Beta oxidation of fatty acids fatty acid Beta-oxidation disorders: a brief review Mechanisms mediating the regulation of peroxisomal fatty acid Beta-oxidation by PPARα Inhibition of mitochondrial Beta-oxidation as a mechanism of hepatotoxicity Rat liver peroxisomes catalyze the Beta oxidation of fatty acids. Beta-oxidation of fatty acids: a century of discovery Beta-oxidation is essential for mouse oocyte developmental competence and early embryo development The enzymology of mitochondrial fatty acid Beta-oxidation and its application to follow-up analysis of positive neonatal screening results Dynamic simulations on the mitochondrial fatty acid Beta-oxidation network Beta-oxidation of unsaturated fatty acids: a revised pathway Functions and organization of peroxisomal Beta-oxidation Clinical and biological features at diagnosis in mitochondrial fatty acid Beta‐oxidation defects: a French pediatric study of 187 patients Beta (β)-oxidation of fatty Acid and its associated Disorders TFPa/HADHA is required for fatty acid Beta-oxidation and cardiolipin re-modeling in human cardiomyocytes Peroxisomal multifunctional Beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product. Hepatic mitochondrial Beta-oxidation in patients with nonalcoholic steatohepatitis assessed by 13C-octanoate breath test Amiodarone inhibits the mitochondrial Beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. Glucocorticoids inhibit mitochondrial matrix acyl-CoA dehydrogenases and fatty acid Beta-oxidation Human liver long-chain 3-hydroxyacyl-coenzyme A dehydrogenase is a multifunctional membrane-bound Beta-oxidation enzyme of mitochondria Bezafibrate for an inborn mitochondrial Beta-oxidation defect Metabolic reprogramming from glycolysis to fatty acid uptake and Beta-oxidation in platinum-resistant cancer cells Production of lactones and peroxisomal Beta-oxidation in yeasts Novel fatty acid Beta-oxidation enzymes in rat liver mitochondria. I. Purification and properties of very-long-chain acyl-coenzyme A dehydrogenase. Stereoselective and nonstereoselective effects of ibuprofen enantiomers on mitochondrial Beta-oxidation of fatty acids. oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid Beta-oxidation in rats fed a methionine-choline deficient diet Hepatic steatosis and peroxisomal fatty acid Beta-oxidation SIRT6 promotes hepatic Beta-oxidation via activation of PPARα Assessment of fatty acid Beta oxidation in cells and isolated mitochondria Human trifunctional protein alpha links cardiolipin remodeling to Beta-oxidation Increased Beta-oxidation and Improved Oocyte Developmental Competence in Response to l-Carnitine During Ovarian In Vitro Follicle Development in Mice Inducible Beta-oxidation pathway in Neurospora crassa Peroxisomal Beta-oxidation Studies on the Beta-oxidation of valproic acid in rat liver mitochondrial preparations. A systematic optimization of medium chain fatty acid biosynthesis via the reverse Beta-oxidation cycle in Escherichia coli Beta oxidation defects: biochemistry and clinical Comparative importance of fatty acid Beta-oxidation to nuclear maturation, gene expression, and glucose metabolism in mouse, bovine, and porcine cumulus oocyte … The fatty acid Beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice A novel mechanism of monoethylhexyl phthalate in lipid accumulation via inhibiting fatty acid Beta-oxidation on hepatic cells Bergamot polyphenol extract reduces hepatocyte neutral fat by increasing Beta-oxidation A whole body, in vivo, fatty acid balance method to quantify PUFA metabolism (desaturation, elongation and Beta-oxidation) Beta-oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2, 4-dienoyl-coenzyme A reductase in peroxisomal Beta-oxidation. Association of glyoxylate and Beta-oxidation enzymes with peroxisomes of
CD36 and macrophages in atherosclerosis CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism CD36: a critical anti-angiogenic receptor Hepatic fatty acid transporter CD36 is a common target of LXR, PXR, and PPARγ in promoting steatosis CD36 is a receptor for oxidized low density lipoprotein CD36 mediates the in vitro inhibitory effects of thrombospondin-1 on endothelial cells Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice CD36 is a sensor of diacylglycerides Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic … Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β … Scavenger receptors class AI/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in … A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice Expression cloning of SR-BI, a CD36-related class B scavenger receptor. CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation Malaria susceptibility and CD36 mutation Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36 A CD36-dependent signaling cascade is necessary for macrophage foam cell formation Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL Identification of CD36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats … membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. Oxidized LDL binds to CD36 on human monocyte-derived macrophages and transfected cell lines: evidence implicating the lipid moiety of the lipoprotein as the … Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria CD36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. Plasmodium falciparum erythrocyte membrane protein 1 is
A combined experimental and computational study of chrysanthemin as a pigment for dye-sensitized solar cells Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix Current knowledge of anthocyanin metabolism in the digestive tract: Absorption, distribution, degradation, and interconversion Anti-Inflammatory Activity of Bilberry (Vaccinium myrtillus L.) Jabuticaba (Plinia sp.) Peel as a Source of Pectin: Characterization and Effect of Different Extraction Methods Natural Anthocyanins from Subtropical Fruits for Cardiac Disease Prevention Identification of drought-responsive phenolic compounds and their biosynthetic regulation under drought stress in Ligularia fischeri Antioxidant Activities of Co-Encapsulated Natal Plum (Carissa macrocarpa) Juice Inoculated with Ltp. plantarum 75 in Different Biopolymeric Matrices after In Vitro … Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis The monomer TEC of blueberry improves NASH by augmenting tRF-47-mediated autophagy/pyroptosis signaling pathway Current advances in anthocyanins: structure, bioactivity and human health. Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review Antioxidant Effect of Lonicera caerulea L. in the Cardiovascular System of Obese Zucker Rats Anthocyanins: traditional uses, structural and functional variations, approaches to increase yields and products' quality, hepatoprotection, liver longevity, and … Purple Napiergrass (Pennisetum purpureum Schumach) Hot Water Extracts Ameliorate High-Fat Diet-Induced Obesity and Metabolic Disorders in Mice Protective Effects of Morus nigra and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies Anthocyanins: Promising natural products with diverse pharmacological activities Unveiling the Metabolic Modulatory Effect of Anthocyanin and Gut Microbiota Involvement Employ of anthocyanins in nanocarriers for nano delivery: In vitro and in vivo experimental approaches for chronic diseases Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its glucoside—A Theoretical Approach The activation of liver X receptors in Madin-Darby bovine kidney cells and mice restricts infection by bovine viral diarrhea virus Hypolipidemic and Anti‐Obesity Effect of Anserine on Mice Orally Administered with High‐Fat Diet via Regulating SREBP‐1, NLRP3, and UCP‐1 Targets and mechanisms of dietary anthocyanins to combat hyperglycemia and hyperuricemia: A comprehensive review Chemistry and pharmacological actions of delphinidin, a dietary purple pigment in anthocyanidin and anthocyanin forms Phytochemicals: targeting mitophagy to treat metabolic disorders Peach (Prunus Persica): Phytochemicals and Health Benefits Natural bioactive compounds as potential browning agents in white adipose tissue Role of polyphenols in combating Type 2 Diabetes and insulin resistance Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin Extract Enhances PPAR-α, PPAR-γ Expression and Reduces I/M Ratio in Aorta, Increases LXR-α … Targeting inflammation by anthocyanins as the novel therapeutic potential for chronic diseases: An update Single anthocyanins effectiveness modulating inflammation markers in obesity: dosage and matrix composition analysis Mediterranean Diet Polyphenols: Anthocyanins and Their Implications for Health Vascular protective effect and its possible mechanism of action on selected active phytocompounds: a review Anthocyanins-gut microbiota-health axis: A review Hepatoprotective potential of bioflavonoids Black corn (Zea mays L.) whole flour improved the antioxidant capacity and prevented adipogenesis in mice fed a high-fat diet Computational insight into stability-enhanced systems of anthocyanin with protein/peptide Cytoprotective effects of iridoids from Gaultheria
Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids Evidence for mechanisms of the hypotriglyceridemic effect of n− 3 polyunsaturated fatty acids hypotriglyceridemic effect of corticotropin in man Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oil in humans The hypotriglyceridemic effect of dietary n− 3 FA is associated with increased β‐oxidation and reduced leptin expression hypotriglyceridemic effect of Anka (a Fermented Rice Product of Monascus sp.) in Rats The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis hypotriglyceridemic effect of dietaryn− 3 fatty acids in rats fed low versus high levels of linoleic acid Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARα The hypotriglyceridemic effect of fish oil in adult-onset diabetes without adverse glucose control. Can the hypotriglyceridemic effect of fish oil concentrate be sustained? Role of soy isoflavones in the hypotriglyceridemic effect of soy protein in the rat Antihyperlipidemic effect of flavonoids from Prunus davidiana effects of omega-3 fatty acids in hypertriglyceridemic states Metabolic basis of hypotriglyceridemic effects of insulin in normal men Metabolic effects of glucagon in endogenous hypertriglyceridemia Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism The hypotriglyceridemic effect of chenodeoxycholic acid in type IV hyperlipemia. Estradiol is a potent inhibitor of the hypotriglyceridemic effect of levonorgestrel in female rats On the mechanism of the hypolipidemic effect of sulfur-substituted hexadecanedioic acid (3-thiadicarboxylic acid) in normolipidemic rats hypotriglyceridemic effect of globin digest on subjects with borderline hyperlipidemia. hypotriglyceridemic effect of dietary linseed oil in rats. effects of fructans-type prebiotics on lipid metabolism Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model Mechanism of the hypolipemic effect of clofibrate in postabsorptive man Potential on hypotriglyceridemic effect of Chloroform-Methanol Extract of Adlay Diabetic Rats hypotriglyceridemic effect of chenodeoxycholic acid after a short time of administration. Thiazolidinediones exert a hypotriglyceridemic effect by a distinct, but complementary mechanism relative to fibrates Clofibrate enhancement of mitochondrial carnitine transport system of rat liver and augmentation of liver carnitine and γ-butyrobetaine hydroxylase activity by thyroxine Can the hypotriglyceridemic effect of fish oil concentrate be sustained? Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats Reciprocal responses to exercise in hepatic ketogenesis and lipid secretion in the rat Vitamin C and plasma triglycerides in experimental animals and in humans Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor The hypolipidemic action of bezafibrate therapy in hypertriglyceridemia is mediated by upregulation of lipoprotein lipase: no effects on VLDL substrate affinity to … The acute effects of a single very high dose of n− 3 fatty acids on plasma lipids and lipoproteins in healthy subjects effects of modest doses of omega-3 fatty acids on lipids and lipoproteins in hypertriglyceridemic subjects: a randomized controlled trial hypotriglyceridemic effect of the antler-shaped fruiting body of Ganoderma lucidum on the high-fat diet induced hyperlipidemia in Syrian hamsters
The factors related to a sedentary lifestyle: A meta‐analysis review Physiological and health implications of a sedentary lifestyle sedentary lifestyle: overview of updated evidence of potential health risks A step-defined sedentary lifestyle index:< 5000 steps/day sedentary lifestyle as a risk factor for low back pain: a systematic review Physical inactivity, sedentary lifestyle and obesity in the European Union sedentary lifestyle and risk of obesity and type 2 diabetes The escalating pandemics of obesity and sedentary lifestyle: a call to action for clinicians sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome. Physical activity and sedentary lifestyle in university students: changes during confinement due to the COVID-19 pandemic The descriptive epidemiology of a sedentary lifestyle in adult Australians Nutritional status and sedentary lifestyle of individuals a review sedentary lifestyle and nonspecific low back pain in medical personnel in North-East Poland Contribution of a sedentary lifestyle and inactivity to the etiology of overweight and obesity: current evidence and research issues. New low back pain in nurses: work activities, work stress and sedentary lifestyle Prevalence of sedentary lifestyle and associated factors in adolescents 10 to 12 years of age sedentary lifestyle in Italian Regions sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile Disease prevention—should we target obesity or sedentary lifestyle? Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects Portrait of the sedentary lifestyle among students from public health school Obesity and its relation to depressive symptoms and sedentary lifestyle in middle-aged women sedentary lifestyle in individuals with hypertension Prospective associations between sedentary lifestyle and BMI in midlife Cognitive–behavioral mediators of changing multiple behaviors: smoking and a sedentary lifestyle Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer High-intensity interval training for improving maximum aerobic capacity in women with sedentary lifestyle: a systematic review and meta-analysis Relationship of sedentary lifestyle with Obesity and Comorbidities Coupling aging immunity with a sedentary lifestyle: has the damage already been done?–a mini-review The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom Arterial stiffness and sedentary lifestyle: Role of oxidative stress Is sedentary lifestyle associated with testicular function? A cross-sectional study of 1,210 men Dietary behaviors, physical activity and sedentary lifestyle associated with overweight and obesity, and their socio-demographic correlates, among Pakistani … Fast food and sedentary lifestyle: a combination that leads to obesity sedentary lifestyle is associated with metabolic and cardiovascular risk factors independent of physical activity Physical exercise and sedentary lifestyle: health consequences. sedentary lifestyle in middle-aged women is associated with severe menopausal symptoms and obesity Television viewing and its associations with overweight, sedentary lifestyle, and insufficient consumption of fruits and vegetables among US high school students … sedentary lifestyle and antecedents of cardiovascular disease in young adults Clinical indicators and aetiological factors of sedentary lifestyle in patients with arterial hypertension Comparison of the health aspects of swimming with other types of physical activity and sedentary lifestyle habits Relations between subdomains of physical
Resting energy expenditure: systematic organization and critique of prediction methods Relative changes in Resting energy expenditure during weight loss: a systematic review A new predictive equation for Resting energy expenditure in healthy individuals Dietary intake, Resting energy expenditure, weight loss and survival in cancer patients Resting energy expenditure in patients with pancreatitis Skeletal muscle metabolism is a major determinant of Resting energy expenditure. A new device for measuring Resting energy expenditure (REE) in healthy subjects Effect of different tumor types on Resting energy expenditure Comparison of Resting energy expenditure prediction methods with measured Resting energy expenditure in obese, hospitalized adults Assessment of Resting energy expenditure in mechanically ventilated patients Determinants of Resting energy expenditure in young children World Health Organization equations have shortcomings for predicting Resting energy expenditure in persons from a modern, affluent population: generation of a new … Resting energy expenditure in patients with chronic obstructive pulmonary disease Influence of methods used in body composition analysis on the prediction of Resting energy expenditure Resting energy expenditure and body composition in patients with newly detected cancer Measured Resting energy expenditure in children Cytokines, the acute-phase response, and Resting energy expenditure in cachectic patients with pancreatic cancer. Dietary intake and Resting energy expenditure in relation to weight loss in unselected cancer patients Prediction of Resting energy expenditure from fat-free mass and fat mass Increased Resting energy expenditure in patients with end‐stage renal disease Resting energy expenditure, activity energy expenditure and total energy expenditure at age 91–96 years Resting energy expenditure-fat-free mass relationship: new insights provided by body composition modeling Ascites increases the Resting energy expenditure in liver cirrhosis Raised Resting energy expenditure in Parkinson's disease and its relationship to muscle rigidity Metabolically active components of fat‐free mass and Resting energy expenditure in humans: recent lessons from imaging technologies Investigating heterogeneity in studies of Resting energy expenditure in persons with HIV/AIDS: a meta-analysis Measurement of Resting energy expenditure in a clinical setting Increased Resting energy expenditure and weight loss are related to a systemic inflammatory response in lung cancer patients. Total daily energy expenditure relative to Resting energy expenditure in clinically stable patients with COPD Validation of predictive equations for Resting energy expenditure in adult outpatients and inpatients Metabolically active components of fat free mass and Resting energy expenditure in nonobese adults Sex hormone suppression reduces Resting energy expenditure and β-adrenergic support of Resting energy expenditure The cystic fibrosis gene and Resting energy expenditure Estimation of Resting energy expenditure considering effects of race and diabetes status Resting energy expenditure should be measured in patients with cirrhosis, not predicted Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine Resting energy expenditure is increased in stable, malnourished HIV-infected patients Association between blood pressure and Resting energy expenditure independent of body size Resting energy expenditure and its determinants in hemodialysis patients Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement Resting energy expenditure and subsequent mortality risk in peritoneal dialysis
Exercise and insulin sensitivity: a review Influence of Exercise on insulin sensitivity Invited review: Effects of acute Exercise and Exercise training on insulin resistance Effects of Exercise and lack of Exercise on glucose tolerance and insulin sensitivity Glucose, Exercise and insulin: emerging concepts Exercise, glucose transport, and insulin sensitivity The effect of physical Exercise on the dynamics of glucose and insulin Effect of physical Exercise on sensitivity and responsiveness to insulin in humans insulin resistance with aging: effects of diet and Exercise Role of Exercise training in the prevention and treatment of insulin resistance and non-insulin-dependent diabetes mellitus insulin signaling and insulin sensitivity after Exercise in human skeletal muscle. The effect of Exercise on insulin action in diabetes Muscle Glucose Metabolism following Exercise in the Rat: INCREASED SENSITIVITY TO insulin Effects of Exercise and lack of Exercise on insulin sensitivity and responsiveness Effect of Exercise on insulin action in human skeletal muscle Human muscle glycogen resynthesis after Exercise: insulin-dependent and-independent phases Invited review: effect of acute Exercise on insulin signaling and action in humans Interaction of Exercise and insulin action in humans Synergistic interaction between Exercise and insulin on peripheral glucose uptake. Intense Exercise has unique effects on both insulin release and its roles in glucoregulation: implications for diabetes Effects of Exercise intensity on insulin sensitivity in women with non-insulin-dependent diabetes mellitus Effects of Exercise on insulin sensitivity in humans Effects of Exercise on glucose tolerance and insulin resistance: brief review and some preliminary results Exercise in the Management of Non—insulin-Dependent Diabetes Mellitus Effect of Exercise on insulin action, glucose tolerance, and insulin secretion in aging Effective Exercise modality to reduce insulin resistance in women with type 2 diabetes Effects of leg Exercise on insulin absorption in diabetic patients Glucoregulation during moderate Exercise in insulin treated diabetics Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin-receptor … Glucoregulation and hormonal responses to maximal Exercise in non-insulin-dependent diabetes Effect of brief Exercise on circulating insulin-like growth factor I Eccentric Exercise induces transient insulin resistance in healthy individuals The effect of different diets and of insulin on the hormonal response to prolonged Exercise insulin signalling, Exercise and cellular integrity Effects of insulin and Exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. Increased muscle glucose uptake after Exercise: no need for insulin during Exercise Invited review: Exercise training-induced changes in insulin signaling in skeletal muscle Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice Effects of prior high-intensity Exercise on glucose metabolism in normal and insulin-resistant men Circulating insulin-like growth factor I mediates effects of Exercise on the brain insulin signalling: effects of prior Exercise Prolonged increase in insulin-stimulated glucose transport in muscle after Exercise insulin signaling in human skeletal muscle: time course and effect of Exercise Adiponectin is not altered with Exercise training despite enhanced insulin action Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin-and Exercise-recruitable
Smoking induces insulin resistance—a potential link with the insulin resistance syndrome Acute pain induces insulin resistance in humans High uric acid directly inhibits insulin signalling and induces insulin resistance Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus A single night of partial sleep deprivation induces insulin resistance in multiple metabolic pathways in healthy subjects CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice Olanzapine induces insulin resistance: results from a prospective study Central resistin overexposure induces insulin resistance through Toll-like receptor 4 Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria Porphyromonas gingivalis induces insulin resistance by Increasing BCAA Levels in Mice Angiotensin II induces insulin resistance independent of changes in interstitial insulin Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin … The Estrogenic Effect of Bisphenol A Disrupts Pancreatic β-Cell Function In Vivo and induces insulin resistance In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. Benzene exposure induces insulin resistance in mice Acute noradrenergic activation induces insulin resistance in human skeletal muscle Deficiency of adrenomedullin induces insulin resistance by increasing oxidative stress High Uric Acid induces insulin resistance in Cardiomyocytes In Vitro and In Vivo ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes Hyperinsulinemia induces insulin resistance in dorsal root ganglion neurons Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules Increased tumor necrosis factor α–converting enzyme activity induces insulin resistance and hepatosteatosis in mice Resistin: a hormone which induces insulin resistance is increased in normal pregnancy Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivo Ethanol feeding induces insulin resistance with enhanced PI 3-kinase activation Hyperhomocysteinemia induces insulin resistance in male Sprague–Dawley rats Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity. A high-selenium diet induces insulin resistance in gestating rats and their offspring High glucose inhibits myogenesis and induces insulin resistance by down-regulating AKT signaling Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice Resistin is expressed in human hepatocytes and induces insulin resistance Iron induces insulin resistance in cardiomyocytes via regulation of oxidative stress Tumor necrosis
Many ceramides Ceramides and skin function Chain length-specific properties of Ceramides Ceramides–lipotoxic inducers of metabolic disorders Ceramides and depression: A systematic review Ceramides in the skin barrier Roles of diacylglycerols and Ceramides in hepatic insulin resistance Role of Ceramides in nonalcoholic fatty liver disease The composition of the Ceramides from human stratum corneum and from comedones Ceramides of pig epidermis: structure determination Ceramides in insulin resistance and lipotoxicity Ceramides modulate programmed cell death in plants Mammalian Lass6 and its related family members regulate synthesis of specific Ceramides Ceramides as modulators of cellular and whole-body metabolism Serum sphingomyelins and Ceramides are early predictors of memory impairment Role of Ceramides in barrier function of healthy and diseased skin Circulating Ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort Ceramides and glucosylCeramides are independent antagonists of insulin signaling Ceramides in the skin lipid membranes: length matters Relationship between covalently bound Ceramides and transepidermal water loss (TEWL) Synthesis and degradation pathways, functions, and pathology of Ceramides and epidermal acylCeramides Quantitative analysis of Ceramides using a novel lipidomics approach with three dimensional response modelling Ceramides and sphingomyelinases in senile plaques Plasma Ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance Long chain Ceramides and very long chain Ceramides have opposite effects on human breast and colon cancer cell growth Elevated plasma Ceramides in depression Quantification of stratum corneum Ceramides and lipid envelope Ceramides in the hereditary ichthyoses Potential applications of phyto-derived Ceramides in improving epidermal barrier function Hydroxylation of Saccharomyces cerevisiae Ceramides requires Sur2p and Scs7p Quantitative determination of the neutral glycosyl Ceramides in human blood Epidermal sphingomyelins are precursors for selected stratum corneum Ceramides Modulation of cell signalling by Ceramides CERT mediates intermembrane transfer of various molecular species of Ceramides Serum Ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases Human epidermal glucosylCeramides are major precursors of stratum corneum Ceramides Decreased level of Ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? Key role for Ceramides in mediating insulin resistance in human muscle cells Rapid Transbilayer Movement of Ceramides in Phospholipid Vesicles and inHumanErythrocytes Link between plasma Ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease Association of Ceramides in human plasma with risk factors of atherosclerosis Properties of Ceramides and Their Impact on the Stratum Corneum Structure: A Review: Part 1: Ceramides FTIR spectroscopy studies of the conformational order and phase behavior of Ceramides Intercellular and intracellular functions of Ceramides and their metabolites in skin Ceramides are bound to structural proteins of the human foreskin epidermal cornified cell envelope The structure, function, and importance of Ceramides in skin and their use as therapeutic agents in skin-care products Skeletal muscle triglycerides, diacylglycerols, and Ceramides in insulin resistance: another paradox in endurance-trained athletes? Apoptosis in skeletal muscle myotubes is induced by Ceramides and is positively
Ceramides in insulin resistance and lipotoxicity Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and the liver, and researchers have recently proposed two mechanisms by which excess adiposity antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their storage capacity, fat begins to accumulate in tissues not suited for lipid storage, leading to the formation of specific metabolites that inhibit insulin signal transduction. Second, obesity triggers a chronic inflammatory state, and cytokines released from either adipocytes or from macrophages infiltrating adipose tissue antagonize insulin action. The sphingolipid ceramide is a putative intermediate linking both excess nutrients (i.e. saturated fatty acids) and inflammatory cytokines (e.g. tumor necrosis factor-alpha, TNFalpha) to the induction of insulin resistance. Moreover, ceramide has been shown to be toxic in a variety of different cell types (e.g. pancreatic beta-cells, cardiomyocytes, etc.), and review of the literature reveals putative roles for the sphingolipid in the damage of cells and tissues which accompany diabetes, hypertension, cardiac failure, atherosclerosis, etc. In this review, I will evaluate the contribution of ceramides in the development of insulin resistance and the complications associated with metabolic diseases. Lipotoxicity What is Lipotoxicity? Lipotoxicity: when tissues overeat Lipotoxicity in the heart Lipotoxicity in the liver Oxidative stress and Lipotoxicity Insulin resistance, obesity and Lipotoxicity Diabetes and apoptosis: Lipotoxicity Fatty liver and Lipotoxicity Lipotoxicity in the heart Molecular mechanisms of Lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease Obesity and Lipotoxicity New aspects of Lipotoxicity in nonalcoholic steatohepatitis Mechanisms of Lipotoxicity in the cardiovascular system Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications Lipotoxicity, overnutrition and energy metabolism in aging Renal lipid metabolism and Lipotoxicity Lipotoxicity and glucotoxicity in type 2 diabetes: effects on development and progression Mitochondrial dysfunction and Lipotoxicity Lipid homeostasis, Lipotoxicity and the metabolic syndrome Role of Lipotoxicity in endothelial dysfunction The role of ER stress in lipid metabolism and Lipotoxicity Lipotoxicity in NASH Fatty acids, Lipotoxicity and insulin secretion Underlying mechanisms of renal Lipotoxicity in obesity Lipid accumulation in non-adipose tissue and Lipotoxicity Molecular mechanisms of Lipotoxicity in nonalcoholic fatty liver disease Mechanisms of Lipotoxicity in NAFLD and clinical implications Cardiac Lipotoxicity: molecular pathways and therapeutic implications Saturated with fat: new perspectives on Lipotoxicity Role of obesity and Lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications The role of adipose tissue and Lipotoxicity in the pathogenesis of type 2 diabetes Role of glucotoxicity and Lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies Ceramides in insulin resistance and Lipotoxicity Adipose tissue expandability, Lipotoxicity and the metabolic syndrome—an allostatic perspective Gluttony, sloth and the metabolic syndrome: a roadmap to Lipotoxicity Insulin resistance, Lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009 Lipotoxicity in type 2 diabetic cardiomyopathy Oxidative capacity, Lipotoxicity, and mitochondrial damage in type 2 diabetes Triglyceride accumulation protects against fatty acid-induced Lipotoxicity Lipotoxicity: effects of dietary saturated and transfatty acids Dysfunctional fat cells, Lipotoxicity and type 2 diabetes Lipid signaling and Lipotoxicity