Chronic, low-grade inflammation is a hallmark of many age-related diseases, including heart disease, arthritis, and Alzheimer's. Flavonoids and polyphenols, found abundantly in fruits, vegetables, and beverages like tea and coffee, come to the rescue with their potent anti-inflammatory properties. These natural compounds can dampen the activity of inflammatory enzymes and signaling molecules, reducing the body's inflammatory response. By keeping inflammation in check, they offer a promising strategy to promote overall health and potentially slow down the aging process. Research suggests that consuming a diet rich in these flavonoid and polyphenol-rich foods may help reduce the risk of chronic diseases and improve cognitive function in later life. While the exact mechanisms are still being explored, the anti-inflammatory effects of these dietary components are a key area of research in promoting healthy aging. A hydroxyl group of Flavonoids affects oral Anti-inflammatory activity and inhibition of systemic tumor necrosis factor-α production A lipidomic study on the regulation of Inflammation and oxidative stress targeted by marine ω-3 PUFA and polyphenols in high-fat high-sucrose diets A New Clerodane Diterpene, Flavonoids and Sterols from Cassia nodosa Growing in Egypt: Anti-inflammatory Activity of Plant Extracts A New Cytotoxic Sesquiterpene and Three Anti-inflammatory Flavonoids from Egyptian Tanacetum Santolinoides A new flavan-3-ol and the Anti-inflammatory effect of Flavonoids from the fruit peels of Wisteria floribunda A new lignan and Anti-inflammatory Flavonoids from Kerria japonica A Review: The Anti-inflammatory, Anticancer, Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice Actions of Flavonoids and the novel Anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation Advance in Studies on Anti-inflammatory Mechanism of Flavonoids Advances in Research on the Common Mechanisms of Anti-inflammatory Activity and Antitumor Activity by Flavonoids [J] Advantages of a combination of proteolytic enzymes, Flavonoids and ascorbic acid in comparison with non-steroid Anti-inflammatory agents. An in vitro study of Anti-inflammatory effect of Quercetin and Resveratrol polyphenols in ocular surface epithelial cells. An in vivo study of Anti-inflammatory effect of Quercetin and Resveratrol polyphenols in a desiccating stress mouse model of dry eye. An Investigation of the Analgesic and Anti-inflammatory Effects of Nigella sativa Seed polyphenols An overview on immunoregulatory and Anti-inflammatory properties of chrysin and Flavonoids substances Analgesic and Anti-inflammatory Effects of an Extract and Flavonoids from Artemisia Herba-Alba and Their Mechanisms of Action Analgesic and topical Anti-inflammatory activity of terpenoids and Flavonoids from species of the genus Teucrium and Salvia in mice Angiogenesis and Inflammation signaling are targets of beer polyphenols on vascular cells Antagonism by bioactive polyphenols against Inflammation: a systematic view Anti inflammatory Activities of Selected Flavonoids A Pathophysiological Studies in Guinea Pigs Anti inflammatory activity of Cynodon dactylon Linn. In carrageenan induced paw edema in rats and its comparison with some standard Flavonoids Anti-atherosclerotic activities of Flavonoids from the flowers of Helichrysum arenarium L. MOENCH through the pathway of anti-Inflammation Anti-atherosclerotic and Anti-inflammatory activities of catecholic xanthones and Flavonoids isolated from Cudrania tricuspidata Anti-hypertensive effect of total Flavonoids of cydonia oblonga leaves and its mechanism based on Anti-inflammatory function Anti-inflammatory Action of Blueberry polyphenols

Inflammation and depression are increasingly recognized as significant factors influencing human health and aging.Chronic, low-grade inflammation disrupts healthy cellular function and is linked to various age-related diseases like heart disease and Alzheimer's. Research suggests a two-way street between inflammation and depression. Chronic inflammation can trigger the release of molecules that disrupt neurotransmitter production, essential for mood regulation, potentially leading to depression. Conversely, depression can weaken the immune system, making individuals more susceptible to infections and further inflammation. This complex interplay highlights the importance of managing both conditions for healthy aging. A biological pathway linking inflammation and depression: activation of indoleamine 2, 3-dioxygenase A human in vitro model to investigate the effects of inflammation on adult hippocampal neurogenesis in the context of depression A new paradigm for depression in new mothers: the central role of inflammation and how breastfeeding and anti-inflammatory treatments protect maternal … A new perspective on cancer-related fatigue: Negative affectivity, depression, and inflammation leading to increased effort expenditure A prospective evaluation of the directionality of the depression–inflammation relationship A role for inflammation-related molecules in behavioral depression induced by repeated stress in mice A32 ASTHMA AND ALLERGY CLINICAL STUDIES: Relationships Between depression And Bronchodilator Response And Airway Or Systemic inflammation In … Abstract MP074: Pathway Linking depression & inflammation: A 5-year Longitudinal Twin Difference Study Abstract P247: Combination of Obesity and Metabolic Syndrome is Associated With Highest Rate of depression Secondary to Increased inflammation Abstract P288: Dietary inflammation is Associated With depression Independent of Traditional Cardiovascular Disease Risk Factors in the National Health and … Abstract# 1724 depression and inflammation are independent predictors of fatigue in breast cancer survivors Abstract# 1767 Combined influence of depression and systemic inflammation on cardiovascular disease and all-cause mortality: Evidence for differential effects by … Abstract# 1811 Is there a causal association between inflammation and depression? Abstract# 1859 A new LPS-based mouse model of chronic inflammation and depression Abstract# 3091 inflammation is Associated with Decreased Amygdala to Ventromedial Prefrontal Functional Connectivity in Association with Symptoms of Anxiety in … Abstract# 3112 Childhood adversity predicts changes in inflammation, fatigue, and depression during breast cancer survivorship Abstract# 3141 Association between depression and inflammation among bereaved adults Acculturation, inflammation, and depression Among Hispanic Adults in the United States Acute Clinical Deterioration With Increased Systemic inflammation as a Risk Factor for depression: An Alternative Interpretation of the Data Adolescent-onset depression: are obesity and inflammation developmental mechanisms or outcomes? Adolescent-onset depression: the interplay between family relationships, brain development and inflammation Adrenarchal status as a moderator of a depression–inflammation relation in children Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guerin Airway inflammation and hypothalamic-pituitary-adrenal axis activity in asthmatic adults with depression Alcohol, inflammation, and depression: The Gut-Brain Axis Alexithymia, depression, inflammation, and pain in patients with rheumatoid arthritis Alkaloid Compounds For Treating depression, Substance Addictions, And Indications Associated With Chronic inflammation Altered expression of genes involved in

Centenarians, individuals reaching 100 years or beyond, offer a wealth of information for researchers studying human health and aging. Their unique biology provides clues to exceptional longevity and resilience against diseases. By studying their genes, researchers can identify genetic variants that promote healthy aging and potentially counteract age-related illnesses like heart disease and Alzheimer's. Additionally, centenarians' immune systems often show a remarkable ability to function well into extreme old age. Understanding the mechanisms behind this immune resilience could lead to the development of therapies that promote a healthier immune response throughout life. In essence, centenarians serve as a living testament to the potential for extended healthspan, and unlocking the secrets of their biology holds immense potential for improving health and well-being for the broader population. (Cd45Ra+) And Memory (Cd45R0+) Cells Between Cd4+ And Cd8+ Lymphocytes-T In Humans-A Study From Newborns To Centenarians 166: Out-Of-Hospital Cardiac Arrest (Ohca) In Centenarians In Japan 56Demographics Of Centenarians Admitted Through Medical Receiving In Raigmore Hospital A Baseline Investigation Of Independence Among 100 Community-Dwelling Centenarians In Turkey A Census‐Based Comparison Of Centenarians In New Zealand With Those In The United States A Comparative Analysis On Healthy Longevity Phenotypes Between Chinese And Italian Centenarians A Comparative Study On The Health Status And Behavioral Lifestyle Of Centenarians And Non-Centenarians In Zhejiang Province, China——A Cross-Sectional Study A Comparison Of Anthropometry, Biochemical Variables And Plasma Amino Acids Among Centenarians, Elderly And Young Subjects A Comparison Of Perceived Uselessness Between Centenarians And Non-Centenarians In China A Comprehensive Phenotypic And Genetic Analysis Of Centenarians From 13 Villages Located In The Sardinian Region Of Barbagia-Mandrolisai A Cross-Section Analysis Of Ft3 Age-Related Changes In A Group Of Old And Oldest-Old Subjects, Including Centenarians' Relatives, Shows That A Down-Regulated Thyroid … A Cross-Sectional Study Of Compositional And Functional Profiles Of Gut Microbiota In Sardinian Centenarians A Demographic And Health Profile Of Centenarians In China A Functional Exo1 Promoter Variant Is Associated With Prolonged Life Expectancy In Centenarians A High Plasma Concentration Of Tnf-Α Is Associated With Dementia In Centenarians A Panel Of Multibiomarkers Of Inflammation, Fibrosis, And Catabolism Is Normal In Healthy Centenarians But Has High Values In Young Patients With Myocardial Infarction A Serum Protein Signature Of Apoe Genotypes In Centenarians A Shift To Th0 Cytokine Production By Cd4+ Cells In Human Longevity: Studies On Two Healthy Centenarians A Social And Clinical Evaluation Of Centenarians A Sociological Assessment Of Centenarians From Central Illinois Cemeteries, 1825–1985 A Study Of French Centenarians: Are Ace And Apoe Associated With Longevity? A Study Of The Living Environment And Activities Of Daily Living In Centenarians A Study On Chronic Diseases And Other Related Health Indicators Of Centenarians In Longevity Areas In China A Survey Of Centenarians In Shanghai City And Its Genetic Analysis A Survey Of Habitual Snoring In Centenarians A Survey Of The Dietary Nutritional Composition Of Centenarians. A Survey On Hearing Acuity Of Centenarians In Hainan Province Abstract P119: Prevalence And Coincidence Of Arterial Hypertension And Orthostatic Hypotension In Pre And Centenarians: Preliminary Results Of Moscow

Inflammation plays a crucial role in human health, acting as our body's defense system against injury and infection. Acute inflammation, a short-term response, is beneficial, but chronic, low-grade inflammation can be detrimental. Obesity is a major contributor to chronic inflammation. Fat tissue, particularly visceral fat around organs, releases inflammatory molecules that disrupt normal cellular function. This disrupts how our body regulates blood sugar, blood pressure, and cholesterol, all of which are risk factors for diseases like heart disease, diabetes, and some cancers [1, 2]. This link between obesity and inflammation is especially concerning for aging. Both processes are associated with a heightened inflammatory state, and research suggests they may reinforce each other. Chronic inflammation can accelerate age-related decline, while obesity itself increases the risk of developing age-related diseases. By understanding this connection, researchers are exploring ways to manage inflammation and potentially slow the aging process, with a focus on maintaining a healthy weight through diet and exercise [3]. A Berberis Microphylla Extract Prevents Obesity, Modulates Inflammation And Promotes Thermogenesis In Mice Fed On A High Fat Diet (P06-055-19) A Case Of Xanthogranulomatous Inflammation Of Terminal Ileum Presenting As A Mass In A Woman With Severe Obesity A Combination Of Omega-3 Pufas And Cox Inhibitors: A Novel Strategy To Manage Obesity-Linked Dyslipidemia And Adipose Tissue Inflammation A Dysregulated Acetyl/Sumo Switch Of Fxr Promotes Hepatic Inflammation In Obesity A Genetic Score Of Predisposition To Low-Grade Inflammation Associated With Obesity May Contribute To Discern Population At Risk For Metabolic Syndrome A High Ratio Of Dietary N-3/N-6 Polyunsaturated Fatty Acids Improves Obesity-Linked Inflammation And Insulin Resistance Through Suppressing Activation Of Tlr4 In Sd … A Macrophage Activation Marker Chitotriosidase In Women With Pcos: Does Low-Grade Chronic Inflammation In Pcos Relate To Pcos Itself Or Obesity? A Macrophage Nbr1-Mekk3 Complex Triggers Jnk-Mediated Adipose Tissue Inflammation In Obesity A Major Role Of Insulin In Promoting Obesity-Associated Adipose Tissue Inflammation A Mathematical Model Of The Immune System'S Role In Obesity-Related Chronic Inflammation A Novel Anti‐Inflammatory Role For Spleen‐Derived Interleukin‐10 In Obesity‐Induced Hypothalamic Inflammation A Novel Anti-Inflammatory Role For Spleen-Derived Interleukin-10 In Obesity-Induced Inflammation In White Adipose Tissue And Liver A Novel Isoquinoline Alkaloid, Attenuates Obesity-Associated Non-Alcoholic Fatty Liver Disease In Mice By Suppressing Lipogenesis, Inflammation And … A Novel Regulator Of Macrophage Activation: Mir-223 In Obesity-Associated Adipose Tissue Inflammation A Novel Resveratrol Analog Pa19 Attenuates Obesity‑Induced Cardiac And Renal Injury By Inhibiting Inflammation And Inflammatory Cell Infiltration A Platelet-Activating Factor (Paf) Receptor Deficiency Exacerbates Diet-Induced Obesity But Paf/Paf Receptor Signaling Does Not Contribute To The Development Of Obesity-Induced Chronic Inflammation A Polyphenol-Rich Cranberry Extract Protects From Diet-Induced Obesity, Insulin Resistance And Intestinal Inflammation In Association With Increased Akkermansia Spp … A Potential Role For Dendritic Cell/Macrophage-Expressing Dpp4 In Obesity-Induced Visceral Inflammation A Proposed Model Linking Inflammation To Obesity, Diabetes, And Periodontal Infections A Qtl On 12Q Influencing An Inflammation Marker And Obesity In White Women: The Nhlbi Family Heart Study A Role For 5-Lipoxygenase Products In Obesity-Associated Inflammation And Insulin Resistance A Role For Adipocyte-Derived Lipopolysaccharide-Binding Protein

  13C, 15N CP-MAS as well as FT-IR studies of gossypol derivatives with aromatic substituents in solid 13C, 15N CP-MAS, FT–IR and PM5 studies of some Schiff bases of gossypol in solid 13C, 15N NMR and CP-MAS as well as FT-IR and PM5 studies of Schiff base of gossypol with l-phenylalanine methyl ester in solution and solid 145 Inhibitory effects of gossypol on bovine in vitro embryo production 1H and 13C NMR Experiments and Chemical Shifts Calculations on gossypol: a Compound Extracted from Cottonseeds 1H AND 13C NMR Studies of Tetrabutylammonium Salts of gossypol in Chloroform Solution 1H‐ and 13C‐NMR, FTIR, UV‐VIS, ESI‐MS, and PM5 studies as well as emission properties of a new Schiff base of gossypol with 5‐methoxytryptamine and a new hydrazone of gossypol with dansylhydrazine 1H and13C NMR spectra of transformation products of gossypol in solutions 1H NMR studies of gossypol and its complexes with some organic compounds 1H NMR study on the solvent effect on imine-enamine tautomerism of the condensation product of gossypol with 4-aminoantipyrine 1H NMR, FT‐IR and MS studies and PM5 semiempirical calculations of complexes between the Schiff base of gossypol with 2‐(aminomethyl)‐15‐crown‐5 and Ca2+, Pb2+ … 1H, 13C and 15N NMR, FT-IR as well as PM5 studies of a new Schiff base of gossypol with 3, 6-dioxadecylamine in solution 1H, 13C NMR, FT-IR as well as PM5 semiempirical studies of new hydrazone of gossypol with 2, 2′-diethoxyethyl hydrazine 3‐amino‐1‐propanol as a complexing agent in the determination of total gossypol A beam of dawn light of study on gossypol as a safe, effective, and reversible male antifertility contraceptive--evaluation of the studies by using low dose gossypol combined with steroid hormone for male contraception A bioenergetic model of gossypol action: effects of gossypol on adult rat spermatogenic cells A circular dichroism study of (+) gossypol binding to proteins A combined regimen of gossypol plus methyltestosterone and ethinylestradiol as a contraceptive induces germ cell apoptosis and expression of its related genes in … A Comparative Study on Rapid and Slow Loading of gossypol in Treatment of Gynecological Diseases [J] A COMPARATIVE STUDY ON THE INHIBITORY EFFECT OF gossypol ON SPERM ATPASE IN DIFFERENT ANIMAL SPECIES [J] A comparison between the cytotoxicity induced by gossypol in two testicular cell lines A developmental toxicity evaluation of gossypol A gossypol biosynthetic intermediate disturbs plant defence response A HISTOLOGICAL STUDY OF THE EFFECT OF gossypol ON THE ANTERIOR LOBE OF PITUITARY OF CASTRATED HOGS. A histopathologic study of the effects of gossypol on the female rat A liposomal delivery vehicle for the anticancer agent gossypol A method for the preparation of labelled gossypol by the incorporation of 14C acetate A method for the preparation of labelled gossypol by the incorporation of sup 14 C acetate A Microbial Fermentation of Soybean and Cottonseed Meal Increases Antioxidant Activity and gossypol Detoxification in Diets for Nile tilapia, Oreochromis niloticus A mixture of cottonseed meal, soybean meal and animal byproduct mixture as a fish meal substitute: growth and tissue gossypol enantiomer in juvenile rainbow