Studies on SENESCENT CELLS, SASP & SENOLYTICS | Interstellar Blends

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January 10, 2020

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January 14, 2020

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[HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

H Thoppil, K Riabowol – Frontiers in Cell and Developmental Biology, 2019

… Huang et al., 1999; Montero et al., 2011). These compounds form one of the first discovered members of the senolytic class of drugs that selectively induce apoptosis in senescent cells. Four years after their initial identification as …

BIOMARKERS FOR CELLULAR SENESCENCE

M Demaria – US Patent App. 16/492,410, 2020

… 15. The drug conjugate according to claim 12, wherein the cytotoxic agent is a senolytic agent, a radioisotope, a toxin or a toxic peptide. 16 … The cytotoxic agent can be a radioisotope, a toxin, toxic peptide or a senolytic drug …

[HTML] Potential Role of Cellular Senescence in Asthma

ZN Wang, RN Su, BY Yang, KX Yang, LF Yang, Y Yan… – Frontiers in Cell and …, 2020

… proteases expressed by senescent lung fibroblasts could result in low-level inflammation and fibrosis (Schafer et al., 2017; Álvarez et al., 2017). Clearance of these senescent fibroblasts by senolytic drugs would render the reso.

The Heterogeneity of Senescent Cells

LITO Salon

… However, there is no single senolytic that has been shown to target all of our senescent cells … One example is Cleara Biotechnologies, whose founder, Dr. Peter De Keizer, has talked about senolytic “cocktails” and the problem …

Perspectives of the potential implications of polyphenols in influencing the interrelationship between oxi-inflammatory stress, cellular senescence and …

R Sharma, Y Padwad – Trends in Food Science & Technology, 2020

JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …

[PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

BA Benayoun, RA Veitia

… aging. From the perspective of precision medicine, it will be possible to identify individu- als at higher risk of developing single or multiple morbidi- ties for devising new preventive measures, such as specific senolytic treatments …

Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

S Saxena, S Kumar – GeroScience

… 2017). Senescent cells also upregulate the expression of anti-apoptotic proteins BCL-W and BCL-XL, the inhibition of which with siRNA or small molecules ABT-737 or ABT-263 (senolytic drugs) leads to apoptosis (Chang …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020

… the nonpermissive temperature. This suggests that the maintenance of the senescent phenotype results in a low level of p38 signaling and that p38 activators might be effective in mediating senolytic therapies. Consistent with …

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020

Why do we get cancer mostly when we are old? According to current paradigms, the answer is simple: mutations accumulate in our tissues throughout life, and some of these mutations contribute to cancers.

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology

… Working on green tea EGCG, we have previously reported its anti- immunosenescence, anti-inflammatory, anti-senescence, senolytic and synbiotic attributes thereby suggesting its multi-faceted potency as an …

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020

Page 1. From the Department of Cell and Molecular Biology Karolinska Institutet, Stockholm, Sweden Novel properties of mature adipocytes in obesity and hyperinsulinemia Qian Li 李倩 Stockholm 2020 Page 2. Cover picture …

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

A Costa, MY Bonner, S Rao, L Gilbert, M Sasaki… – Cancers, 2020

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

E Laconi, F Marongiu, J DeGregori – British Journal of Cancer, 2020

Preadipocyte secretory factors differentially modulate murine macrophage functions during aging which are reversed by the application of phytochemical EGCG

R Kumar, A Sharma, Y Padwad, R Sharma – Biogerontology

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

Q Li – 2020

Targeted reduction of senescent cell burden alleviates focal radiotherapy-related bone loss.

A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park… – Journal of bone and mineral …, 2020

… To test if senolytic drugs, which clear senescent cells, alleviate FRT-related bone damage, we administered the senolytic agents, Dasatinib (D), Quercetin (Q), Fisetin (F), and a cocktail of D and Q (D+Q). We found moderate …

Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue

RM Laberge, J Campisi, M Demaria, N David… – US Patent App. 16/584,638, 2020

… US 20200030323 A1 US20200030323 A1 US 20200030323A1 US 201916584638 A US201916584638 A US 201916584638A US 2020030323 A1 US2020030323 A1 US 2020030323A1 Authority US United States Prior …

[HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

T Montero-Melendez, A Nagano, C Chelala, A Filer… – Nature Communications, 2020

Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific …

[HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

CL Xu, B Sang, GZ Liu, JM Li, XD Zhang, LX Liu… – Nucleic Acids Research, 2020

… Moreover, SENEBLOC was shown to be involved in both oncogenic and replicative senes- cence, and from the perspective of senolytic agents we show that the antagonistic actions of rapamycin on senescence are dependent on SENEBLOC ex- pression …

Repurposing cell penetrating peptides and their novel derivatives and iopromide and iodo-aryl carbonates for treatment of senescence-related diseases and disorders

SS Çinarouglu, E Timucin, GB Akcapinar, U Sezerman… – US Patent App. 16/526,997, 2020

… US2020031873A1 US 20200031873 A1 US20200031873 A1 US 20200031873A1 US 201916526997 A US201916526997 A US 201916526997A US 2020031873 A1 US2020031873 A1 US 2020031873A1 …

[HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

A Barbouti, PVS Vasileiou, K Evangelou, KG Vlasis… – Oxidative Medicine and …, 2020

The human thymus is a primary lymphoepithelial organ which supports the production of self-tolerant T cells with competent and regulatory functions. Paradoxically, despite the crucial role that it exerts in T cell-mediated immunity …

[HTML] Taking in consideration the bystander effects of articular senescence

JM Brondello, YM Pers – Annals of Translational Medicine, 2019

… harboring shorten telomeres, by accumulating cycle-dependent kinases inhibitors driving senescence such as p16 Ink4a , p21 Cdkn1A and p57 KIP2 , and finally by producing deleterious catabolic and inflammatory mediators …

RNA Biology Provides New Therapeutic Targets for Human

LW Harries – Role of RNA Modification in Disease, 2020

… For example, strategies are emerging now which allow selective delivery of senolytic cargoes to senescent cells only using galactosaccharide nanoparticles, which harness the observation that senescent cells harbor …

The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte – Nature Reviews Molecular Cell Biology, 2020

Ageing is characterized by the functional decline of tissues and organs and the increased risk of ageing-associated disorders. Several ‘rejuvenating’ interventions have been proposed to delay ageing and the onset of …

[PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

F Triana-Martínez, MI Loza, E Domínguez – Cells, 2020

… with the promise of future directions on innovative anticancer therapies. Keywords: cellular senescence; stemness; dormancy; quiescence; senolytic 1. Introduction Natural tumor evolution is a complex process, composed of …

The Heterogeneity of Senescent Cells

NK September

[PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

B Cucarull, A Tutusaus, M Subías, M Stefanovic… – Cancers, 2020

… A-1331852 has been proposed as an agent in cancer therapy [42,43] and, more recently, as a senolytic compound [44]. Interestingly, through a dual mechanism acting on senescent cholangiocytes and activated fibroblasts …

Cellular Senescence and Tumor Promotion

M Demaria – Geriatric Oncology

… rejuvenation of aged-tissue stem cells (Childs et al. 2017; Soto- Gamez and Demaria 2017). Currently, a limited number of senolytic agents have been identified. 2-DG, a false substrate for the glycolytic metabolism, or bafilomycin A1, a

[PDF] Henry Ford Health System Scholarly Common s

DE Citrin, PGS Prasanna, AJ Walker, ML Freeman…

… this setting. Although preventing premature senescence has shown promise in preventing RIF, there is increasing interest in agents that can clear prematurely senescent cells from tissues using “senolytic” drugs. Indeed, clearance …

The role of adipose tissue senescence in obesity-and ageing-related metabolic disorders

Z Liu, KKL Wu, X Jiang, A Xu, KKY Cheng – Clinical Science, 2020

Skip to Main Content …

[PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

S KOBASHIGAWA, YM SAKAGUCHI, S MASUNAGA… – Thermal Medicine, 2019

… In addition, a recent study demonstrated the efficacy of senolytic drugs in the selective elimination of senescent cells123); a combined treatment of dasatinib and quercetin (D＋Q) was found to reduce the number of senescent …

[PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

MJ Yousefzadeh, J Zhao, C Bukata, EA Wade… – Aging Cell

Abstract Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, includi…

Cardiac Glycosides as Senolytic Compounds

N Martin, O Soriani, D Bernard – Trends in Molecular Medicine, 2020

The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al …

[HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

AJ Barinda, K Ikeda, DB Nugroho, DA Wardhana… – Nature Communications, 2020

Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that …

[HTML] Urogenital Support

BI Blog, ADN Booster

… Current research has shown that certain plant polyphenols (ie quercetin and fisetin) are strong senolytic agents (molecules that stop senescence), and have exciting potential for reducing and preventing senescence, which …

[PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

B Wang, Z Liu, VP Chen, L Wang, CL Inman, Y Zhou… – Aging Cell

… Our study potentially begins new avenues of research to discover whether pharmacological interventions, such as senolytic drugs (Tchkonia & Kirkland, 2018) or anti‐inflammatory drugs, can prevent or reverse dysfunction caused …

[PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… – Molecules, 2020

Page 1. Molecules 2020, 25, 467; doi:10.3390/molecules25030467 www.mdpi.com/ journal/molecules Review Preclinical Pharmacological Activities of Epigallocatechin- 3-gallate in Signaling Pathways: An Update on Cancer

Senolytic compositions and uses thereof

MA Gallop, J Klein, M Quarta – US Patent App. 16/508,477, 2020

UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound data: image/svg+xml; base64, PD94bWwgdmVyc2lvbj0nMS4wJyBlbm…/+ IDwvcmVjdD4KPHBhdGggY2xhc3M9J2…+Cjx0ZXh0IHg9JzIyOS45MjQnIHk9JzE1… PHRzcGFuPkg8L3RzcGFuPjwvdGV4d …

Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging

K Kato, NJ Logsdon, YJ Shin, S Palumbo, A Knox… – American Journal of …, 2020

… One study demonstrated that the senolytic agent, quercetin, restored apoptosis susceptibility in IPF lung myofibroblasts, and inhibited fibrotic responses to lung injury in aged mice (62). Further, the first-in-human pilot study with a senolytic …

[HTML] Browsed by Tag: Mitochondrial mutations

N Bagalà, S Hill

[PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

FJ Alibhai, F Lim, A Yeganeh, PV DiStefano… – Aging Cell

… Instead, we show that cellular senescence contributes to changes in particle cargo and function. Notably, senolytictreatment of old mice shifted plasma particle cargo and function toward that of a younger phenotype.

Therapy-induced senescence—an induced synthetic lethality in liver cancer?

K Wolter, L Zender – Nature Reviews Gastroenterology & Hepatology, 2020

… cells. Therefore, the directed use of senolytic therapies in human cancers necessitates imaging modalities to non-invasively visualize TIS, thereby enabling image-guidedapplications of senolytic therapies. Full size image. Two …

Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice.

MB Cavalcante, TD Saccon, ADC Nunes, JL Kirkland… – Aging, 2020

… Collagen deposition in the uterus is related to uterine aging. Senolytic therapies are an option for reducing health complications related to aging. We investigated effects of agingand the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis …

[HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

C Martin-Ruiz, J Hoffmann, E Shmeleva, T von Zglinicki… – npj Aging and Mechanisms …, 2020

… p < 0.001; **p < 0.01; *p < 0.05 using 1-way ANOVA. Full size image. Senolytic therapy … The gating scheme is depicted in Fig. 2a. Animals, procedures and senolytictreatment. C57BL/6 mice were analyzed at either …

Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes

B Kang, Y Kim, TJ Park, HY Kang – Biochemical and Biophysical Research …, 2020

… allergic asthma. Br. J. Pharmacol., 173 (2016), pp. 1236-1247. Google Scholar. [8] JL Kirkland, T. Tchkonia, Y. Zhu, LJ Niedernhofer, PD RobbinsThe clinical potential of senolytic drugs. J. Am. Geriatr. Soc., 65 (2017), pp. 2297 …

[PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

PW O’Toole, PG Shiels – Journal of Internal Medicine, 2020

… Nrf2 regulates over 390 stress defence genes linked to longevity and health span. Moreover, alkyl catechols comprise a group of chemicals that include the senolytic agents fisetin and quercetin, which have proven efficacy in …

[HTML] Browsed by Tag: cancer

G Stolyarov II, A Grases

… When I am 85, the senolytic DNA machinery will be far from the only addition to my cells … Inflammatory conditions of aging will be a shadow of what they once were, because of senolytic therapies presently under development …

Pharmacological or genetic depletion of senescent astrocytes prevents whole brain irradiation–induced impairment of neurovascular coupling responses protecting …

A Yabluchanskiy, S Tarantini, P Balasubramanian… – GeroScience

… Data are expressed as mean ± SEM. Results. WBI induces astrocyte senescence: protective effects of senolytictreatments … 3d, e). WBI impairs eicosanoid gliotransmitter-mediated NVC responses: protective effects of senolytictreatments …

[HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

CM Willis, AM Nicaise, ER Bongarzone, M Givogri… – Scientific Reports, 2020

The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy …

[HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

H Chen, H Chen, J Liang, X Gu, J Zhou, C Xie, X Lv… – Experimental & Molecular …, 2020

To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 …

[HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

MA Khan, X Wang, KTK Giuliani, P Nag, A Grivei… – International Journal of …, 2020

Proximal tubular epithelial cells (PTEC) are key players in the progression of kidney diseases. PTEC studies to date have primarily used mouse models and transformed human PTEC lines. However, the translatability of these …

[HTML] Metabolic Syndrome Support

BI Blog, HIA You

PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

AH El-Far, NHE Darwish, SA Mousa – Integrative Cancer Therapies, 2020

Cellular senescence is a process of physiological growth arrest that can be induced by intrinsic or extrinsic stress signals. Some cancer therapies are associated with senescence of cancer cells wi…

Targeting defective pulmonary innate immunity–A new therapeutic option?

KBR Belchamber, LE Donnelly – Pharmacology & Therapeutics, 2020

Targeting the progression of chronic kidney disease

M Ruiz-Ortega, S Rayego-Mateos, S Lamas, A Ortiz… – Nature Reviews Nephrology, 2020

Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well as ageing of the population. Regardless …

Cellular senescence: from anti-cancer weapon to anti-aging target

L Yuan, PB Alexander, XF Wang – Science China Life Sciences, 2020

Cellular senescence (CS) is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory molecules. Early studies desc.

[PDF] Targeting Age-Related Pathways in Heart Failure

H Li, MH Hastings, J Rhee, LE Trager, JD Roh… – Circulation Research, 2020

During aging, deterioration in cardiac structure and function leads to increased susceptibility to heart failure. The need for interventions to combat this age-related cardiac decline is becoming i…

[HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

X Li, J Wu, X Sun, Q Wu, Y Li, K Li, Q Zhang, Y Li… – Stem Cell Reports, 2020

JavaScript is disabled on your browser. Please enable JavaScript to use all the features on this page. Skip to main content Skip to article …

[HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …

Y Li, J Lu, X Cao, H Zhao, L Gao, P Xia, G Pei – Oxidative Medicine and Cellular …, 2020

Oxidative stress-induced mitochondrial dysfunction and cell senescence are considered critical contributors to Alzheimer’s disease (AD), and oxidant/antioxidant imbalance has been a therapeutic target in AD. SIRT3 …

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MDM2

Andrographis Paniculata

[HTML] Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging

[HTML] Potential Role of Cellular Senescence in Asthma

[PDF] Special issue on “Molecular genetics of aging and longevity”: a critical time in the field of geroscience

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

[PDF] Establishment of a Temperature-Sensitive Model of Oncogene-Induced Senescence in Angiosarcoma Cells

[PDF] Novel properties of mature adipocytes in obesity and hyperinsulinemia

[HTML] Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis

[HTML] SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms

[HTML] Implications of Oxidative Stress and Cellular Senescence in Age-Related Thymus Involution

[HTML] Taking in consideration the bystander effects of articular senescence

[PDF] Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

[PDF] Regorafenib Alteration of the BCL-xL/MCL-1 Ratio Provides a Therapeutic Opportunity for BH3-Mimetics in Hepatocellular Carcinoma Models

[PDF] Henry Ford Health System Scholarly Common s

[PDF] Stress-induced Cellular Senescence Contributes to Chronic Inflammation and Cancer Progression

[PDF] Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

[HTML] Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype

[HTML] Urogenital Support

[PDF] Transplanting cells from old but not young donors causes physical dysfunction in older recipients

[PDF] Preclinical Pharmacological Activities of Epigallocatechin-3-gallate in Signaling Pathways: An Update on Cancer

[HTML] Browsed by Tag: Mitochondrial mutations

[PDF] Cellular senescence contributes to age‐dependent changes in circulating extracellular vesicle cargo and function

[HTML] CMV-independent increase in CD27− CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians

[PDF] The role of the microbiota in sedentary life style disorders and ageing: Lessons from the animal kingdom

[HTML] Browsed by Tag: cancer

[HTML] Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

[HTML] TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

[HTML] Underlying Histopathology Determines Response to Oxidative Stress in Cultured Human Primary Proximal Tubular Epithelial Cells

[HTML] Metabolic Syndrome Support

PDF] Senescent Colon and Breast Cancer Cells Induced by Doxorubicin Exhibit Enhanced Sensitivity to Curcumin, Caffeine, and Thymoquinone

[PDF] Targeting Age-Related Pathways in Heart Failure

[HTML] Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury

[HTML] A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through …

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