 activating drugs in rat urine, dried blood spots, and plasma samples for doping control …
- Expression of SIRT1 and FoxP3 in classical Hodgkin lymphoma and tumor infiltrating lymphocytes: implications for immune dysregulation, prognosis and …
- JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression
- The TRPA1 channel is a cardiac target of mIGF-1/SIRT1 signaling
- Taurine attenuates amyloid β 1–42-induced mitochondrial dysfunction by activating of SIRT1 in SK-N-SH cells
- Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1α/PPARα-FGF21 signaling pathway in male Sprague Dawley rats …
- MicroRNA-212 negatively regulates starvation induced autophagy in prostate cancer cells by inhibiting SIRT1 and is a modulator of angiogenesis and cellular …
- MicroRNA-449 suppresses proliferation of hepatoma cell lines through blockade lipid metabolic pathway related to SIRT1
- Resveratrol could reverse the expression of SIRT1 and MMP-1 in vitro
- Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet
- The SIRT1/TP53 axis is activated upon B-cell receptor triggering via miR-132 up-regulation in chronic lymphocytic leukemia cells
- Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway
- Insulin attenuates arsenic-induced neurite outgrowth impairments by activating the PI3K/Akt/SIRT1 signaling pathway
- Effect of nasal CPAP on SIRT1 and endothelial function in obstructive sleep apnea syndrome
- SIRT1 and HMGB1 Regulate the AGE-Induced Pro-Inflammatory Cytokines in Human Retinal Cells.
- miR-27b overexpression improves mitochondrial function in a SIRT1-dependent manner
- CTGF siRNA ameliorates tubular cell apoptosis and tubulointerstitial fibrosis in obstructed mouse kidneys in a SIRT1-independent manner
- Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model
- Myeloid-specific SIRT1 deletion aggravates hepatic inflammation and steatosis in high-fat diet-fed mice
- Role of SIRT1 in the protection of intestinal epithelial barrier under hypoxia and its mechanism
- SIRT1 downregulation enhances chemosensitivity and survival of adult T-cell leukemia-lymphoma cells by reducing DNA double-strand repair
- Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation
- SIRT1 expression is associated with lymphangiogenesis, lymphovascular invasion and prognosis in pN0 esophageal squamous cell carcinoma
- … peroxisome proliferator-activated receptor-δ and-γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1
- SIRT1 activity in peripheral blood mononuclear cells from patients with rheumatoid arthritis
- Chikusetsu saponin V attenuates MPP+-induced neurotoxicity in SH-SY5Y cells via regulation of SIRT1/Mn-SOD and GRP78/caspase-12 pathways
- … ‑enriched exopolysaccharides produced by Enterobacter cloacae Z0206 alleviate adipose inflammation in diabetic KKAy mice through the AMPK/SIRT1 …
- Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities
- Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells
- Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target
- Ablation of Lgr4 enhances energy adaptation in skeletal muscle via activation of Ampk/SIRT1/Pgc1α pathway
- Effect of pure total flavonoids from citrus on hepatic SIRT1/PGC-1alpha pathway in mice with NASH
- Alteration in bioenergetic regulators, SIRT1 and Parp1 expression precedes oxidative stress in rats subjected to transient cerebral focal ischemia: molecular and …
- MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1
- Fuzhisan, a chinese herbal medicine, suppresses beta-secretase gene transcription via upregulation of SIRT1 expression in N2a-APP695 cells
- SIRT1 is reduced in gastric adenocarcinoma and acts as a potential tumor suppressor in gastric cancer
- Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem
- Association of SIRT1 and tumor suppressor gene TAp63 expression in head and neck squamous cell carcinoma
- Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case …
- CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase
- Morphoproteomics identifies constitutive activation of the mTORC2/Akt and NF-κB pathways and expressions of IGF-1R, SIRT1, COX-2, and FASN in peripheral …
- SIRT1 regulates microtubule dynamics through negative regulation of Plk1 in mitosis
- Synthesis and Characterization of 4,11-Diaminoanthra[2,3-b]furan-5,10-diones: Tumor Cell Apoptosis through tNOX-Modulated NAD+/NADH Ratio and SIRT1
- … the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome …
- The Effect of SIRT1 Gene Polymorphisms on Ambulatory Blood Pressure of Hypertensive Patients in the Kazakh Population
- Interaction between NLRP3 inflammasome and SIRT1/6: metabolomics approach
- Down-regulation of the miR-543 alleviates insulin resistance through targeting the SIRT1
- IL-15 is required for postexercise induction of the pro-oxidative mediators PPARδ and SIRT1 in male mice
- The effect of SIRT1 protein knock down on PGC-1α acetylation during skeletal muscle contraction
- Role of SIRT1 in Streptococcus pneumoniae-induced human β-defensin-2 and interleukin-8 expression in A549 cell
- The role of SIRT1 in bile acid regulation during calorie restriction in mice
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- A Nampt inhibitor FK866 mimics vitamin B 3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD+-SIRT1 signaling
- SIRT1 promote GTM cell DSBs repair and resist cellular senescence
- PPARα agonist WY-14643 induces SIRT1 activity in rat fatty liver ischemia-reperfusion injury
- 3, 5, 4′-Tri-O-acetylresveratrol attenuates lipopolysaccharide-induced acute respiratory distress syndrome via MAPK/SIRT1 pathway
- VEGF receptor-2–linked PI3K/calpain/SIRT1 activation mediates retinal arteriolar dilations to VEGF and shear stress
- Resveratrol: brain effects on SIRT1, GPR50 and photoperiodic signaling
- Transgenic supplementation of SIRT1 fails to alleviate acute loss of nigrostriatal dopamine neurons and gliosis in a mouse model of MPTP-induced …
- Differential effect of estradiol and bisphenol A on Set8 and SIRT1 expression in prostate cancer
- Nontoxic-dose of deguelin induce NPMC+ aml cell differentiation by selectively targeting MT NPM1/SIRT1 instead of HDAC1/3
- Inflammation contributes to NKX3. 1 loss and augments DNA damage but does not alter the DNA damage response via increased SIRT1 expression
- Growth inhibition of human hepatocellular carcinoma by miRNA-204 via down-regulation of Bcl-2 and SIRT1 expression
- CYP epoxygenase metabolites of docosahexaenoic acid protect HL-1 cardiac cells against LPS-induced cytotoxicity through SIRT1
- … acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon …
- Vitamin D (VD) prevents oxidative stress via regulating NOX4/Nrf2/Trx signaling cascade and upregulates SIRT1‐mediated AMPK/IRS1/GLUT4 pathway and glucose …
- The effect of the SIRT1 2827 A> G polymorphism, resveratrol, exercise, age and occupation in Turkish population with cardiovascular disease
- Up-regulation of the Sirtuin 1 (SIRT1) and Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Genes in White Adipose Tissue of Id1 Protein-deficient …
- Photobiomodulation on Bax and Bcl-2 Proteins and SIRT1/PGC-1α Axis mRNA Expression Levels of Aging Rat Skeletal Muscle
- Inhibition of P-TEFb by DRB suppresses SIRT1/CK2α pathway and enhances radiosensitivity of human cancer cells
- The SIRT1 promoter polymorphic site rs12778366 increases IL-6 related human mortality in the prospective study “Treviso Longeva (TRELONG)”
- Upregulation of Unc-51-like kinase 1 by nitric oxide stabilizes SIRT1, independent of autophagy
- Improved Expression of SIRT1 on Thymic Epithelial Cells of SAMP10 after Intrabone Marrow–Bone Marrow Transplantation
- β-Lapachone ameliorates murine cisplatin nephrotoxicity: NAD+, NQO1, and SIRT1 at the crossroads of metabolism, injury, and inflammation
- SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights
- MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function
- SIRT1 silencing suppresses prostate cancer growth and metastasis in an orthotopic prostate cancer mouse model
- SIRT1 inhibition suppresses multiple sclerosis
- The cytokine homeostasis was regulated by over-expression of SIRT1 in collagen-induced arthritis mice
- The role of SIRT1 in the treatment of diabetic nephropathy
- Structure–activity relationship and interaction studies of new SIRT1 inhibitors with the scaffold of 3-(furan-2-yl)-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazole
- The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2− 866 G/A and SIRT1− 1400 T/C polymorphisms with T2D in …
- Rosuvastatin improves insulin sensitivity in overweight rats induced by high fat diet. Role of SIRT1 in adipose tissue
- Effects of Vam3 on sodium nitroprusside-induced apoptosis and SIRT1 and p53 expression in rat articular chondrocytes
- RETRACTED: Role of mammalian sirtuin 1 (SIRT1) in lipids metabolism and cell proliferation of goose primary hepatocytes
- Retraction Notice to: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10
- SIRT1 and rRNA in the nucleolus: regulating the regulator
- Effect of SIRT1 on cellular apoptosis and steroidogenesis in bovine ovarian granulosa cells in vitro
- Effects of single and combined genotypes of SIRT1 and SIRT2 genes on meat quality traits in Qinchuan cattle.
- Phosphoproteomics combined with quantitative 14-3-3-affinity capture identifies SIRT1 and RAI as novel regulators of cytosolic double-stranded RNA …