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175 SCIENCE BASED INGREDIENTS
THE MOST COMPREHENSIVE ALL NATURAL ANTIVIRAL FORMULA EVER CREATED
Featuring: 1-Dehydrogingerdione – Zingiber Officinale (Ginger)• 3,2᾿Dihydroxyflavone (3,2᾿Dhf) & 3,4᾿Dihydroxyflavone (3,4᾿Dhf) – Trifolium Repens L. • 6-Gingerol – Zingiber Officinale (Ginger)• Acidicheteroglucan – Tremella Fuciformis • Aconitum Carmichaelii Debx • Ailanthus Altissima Stem Bark • Allantoin – Glyoxylic Acid • Alphitonia Philippinensis Stems • Amygdalin – Semen Armeniacae Amarum • Anemarrhena Asphodeloides • Angelica Sinensis (Oliv.) Diels • Apigenin – Celery • Arctigerin, Arctin – Burdock (Arctium Lappa) • Artemisinin – Artemisia Annua • Aspalathin – Rooibos Tea • Atractylodin ,Β-Eudesmol, Hinesol, Hydroxy-Atractylo – Rhizoma Areactylodis Lanceae • Baicalein – Scutellaria Baicalensis Georgi • Benzaldehyde – Laurus Nobilis Leaves • Berberine – Coptis Chinensis • Beta-Sitosterol – Rice Bran Oil • Betulinic Acid – Betula Platyphylla Suk Bark • Bisdemethoxycurcumin – Turmeric Rhizome • Brachyamide B – Piper Boehmeriaefolium (Miq.) C. Dc • Bulbocapnine – Corydalis Decumbens(Thunb.) • Caffeic Acid – Cimicifuga Simplex (Dc.) Wormsk. Ex Turcz.Root • Calanolide A – Calophyllum Lanigerum • Campesterol – Rapeseed Oil • Carvacrol – Oregano • Chavicine – Black Pepper • Chelidimerine – Chelidonium Majus • Chlorogenic Acid – Green Coffee Bean • Chrysin – Pinus Mon-Ticola Dougl • Cinanserin – Cinnamic Acid • Cinnamomum Cassia Presl Dried Bark • Cirsilineol – Cirsium Lineare (Thunb.) Sch. • Cirsimaritin – Rabdosia Eriocalyx • Cis-Capsaicin (Civamide) – • Colchicine – Colchicum Autumnale L. • Cordifolioside A – Viola Verecunda • Crategolic Acid – Hawthorn • Curcumin – Turmeric Root • Cycloastragenol – Astragalus Membranaceus • Cyclocurcumin – Turmeric Root • Demethoxycurcumin – Turmeric Root • Dianthus Caryophyllus Seed – Carnation • Dioscin, Diosgenin – Wild Yam （Dioscorea Oppositae Thunb）• Douchi (Semen Sojae Praepatum) – Semen Sojae Praepatum • Egcg – Green Tea • Emodin – Rhubarb • Eriodictyol – Lemon • Eugenitin – Clove • Ferruginol – Podocarpus Ferruginea • Fisetin – Rhus Succedanea L • Flavonol Glucoside – Trichilia Connaroides Leaves • Forskolin – Coleus Forskohlii • Fructus Perillae – Perillafrutescens • Fumarophycine – Laptopyrum Reichb • Galangin – Alpinia Officinarum Hance Root • Gallic Acid – Rheumpalmatum L.Root • Genistein – Genista Tinctoria Linn Root • Glycyrrhizic Acid – Licorice Root • Gossypol – Cotton Seed • Guineensine – Piper Longum L. • Gypsum Fibrosum – Gypsum • Hawthorn Flavone – Crataegus Pinnatifida Bunge • Herba Dendrobii – Dendrobium Nobile Lindl • Herbacetin – Flaxseed • Hesperetin – Citrus Aurantium • –Hesperidin Nobiletin B-Phellandrene – Pericarpium Citri Reticulatae • Himachalol – Cupressus Funebris Endl. • Honokiol – Magnolia Officinalis • Houttuynia Cordata – Houttuynia Cordata Thunb • Hypericin Pseudohypericin Protohypericin – Forsythia Suspensa • Isochavicine – Pepper • Isoliquiritigenin – Glycyrrhiza Uralensisfisch Root • Isopiperine – Pepper • Isothymonin – Kaempferia Galanga L • Jatrorrhizine – Phellodendron Amurense Rupr. • Jujuboside A+B – Jujube • Kaempferol – Kaempferol Galanga L • Kaempferol 3-O-Robinobioside – Robinia Pseudoacacia L. • Leachianone – Morus Alba Root Bark • Lepidium Meyenii (Maca ) • Lily – Lilium Auratum • Luteoforol (A Flavan-4-Ol) – Peanut Shell • Luteolin – Peanut Shell • Lycoris Radiata – Lycoris Radiata (L’her.) Herb. • Macaranga Barteri Leaves • Maclura Cochinchinensis (Loureiro) Corner Root • Magnoflorine – Thalictrum Aquilegifolium Root • Marrubium Peregrinum L (Lamiaceae) • Meliacine – Melia Azedarach L • Mint – Mentha Haplocalyx Briq.• Morroniside,7-0-Methylmorroniside, Sweroside, Loganin, Cornus-Tannin 1,2,3 – Cornus Officinalis (Fructus Corni) • Morroniside,Cornus-Tannin 1,2,3 – Fructus Corni • Myricetin – Black Bayberry Fruit • Naringenin – Amacardi-Um Occidentale L.) • Ndoxyl-Β-Glucoside Uridine, Salicylic Acid,Daucosterol, Β-Sitostero – Radix Isatidis P.E (Satis Tinctoria L. Isatis Indigotica Fort.) • Nothofagin – Aspalathus Linearis • Oleanolic Acid – Olea Europaea L.Leaves • Olomoucine Ii – • Ophiocarpine – Corydalis Ophiocarpa Hook. F. Et Thoms • Ophiopogonin A B C D – Ophiopogon Root • Orientin – Globeflower • Oxypeucedanin Stiamasterol Β-Sitosterol Β-Daucosterin – Angelica Dahurica • Paeoniflorin – Radix Paeoniae Rubra • Patrinia Villosa Juss. – Patrinia Villosa (Thunb. ) Juss. • Peach Kernel – Emen Persicae • Pectolinarin – Linaria Vulgaris Hill Subsp. • Pelargonium Sidoides – Pelargonium Peltatum (L.) Ait. • Pentadienoylpiperidine – Pepper • Phragmitescommunis Trin – Phragmites Australis (Cav.) Trin. Ex Steud • Phyllanthus Orbicularis – Phyllanthus Orbicularis Kunth • Pinusolidic Acid – Vanillin & Malonic Acid • Piperettine – Pepper • Pipericide – Pepper • Piperine – Pepper • Piperolein B – Pepper • Poria Cocos Polysaccharide – Poria Cocos(Schw.)Wolf. • Protocatechuic Acid – Stenoloma Chusanum(L.) Ching Leaves • Protopine – Corydalis Yanhusuo W.T.Wang • Quercetin – Sophora Japonica • Quercetin-3-B-Galactoside – St. John’s Wort • Quercetin-3,7-O-Α-L-Dirhamnoside （Quercitrin） – Sabina Pingii Var. Wilsonii • Quinic Acid – Cinchona Bark • Radix Codonopsis Root • Radix Glehniae – Coasiai Giehnia Root • Radix Platycodonis Platycodigenin, Polygalacic Acid – Platycodon Grandiflorum Root • Radix Scrophulariae Root • Reserpine – Rauvolfia Verticillata (Lour.) Baill. • Resveratrol – Polygonum Cuspidatum • Retrofractamide A – Black Pepper • Rhamnetin – Syzygium Aromaticum • Rhizoma Atractylodis Macrocephalae Root • Rhizoma Pinelliae – Pinellia Ternata (Thunb.) Breit • Rhoifolin – Turpinia Arguya Seem Leaves • Rosmarinic Acid – Rosemary • Rupestonic Acid – Artemisia Rupestris L. • Rutin – Ruta Graveolens L. • Saikosapoins A B C D – Bupleurum (Radix Stellariae) • Salicin – Salix Babylonical Bark • Salidroside, Rosavine, Rosin，Rosarin，Rhodiolin – Rhodiola Rosea • Samarangenin B – Limonium Bicolor (Bag.) Kuntze • Saposhnikovia Divaricata (Trucz.) Schischk Root • Savinin • Schisandrin, Deoxyschisandrin, Neoschisandrin – Schisandra Chinensis • Schizonepeta Tenusfolia Briq Dried Flower • Selaginella Moellendorfii Hieron • Semen Lepidii Semen Descurainiae – Eruca Sativa Mill • Silibinin – Milk Thistle • Silymarin – Milk Thistle • Solanum Rantonnetii Aerial Parts Extact – Lycianthes Rantonnetii Bitter • Somniferine – Ashwagandha/Ajagandha/Kanaje • Stigmasterol – Soybean • Synephrine – Citrus Aurantium Powde • Taxillus Sutchuenensis – Taxillus Sutchuenensis (Lecomte ) Danser • Tinocordifolin – Tinospora Cordifolia • Tinocordifolioside – Tinospora Cordifolia • Tinosporide – Tinospora Cordifolia • Trichostachine – Piper Hancei Maxim • Triterpenoid Saponins – Trichosanthes Kirilowii (Mongolian Snakegourd Fruit) • Umbelliferone – Ruta Graveolens L. • Ursolic Acid – Loquat Leaf • Valinomycin – Bacterium Streptomyces • Verbascum Thapsus L – Mullein • Vicenin – Desmodium Styracifolium • Vincamine – Catharanthus Roseus （L.）G. Don • Vitex Polygama – Vitex Negundo L. Var. Cannabifolia (Sieb. Et Zucc.) Hand.-Mazz • Withaferin A – Ashwagandha • Withanolide – Ashwagandha • Withanolide B – Ashwagandha • Withanone – Ashwaganda • Wogonin – Scutellaria Baicalensis （Radix Scutellariae） • Wrinkled Gianthyssop Herb – Agastache Rugosa (Fisch. Et Mey.) O. Ktze. • Yohimbine – Yohimbe Bark
300 1/8 tsp servings per 100g bag.
Take 1/8 -1/4 serving 2-4 times a day.
Overall, this evidence suggests that polyphenols may exert a marked and well-demonstrated activity against coronaviruses, at least in vitro, in addition to the previously demonstrated antiviral activity in vivo. Studies available in the literature agree in establishing that the reduction of virus titer and the inhibition of nucleocapsid protein expression are their main general mechanisms of action at the base of this promising effect of polyphenols. These elucidated mechanisms are of great interest, since nowadays no effective treatments have been licensed, and the development of novel synthetic drugs against specific coronavirus molecular targets are still far from being achieved.
(3,2᾿DHF) & 3,4᾿dihydroxyflavone (3,4᾿DHF)
(Trifolium repens L.)
Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2᾿dihydroxyflavone (3,2᾿DHF) and 3,4᾿dihydroxyflavone (3,4᾿DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4᾿DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4᾿DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.
(Tremella fuciformis extract)
Aconitum carmichaelii Debx extract
(Aconitum carmichaelii Debx)
Four diterpenoid alkaloids, namely, (a) hypaconitine, (b) songorine, (c) mesaconitine and (d) aconitine, were isolated from the ethanol root extract of Aconitum carmichaelii Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were evaluated. Antiviral activity test in vivo showed that compounds a and c, which were C19-diterpenoid alkaloids, showed inactivation efficacy values of 82.4 and 85.6% against TMV at 500 μg/mL, respectively. By contrast, compound c presented inactivation activity of 52.1% against CMV at 500 μg/mL, which was almost equal to that of the commercial Ningnanmycin (87.1% inactivation activity against TMV and 53.8% inactivation activity against CMV). C19-Diterpenoid alkaloids displayed moderate to high antiviral activity against TMV and CMV at 500 μg/mL, dosage plays an important role in antiviral activities. This paper is the first report on the evolution of aconite diterpenoid alkaloids for antiviral activity against CMV.
Ailanthus altissima stem bark extract
(Ailanthus altissima (Mill.) Swingle)
In order to search for the anti-HIV agents from natural products, eighty MeOH extracts of medicinal plants were applied to a syncytia formation inhibition assay which is based on the interaction between the HIV-1 envelope glycoprotein gp120/gp41 and the cellular membrane protein CD4 of T lymphocytes. Among them, Ailanthus altissima showed a potent virus-cell fusion inhibitory activity.
Alphitonia philippinensis stems
(Alphitonia philippinensis Braid)
Three new flavonol glycosides, namely, isorhamnetin 3-O-(6″-O-(Z)-p-coumaroyl)-β-d-glucopyranoside, quercetin 3-O-α-l-rhamnopyranosyl(1-2)-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, and quercetin 3-O-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, were isolated from the stems of Alphitonia philippinensis collected from Hainan Island, China. Some of the isolated triterpenoids and flavonoid glycosides showed cytotoxicity against human PC-3 cells and hepatoma HA22T cells, and the inhibition of replication on HSV-1 (131). Viral diseases, especially of skin, can be treated with a virucide encapsulated in multilamellar phospholipid liposomes. Rosmarinic acid (70), incorporated in phospholipid mixture demonstrated effectiveness in humans afflicted with HSV (132). Flavonol glycosides (from quercetin and isorhamnetin) derived from the stems of Alphitonia philippinensis have been reported to inhibit the replication of HSV-1.
(Semen Armeniacae Amarum Extract)
Amygdalin could Inhibit IFN-γ, NF-κB and NLRP3 signaling pathways so as to reduce the inflammatory response (Paoletti et al., 2013; Zhang et al., 2017). These reports provided the scientific ground of integrating TCM therapy from the aspects of their compositions’ potential targeting proteins and signaling pathways in the treatment of COVID-19.
Anemarrhena asphodeloides extract
(Anemarrhena asphodeloides Bunge)
Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.
Increased oxidative stress and disturbed glutathione redox system play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. Depletion in intracellular levels of reduced glutathione (GSH) contributes to an increment in tumor necrosis factor α (TNF-α)-stimulated-HIV-1-transcription, activation of HIV-1-replication, sensitivity to TNF-α-induced cell death, and impairment of CD4+ cell function and survival. Therefore, several studies have investigated the effect of GSH-enhancer agents such as N-acetyl cystein in the treatment of patients with HIV infection. With regard to the beneficial effects of Angelica sinensis, a Chinese medicinal herb, on GSH redox system and the pathogenic role of GSH depletion in HIV infection and the immunomodulator effects of active ingredients of this herb, we postulated that Angelica sinensis may be of value in the treatment of HIV-infected patients.
Apigenin has shown potent antiviral activity against hepatitis B virus, adenoviruses, african swine fever virus and some RNA viruses in vitro.
(Burdock extract (Arctium Lappa))
Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir. Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.
(Artemisia annua extract)
The applications of traditional Chinese medicine (TCM) have been playing an important role in treating the epidemics of Coronavirus Disease 2019 (COVID-19), which is now prevalent all over the world. Exploring the mechanisms of TCM compound prescriptions might be difficult though, pharmacological studies on elucidating the effective components of TCM could serve as the experimental basis in the application of TCM compound prescription in treating COVID-19. As the critical active ingredients of Qinghao (Artemisia annua), artemisinin was initially used as antimalaria drug. Artemisia annua prescriptions take significant effect against pneumonia. Sharing similarities in pharmacology with artemisinin, chloroquine has been confirmed effective in inhibiting Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) both in vitro and practically. In this context, we discussed the application of Artemisia annua prescriptions against COVID-19 along with the antiviral effect of chloroquine.
With similar pharmacological effects between chloroquine and artemisinin in treating infectious diseases, this paper discusses the modern scientific basis for the application of Artemisia annua prescriptions in COVID-19. Except for antimalarial, most of the other pharmacological studies on artemisinin and its derivatives are still on the bench or at animal level, with only a few in clinical trials. Artemisinin treatment on COVID-19 has not been reported yet. As a treasure of TCM, compound prescription has played an important role in plagues in history. The main cause of COVID-19 in Wuhan is damp-heat according to TCM theory. The prescription for clearing heat and eliminating dampness based on Artemisia annua is widely used in this epidemic. Based on the antiviral and anti-inflammatory effects of artemisinin and its derivatives, Artemisia annua prescriptions have great value to dig into and are promising to be used in more infectious diseases. But more in vitro experiments need to be carried out to provide more evidence, such as the influence of Artemisia or Artemisia annua prescriptions on inflammatory factors express