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    Sulforaphane
    January 15, 2020
    Ursolic Acid
    January 15, 2020

    Thymoquinone

    1. Thymoquinone is a potent superoxide anion scavenger
    2. Hepatoprotective activity of Thymoquinone in isolated rat hepatocytes
    3. Thymoquinone: potential cure for inflammatory disorders and cancer
    4. Thymoquinone: a promising anti-cancer drug from natural sources
    5. Fixed oil of Nigella sativa and derived Thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    6. The influence of Thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    7. Thymoquinone and its therapeutic potentials
    8. Thymoquinone protects against carbon tetrachloride hetatotoxicity in mice via an antioxidant mechanism
    9. Inhibitory effects of Thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis.
    10. In vitro toxicological properties of Thymoquinone
    11. Antinociceptive effects of Nigella sativa oil and its major component, Thymoquinone, in mice
    12. Effects of Thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models
    13. Thymoquinone protects against experimental colitis in rats
    14. Anticonvulsant effects of Thymoquinone, the major constituent of Nigella sativa seeds, in mice
    15. Antitumor activity of gemcitabine and oxaliplatin is augmented by Thymoquinone in pancreatic cancer
    16. Acute and subchronic toxicity of Thymoquinone in mice
    17. Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity.
    18. Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by Thymoquinone.
    19. In Vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives Thymoquinone and thymohydroquinone
    20. Review on molecular and therapeutic potential of Thymoquinone in cancer
    21. Oral and intraperitoneal LD50 of Thymoquinone, an active principle of Nigella sativa, in mice and rats
    22. Improvement of experimental allergic encephalomyelitis (EAE) by Thymoquinone; an oxidative stress inhibitor.
    23. Thymoquinone reduces hepatic glucose production in diabetic hamsters
    24. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by Thymoquinone
    25. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages
    26. Androgen receptor–and E2F-1–targeted Thymoquinone therapy for hormone-refractory prostate cancer
    27. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    28. Neuroprotective effects of Thymoquinone against transient forebrain ischemia in the rat hippocampus
    29. Anti-inflammatory effect of Thymoquinone in a mouse model of allergic lung inflammation
    30. Protective effects of Thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice
    31. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity
    32. Thymoquinone-in-rats/” target=”_blank” rel=”noopener” data-saferedirecturl=”https://www.google.com/url?hl=en&q=https://vlibrary.emro.who.int/imemr/a-study-of-the-anti-inflammatory-activity-of-nigella-sativa-l-and-Thymoquinone-in-rats/&source=gmail&ust=1578765043452000&usg=AFQjCNEz35n-wi7Hac9DaSgvN3Tu5YC5bA”>Study of the anti-inflammatory activity of Nigella sativa L and Thymoquinone in rats, Saudi Pharm
    33. Anti-inflammatory effects of the Nigella sativa seed extract, Thymoquinone, in pancreatic cancer cells
    34. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, Thymoquinone
    35. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    36. Reactive oxygen species mediate Thymoquinone-induced apoptosis and activate ERK and JNK signaling
    37. Nigella sativa oil, nigellone and derived Thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats
    38. Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling
    39. Effects of alpha-hederin and Thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    40. Nonenzymatic reduction of Thymoquinone in physiological conditions
    41. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    42. Lack of p53 augments Thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells
    43. Targeting nuclear factor-κB activation pathway by Thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
    44. Thymoquinone: fifty years of success in the battle against cancer models
    45. Anticancer activity of Thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway
    46. Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation
    47. Thymoquinone supplementation prevents the development of gentamicin‐induced acute renal toxicity in rats
    48. Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells
    49. The effect of Thymoquinone on blood lipids in rats
    50. Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    51. Beneficial effects of Thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats
    52. Effects of Thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT‐diaphorase in different tissues of mice: a possible mechanism of action
    53. Effect of Thymoquinone and Nigella sativa seeds oil on lipid peroxidation level during global cerebral ischemia-reperfusion injury in rat hippocampus
    54. Protective effects of propolis and Thymoquinone on development of atherosclerosis in cholesterol-fed rabbits
    55. Nigella sativa Thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    56. Thymoquinone protects dopaminergic neurons against MPP+ and rotenone
    57. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo
    58. Gastroprotective activity of Nigella sativa L oil and its constituent, Thymoquinone against acute alcohol-induced gastric mucosal injury in rats
    59. The effect of Thymoquinone on intractable pediatric seizures (pilot study)
    60. Gastroprotective activity of Nigella sativa oil and its constituent, Thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats
    61. Thymoquinone supplementation attenuates cyclophosphamide‐induced cardiotoxicity in rats
    62. Thymoquinone: Novel gastroprotective mechanisms
    63. Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells
    64. Protective effects of Thymoquinone against methotrexate-induced testicular injury
    65. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells
    66. The protective effect of Thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review
    67. RETRACTED: Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential
    68. The antioxidative and antihistaminic effect of Nigella sativa and its major constituent, Thymoquinone on ethanol-induced gastric mucosal damage
    69. The antitumor activity of Thymoquinone and thymohydroquinone in vitro and in vivo
    70. Combinatorial effects of Thymoquinone on the anti-cancer activity of doxorubicin
    71. Inhibition of 5-lipoxygenase and Leukotriene C4 Synthase in Human Blood Cells by Thymoquinone
    72. Neuroprotection with metformin and Thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons
    73. Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats
    74. Nigella sativa and Derived Thymoquinone Prevents Hippocampal Neurodegeneration After Chronic Toluene Exposure in Rats
    75. Fatty acid profile, Thymoquinone content, oxidative stability, and antioxidant properties of cold-pressed black cumin seed oils
    76. Antibacterial activity of Thymoquinone and thymohydroquinone of Nigella sativa L. and their interaction with some antibiotics
    77. Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity
    78. Anticlastogenic activity of Thymoquinone against benzo (a) pyrene in mice
    79. Modulation of the oxidative stress and inflammatory cytokine response by Thymoquinone in the collagen induced arthritis in Wistar rats
    80. Elucidation of molecular mechanisms underlying the protective effects of Thymoquinone against rheumatoid arthritis
    81. Thymoquinone in the clinical treatment of cancer: Fact or fiction?
    82. Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models
    83. Effect of Thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation
    84. Effects of Nigella sativa and its Major Constituent, Thymoquinone on Sciatic Nerves in Experimental Diabetic Neuropathy
    85. Black cumin (Nigella sativa) and its constituent (Thymoquinone): a review on antimicrobial effects
    86. Protective effects of Nigella sativa oil and Thymoquinone against toxicity induced by the anticancer drug cyclophosphamide
    87. The protective effect of Thymoquinone on ethanol-induced acute gastric damage in the rat
    88. Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome
    89. Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer
    90. Thymoquinone triggers inactivation of the stress response pathway sensor CHEK1 and contributes to apoptosis in colorectal cancer cells
    91. Thymoquinone-induced relaxation of guinea-pig isolated trachea.
    92. Protective effects of Thymoquinone on streptozotocin-induced diabetic nephropathy
    93. Effect of Nigella Sativa (Black Seed) and Thymoquinone on Blood Glucose in Albino Rats
    94. Intracerebroventricular administration of Thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
    95. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats
    96. Antitumor and anti-angiogenesis effects of Thymoquinone on osteosarcoma through the NF-κB pathway
    97. Effects of Nigella sativa and Thymoquinone on biochemical and subcellular changes in pancreatic β‐cells of streptozotocin‐induced diabetic rats
    98. Effects of borneol and Thymoquinone on TNBS-induced colitis in mice
    99. Antineoplastic and apoptotic potential of traditional medicines Thymoquinone and diosgenin in squamous cell carcinoma
    100. Development and evaluation of Thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study
    101. Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer
    102. Thymoquinone attenuates cisplatin-induced hepatotoxicity via nuclear factor kappa-β
    103. Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels
    104. Effects of Nigella sativa oil and Thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats
    105. Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver
    106. TLC Assay of Thymoquinone in Black Seed Oil (Nigella Sativa Linn) and Identification of DiThymoquinone and Thymol
    107. Thymoquinone inhibits the activation of NF-kappaB in the brain and spinal cord of experimental autoimmune encephalomyelitis.
    108. Targeted apoptotic effects of Thymoquinone and tamoxifen on XIAP mediated Akt regulation in breast cancer
    109. Cytogenetic studies on Nigella sativa seeds extract and Thymoquinone on mouse cells infected with schistosomiasis using karyotyping
    110. Chemical composition, antimicrobial potential against cariogenic bacteria and cytotoxic activity of Tunisian Nigella sativa essential oil and Thymoquinone
    111. Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats
    112. Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats
    113. Modes of action of alpha-hederin and Thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells
    114. Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells
    115. Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro
    116. Cadmium‐induced hepatotoxicity and its abrogation by Thymoquinone
    117. Thymoquinone supplementation induces quinone reductase and glutathione transferase in mice liver: possible role in protection against chemical carcinogenesis and …
    118. Protective Effect of Nigella sativa Extract and Thymoquinone on Serum/Glucose Deprivation-Induced PC12 Cells Death
    119. Protective effect of Thymoquinone in experimental testicular torsion
    120. Studies on molecular mechanisms of growth inhibitory effects of Thymoquinone against prostate cancer cells: role of reactive oxygen species
    121. Successful abrogation by Thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism
    122. Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation
    123. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and Thymoquinone on colon cancer cells.
    124. Thymoquinone and proanthocyanidin attenuation of diabetic nephropathy in rats
    125. Protective effect of pretreatment with Thymoquinone against Aflatoxin B1 induced liver toxicity in mice
    126. Mechanisms of Thymoquinone hepatorenal protection in methotrexate-induced toxicity in rats
    127. Thymoquinone: an emerging natural drug with a wide range of medical applications
    128. A simple and efficient synthesis of Thymoquinone and methyl p-benzoquinone
    129. Terpene Conjugates of the Nigella sativa Seed‐Oil Constituent Thymoquinone with Enhanced Efficacy in Cancer Cells
    130. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of …
    131. Thymoquinone from Eupatorium ayapana
    132. HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with Thymoquinone
    133. Preclinical and clinical effects of Nigella sativa and its constituent, Thymoquinone: A review
    134. Downregulation of leukotriene biosynthesis by Thymoquinone attenuates airway inflammation in a mouse model of allergic asthma
    135. Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells
    136. Phase I safety and clinical activity study of Thymoquinone in patients with advanced refractory malignant disease
    137. Protective effects of Thymoquinone on vancomycin-induced nephrotoxicity in rats
    138. Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo
    139. Effect of Thymoquinone on mouse dendritic cells
    140. Levels of selenium, dl-α-tocopherol, dl-γ-tocopherol, all-trans-retinol, Thymoquinone and thymol in different brands of Nigella sativa seeds
    141. Thymoquinone decreases AGE‐induced NF‐κB activation in proximal tubular epithelial cells
    142. Anti-cancer properties of Nigella spp. essential oils and their major constituents, Thymoquinone and β-elemene
    143. Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats
    144. Anti-metastasis effect of Thymoquinone on human pancreatic cancer
    145. Antibacterial and resistance-modifying activities of Thymoquinone against oral pathogens
    146. The protective effect of Thymoquinone against sepsis syndrome morbidity and mortality in mice
    147. Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
    148. Is Thymoquinone an antioxidant?
    149. Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4
    150. Immunomodulatory and anti-inflammatory action of Nigella sativa and Thymoquinone: A comprehensive review
    151. Attenuation of Aβ-induced neurotoxicity by Thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress
    152. Effects of Thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies
    153. Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of Thymoquinone
    154. Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo
    155. Induction of apoptosis by Thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator …
    156. Nanocarrier based formulation of Thymoquinone improves oral delivery: stability assessment, in vitro and in vivo studies
    157. In search of novel highly active mitochondria‐targeted antioxidants: Thymoquinone and its cationic derivatives
    158. Regulation of renal organic anion and cation transporters by Thymoquinone in cisplatin induced kidney injury
    159. Inhibitory effects of topical Thymoquinone on corneal neovascularization
    160. Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1–AMPK signaling pathway in mice
    161. Thymoquinone-induced suicidal erythrocyte death
    162. Black cumin (Nigella sativa) and its active constituent, Thymoquinone: an overview on the analgesic and anti-inflammatory effects
    163. Effect of Thymoquinone on ethylene glycol-induced kidney calculi in rats
    164. Effect of Thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs
    165. Synergism from combinations of cisplatin and oxaliplatin with quercetin and Thymoquinone in human ovarian tumour models
    166. Thymoquinone accelerates new bone formation in the rapid maxillary expansion procedure
    167. Comparative evaluation of anti-inflammatory properties of Thymoquinone and curcumin using an asthmatic murine model
    168. Anti-fibrotic effect of Thymoquinone on hepatic stellate cells
    169. Effects of (-) epigallocatechin gallate and Thymoquinone on proliferation of a PANC-1 cell line in culture.
    170. Neuroprotective effect of Thymoquinone in acrylamide-induced neurotoxicity in Wistar rats
    171. Effects of Thymoquinone on isolated and cellular proteasomes
    172. Thymoquinone protects renal tubular cells against tubular injury
    173. Thymoquinone ameliorates the immunological and histological changes induced by exposure to imidacloprid insecticide
    174. Mechanistic perspectives on cancer chemoprevention/chemotherapeutic effects of Thymoquinone
    175. The effect of route of administration in Thymoquinone toxicity in male and female rats
    176. Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS
    177. Neuroprotective effect of Thymoquinone, the nigella sativa bioactive compound, in 6-hydroxydopamine-induced hemi-parkinsonian rat model
    178. Antitussive effect of Thymoquinone, a constituent of Nigella sativa seeds, in guinea pigs
    179. Radiosensitization in human breast carcinoma cells by Thymoquinone: role of cell cycle and apoptosis
    180. Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of Thymoquinone
    181. Hypolipidemic and antioxidant activities of Thymoquinone and limonene in atherogenic suspension fed rats
    182. Simple HPLC method for the determination of Thymoquinone in black seed oil (Nigella sativa Linn)
    183. Perinatal supplementation with Thymoquinone improves diabetic complications and T cell immune responses in rat offspring
    184. Effect of Thymoquinone on malformations and oxidative stress-induced diabetic mice
    185. Protective effect of Thymoquinone against cisplatin-induced ototoxicity
    186. The effect of Thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs
    187. Protective effect of Thymoquinone on sodium fluoride-induced hepatotoxicity and oxidative stress in rats
    188. Inhibition of the formation of advanced glycation end products by Thymoquinone
    189. Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, Thymoquinone
    190. Delivery of phytochemical Thymoquinone using molecular micelle modified poly (D, L lactide-co-glycolide)(PLGA) nanoparticles
    191. Molecular targeting of Akt by Thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells
    192. Structural and vibrational analysis of Thymoquinone
    193. Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular …
    194. Therapeutic potential of Thymoquinone against anti-tuberculosis drugs induced liver damage
    195. Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells
    196. Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice
    197. Anti-inflammatory effects of Thymoquinone in activated BV-2 microglial cells
    198. Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition
    199. Anti-inflammatory Effect of Seeds and Callus of Nigella sativa L. Extracts on Mix Glial Cells with Regard to Their Thymoquinone Content
    200. Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein
    201. Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats
    202. Preventive effects of Thymoquinone in a rat periodontitis model: a morphometric and histopathological study
    203. Investigation of antioxidant synergisms and antagonisms among thymol, carvacrol, Thymoquinone and p-cymene in a model system using the Briggs–Rauscher …
    204. A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and Thymoquinone, delivered by sustained drug delivery on colon cancer cells.
    205. Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury
    206. Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin
    207. Redox cycling of endogenous copper by Thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of …
    208. Thymoquinone ameliorates acute renal failure in gentamicin-treated adult male rats
    209. Enrichment of the Thymoquinone content in volatile oil from Satureja montana using supercritical fluid extraction
    210. Protective role of Thymoquinone against liver damage induced by tamoxifen in female rats
    211. Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery
    212. Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition
    213. Protective effect of Nigella sativa and Thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells
    214. Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway
    215. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis
    216. Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of Thymoquinone in a rabbit model
    217. Therapeutic implications of black seed and its constituent Thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways
    218. Aqueous solubility and degradation kinetics of the phytochemical anticancer Thymoquinone; probing the effects of solvents, pH and light
    219. Thymoquinone induces apoptosis in malignant T-cells via generation of ROS.
    220. The effect of nigellone and Thymoquinone on inhibiting trachea contraction and mucociliary clearance
    221. Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons
    222. … -density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by Thymoquinone-rich fraction and Thymoquinone in HepG2 cells
    223. Thymoquinone attenuates lung injury induced by chronic toluene exposure in rats
    224. A review of the effects of Nigella sativa L. and its constituent, Thymoquinone, in metabolic syndrome
    225. Crystal structure determination of Thymoquinone by high-resolution X-ray powder diffraction
    226. Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
    227. Thymoquinone blocks pSer/pThr recognition by Plk1 Polo-box domain as a phosphate mimic
    228. Thymoquinone therapy abrogates toxic effect of cadmium on rat testes
    229. Anti-cancer effects of Thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP
    230. Thymoquinone-induced relaxation of isolated rat pulmonary artery
    231. Protective effect of Thymoquinone on glucose or methylglyoxal-induced glycation of superoxide dismutase
    232. Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation
    233. Thymoquinone blocks lung injury and fibrosis by attenuating bleomycin-induced oxidative stress and activation of nuclear factor Kappa-B in rats
    234. Thymoquinone decreases F-actin polymerization and the proliferation of human multiple myeloma cells by suppressing STAT3 phosphorylation and Bcl2/Bcl …
    235. Thymoquinone‐induced platelet apoptosis
    236. The effects of Nigella sativa hydro-alcoholic extract and Thymoquinone on lipopolysaccharide-induced depression like behavior in rats
    237. Antihyperglycemic effect of Thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals
    238. Thymoquinone and curcumin attenuate gentamicin-induced renal oxidative stress, inflammation and apoptosis in rats
    239. PEGylated-Thymoquinone–nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a
    240. Thymoquinone anticancer discovery: possible mechanisms
    241. Protective effects of Thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure
    242. Thymoquinone attenuates cypermethrin induced oxidative stress in Swiss albino mice
    243. Effects of Thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study
    244. Thymoquinone reestablishes spermatogenesis after testicular injury caused by chronic toluene exposure in rats
    245. Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation
    246. Effect of Thymoquinone, a constituent of Nigella sativa L., on ischemia–reperfusion in rat skeletal muscle
    247. Protective effect of Thymoquinone against lead-induced hepatic toxicity in rats
    248. The use of Thymoquinone in nephrotoxicity related to acetaminophen
    249. Thymoquinone: a promising antidiabetic agent
    250. Effect of Thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N‐1‐acetyl‐transferase gene expression induced by renal …
    251. Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon …
    252. Thymoquinone-loaded PLGA nanoparticles: antioxidant and anti-microbial properties
    253. Thymoquinone inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing NF-κB and MAPKs signaling pathway
    254. Thymoquinone attenuates tumor growth in Apc Min mice by interference with Wnt-signaling
    255. Cellular responses with Thymoquinone treatment in human breast cancer cell line MCF-7
    256. Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, Thymoquinone against pathogenic dermatophyte …
    257. Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in …
    258. Protective effects of Thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats
    259. Effect of Thymoquinone on 1, 2-dimethyl-hydrazine-induced oxidative stress during initiation and promotion of colon carcinogenesis
    260. Synthesis, characterization and anti-tumor activity of novel Thymoquinone analogs against pancreatic cancer
    261. Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage
    262. Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway
    263. Physiological responses of ES-2 ovarian cell line following administration of epigallocatechin-3-gallate (EGCG), Thymoquinone (TQ), and selenium (SE).
    264. Inhibitory effects of Thymoquinone from Nigella sativa on pathogenic Saprolegnia in fish
    265. Effects of Thymoquinone rich fraction and Thymoquinone on plasma lipoprotein levels and hepatic low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl …
    266. Thymoquinone attenuates toxicity and oxidative stress induced by bisphenol A in liver of male rats
    267. Quantification and evaluation of Thymoquinone loaded mucoadhesive nanoemulsion for treatment of cerebral ischemia
    268. In vitro challenge using Thymoquinone on hepatocellular carcinoma (HepG2) cell line
    269. Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular …
    270. Neuroprotective effects of mitochondria-targeted plastoquinone and Thymoquinone in a rat model of brain ischemia/reperfusion injury
    271. Protective effects of Thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney
    272. A new agent for treatment of acute respiratory distress syndrome: Thymoquinone. An experimental study in a rat model
    273. Regulation of apolipoprotein A‐1 and apolipoprotein B100 genes by Thymoquinone rich fraction and Thymoquinone in HepG2 cells
    274. The comparison of anticancer activity of Thymoquinone and nanoThymoquinone on human breast adenocarcinoma
    275. Protective effects of Thymoquinone and methotrexate on the renal injury in collagen-induced arthritis
    276. Neuroprotective effects of Thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis
    277. Rearrangement of azidoquinones. Reaction of Thymoquinone and 2, 5-dimethyl-1, 4-benzoquinone with sodium azide in trichloroacetic acid
    278. Impact of protein binding on the analytical detectability and anticancer activity of Thymoquinone
    279. On the structure of the photodimer of Thymoquinone
    280. Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK …
    281. Attenuation of the development of hypercholesterolemic atherosclerosis by Thymoquinone
    282. Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using Thymoquinone-biomed 2009.
    283. Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in Thymoquinone-induced acute lymphoblastic …
    284. Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats
    285. Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent …
    286. Extractive components from INCENSE-cedar heartwood (Libocedrus decurrens Torrey) I. Occurrence of carvacrol, hydroThymoquinone, and Thymoquinone
    287. Anti-inflammatory and antioxidant activity of Thymoquinone in a rat model of acute bacterial prostatitis
    288. Effects of Thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture.
    289. Elucidation of mechanisms of actions of Thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters …
    290. A simple differential pulse polarographic method for the determination of Thymoquinone in black seed oil
    291. Immunomodulatory and cytotoxic effects of Nigella sativa and Thymoquinone on rat splenocytes
    292. Thymoquinone ameliorates cadmium-induced nephrotoxicity, apoptosis, and oxidative stress in rats is based on its anti-apoptotic and anti-oxidant properties
    293. Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway
    294. Antioxidative and anti-inflammatory effect of Thymoquinone in an acute Pseudomonas prostatitis rat model
    295. Thymoquinone inhibits lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells
    296. Therapeutic effects of Thymoquinone in a model of neuropathic pain
    297. Dual drug-loaded paclitaxel–Thymoquinone nanoparticles for effective breast cancer therapy
    298. Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by Thymoquinone attenuates the development of morphine tolerance and …
    299. Thymoquinone Restores Radiation‐Induced TGF‐β Expression and Abrogates EMT in Chemoradiotherapy of Breast Cancer Cells
    300. Anti-asthmatic and anti-allergic effects of Thymoquinone on airway-induced hypersensitivity in experimental animals
    301. Protective effect of Thymoquinone against high-fructose diet-induced metabolic syndrome in rats
    302. Cytotoxicity of Thymoquinone (TQ) from Nigella sativa towards human cervical carcinoma cells (HeLa)
    303. Enhancement of bioavailability and pharmacodynamic effects of Thymoquinone via nanostructured lipid carrier (NLC) formulation
    304. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation
    305. Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo
    306. Beneficial interaction of Thymoquinone and sodium valproate in experimental models of epilepsy: reduction in hepatotoxicity of valproate
    307. Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo
    308. Study on the potential toxicity of a Thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats
    309. Upregulation of Chemoprotective Enzymes and Glutathione by Nigella sativa (Black Seed) and Thymoquinone in CCl4-Intoxicated Rats
    310. Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53
    311. Thymoquinone attenuates astrogliosis, neurodegeneration, mossy fiber sprouting, and oxidative stress in a model of temporal lobe epilepsy
    312. NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to Thymoquinone-induced apoptosis
    313. Attenuation of high cholesterol-induced oxidative stress in rabbit liver by Thymoquinone
    314. Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue
    315. Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2-and Src‑mediated phosphorylation of …
    316. Apoptotic activities of Thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines
    317. Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice
    318. Effects of combinations of curcumin, linalool, rutin, safranal, and Thymoquinone on glucose/serum deprivation-induced cell death
    319. Thymoquinone supplementation ameliorates lead-induced testis function impairment in adult rats
    320. Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative …
    321. Thymoquinone-loaded nanostructured lipid carrier exhibited cytotoxicity towards breast cancer cell lines (MDA-MB-231 and MCF-7) and cervical cancer cell lines …
    322. Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer
    323. The effect of Thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury
    324. Mitigation of Obesity-Promoted Diseases by Nigella sativa and Thymoquinone
    325. Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis
    326. Protective effects of Thymoquinone and melatonin on intestinal ischemia–reperfusion injury
    327. Intestinal, airway, and cardiovascular relaxant activities of Thymoquinone
    328. Evaluation of the protective effect of Nigella sativa extract and its primary active component Thymoquinone against DMBA-induced breast cancer in female rats
    329. Thymoquinone hydrazone derivatives cause cell cycle arrest in p53-competent colorectal cancer cells
    330. Pronounced transcriptional regulation of apoptotic and TNF–NF-kappa-B signaling genes during the course of Thymoquinone mediated apoptosis in HeLa cells
    331. Overcoming Akt induced therapeutic resistance in breast cancer through siRNA and Thymoquinone encapsulated multilamellar gold niosomes
    332. Antioxidant Property, Thymoquinone Content and Chemical Characteristics of Different Extracts from Nigella sativa L. Seeds
    333. Thymoquinone chemosensitizes colon cancer cells through inhibition of NF‑κB
    334. Novel combination of docetaxel and Thymoquinone induces synergistic cytotoxicity and apoptosis in DU-145 human prostate cancer cells by modulating PI3K–AKT …
    335. Thymoquinone ameliorates bacterial translocation and inflammatory response in rats with intestinal obstruction
    336. Ameliorative effect of Thymoquinone on ovalbumin-induced allergic conjunctivitis in Balb/c mice
    337. Thymoquinone inhibits Escherichia coli ATP synthase and cell growth
    338. Thymoquinone alleviates the experimental diabetic peripheral neuropathy by modulation of inflammation
    339. Modulation of hepatic drug metabolizing enzymes by dietary doses of Thymoquinone in female New Zealand White rabbits
    340. Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro
    341. The effect of single dose of Thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
    342. Thymoquinone improves the kidney and liver changes induced by chronic cyclosporine A treatment and acute renal ischaemia/reperfusion in rats
    343. A review on the hypoglycemic effect of Nigella sativa and Thymoquinone
    344. Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
    345. Anti-neoplastic agent Thymoquinone induces degradation of α and β tubulin proteins in human cancer cells without affecting their level in normal human fibroblasts
    346. Antidepressant effect of Thymoquinone in animal models of depression
    347. Thymoquinone a potential therapy for cerebral oxidative stress
    348. The effect of conventional and sustained delivery of Thymoquinone and levodopa on SH-SY5Y human neuroblastoma cells.
    349. Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line
    350. Thymoquinone, the active ingredient of Nigella sativa seeds, enhances survival and activity of antigen-specific CD8-positive T cells in vitro
    351. Identification of potential sources of Thymoquinone and related compounds in Asteraceae, Cupressaceae, Lamiaceae, and Ranunculaceae families
    352. Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced Seizures Via Activation of GABAB1 Receptor in Adult Rats Cortex and Hippocampus
    353. The histopathological effect of Thymoquinone on experimentally induced rhinosinusitis in rats
    354. Protective effects of Thymoquinone against methotrexate-induced germ cell apoptosis in male mice
    355. Stability‐indicating ultra‐performance liquid chromatography method for the estimation of Thymoquinone and its application in biopharmaceutical studies
    356. Thymoquinone pretreatment overcomes the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of Notch1, PI3K/Akt/mTOR regulated …
    357. Characterization of Thymoquinone binding to human α1-acid glycoprotein
    358. The Thymoquinone-induced production of reactive oxygen species promotes dedifferentiation through the ERK pathway and inflammation through the p38 and …
    359. Preparation, characterization and antiproliferative activity of Thymoquinone-β-cyclodextrin self assembling nanoparticles
    360. Effect of Thymoquinone on oxidative stress in Escherichia coli–induced pyelonephritis in rats
    361. Natural products as topoisomerase II poisons: Effects of Thymoquinone on DNA cleavage mediated by human topoisomerase IIα
    362. A structural study on the protection of glycation of superoxide dismutase by Thymoquinone
    363. Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and …
    364. Thymoquinone supplementation reverses lead-induced oxidative stress in adult rat testes.
    365. The physiological effect of conventional treatment with epigallocatechin-3-gallate, Thymoquinone, and tannic acid on the LNCaP cell line.
    366. Role of NF-κB in the anti-tumor effect of Thymoquinone on bladder cancer
    367. Thymoquinone inhibits microtubule polymerization by tubulin binding and causes mitotic arrest following apoptosis in A549 cells
    368. Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress
    369. Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro
    370. Nigella sativa and its active constituent Thymoquinone in oral health
    371. Thymoquinone synergistically potentiates temozolomide cytotoxicity through the inhibition of autophagy in U87MG cell line
    372. Effects of intraperitoneal Thymoquinone on chronic neuropathic pain in rats
    373. Nigella sativa seed extract and its bioactive compound Thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores
    374. Combinatorial effects of Thymoquinone on the anticancer activity and hepatotoxicity of the prodrug CB 1954
    375. Effect of Thymoquinone on P53 gene expression and consequence apoptosis in breast cancer cell line
    376. Mesalazine and Thymoquinone attenuate intestinal tumour development in Msh2loxP/loxP Villin-Cre mice
    377. Maternal supplementation of diabetic mice with Thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and …
    378. Analysis on chemical components of volatile oil and determination of Thymoquinone from seed of Nigella glandulifera
    379. Protective effect of Thymoquinone against cyclophosphamide-induced hemorrhagic cystitis through inhibiting DNA damage and upregulation of Nrf2 …
    380. Validated high‐performance thin‐layer chromatographic method for the quantification of Thymoquinone in Nigella Sativa extracts and formulations
    381. Thymoquinone protects against myocardial ischemic injury by mitigating oxidative stress and inflammation
    382. Chemopreventive and therapeutic potentials of Thymoquinone in HepG2 cells: mechanistic perspectives
    383. Alleviation of plasma, erythrocyte and liver lipidemic-oxidative stress by Thymoquinone and limonene in atherogenic suspension fed rats
    384. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via …
    385. Cardioprotective effect of Thymoquinone: A constituent of Nigella sativa L., against myocardial ischemia/reperfusion injury and ventricular arrhythmias in …
    386. Characterization and stability evaluation of Thymoquinone nanoemulsions prepared by high-pressure homogenization
    387. Mitigating role of Thymoquinone rich fractions from Nigella sativa oil and its constituents, Thymoquinone and limonene on lipidemic-oxidative injury in rats
    388. Biophysical investigation of Thymoquinone binding to ‘N’and ‘B’isoforms of human serum albumin: exploring the interaction mechanism and radical scavenging activity
    389. Effect of Thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats
    390. Synergistic effects of Thymoquinone and curcumin on immune response and anti-viral activity against avian influenza virus (H9N2) in turkeys
    391. Effect of Thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse dendritic cells
    392. Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and Thymoquinone-based therapy
    393. Protective effect of Thymoquinone against testicular torsion induced oxidative injury
    394. Thymoquinone enhances cisplatin-response through direct tumor effects in a syngeneic mouse model of ovarian cancer
    395. Reduction of hypervalent states of myoglobin and hemoglobin to their ferrous forms by Thymoquinone: the role of GSH, NADH and NADPH
    396. Liposomal Thymoquinone effectively combats fluconazole-resistant Candida albicans in a murine model
    397. Ameliorative effects of Thymoquinone against eye lens changes in streptozotocin diabetic rats