A glaucolide-type sesquiterpene lactone from Vernonia galamensis ssp. nairobensis A review of plant species assessedin vitro for antiamoebic activity or both antiamoebic and antiplasmodial properties A study on the involvement of TLR4/STAT3 signaling in the antimelanoma effects of atractylenolide II/Fu Xiuqiong. Allergic contact dermatitis from sesquiterpenoids of the Compositae family of plants Annexin A2 upregulation protects human retinal endothelial cells from oxygen‑glucose deprivation injury by activating autophagy Antibacterial constituents of the Nepalese medicinal herb, Centipeda minima Antimalarial activity of plant metabolites Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha, India Antiproliferative effects of short-chain fatty acids on human colorectal cancer cells via gene expression inhibition Antiprotozoal activities of Centipeda minima Anti-Protozoal Potential of Heterocyclic Compounds Against Giardiasis Antiviral Activity of the Sesquiterpene Lactones from Centipeda minima against Influenza a Virus in vitro Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive … Biomarker development for hepatocellular carcinoma early detection: current and future perspectives Bioprospecting for drug research and functional foods for the prevention of diseases—Role of flavonoids in drug development Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells Brevilin A , a novel natural product, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells Brevilin A , a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo Bulbine frutescens Phytochemicals as a Promising Anti-cancer Drug Discovery Source: A Computational Study Centipeda minima extract exerts antineuroinflammatory effects via the inhibition of NF-κB signaling pathway Chemical constituents from Centipeda minima Constituents of Helenium Species. VII. Bitter Principles of H. pinnatifidum (Nutt.) Rydb., H vernale Walt., H. brevifolium (Nutt.) A. Wood and H. flexuosum Raf.1 Constituents of Helenium species. XXI. Sesquiterpene lactones of Helenium alternifolium. Structures of Brevilin A , linifolin A, and alternilin Cryptotanshinone, a Stat3 inhibitor, suppresses colorectal cancer proliferation and growth in vitro Dehydrocrenatidine is a novel janus kinase inhibitor Detarium microcarpum Stem Bark Extracts Induce Apoptosis in Human Breast Adenocarcinoma MDA MB 231 Cells via cJNK Activation and Mitochondrial Cytochrome … Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3 EGFL7 promotes hepatocellular carcinoma cell proliferation and inhibits cell apoptosis through increasing CKS2 expression by activating Wnt/β‐catenin signaling Exploring QSAR of antiamoebic agents of isolated natural products by MLR, ANN, and RTO Functions and Implications of Autophagy in Colon Cancer Handbook of compounds with antiprotozoal activity isolated from plants Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line Helenanolides, guaianolide glucosides and other constituents of two Helenium donianum varieties Hepatocellular carcinoma confirmation,
1, 25-Dihydroxyvitamin D3 Treatment Delays Cellular Aging In Human Mesenchymal Stem Cells While Maintaining Their Multipotent Capacity 14Th Napreca Symposium And Aamps Ethnoveterinary Medicine... 1-Deoxynojirimycin Attenuates High Glucose-Accelerated Senescence In Human Umbilical Vein Endothelial Cells 24: Cerebral White Matter Lesions In Formerly (Pre)-Eclamptic Women A Deficit In Collagenase Activity Contributes To Impaired Migration Of Aged Microvascular Endothelial Cells A Drug-Induced Accelerated Senescence (Dias) Is A Possibility To Study Aging In Time Lapse A Functional Study Of Adamts7 Gene Variants. A G2/M Growth Arrest Response To Low-Dose Intermittent H2O2 In Normal Uroepithelial Cells. A Genetic Screening Identifies A Component Of The Swi/Snf Complex, Arid1B As A Senescence Regulator A Method For Fluorescent Hplc Analysis Of Cs/Ds Glycosaminoglycans A New 4-(Pyridinyl)-4H-Benzo[G]Chromene-5,10-Dione Ruthenium(Ii) Complex Inducing Senescence In 518A2 Melanoma Cells A Novel Keratanase‐Generated Keratan Sulfate Antibody And Its Application To Structural Analysis Of Skeletal And Corneal Keratan Sulfate A P53-Dependent Response Limits Epidermal Stem Cell Functionality And Organismal Size In Mice With Short Telomeres A Possible Role Of Stress-Induced Premature Senescence , Sips, As A Producer Of The Stress-Resistant Microenvironment A Study Of Cell Death Pathways And Innate Immunity In Cancer Chemotherapy A Synthetic Formulation, Dhanwantharam Kashaya, Delays Senescence In Stem Cells A Triad Of Nrp2, Dlx And P53 Proteins In Lung Cancer Metastasis Absence Of Replicative Senescence In Cultured Cells From The Short-Lived Killifish Nothobranchius Furzeri Abstract B175: Rational Combination Of Mtor And Aurora Kinase A Inhibition In Preclinical Models Of Triple-Negative Breast Cancer Abstract B63: Differences Between Replicative Senescence -Versus Radiation-Associated Secretory Phenotype Abstract Lb-32: Glioma Treatment With Temozolomide And Notch Inhibition Suppresses Neurosphere Formation And Xenograft Formation Abstract# 2194: Otx2 In Medulloblastoma: Its Function And Targets Accelerated Senescence Of Cord Blood Endothelial Progenitor Cells From Premature Neonates Is Driven By Sirt1 Decreased Expression Accelerated Tubular Cell Senescence In Smp30 Knockout Mice Activation Of A Camp Pathway And Induction Of Melanogenesis Correlate With Association Of P16Ink4 And P27Kip1 To Cdks, Loss Of E2F-Binding Activity, And … Acute Activation Of Amp-Activated Protein Kinase Prevents H2O2-Induced Premature Senescence In Primary Human Keratinocytes Acute Effects Of Rb In Retinoblastoma Cells Acyl-Coenzyme A Synthetase 5 Levels In Urothelial Cellines And Bladder Cancer Tissues Reflect Cellular Differentiation And Senescence . Adamts‐4 Activity On A Proteoglycan Vs. A Polypeptide Is Controlled By The Ancillary Domains Adenoviral P16/Cdkn2 Gene Transfer To Malignant Glioma: Role Of P16 In Growth, Invasion, And Senescence Administration Of L-Arginine Plus L-Citrulline Or L-Citrulline Alone Successfully Retarded Endothelial Senescence Ageing Of Neural Stem Cells In A Parkinson'S Disease Model Age-Like Phenotype Of Microglia During Hiv-1 Infection Age‐Related Changes In Human Meniscal Glycosaminoglycans Aging Alters The Molecular Dynamics Of Synapses In A Sexually Dimorphic Pattern In Zebrafish (Danio Rerio) Aging Decreases Collagen Iv Expression In Vivo In The Dermo-Epidermal Junction And In Vitro In Dermal Fibroblasts: Possible Involvement Of Tgf-Β1 Alain Meybeck Alpha-Ketoglutarate, An Endogenous Metabolite, Extends Lifespan And Compresses Morbidity In Aging Mice Altered Signal Transduction Pathways In Melanoma Alternative Splicing Targeting The Htaf4-Tafh Domain Of Taf4 Represses Proliferation And Accelerates Chondrogenic Differentiation Of
Neuroprotective effects of flavonoids and polyphenols A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders A bird's-eye view of the multiple biochemical mechanisms that propel pathology of Alzheimer's disease: recent advances and mechanistic perspectives on … A blueberry extract-supplemented diet rescues phenotypes in drosophila melanogaster models of parkinson disease A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples A Comparison of the Antioxidant Activity with the Total Phenolic and Total flavonoid contents of the Leaves and Stem-bark of Anogeissus leiocarpa (DC.) Guill& Pirr … A comprehensive database and analysis framework to incorporate multiscale data types and enable integrated analysis of bioactive polyphenols A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis of Scutellaria baicalensis A Current Understanding of Alzheimer's Disease and the Prospects of Phytopharmacological Intervention as a Management Strategy A meta-analysis of tea drinking and risk of Parkinson's disease A molecular approach in drug development for Alzheimer's disease A Narrative Review of Lifestyle Factors Associated with Parkinson's Disease Risk and Progression A Novel GSK3β Inhibitor Reduces Tau Pathology in Alzheimer's Disease A Paradigm Shift to Prevent and Treat Alzheimer's Disease: From Monotargeting Pharmaceuticals to Pleiotropic Plant Polyphenols A pharmacological appraisal of neuroprotective and neurorestorative flavonoids against Neurodegenerative diseases A review of antioxidant and pharmacological properties of phenolic compounds in Acacia confusa A Review of Antioxidants and Alzheimer A review of antioxidants and Alzheimer's disease A review of genome mutation and Alzheimer's disease A review on cholinesterase inhibitors for Alzheimer's disease A Review on Current Strategies and Future Perspective in Respect to Alzheimer's Disease Treatment A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer's and Parkinson's diseases A Review on Medicinal Plants for Alzheimer's disease A review on mitochondrial restorative mechanism of antioxidants in Alzheimer's disease and other neurological conditions A review on potential mechanisms of Terminalia chebula in Alzheimer's disease A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease A review on the beneficial effects of tea polyphenols on human health A review on the status of the phenolic compounds and antioxidant capacity of the flour: Effects of cereal processing A review--probable mechanism of action of curcumin for the treatment of Alzheimer disease (AD) A review: inflammatory process in Alzheimer's disease, role of cytokines A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model A Study on the Role of Mimosa Pudica (Thottar Chinungi) on the Experimental Models of Parkinsonism (Nadukku Vatham) A synopsis on the linkage between age-related dementias and vascular disorders A systematic review on the role of natural products in modulating the pathways in Alzheimer's disease Acacetin—A simple flavone exhibiting diverse pharmacological activities Accumulation of citrus flavanones in bovine milk following citrus pulp incorporation into the diet of dairy cows Acetyl-cholinesterase Inhibition by Extracts and Isolated Flavones from Linaria reflexa Desf. (Scrophulariaceae) Acetylated flavonoid Glycosides Potentiating NGF Action from Scoparia dulcis Activation
12P Individualized Breast Cancer Therapy Using Mcl-1 Inhibition Based Combination 155: Trem-1 Protects Monocyte From Apoptosis Via Mcl-1-Dependent Mechanism 1-Phenyl-1H-Indole Derivatives As A New Class Of Bcl-2/Mcl-1 Dual Inhibitors: Design, Synthesis, And Preliminary Biological Evaluation 2-Deoxyglucose Pretreatment Sensitizes Colon Cancer Cells To Cisplatin And Killer Trail Induced Apoptosis By Mcl-1 Downregulation 3656: Apoptosis In Human Cancer Cells In A Bcl-Xl, Bcl2 And Mcl-1 … 3-Bromopyruvate Induces Apoptosis In Breast Cancer Cells By Downregulating Mcl-1 Through The Pi3K/Akt Signaling Pathway 3-Substituted-N-(4-Hydroxynaphthalen-1-Yl)Arylsulfonamides As A Novel Class Of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, Sar, And Biological … 3-Thiomorpholin-8-Oxo-8H-Acenaphtho [1, 2-B] Pyrrole-9-Carbonitrile (S1) Derivatives As Pan-Bcl-2-Inhibitors Of Bcl-2, Bcl-Xl And Mcl-1 5-Fluorouracil Induction Of Fas And Apoptosis In Colon Cancer Patients: Relation Of Clinical Outcome With Thymidylate Synthase, Mcl-1 And Rb 7-Isopenthenyloxycoumarin, Arctigenin, And Hesperidin Modify Myeloid Cell Leukemia Type-1 (Mcl-1) Gene Expression By Hormesis In K562 Cell Line A Chemotherapy-Driven Increase In Mcl-1 Mediates The Effect Of Mir-375 On Cisplatin Resistance In Osteosarcoma Cells. A Competitive Stapled Peptide Screen Identifies A Selective Small Molecule That Overcomes Mcl-1-Dependent Leukemia Cell Survival A Critical Epithelial Survival Axis Regulated By Mcl-1 Maintains Thymic Function A Critical Epithelial Survival Axis Regulated By Mcl-1 Maintains Thymic Function In Mice A Inhibits Sodium Nitroprusside-Induced Cardiac H9C2 Cell Death Through Suppressing Activation Of Jnk And Preserving Mitochondrial Anti-Apoptotic Bcl-2 And Mcl-1 A Kinase Inhibitor Screen Identifies Mcl-1 And Aurora Kinase A As Novel Treatment Targets In Antiestrogen-Resistant Breast Cancer Cells A Luciferase-Based Assay Identifies Niclosamide Derivatives Antagonizing Mcl-1 Through Post-Translational Down-Regulation A Major Role For Mcl-1 Antiapoptotic Protein In The Il-6-Induced Survival Of Human Myeloma Cells A Non-Apoptotic Function For Mcl-1 As An Activator Of Canonical Wnt Signaling In Keratinocytes A Non-Apoptotic Function Of Mcl-1 In Promoting Pluripotency And Modulating Mitochondrial Dynamics In Stem Cells A Novel Allosteric Mechanism For Molecular Inhibition Of Anti-Apoptotic Mcl-1 A Novel Atp-Competitive Mek/Aurora Kinase Inhibitor Bi-847325 Reverses Acquired Braf Inhibitor Resistance Through Suppression Of Mcl-1 And Inhibition Of Mek … A Novel Bh 3 Mimetic Efficiently Induces Apoptosis In Melanoma Cells Through Direct Binding To Anti‐Apoptotic Bcl‐2 Family Proteins, Including Phosphorylated Mcl‐1 A Novel Bh3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed Without Mcl-1 Degradation A Novel Bh3 Mimetic S1 Potently Induces Bax/Bak‐Dependent Apoptosis By Targeting Both Bcl‐2 And Mcl‐1 A Novel Biomarker Approach In Mcl-1 Dependent Relapsed/Refractory Aml A Novel Histone Deacetylase Inhibitor, Cg200745, Potentiates Anticancer Effect Of Docetaxel In Prostate Cancer Via Decreasing Mcl-1 And Bcl-Xl A Novel Pan Inhibitor Of Bcl-2 And Mcl-1 Apogossypolone (Apog2) With Superior Stability And Improved Activity Against Human Leukemia And Lymphoma Cells. A Novel Selective Mcl-1 Inhibitor Exhibits In Vitro And In Vivo Efficacy In Melanoma A Novel Small Molecule Fl118 That Selectively Inhibits Survivin, Mcl-1, Xiap And Ciap2 In A P53-Independent Manner, Shows Superior Antitumor Activity A Novel Small-Molecule Iap Antagonist, Azd5582, Draws Mcl-1 Down-Regulation For Induction Of Apoptosis Through Targeting Of Ciap1 And Xiap In Human … A Novel Small-Molecule Inhibitor Of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro And
A Combination Of Remote Ischemic Perconditioning And Cerebral Ischemic Postconditioning Inhibits Autophagy To Attenuate Plasma Hmgb1 And Induce Neuroprotection … A Comparison Of Hmgb1 Concentrations Between Cerebrospinal Fluid And Blood In Patients With Neurological Disease A Critical Cysteine Is Required For Hmgb1 Binding To Toll-Like Receptor 4 And Activation Of Macrophage Cytokine Release A Critical Role In Structure-Specific Dna Binding For The Acetylatable Lysine Residues In Hmgb1 A Critical Role Of Hmgb1 In Liver Tumor Development Under Autophagy Deficiency A Cycle Involving Hmgb1, Ifn-Γ And Dendritic Cells Plays A Putative Role In Anti-Tumor Immunity A Dalbergia Odorifera Extract Improves The Survival Of Endotoxemia Model Mice By Inhibiting Hmgb1 Release A Direct Inhibitor Of Hmgb1 Cytokine A Dual Regulatory Role Of Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 In Hmgb1-Induced Inflammatory Responses A Dual-Role Of Gu-4 In Suppressing Hmgb1 Secretion And Blocking Hmgb1 Pro-Inflammatory Activity During Inflammation A Functional Variant At The Mirna Binding Site In Hmgb1 Gene Is Associated With Risk Of Oral Squamous Cell Carcinoma A High Mobility Group Box 1 (Hmgb1) Gene From Chlamys Farreri And The Dna-Binding Ability And Pro-Inflammatory Activity Of Its Recombinant Protein A High-Sensitivity Method For Detection And Measurement Of Hmgb1 Protein Concentration By High-Affinity Binding To Dna Hemicatenanes A Janus Tale Of Two Active High Mobility Group Box 1 (Hmgb1) Redox States A Limited Series Of Synthetic Tetrahydroisoquinoline Alkaloids Reduce Inflammatory Gene Inos Via Inhibition Of P-Stat-1 And Suppress Hmgb1 Secretion In Lps-Treated … A Major Ingredient Of Green Tea Rescues Mice From Lethal Sepsis Partly By Inhibiting Hmgb1 A Multicenter Matched Case-Control Analysis On Seven Polymorphisms From Hmgb1 And Rage Genes In Predicting Hepatocellular Carcinoma Risk A Negative Acute Phase Protein, Fetuin, Inhibits Hmgb1 Release, And Protects Mice Against Lethal Endotoxemia.: 5 A Neutrophil Elastase Inhibitor, Sivelestat, Reduces Lung Injury Following Endotoxin-Induced Shock In Rats By Inhibiting Hmgb1 A Novel Disulfide Bond-Mediated Cleavable Rgd-Modified Pamam Nanocomplex Containing Nuclear Localization Signal Hmgb1 For Enhancing Gene … A Novel Hypothesis: Up-Regulation Of Ho-1 By Activation Of Pparγ Inhibits Hmgb1-Rage Signaling Pathway And Ameliorates The Development Of Ali/Ards A Novel Mrm-Based Mass Spectrometry Assay To Quantify Hmgb1 A Novel Pathway Of Hmgb1-Mediated Inflammatory Cell Recruitment That Requires Mac-1-Integrin A Novel Pathway Of Hmgb1‐Mediated Inflammatory Cell Recruitment That Requires Mac‐1‐Integrin A Novel Rag1 Mutation Reveals A Critical In Vivo Role For Hmgb1/2 During V(D)J Recombination A Novel Regulatory Variant Of Hmgb1 Gene Is Associated With The Disease Progression In Chronic Hepatitis B Virus Carriers A Novel Role For Hmgb1 In Tlr9-Mediated Inflammatory Responses To Cpg-Dna A Novel Role For Hmgb1 In Tlr9-Mediated Inflammatory Responses To Cpg-Dna (89.24) A Possible Role Of Hmgb1 In Dna Demethylation In Cd4 A Possible Role Of Hmgb1 In Dna Demethylation In Cd4+ T Cells From Patients With Systemic Lupus Erythematosus A Proatherogenic Role For Hmgb1 In Atherosclerosis A Role For Extracellular Hmgb1 In Regulation Of Dendritic Cell Maturation And Function. A Role For Hmgb1, Hsp60 And Myd88 In Growth Of Murine Mammary Carcinoma In Vitro A Small Molecule Binding Hmgb1 And Hmgb2 Inhibits Microglia-Mediated
… -biochemical profile, and organs histology of broiler chickens fed diets supplemented with a seasoning named Jumbo Cube as source of monosodium glutamate … -D-aspartate receptor-, glutamate-and aspartate-immunoreactive neurons in the mouse arcuate nucleus: effects of neonatal treatment with monosodium glutamate … -releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus of rats neonatally treated with monosodium glutamate can respond to different … … -rich extract of Syzygium cumini leaf dually improves peripheral insulin sensitivity and pancreatic islet function in Monosodium L-glutamate-induced obese rats … ‐Activated Receptor δ‐Agonist, GW501516, Ameliorates Insulin Resistance, Improves Dyslipidaemia in Monosodium l‐Glutamate Metabolic Syndrome Mice … . Roger's letter: further studies are necessary in order to conclude a causal association between the consumption of Monosodium L-glutamate (MSG) and the … … (2011) B. Zoology Email: egyptianacademic@ yahoo. com ISSN: 2090–0759 Received: 21/11/2011 www. eajbs. eg. net monosodium glutamate Toxic Effect on … … (Loranthus micranthus Linn) aqueous leaves extract modulates some cardiovascular disease risk factors in monosodium glutamate induced metabolic dysfunction … 2A2 and 3A2: induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate. … Activity in the Optic Tectum of Developing Chick Embryos and the Effects of 3′, 5′‐Cyclic Nucleotides and monosodium glutamate on Enzyme Activity … activity of dorsomedial arcuate neurons and diurnal changes of tuberoinfundibular dopaminergic neuron activity in female rats with neonatal monosodium glutamate … … administration of sodium ferulate on repair following excitotoxic neuronal damages induced by maternal oral administration of monosodium glutamate at a late … … and Active Components of Parasporal Crystral Produced by the Tamed Bt Strains Capable of Utilizing high Concentration monosodium glutamate Waste-water [J] … and changes of alkaline phosphatase activity in the small intestine of 40-and 80-day-old rats subjected to early postnatal overfeeding or monosodium glutamate … and dopamine concentrations occur concomitantly with the development of type II diabetes in rats treated neonatally with monosodium glutamate (MSG): a possible … … and ultrastructural studies concerning the protective effect of some micronutrients-antioxidant factors, against L-monosodium glutamate administration on some … … ARCUATE NUCLEUS OF THE HYPOTHALAMUS OF THE INFANT MOUSE FOLLOWING SUBCUTANEOUS ADMINISTRATION OF monosodium glutamate1 … basic tastes are per-ceived, namely sweet (eg glucose), salty (eg sodium chloride, NaCl), umami (the taste of glutamate or “monosodium glutamate (MSG)), bitter (eg … … CHANGES AT THE HYPOTHALAMIC NUCLEUS ARCUATUS AND THYROID LEVEL IN RATS TREATED WITH monosodium glutamate … characteristics of light-induced fos immunoreactivity in suprachiasmatic nuclei are not modified in Syrian hamsters treated neonatally with monosodium glutamate … chromatographic determination of retinol palmitate in emulsified nutritional supplements by solid-phase extraction using Monosodium L-glutamate as dissolving agent … concentration of tea [Camellia sinensis] leaves produced at the sea-side area: Inapplicability as the index of discriminating monosodium glutamate added green tea … crystallographic form under defined conditions of reactant supersaturation as associated with the batch crystallization of monosodium glutamate from aqueous solution … depression features and Iba1 immunoreactivity in the cerebral cortex of developing rats
Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models Abstract Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor nuclear factor (erythroid-derived 2)-like 2 is the “master regulator” of cellular antioxidant defenses. Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity. However, Nrf2 expression and activity in long-lived models have not been well described. Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means. 1. Introduction The incidence of chronic disease increases with age. Understanding the relationships between the processes of aging and age-related diseases is an important initiative of the National Institutes of Health to improve the health of the aging population [1]. Slowing the aging process limits the burden of age-related chronic disease [2]. Identifying characteristics that slow aging may also provide approaches for preventing chronic diseases. Animals with increased lifespan aid in understanding the aging process by allowing the study of physiological and biochemical adaptations associated with slowed aging. Further, studying characteristics shared among long-lived models provides insight into pathways that are key to slowing the aging process and age-associated chronic diseases. Lifespan can be extended by genetic, dietary, and pharmacological interventions. Additionally, multiple species have independently evolved long lifespan, including humans and naked mole rats, both of which live more than four times longer than predicted by body size [3]. Some of the earliest discoveries of lifespan extension were single-gene mutations associated with the insulin-like growth factor I (IGF-1) and growth hormone (GH) pathways. These mice, including the Snell dwarf [4], are smaller than their heterozygote counterparts and significantly longer-lived, some by 40% or more compared with controls. Long-term caloric restriction is the most consistent dietary manipulation to extend lifespan and recent evidence suggests that short-term transient nutrition restriction prior to weaning, accomplished by litter enlargement, also increases mean and maximal lifespan in mice [5]. Pharmaceutical manipulation of lifespan is in its infancy, with evidence that rapamycin can extend lifespan in mice [6]. It is well established that oxidant stress increases with age across a variety of tissues, including cardiac [7] and skeletal muscle [8], liver [9], and brain [10], and is associated with a wide variety of chronic age-related diseases including cancer, neurodegeneration, sarcopenia, and cardiovascular disease. Although the oxidative stress theory of aging has received criticism [11], it remains true that oxidant stress is associated with the aging process. In response to oxidative stress, cells upregulate antioxidant pathways, including activation of the transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses and the proposed “master regulator” of the aging process [3]. Further, the therapeutic potential of Nrf2 is well supported in neurodegeneration and cancer (reviewed in [12,
… corresponding anthocyanins). Cyanidin inhibits epidermal growth factor receptor tyrosine kinase (EGF-RTK),-glycosidase and COX-1 and COX-2. Delphinidin (3, 5, 7 … … in acid, for example, as indicated in parentheses as follows: procyanidins (product cyanidin, 3, 5, 7, 3, 4-penta-hydroxyflavylium), proDelphinidins (Delphinidin, 3, 5, 7 … … OF A QUANTITATIVE HIGH PERFORMANCE THIN LAYER CROMATOGRAPHIC METHOD FOR ANALYSIS OF Delphinidin 3-GLUCOSIDE IN BERRY … … of flavonoid 3'-hydroxylase, flavonoid 3', 5'-hydroxylase genes and related metabolite profiling of red cyanidin-/blue Delphinidin-based anthocyanins in berry … … of miR-137 mimics is more effective than DNA demethylation of miR-137 promoter to augment anti-tumor mechanisms of Delphinidin in human glioblastoma U87MG … … type. Part XIX. A synthesis of Delphinidin chloride not involving a demethylation process, and syntheses of hirsutidin chloride and of Delphinidin chloride 3′-methyl … (Delphinidin 3-gentiobiosyl)(apigenin 7-glucosyl) malonate from the flowers of Eichhornia crassipes 0397: Delphinidin and calcium signaling in human T lymphocytes: a basis to elucidate pathways leading to proliferation and apoptosis 20 The polyphenol Delphinidin induces antioxidant effects in human umbilical vein endothelial cells through activation of endogenous glutathione: importance of using … 7-Polyacylated Delphinidin 3, 7-diglucosides from the blue flowers of Leschenaultia cv. Violet Lena A Delphinidin-Enriched Maqui Berry Extract Improves Bone Metabolism and Protects against Bone Loss in Osteopenic Mouse Models A dietary anthocyanidin Delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-κB signaling A role for miR-137 in enhancing efficacy of Delphinidin in human glioblastoma. A simple and rapid method for the preparation of pure Delphinidin-3-O-sambubioside from Roselle and its antioxidant and hypoglycemic activity Ab initio study regarding the evaluation of the antioxidant character of cyanidin, Delphinidin and malvidin Absorption and metabolism of Delphinidin 3-O-β-d-glucopyranoside in rats Absorption and metabolism of Delphinidin 3-O-β-D-glucoside in rats Abstract LB-426: Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase Abstract# 2699: Dietary anthocyanidin Delphinidin interacts with androgen receptor and accelerates its decay in human prostate cancer cells and in a xenograft mouse … Activity of Delphinidin on microvascular damage models in rodents Acylated Delphinidin 3-rutinoside-5-glucosides in the flowers of Petunia reitzii Acylated Delphinidin Glycosides from Violet and Violet-Blue Flowers of Clematis Cultivars and their Coloration Acylated Delphinidin glycosides in the blue-violet flowers of Consolida armeniaca An acylated Delphinidin glycoside in the blue flowers of Evolvulus pilosus Analysis of Delphinidin and luteolin genotoxicity in human lymphocyte culture Analysis of inhibitory activity of Delphinidin on chromosome aberrations frequencies in human peripheral blood lymphocytes in vitro. Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway Anthocyanins derived only from Delphinidin in the blue petals of Clitoria ternatea Anthocyanins in The Dark Purple Anthers of Tulipa gesneriana: Identification of Two Novel Delphinidin 3-O-(6-O-(Acetyl-or-Rhamnopyranosyl)- Anthocyanins in The Dark Purple Anthers of Tulipa gesneriana: Identification of Two Novel Delphinidin 3-O-(6-O-(Acetyl-α-Rhamnopyranosyl)-β-Glucopyranosides) Anthocyanins, Delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico Anti-adipogenic Effect of Delphinidin-3-O-β-glucoside in 3T3-L1 Preadipocytes and
(S)-(+)-Decursin and its Analogues as Inhibitors of Cytokines Secretion Induced by DpE in THP-1/EoL-1 Cell Line [P8-06] Effect of Decursin on the Body weight and Glucose tolerance in C57/BL/6 Mice Fed High Fat Diet 183: Decursin affects Wnt/beta catenin pathway on prostate cancer cell lines. 3D-QSAR Study of Melanin Inhibiting (S)-(+)-Decursin and its Analogues by Pharmacophore Mapping A (S)-(+)-Decursin derivative,(S)-(+)-3-(3, 4-dihydroxy-phenyl)-acrylic acid 2, 2-dimethyl-8-oxo-3, 4-dihydro-2H, 8H-pyrano [3, 2-g]-chromen-3-yl-ester, attenuates the … A COMPOSITION COMPRISING NOVEL (+)-Decursin-ETHER DERIVATIVE FOR TREATING AND PREVENTING ATOPIC DERMATITIS DISEASE A novel (S)-(+)-Decursin derivative,(S)-(+)-3-(3, 4-dihydroxy-phenyl)-acrylic acid 2, 2-dimethyl-8-oxo-3, 4-dihydro-2H, 8H-pyrano [3, 2-g] chromen-3-yl-ester, inhibits … A novel anticancer agent, Decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells A novel anticancer agent, Decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells: Yim D, Singh RP, Agarwal C, Lee S, Chi H, Agarwal R … A novel anticancer agent, Decursin, induces G1 arrest and apoptosis in human prostate carcinoma DU145 cells A Novel Anticancer Agent, Decursin, Induces G1 Arrest in Human Prostate Carcinoma DU-145 A novel derivative of Decursin, CSL‐32, blocks migration and production of inflammatory mediators and modulates PI3K and NF‐κB activities in HT1080 cells A synthetic Decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo Absorption, distribution, metabolism, and excretion of Decursin and Decursinol angelate from Angelica gigas Nakai Abstract LB-428: Decursin inhibits advanced human prostate tumor xenograft growth involving antiproliferative and antiangiogenic mechanisms Analytical Validation of Decursin in Aerial Parts of Angelica gigas Nakai Angelica gigas Nakai and Decursin downregulate Myc expression to promote cell death in B-cell lymphoma Anti-Angiogenic Effect of Decursin on Retinal Neovasularization of Oxygn-Induced Retinopathy Anti-tumor activities of Decursinol angelate and Decursin fromAngelica gigas Antibacterial activity of Decursin from Streptomyces sp. GMT-8; an endophyte in Zingiber officinale Rosc. Availability of Decursin and Decursinol Angelate and antioxidant activity in the seeds of Angelica gigas Nakai Axial conformation of 3-methyl-2-butenoyl group in pyranocoumarin ring endows biological activity of (+)-Decursin Biopharmaceutical characterization of Decursin and their derivatives for drug discovery Biotransformation of plant secondary metabolite Decursin by Mycobacterium sp. PYR1001 Changes in the growth characteristics and the content of Decursin and Decursinol angelate in Angelica gigas Nakai by mineral and hormonal agent treatment Comparison of skin sensitization potentials of Decursin with different purities by evaluating the expression of surface markers on THP-1 cells (초) Compositions for urinary dysfunction and edema containing Decursin and/or Decursinol angelate, or angelica extract containing Decursin and/or Decursinol angelate Computational approaches to predict binding interactions between mammalian tyrosinases and (S)-(+)-Decursin and its analogues as potent inhibitors Cytochrome P450 isoforms in the metabolism of Decursin and Decursinol angelate from Korean Angelica Decursin and Decursinol angelate affect spermatogenesis in the adult rat at oral administration Decursin and Decursinol angelate from Angelica gigas Nakai induce apoptosis via induction of TRAIL expression on cervical cancer cells Decursin and Decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory … Decursin and Decursinol angelate inhibit estrogen-stimulated and
’Inflammaging’ refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules resulting from damaged and/or dead cells and organelles (cell debris), recognized by receptors of the innate immune system. While their production is physiological and increases with age, their disposal by the proteasome via autophagy and/or mitophagy progressively declines. This ‘autoreactive/autoimmune’ process fuels the onset or progression of chronic diseases that can accelerate and propagate the aging process locally and systemically. Consequently, inflammaging can be considered a major target for antiaging strategies. … Bone Marrow Progenitors Have a Proliferative Advantage in the Presence of TNF-Alpha and IFN-Gamma: Implications for Clonal Dominance in inflammaging and … … enrichment modified epigenetic mechanisms in SAMP8 mouse hippocampus by reducing oxidative stress and inflammaging and achieving neuroprotection “inflammaging” and Estradiol among Older US Women: A Nationally Representative Longitudinal Study “inflammaging” AND ITS MANAGEMENT IN PRESBYCUSIS “inflammaging” as a druggable target: a senescence-associated secretory phenotype—centered view of type 2 diabetes 029 inflammaging and Bone Health in Later Life: The Hertfordshire Cohort Study 115.“inflammaging” and psychosocial stress in a murine orthotopic prostate cancer model 2036–inflammaging AND T-ALL: ONCOGENE-CYTOKINE INTERACTIONS AND THEIR ROLE IN LEUKEMOGENESIS 25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice A robust characterization of inflammaging and other immune processes through multivariate analysis of cytokines from longitudinal studies Absence of CCR2 results in an inflammaging environment in young mice with age‐independent impairments in muscle regeneration Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging Age-related Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation (inflammaging) Age-related thymic involution perturbs negative selection leading to autoreactive T Cells that induce chronic inflammation (inflammaging)(BA11P. 141) Aged gut microbiota contributes to systemical inflammaging after transfer to germ-free mice Aging and Parkinson's Disease: inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis Aging-related frailty and sarcopenia. The relationship between" inflammaging" and frailty/sarcopenia. An Efficient Means to Mitigate Skin inflammaging by Inhibition of the NLRP3 Inflammasome and Nfκb Pathways: A Novel Epigenetic Mechanism Anti-inflammaging and antiglycation activity of a novel botanical ingredient from African biodiversity (Centevita™) Anti-inflammaging effect of human alpha 1 antitrypsin Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice Anti‐inflammaging effects of human alpha‐1 antitrypsin Are There Reliable Biomarkers for Immunosenescence and inflammaging? Arterial “inflammaging” drives vascular calcification in children on dialysis Association of inflammaging (inflammation+ aging) with higher prevalence of OAB in elderly population Budesonide, aclidinium and formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke Cachexia, sarcopenia, inflammaging and outcomes in hospitalised older people (the CaSIO study): Study protocol and preliminary results Can latent synergism of intestinal pathogens be responsible for inflammaging process causing Reiter's syndrome in a young patient