HYPNOTIC : Ultimate Sleep Formula 200:1 – NEW!
May 20, 2020
AUTONOMOUS / NOOTROPIC TOUR DE FORCE 200:1 – New!
September 18, 2020
VICTORIOUS : Science Based Anti Viral Formula 200:1 —NEW!
$175.00 – $750.00
MANDATORY FDA DISCLAIMER
ATTENTION: ZERO CLAIMS ARE MADE HERE OR ANYWHERE ON WEBSITE TO CURE ANYONE OF ANYTHING; INSTEAD WE SIMPLY PRESENT THE SCIENTIFIC STUDIES AND ALLOW THE READER TO READ, CRITICALLY THINK AND REACH THEIR OWN CONCLUSIONS. WE DO NOT ENCOURAGE ANYONE TO NOT LISTEN TO THEIR DOCTOR OR TO STOP TAKING THEIR PRESCRIBED MEDICATIONS.
PLEASE READ AND UNDERSTAND TERMS AND CONDITIONS BEFORE PURCHASING.
175 SCIENCE BASED INGREDIENTS
THE MOST COMPREHENSIVE ALL NATURAL ANTIVIRAL FORMULA EVER CREATED
Featuring: 1-Dehydrogingerdione – Zingiber Officinale (Ginger)• 3,2᾿Dihydroxyflavone (3,2᾿Dhf) & 3,4᾿Dihydroxyflavone (3,4᾿Dhf) – Trifolium Repens L. • 6-Gingerol – Zingiber Officinale (Ginger)• Acidicheteroglucan – Tremella Fuciformis • Aconitum Carmichaelii Debx • Ailanthus Altissima Stem Bark • Allantoin – Glyoxylic Acid • Alphitonia Philippinensis Stems • Amygdalin – Semen Armeniacae Amarum • Anemarrhena Asphodeloides • Angelica Sinensis (Oliv.) Diels • Apigenin – Celery • Arctigerin, Arctin – Burdock (Arctium Lappa) • Artemisinin – Artemisia Annua • Aspalathin – Rooibos Tea • Atractylodin ,Β-Eudesmol, Hinesol, Hydroxy-Atractylo – Rhizoma Areactylodis Lanceae • Baicalein – Scutellaria Baicalensis Georgi • Benzaldehyde – Laurus Nobilis Leaves • Berberine – Coptis Chinensis • Beta-Sitosterol – Rice Bran Oil • Betulinic Acid – Betula Platyphylla Suk Bark • Bisdemethoxycurcumin – Turmeric Rhizome • Brachyamide B – Piper Boehmeriaefolium (Miq.) C. Dc • Bulbocapnine – Corydalis Decumbens(Thunb.) • Caffeic Acid – Cimicifuga Simplex (Dc.) Wormsk. Ex Turcz.Root • Calanolide A – Calophyllum Lanigerum • Campesterol – Rapeseed Oil • Carvacrol – Oregano • Chavicine – Black Pepper • Chelidimerine – Chelidonium Majus • Chlorogenic Acid – Green Coffee Bean • Chrysin – Pinus Mon-Ticola Dougl • Cinanserin – Cinnamic Acid • Cinnamomum Cassia Presl Dried Bark • Cirsilineol – Cirsium Lineare (Thunb.) Sch. • Cirsimaritin – Rabdosia Eriocalyx • Cis-Capsaicin (Civamide) – • Colchicine – Colchicum Autumnale L. • Cordifolioside A – Viola Verecunda • Crategolic Acid – Hawthorn • Curcumin – Turmeric Root • Cycloastragenol – Astragalus Membranaceus • Cyclocurcumin – Turmeric Root • Demethoxycurcumin – Turmeric Root • Dianthus Caryophyllus Seed – Carnation • Dioscin, Diosgenin – Wild Yam （Dioscorea Oppositae Thunb）• Douchi (Semen Sojae Praepatum) – Semen Sojae Praepatum • Egcg – Green Tea • Emodin – Rhubarb • Eriodictyol – Lemon • Eugenitin – Clove • Ferruginol – Podocarpus Ferruginea • Fisetin – Rhus Succedanea L • Flavonol Glucoside – Trichilia Connaroides Leaves • Forskolin – Coleus Forskohlii • Fructus Perillae – Perillafrutescens • Fumarophycine – Laptopyrum Reichb • Galangin – Alpinia Officinarum Hance Root • Gallic Acid – Rheumpalmatum L.Root • Genistein – Genista Tinctoria Linn Root • Glycyrrhizic Acid – Licorice Root • Gossypol – Cotton Seed • Guineensine – Piper Longum L. • Gypsum Fibrosum – Gypsum • Hawthorn Flavone – Crataegus Pinnatifida Bunge • Herba Dendrobii – Dendrobium Nobile Lindl • Herbacetin – Flaxseed • Hesperetin – Citrus Aurantium • –Hesperidin Nobiletin B-Phellandrene – Pericarpium Citri Reticulatae • Himachalol – Cupressus Funebris Endl. • Honokiol – Magnolia Officinalis • Houttuynia Cordata – Houttuynia Cordata Thunb • Hypericin Pseudohypericin Protohypericin – Forsythia Suspensa • Isochavicine – Pepper • Isoliquiritigenin – Glycyrrhiza Uralensisfisch Root • Isopiperine – Pepper • Isothymonin – Kaempferia Galanga L • Jatrorrhizine – Phellodendron Amurense Rupr. • Jujuboside A+B – Jujube • Kaempferol – Kaempferol Galanga L • Kaempferol 3-O-Robinobioside – Robinia Pseudoacacia L. • Leachianone – Morus Alba Root Bark • Lepidium Meyenii (Maca ) • Lily – Lilium Auratum • Luteoforol (A Flavan-4-Ol) – Peanut Shell • Luteolin – Peanut Shell • Lycoris Radiata – Lycoris Radiata (L’her.) Herb. • Macaranga Barteri Leaves • Maclura Cochinchinensis (Loureiro) Corner Root • Magnoflorine – Thalictrum Aquilegifolium Root • Marrubium Peregrinum L (Lamiaceae) • Meliacine – Melia Azedarach L • Mint – Mentha Haplocalyx Briq.• Morroniside,7-0-Methylmorroniside, Sweroside, Loganin, Cornus-Tannin 1,2,3 – Cornus Officinalis (Fructus Corni) • Morroniside,Cornus-Tannin 1,2,3 – Fructus Corni • Myricetin – Black Bayberry Fruit • Naringenin – Amacardi-Um Occidentale L.) • Ndoxyl-Β-Glucoside Uridine, Salicylic Acid,Daucosterol, Β-Sitostero – Radix Isatidis P.E (Satis Tinctoria L. Isatis Indigotica Fort.) • Nothofagin – Aspalathus Linearis • Oleanolic Acid – Olea Europaea L.Leaves • Olomoucine Ii – • Ophiocarpine – Corydalis Ophiocarpa Hook. F. Et Thoms • Ophiopogonin A B C D – Ophiopogon Root • Orientin – Globeflower • Oxypeucedanin Stiamasterol Β-Sitosterol Β-Daucosterin – Angelica Dahurica • Paeoniflorin – Radix Paeoniae Rubra • Patrinia Villosa Juss. – Patrinia Villosa (Thunb. ) Juss. • Peach Kernel – Emen Persicae • Pectolinarin – Linaria Vulgaris Hill Subsp. • Pelargonium Sidoides – Pelargonium Peltatum (L.) Ait. • Pentadienoylpiperidine – Pepper • Phragmitescommunis Trin – Phragmites Australis (Cav.) Trin. Ex Steud • Phyllanthus Orbicularis – Phyllanthus Orbicularis Kunth • Pinusolidic Acid – Vanillin & Malonic Acid • Piperettine – Pepper • Pipericide – Pepper • Piperine – Pepper • Piperolein B – Pepper • Poria Cocos Polysaccharide – Poria Cocos(Schw.)Wolf. • Protocatechuic Acid – Stenoloma Chusanum(L.) Ching Leaves • Protopine – Corydalis Yanhusuo W.T.Wang • Quercetin – Sophora Japonica • Quercetin-3-B-Galactoside – St. John’s Wort • Quercetin-3,7-O-Α-L-Dirhamnoside （Quercitrin） – Sabina Pingii Var. Wilsonii • Quinic Acid – Cinchona Bark • Radix Codonopsis Root • Radix Glehniae – Coasiai Giehnia Root • Radix Platycodonis Platycodigenin, Polygalacic Acid – Platycodon Grandiflorum Root • Radix Scrophulariae Root • Reserpine – Rauvolfia Verticillata (Lour.) Baill. • Resveratrol – Polygonum Cuspidatum • Retrofractamide A – Black Pepper • Rhamnetin – Syzygium Aromaticum • Rhizoma Atractylodis Macrocephalae Root • Rhizoma Pinelliae – Pinellia Ternata (Thunb.) Breit • Rhoifolin – Turpinia Arguya Seem Leaves • Rosmarinic Acid – Rosemary • Rupestonic Acid – Artemisia Rupestris L. • Rutin – Ruta Graveolens L. • Saikosapoins A B C D – Bupleurum (Radix Stellariae) • Salicin – Salix Babylonical Bark • Salidroside, Rosavine, Rosin，Rosarin，Rhodiolin – Rhodiola Rosea • Samarangenin B – Limonium Bicolor (Bag.) Kuntze • Saposhnikovia Divaricata (Trucz.) Schischk Root • Savinin • Schisandrin, Deoxyschisandrin, Neoschisandrin – Schisandra Chinensis • Schizonepeta Tenusfolia Briq Dried Flower • Selaginella Moellendorfii Hieron • Semen Lepidii Semen Descurainiae – Eruca Sativa Mill • Silibinin – Milk Thistle • Silymarin – Milk Thistle • Solanum Rantonnetii Aerial Parts Extact – Lycianthes Rantonnetii Bitter • Somniferine – Ashwagandha/Ajagandha/Kanaje • Stigmasterol – Soybean • Synephrine – Citrus Aurantium Powde • Taxillus Sutchuenensis – Taxillus Sutchuenensis (Lecomte ) Danser • Tinocordifolin – Tinospora Cordifolia • Tinocordifolioside – Tinospora Cordifolia • Tinosporide – Tinospora Cordifolia • Trichostachine – Piper Hancei Maxim • Triterpenoid Saponins – Trichosanthes Kirilowii (Mongolian Snakegourd Fruit) • Umbelliferone – Ruta Graveolens L. • Ursolic Acid – Loquat Leaf • Valinomycin – Bacterium Streptomyces • Verbascum Thapsus L – Mullein • Vicenin – Desmodium Styracifolium • Vincamine – Catharanthus Roseus （L.）G. Don • Vitex Polygama – Vitex Negundo L. Var. Cannabifolia (Sieb. Et Zucc.) Hand.-Mazz • Withaferin A – Ashwagandha • Withanolide – Ashwagandha • Withanolide B – Ashwagandha • Withanone – Ashwaganda • Wogonin – Scutellaria Baicalensis （Radix Scutellariae） • Wrinkled Gianthyssop Herb – Agastache Rugosa (Fisch. Et Mey.) O. Ktze. • Yohimbine – Yohimbe Bark
200:1 CONCENTRATION
VERY POTENT
300 1/8 tsp servings per 100g bag.
Take 1/8 -1/4 serving 2-4 times a day.
SHIPPING NOW!
ANTIVIRAL EFFECTS OF FLAVONOIDS AND POLYPHENOLS (THOUSANDS OF STUDIES – CLICK TO READ)
May Polyphenols Have a Role Against Coronavirus Infection? An Overview of the Evidence
Overall, this evidence suggests that polyphenols may exert a marked and well-demonstrated activity against coronaviruses, at least in vitro, in addition to the previously demonstrated antiviral activity in vivo. Studies available in the literature agree in establishing that the reduction of virus titer and the inhibition of nucleocapsid protein expression are their main general mechanisms of action at the base of this promising effect of polyphenols. These elucidated mechanisms are of great interest, since nowadays no effective treatments have been licensed, and the development of novel synthetic drugs against specific coronavirus molecular targets are still far from being achieved.
Antiviral effect of flavonoids on human viruses
The effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV-1), polio-virus type 1, parainfluenza virus type 3 (Pf-3), and respiratory syncytial virus (RSV) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction. Quercetin caused a concentration-dependent reduction in the infectivity of each virus. In addition, it reduced intracellular replication of each virus when monolayers were infected and subsequently cultured in medium containing quercetin. Preincubation of tissue culture cell monolayers with quercetin did not affect the ability of the viruses to infect or replicate in the tissue culture monolayers. Hesperetin had no effect on infectivity but it reduced intracellular replication of each of the viruses. Catechin inhibited the infectivity but not the replication of RSV and HSV-1 and had negligible effects on the other viruses. Naringin had no effect on either the infectivity or the replication of any of the viruses studied. Thus, naturally occurring flavonoids possess a variable spectrum of antiviral activity against certain RNA (RSV, Pf-3, polio) and DNA (HSV-1) viruses acting to inhibit infectivity and/or replication.
Discovery of anti-2019-nCoV agents toward respiratory diseases via docking screening
The 2019 novel coronavirus (2019-nCoV) causes novel coronavirus pneumonia (NCP). Given that approved drug repurposing becomes a common strategy to quickly find antiviral treatments, a collection of FDA-approved drugs can be powerful resources for new anti-NCP indication discoveries. In addition to synthetic compounds, Chinese Patent Drugs (CPD), also play a key role in the treatment of virus related infections diseases in China. Here we compiled major components from 38 CPDs that are commonly used in the respiratory diseases and docked them against two drug targets, ACE2 receptor and viral main protease. According to our docking screening, 10 antiviral components, including hesperidin, saikosaponin A, rutin, corosolic acid, verbascoside, baicalin, glycyrrhizin, mulberroside A, cynaroside, and bilirubin, can directly bind to both host cell target ACE2 receptor and viral target main protease. In combination of the docking results, the natural abundance of the substances, and botanical knowledge, we proposed that artemisinin, rutin, glycyrrhizin, cholic acid, hyodeoxycholic acid, puerarin, oleanic acid, andrographolide, matrine, codeine, morphine, chlorogenic acid, and baicalin (or Yinhuang Injection containing chlorogenic acid and baicalin) might be of value for clinical trials during a 2019-nCov outbreak.
A recent outbreak of the novel coronavirus, COVID‐19, in the city of Wuhan, Hubei province, China and its ensuing worldwide spread have resulted in lakhs of infections and thousands of deaths. As of now, there are no registered therapies for treating the contagious COVID‐19 infections, henceforth drug repositioning may provide a fast way out. In the present study, a total of thirty-five compounds including commonly used anti-viral drugs were screened against chymotrypsin-like protease (3CLpro) using SwissDock. Interaction between amino acid of targeted protein and ligands was visualized by UCSF Chimera. Docking studies revealed that the phytochemicals such as cordifolin, anisofolin A, apigenin 7-glucoside, luteolin, laballenic acid, quercetin, luteolin-4-glucoside exhibited significant binding energy with the enzyme viz. – 8.77, -8.72, -8.36, -8.35, -8.13, -8.04 and -7.87 Kcal/Mol respectively. Therefore, new lead compounds can be used for drug development against SARS‐CoV‐2 infections.
COVID-19, a rapidly spreading new strain of coronavirus, has affected more than 150 countries and received worldwide attention. The lack of efficacious drugs or vaccines against SARS-CoV-2 has further worsened the situation. Thus, there is an urgent need to boost up research for the development of effective therapeutics and affordable diagnostic against COVID-19. The crystallized form of SARS-CoV-2 main protease (Mpro) was demonstrated by a Chinese researcher Liu et al. (2020) which is a novel therapeutic drug target. This study was conducted to evaluate the efficacy of medicinal plant-based bioactive compounds against COVID-19 Mpro by molecular docking study. Molecular docking investigations were performed by using Molegro Virtual Docker 7 to analyze the inhibition probability of these compounds against COVID-19. COVID-19 Mpro was docked with 80 flavonoid compounds and the binding energies were obtained from the docking of (PDB ID: 6LU7: Resolution 2.16 Å) with the native ligand. According to obtained results, hesperidin, rutin, diosmin, apiin, diacetylcurcumin, (E)-1-(2-Hydroxy-4-methoxyphenyl)-3-[3-[(E)-3-(2-hydroxy-4- methoxyphenyl)-3-oxoprop-1-enyl]phenyl]prop-2-en-1-one, and beta,beta’-(4-Methoxy-1,3- phenylene)bis(2′-hydroxy-4′,6′-dimethoxyacrylophenone have been found as more effective on COVID-19 than nelfinavir. So, this study will pave a way for doing advanced experimental research to evaluate the real medicinal potential of these compounds to cure COVID-19.
Potential of Flavonoid-Inspired Phytomedicines against COVID-19
Flavonoids are widely used as phytomedicines. Here, we report on flavonoid phytomedicines with potential for development into prophylactics or therapeutics against coronavirus disease 2019 (COVID-19). These flavonoid-based phytomedicines include: caflanone, Equivir, hesperetin, myricetin, and Linebacker. Our in silico studies show that these flavonoid-based molecules can bind with high affinity to the spike protein, helicase, and protease sites on the ACE2 receptor used by the severe acute respiratory syndrome coronavirus 2 to infect cells and cause COVID-19. Meanwhile, in vitro studies show potential of caflanone to inhibit virus entry factors including, ABL-2, cathepsin L, cytokines (IL-1β, IL-6, IL-8, Mip-1α, TNF-α), and PI4Kiiiβ as well as AXL-2, which facilitates mother-to-fetus transmission of coronavirus.
Since most of the drug candidates presently available for COVID-19 substantially act on viral main protease, by using molecular docking analysis, we have predicted the protease inhibitor activity of several natural products that can emerge as potential drug candidates inhibiting viral protease. A promising binding of natural products with the COVID-19 main protease was revealed by docking analysis. Among the several natural products screened by docking analysis, glycyrrhizin, tryptanthrine, rhein, and berberine were found to exhibit a higher degree of interaction with the viral protease accompanied by lowest binding energy with favorable drug-like properties. Thus these natural products may emerge as potential COVID-19 main protease inhibitor. However, additional exploration is inevitable for the investigation of the inherent use of the herbs containing these natural products and their in-vivo activity.
Targeting SARS-CoV-2 Spike Protein of COVID-19 with Naturally Occurring Phytochemicals
Spike glycoprotein found on the surface of SARS-CoV-2 (SARS-CoV-2S) is a class I fusion protein which helps the virus in its initial attachment with human Angiotensin converting enzyme 2 (ACE2) receptor and its consecutive fusion with the host cells. The attachment is mediated by the S1 subunit of the protein via its receptor binding domain. Upon binding with the receptor the protein changes its conformation from a pre-fusion to a post-fusion form. The membrane fusion and internalization of the virus is brought about by the S2 domain of the spike protein. From ancient times people have relied on naturally occurring substances like phytochemicals to fight against diseases and infection. Among these phytochemicals, flavonoids and non-flavonoids have been found to be the active source of different anti-microbial agents. Recently, studies have shown that these phytochemicals have essential anti-viral activities. We performed a molecular docking study using 10 potential naturally occurring flavonoids/non-flavonoids against the SARS-CoV-2 spike protein and compared their affinity with the FDA approved drug hydroxychloroquine (HCQ). Interestingly, the docking analysis suggested that C-terminal of S1 domain and S2 domain of the spike protein are important for binding with these compounds. Kamferol, curcumin, pterostilbene, and HCQ interact with the C-terminal of S1 domain with binding energies of -7.4, -7.1, -6.7 and -5.6 Kcal/mol, respectively. Fisetin, quercetin, isorhamnetin, genistein, luteolin, resveratrol and apigenin on the other hand, interact with the S2 domain of spike protein with the binding energies of -8.5, -8.5, -8.3, -8.2, -8.2, -7.9, -7.7 Kcal/mol, respectively. Our study suggested that, these flavonoid and non-flavonoid moieties have significantly high binding affinity for the two main important domains of the spike protein which is responsible for the attachment and internalization of the virus in the host cell and their binding affinities are much higher compared to that of HCQ. In addition, ADME (absorption, distribution, metabolism and excretion) analysis also suggested that these compounds consist of drug likeness property which may help for further explore as anti-SARS-CoV-2 agents. Further, in vitro and in vivo study of these compounds will provide a clear path for the development of novel compounds that would most likely prevent the receptor binding or internalization of the SARS-CoV-2 spike protein and therefore could be used as drugs for COVID-19 therapy.
Roles of flavonoids against coronavirus infection
In terms of public health, the 21st century has been characterized by coronavirus pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged and in 2019 a new human betacoronavirus strain, called SARS-CoV-2, caused the unprecedented COVID-19 outbreak. During the course of the current epidemic, medical challenges to save lives and scientific research aimed to reveal the genetic evolution and the biochemistry of the vital cycle of the new pathogen could lead to new preventive and therapeutic strategies against SARS-CoV-2. Up to now, there is no cure for COVID-19 and waiting for an efficacious vaccine, the development of “savage” protocols, based on “old” anti-inflammatory and anti-viral drugs represents a valid and alternative therapeutic approach. As an alternative or additional therapeutic/preventive option, different in silico and in vitro studies demonstrated that small natural molecules, belonging to polyphenols family, can interfere with various stages of coronavirus entry and replication cycle. Here, we reviewed the capacity of well-known (e.g. quercetin, baicalin, luteolin, hesperetin, gallocatechin gallate, epigallocatechin gallate) and uncommon (e.g. scutellarein, amentoflavone, papyriflavonol A) flavonoids, secondary metabolites widely present in plant tissues with antioxidant and anti-microbial functions, to inhibit key proteins involved in coronavirus infective cycle, such as PLpro, 3CLpro, NTPase/helicase. Due to their pleiotropic activities and lack of systemic toxicity, flavonoids and their derivative may represent target compounds to be tested in future clinical trials to enrich the drug arsenal against coronavirus infections.
In conclusion, the interest of scientists for the antiviral capacity of flavonoids against human coronavirus infections can benefit of the enormous amount of resources that governments, health agencies, and private companies are pouring in the field, searching for a cure against SARS-CoV-2. This situation barely resembles what happened in the eighties-nineties following the AIDS pandemic, when the basic knowledge in the immunological mechanisms controlling the response to HIV infection underwent amazing and unpredictable progresses. Waiting for a valuable vaccine against COVID-19, the pharmacological approach remains a priority and flavonoids may contribute to it. In this scenario, the “pleiotropic” properties of flavonoids that we mentioned at the beginning of this review, risks to become the passepartout to counteract coronaviruses since they can be effective on both sides, viral and host cells, to inhibit infection. In fact, recent works hypothesized that flavonoids can inhibit both TMPRSS2 and Furin, which cleave the SARS-CoV-2 Spike protein facilitating SARS-CoV-2 infectivity. Molecular docking-based screening and in vitro assays using recombinant proteins indicated that (−)-epicatechin 3-O-(3′-O-methyl) gallate for TMPRSS2 [84] and baicalein and oroxylin A glycoside for Furin [85] can bind and inhibit their respective proteases blocking virus propagation.
INGREDIENTS:
3,2᾿dihydroxyflavone
(3,2᾿DHF) & 3,4᾿dihydroxyflavone (3,4᾿DHF)
(Trifolium repens L.)
Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2᾿dihydroxyflavone (3,2᾿DHF) and 3,4᾿dihydroxyflavone (3,4᾿DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4᾿DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4᾿DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.
- Antiviral Activity Of 3, 4′-Dihydroxyflavone On Influenza A virus
- Antiviral effect of methylated flavonol isorhamnetin against influenza
6-gingerol
(ginger extract)
- A Brief Study On Zingiber Officinale-A Review
- A Mini Review On The Phytochemistry, Toxicology And Antiviral Activity Of Some Medically Interesting Zingiberaceae Species
- A Review On Medicinal Uses Of Zingiber Officinale (Ginger)
- Adsorption Of Polyphenols From Ginger Rhizomes On An Anion Exchange Resin Amberlite Ir-400–Study On Effect Of Ph And Temperature
- An Overview: Ginger, A Tremendous Herb
- Anticancer Effect Of Gingerol And Crude Ginger Extract On Ethylene Thiourea Induced Thyroid & Liver Cancer In Albino …
- Antimicrobial Activity Of Ginger (Zingiber Officinale) And Its Application In Food Products
- Antimicrobial Effect And Enzymatic Activity Of Extract Of Zingiber Officinale Roscoe And Stability In Topical Preparations
- Assessment Of Antimicrobial Potential Of 10% Ginger Extract Against Streptococcus Mutans, Candida Albicans, And Enterococcus Faecalis: An In Vitro Study
- Beneficial Therapeutic Effects Of Nigella Sativa And/Or Zingiber Officinale In Hcv Patients In Egypt
- Bioactive Compounds And Bioactivities Of Ginger (Zingiber Officinale Roscoe)
- Bioactive Principles And Nutraceuticals In Zingiberaceous Spices
- Biological Basis For The Use Of Botanicals In Osteoarthritis And Rheumatoid Arthritis: A Review
- Characterisation Of Ginger Extracts Obtained By Subcritical Water
- Chromatographic Analysis, Antioxidant, Anti-Inflammatory, And Xanthine Oxidase Inhibitory Activities Of Ginger Extracts And Its Reference Compounds
- Cyto-Biochemical And Antimicrobial Investigations On Essential Oil Of Zingiber Officinale Roscoe
- Effect Of 6‐Gingerol On Physicochemical Properties Of Grass Carp (Ctenopharyngodon Idellus) Surimi Fortified With Perilla Oil During Refrigerated Storage
- Effects Of Ginger Or Ginger And Thyme Extract In Laying Hens Feeding On Productive Results And Eggs Quality
- Ethanolic Extract Of Ginger On The Histology Of The Pancrease In Adult Wistar Rats
- Experimental Advances In Pharmacology Of Gingerol And Analogues
- Extract From Zingiber Officinale Rosc. In Oral Solid From Of A Drug
- Functional Coffee Substitute Prepared From Ginger By Subcritical Water
- Ginger And Its Bioactive Component Inhibit Enterotoxigenic Escherichia Coli Heat-Labile Enterotoxin-Induced Diarrhea In Mice
- Ginger And Its Constituents: Role In Prevention And Treatment Of Gastrointestinal Cancer
- Ginger As An Alternative Medicine To Urban Population–A Review
- Ginger Extract Inhibits The Replication Of T2 Bacteriophage By Inhibiting The Synthesis Of Nucleosides
- Ginger In Oral Care
- Ginger Rhizomes (Zingiber Officinale): A Spice With Multiple Health Beneficial Potentials
- Ginger: A Functional Herb
- Ginger: Panacea Or Consumer’S Hype?
- Harnessing The Therapeutic Properties Of Ginger (Zingiber Officinale Roscoe) For The Management Of Plant Diseases
- Herbal Antioxidant Agents And Its Pharmacological And Medicinal Properties
- Herbal Extracts As Antiviral Agents
- Inhibition Of Pro-Inflammatory Molecules By Ginger (Zingiber Officinale Roscoe) And Its Anti-Inflammatory Effects On Arthritis Patients
- Nutrient Profiling And Antioxidant Potential Of Three Different Varieties Of Zingiber Officinale.
- Pharmacological Activities Of Ginger (Zingiber Officinale): A Reviw
- Pharmacological Activity Of Zingiber Officinale
- Phytochemistry And Pharmacological Properties Of Ginger (Zingiber Officinale)
- Potential Health Benefits And Scientific Review Of Ginger
- Potential Pharmacological Benefits Of Ginger (Zingiber Officinale)–A
- Preparative Separation Of Gingerols From Zingiber Officinale By High-Speed Counter-Current Chromatography Using Stepwise Elution
- Protective And Therapeutic Potential Of Ginger (Zingiber Officinale) Extract And [6]‐Gingerol In Cancer: A Comprehensive Review
- Proven Health Benefits Of Ginger
- Review On Pharmacological Activities Of Mangifera Indica And Zingiber Officinale
- Some Medicinal Plant Extracts Exhibit Potency Against viral Hepatitis C
- Study On Microwave-Assisted Extraction Of Gingerol In Ginger
- Therapeutic Properties Of Zingiber Officinale Roscoe: A Review
- Toxic, Cytogenetic And Antitumor Evaluations Of [6]-Gingerol In Non-Clinical In Vitro Studies
- Traditional Health Boosters: Onion, Ginger And Garlic
- Zingiber Officinale (Ginger): A Future Outlook On Its Potential In Prevention And Treatment Of Diabetes And Prediabetic States
- Zingiber Officinale Roscoe Aqueous Extract Modulates Matrixmetalloproteinases And Tissue Inhibitors Of Metalloproteinases Expressions In Dengue virus -Infected Cells …
- Zingiberis Rhizoma: A Comprehensive Review On The Ginger Effect And Efficacy Profiles
- [6]-Gingerol Exhibits Potent Anti-Mycobacterial And Immunomodulatory Activity Against Tuberculosis
- 6-Gingerol Exerts Anti-Inflammatory Effects And Protective Properties On Lta-Induced Mastitis
- 6‐Gingerol Mediates Its Anti Tumor Activities In Human Oral And Cervical Cancer Cell Lines Through Apoptosis And Cell Cycle Arrest
- 6-Gingerol: A Therapeutically Potent Lead Candidate In Anti-Inflammatory Drug Discovery
- A Comparative Study Of The Anti-Breast Cancer And Immunomodulatory Effects Of [6]-,[8]-, And [10]-Gingerol
- A Ginger Component, 6-Gingerol Helps Prevention Of Sepsis By Inducing Anti-Bacterial Immune Responses
- A Phase Ii Randomized Double-Blind Placebo-Controlled Study Of 6-Gingerol As An Anti-Emetic In Solid Tumor Patients Receiving Moderately To Highly Emetogenic …
- Analgesic And Anti-Inflammatory Activities Of [6]-Gingerol
- Anti-Helicobacter Pylori Effect Of 6-Gingerol In Vitro
- Anti-Hyperglycaemic, Lipid Lowering And Anti-Oxidant Properties Of [6]-Gingerol In Db/Db Mice
- Anti‐Invasion Effects Of 6‐Shogaol And 6‐Gingerol, Two Active Components In Ginger, On Human Hepatocarcinoma Cells
- Anti-Oxidant Activity Of 6-Gingerol As A Hydroxyl Radical Scavenger By Hydrogen Atom Transfer, Radical Addition And Electron Transfer Mechanisms
- Assessment Of Anti-Cancerous Potential Of 6-Gingerol (Tongling White Ginger) And Its Synergy With Drugs On Human Cervical Adenocarcinoma Cells
- Bioinformatics And Experimental Studies Of Anti-Leukemic Activity From 6-Gingerol Demonstrate Its Role In P53 Mediated Apoptosis Pathway
- Comparative Antioxidant And Anti-Inflammatory Effects Of [6]-Gingerol,[8]-Gingerol,[10]-Gingerol And [6]-Shogaol
- Determination Of 6-Gingerol In Ginger Anti-Dandruff Shampoo By Hplc
- Determination Of 6-Gingerol In Taohua Anti-Diarrhea Granula By Hplc [J]
- Fabrication Of 6-Gingerol, Doxorubicin And Alginate Hydroxyapatite Into A Bio-Compatible Formulation: Enhanced Anti-Proliferative Effect On Breast And Liver …
- In Vitro Anti-Hydatic And Immunomodulatory Effects Of Ginger And [6] Gingerol
- In Vitro Anti-Hydatic And Immunomodulatory Effects Of Ginger And [6]-Gingerol
- Inhibition Of Adipogenesis In 3T3-L1 Cells By The Anti-Inflammatory Agents 6-Gingerol And Retinoic Acid
- Proteasome Inhibition Mediates P53 Reactivation And Anti-Cancer Activity Of 6-Gingerol In Cervical Cancer Cells
- Safety Evaluation Of Anti-Glioma Drug 6-Gingerol
- Structure–Activity Relationships Of 6-And 8-Gingerol Analogs As Anti-Biofilm Agents
- The Anti-Inflammatory Effect Of 6-Gingerol On Focal Ischemia-Reperfusion Injury In Rats
Acidicheteroglucan
(Tremella fuciformis extract)
- Coccidiosis Immunization: Effects Of Mushroom And Herb Polysaccharides On Immune Responses Of Chickens Infected With Eimeria Tenella
- Effects Of Mushroom And Herb Polysaccharides On Cellular And Humoral Immune Responses Of Eimeria Tenella-Infected Chickens
- Effects Of Mushroom And Herb Polysaccharides, As Alternatives For An Antibiotic, On The Cecal Microbial Ecosystem In Broiler Chickens
- In Vitro Fermentation Characteristics Of Two Mushroom Species, An Herb, And Their Polysaccharide Fractions, Using Chicken Cecal Contents As Inoculum
- Interference Of Cranberry Constituents In Cell–Cell Signaling System Of Vibrio Harveyi
- Ringless Honey Mushroom (Armillaria Tabescens): Identification And Info
- Like the maitake and shiitake mushrooms, Tremella can enhance the immune system. The mushroom has acidic polysaccharides that boost the strength of white blood cells that protect the body from bacteria, virus es, and the like. In two separate studies, Tremella ranked alongside the maitake mushroom in terms of effectiveness in immune system enhancement.
Aconitum carmichaelii Debx extract
(Aconitum carmichaelii Debx)
Four diterpenoid alkaloids, namely, (a) hypaconitine, (b) songorine, (c) mesaconitine and (d) aconitine, were isolated from the ethanol root extract of Aconitum carmichaelii Debx. The antiviral activities of these alkaloids against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) were evaluated. Antiviral activity test in vivo showed that compounds a and c, which were C19-diterpenoid alkaloids, showed inactivation efficacy values of 82.4 and 85.6% against TMV at 500 μg/mL, respectively. By contrast, compound c presented inactivation activity of 52.1% against CMV at 500 μg/mL, which was almost equal to that of the commercial Ningnanmycin (87.1% inactivation activity against TMV and 53.8% inactivation activity against CMV). C19-Diterpenoid alkaloids displayed moderate to high antiviral activity against TMV and CMV at 500 μg/mL, dosage plays an important role in antiviral activities. This paper is the first report on the evolution of aconite diterpenoid alkaloids for antiviral activity against CMV.
- Antiviral Activity Of Aconite Alkaloids From Aconitum Carmichaelii Debx
- Alkaloids isolated from the lateral root of Aconitum carmichaelii
- Application of metabolomics in toxicity evaluation of traditional Chinese medicines
- Effects of Magnolia officinalis compatibility with Polygala tenuifolia on mitochondrial metabolism in rats’ liver based on bio-thermodynamics
- Genus Tinospora: ethnopharmacology, phytochemistry, and pharmacology
- Herbs Used in Traditional Chinese Medicine in Treatment of Heart Diseases
- Indexed in Science Citation Index Expanded
- Market Survey On Traditionalmedicine Of The Third Month Fair In Dali Prefecture In Yunnan Province, Southwest China
- Preparative separation of C19-diterpenoid alkaloids from Aconitum carmichaelii Debx by pH‑zone-refining counter-current chromatography
- Protective effect of crude polysaccharide from Pao-Tian-Xiong derived from monkshood, against chronic renal failure in mice.
- Recent pharmaceutical evidence on the compatibility rationality of traditional Chinese medicine
- Safety Evaluation of Awei Capsule: Assessment of Acute and Subchronic Toxicity in rodent
- UPLC‐ESI/MS determination of 17 active constituents in two categorized formulas of traditional Chinese medicine, Sanhuang Xiexin Tang and Fuzi Xiexin Tang …
Ailanthus altissima stem bark extract
(Ailanthus altissima (Mill.) Swingle)
In order to search for the anti-HIV agents from natural products, eighty MeOH extracts of medicinal plants were applied to a syncytia formation inhibition assay which is based on the interaction between the HIV-1 envelope glycoprotein gp120/gp41 and the cellular membrane protein CD4 of T lymphocytes. Among them, Ailanthus altissima showed a potent virus-cell fusion inhibitory activity.
- Chemistry And Biological Activities Of Ailanthus Altissima Swingle: A Review
- Herbicidal Effect Of Ailanthus Altissima Leaves Water Extracts On Medicago Sativa Seeds Germination
- Pharmacological Evaluation Of Anti-Fertility Effect Of Stem Bark Of Ailanthus Altissima In Wistar Albino Rats
- Research On The In Vitro Bacteriostatic Effect Of Quassiawood Alkaloid On Escherichia Coli
- Screening Of Ailanthus Altissima Extract Paste Formula And Biological Determination
- Studies On The Control Efficiency Of Extracts From Leaves Of Ailanthus Altissima Swingle On Myzus Persicae Sulzer
- Verticillium Wilt Of Ailanthus Altissima
- Virus-cell fusion inhibitory compounds from Ailanthus altissima Swingle
- Antiviral effect of Ailanthus altissima and Brucea javanica on tobacco mosaic virus
- Anti-viral activity ofAilanthus altissima crude extract onRice stripe virus in rice suspension cells
- Quassinoids as inhibitors of Epstein-Barr virus early antigen activation
- Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells
- Ailanthus altissima (the Tree of Heaven): In Vitro Culture and the Formation of Alkaloids and Quassinoids
- CAROTENOID PROFILE OF AILANTHUS ALTISSIMA STEM BARK, IN-VITRO ANTIOXIDANT AND ANTINEOPLASTIC ACTIVITIES
- Flavonoids from the leaves of Ailanthus altissima swingle and their antioxidant activity
- Medicinal plants: Prospective drug candidates against the dreaded Coronavirus
- Plants as sources of antimalarial and amoebicidal compounds
- Preclinical toxicology and toxicokinetic evaluation of ailanthone, a natural product against castration-resistant prostate cancer, in mice
- Protein patterns and chemical constituents of Ailanthus altissima (Miller) Swingle and Ailanthus excelsa Roxb.
- The Formation and Regulation of 1-Methoxycanthin-6-one Production in Ailanthus altissima Cell Suspension Cultures
allantoin
(Glyoxylic acid)- A Review Of The Medicinal Properties And Applications Of Pycnanthus Angolensis (Welw) Warb
- Biguanide Related Compounds In Traditional Antidiabetic Functional Foods
- Biodiversity Conservation With Special Reference To Medicinal Climbers: Present Scenario, Challenges, Strategies, And Policies
- Estimation Influences Of Green Tea As Medical Herb For Treating Diabetes Mellitus
- Nitrogen Metabolism In Mosquitoes
- Synthesis And Reactivity Of 5-Methylenehydantoins
- The Utilization Of Urine Processing For The Advancement Of Life Support Technologies
- Compound for the control of herpes simplex virus using glycyrrhizic acid, lipoic acid, allantoin, and slippery elm
- Effect of Wen-Pi-Tang extract on lung damage by influenza virus infection
- The Two of Uninary Allantoin and Urea-N and Induction of Primary Moloney Sarcoma Virus-induced Tumors in Micice
- A quest of Anti-acne Potential of Herbal Medicines for extermination of MDR Staphylococcus aureus
- Acridine—a neglected antibacterial chromophore
- Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules
- An in vitro antimicrobial comparison of miswak extract with commercially available non‐alcohol mouthrinses
- An investigation into multifaceted mechanisms of action of allantoin in wound healing
- An overview of antimicrobial properties of different classes of phytochemicals
- antibacterial Activity of Aristolochia bracteata Root Extracts
- antibacterial ACTIVITY OF SOME TERRESTRIAL GASTROPODS FROM EGYPT AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI
- antibacterial and antifungal activities of proteins extracted from seven different snails
- antibacterial and Antioxidant Activities of the Essential Oil from the Roots of Angelica tennuifolia
- antibacterial potential of secondary metabolites produced by Aspergillus sp., an endophyte of Mitrephora wangii
- antibacterial PROPERTIES OF CRUDE AQUEOUS Hylocereus polyrhizus PEEL EXTRACTS IN LIPSTICK FORMULATION AGAINST GRAM-POSITIVE …
- antibacterial properties of human amniotic membranes
- Anti-Inflammatory and antibacterial Activity of the Chitosan/Chlorhexidine Gel Commercial Preparation for Postexodontia Treatment: An In Vitro Study
- antimicrobial activities of extracts and flavonoid glycosides of corn silk (Zea mays L)
- antimicrobial activities ofStreptomyces pulcher, S. canescens andS. citreofluorescens against fungal and bacterial pathogens of tomatoin vitro
- antimicrobial activity and phytochemical properties of corn (Zea mays L.) silk
- antimicrobial activity of copaiba oil: A review and a call for further research
- antimicrobial activity of enterocins from Enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect
- antimicrobial activity of various parts of Polyalthia longifolia var. pendula: isolation of active principles from the leaves and the berries
- antimicrobial compounds from the excretions of surgical maggots, Lucilia sericata (Meigen) (Diptera, Calliphoridae)
- antimicrobial Effect of Cow Urine and Goat Urine against common Dental Caries Pathogens: An in vitro Comparative Study
- antimicrobial materials derived from the endophytic fungus Fusarium sp. of Eucommia ulmoides
- antimicrobial meroterpenoids from the endophytic fungus Penicillium sp. T2-8 associated with Gastrodia elata
- antimicrobial Metabolites from the Endophytic Fungus Aspergillus sp. of Eucommia ulmoides
- antimicrobial N-brominated hydantoin and uracil grafted polystyrene beads
- antimicrobial treatments of hemp fibers grafted with β-cyclodextrin derivatives
- Antimicrobial, antioxidant and cytotoxic activity of silver nanoparticles synthesized by leaf extract of Erythrina suberosa (Roxb.)
- Antimycobacterial, antimicrobial, antioxidant activities and in silico PASS investigations of root fractions and extract of Cordia dichotoma Forst
- Antioxidant and antibacterial Effects of Some Medicinal Plants of Iran
- Antioxidant and antimicrobial activities of Salvia multicaulis
- Antioxidant and antimicrobial activity of a new generation phyto-gel
- Antioxidative, antimicrobial and anticytotoxic activities of seungmagalgeuntang and fermented seungmagalgeuntang
- Biosynthesis and antibacterial activity of silver and gold nanoparticles from the leaf and callus extracts of Amaranthus dubius, Gunnera perpensa, Ceratotheca …
- Biosynthesis of mixed nanocrystalline Zn–Mg–Cu oxide nanocomposites and their antimicrobial behavior
- Calendula (Calendula officinalis)
- Camphor oil extraction from Cinnamomum camphora and its antibacterial activity [J]
- Catalyst-Free Three-Component Synthesis, Antibacterial, Antifungal, and Docking Studies of Spiroindoline Derivatives
- Characterization, antimicrobial, antioxidant, and anticoagulant activities of silver nanoparticles synthesized from Petiveria alliacea L. leaf extract
- Chemical Composition and antibacterial Effect of Plantago Major Extract on Periodontal Pathogens
- Chemical Constituents and antimicrobial Activity of Branches and Leaves of Cordia insignis (Boraginaceae)
- Comparison of some secondary metabolite content in the seventeen species of the Boraginaceae family
- Copper-releasing, borate-based glasses with antibacterial properties: synthesis and in vitro characterization
- Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids
- Development and evaluation of antimicrobial herbal cosmetic preparation
- Dopa-based facile procedure to synthesize AgNP/cellulose nanofiber composite for antibacterial applications
- Ecofriendly Biosynthesis of Zinc Oxide and Magnesium Oxide Particles from Medicinal Plant Pisonia grandis R.Br. Leaf Extract and Their antimicrobial Activity
- Empirical formula: C4 H9 O7 Al2 Cl N4
- Evaluation for the Antimicrobial, Antioxidant and Antithrombosis Activity of Natural Spices for Fresh-cut yam.
- Evaluation of antibacterial Activity and Phenolic Contents of Four Nigerian Medicinal Plants
- Evaluation of antibacterial and antitumor activities of some Turkish endemic plants
- Evaluation of antimicrobial, antithrombin, and antioxidant activity of Aerial Bulbils of Dioscorea batatas Decne
- Evaluation of antimicrobial, antithrombin, and antioxidant activity of Dioscorea batatas Decne
- Evidence on antimicrobial Efficacy of Commercial Toothpaste
- Experiment-based quantitative modeling for the antibacterial activity of silver nanoparticles
- extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial …
- Fabrication of bioinspired chitosan/gelatin/allantoin biocomposite film for wound dressing application
- Formulation and evaluation of antibacterial creams and gels containing metal ions for topical application
- Genomic analysis unveils important aspects of population structure, virulence, and antimicrobial resistance in Klebsiella aerogenes
- Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and antioxidant activities
- In vitro antibacterial activity of selected medicinal plants traditionally used in Iran against plant and human pathogenic bacteria
- In vivo antioxidative property, antimicrobial and wound healing activity of flower extracts of Pyrostegia venusta (Ker Gawl) Miers
- Isolation and Structural Elucidation of Allantoin a Bioactive Compound from Cleome viscosa L.: A Combined Experimental and Computational Investigation
- Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata
- New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula
- Nigritanine as a New Potential antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections
- Novel streptopyrroles from Streptomyces rimosus with bacterial protein histidine kinase inhibitory and antimicrobial activities
- Preclinical study of the efficacy and safety of wound healing gel containing chitosan, taurine and allantoin
- Preparation and characteristics of antibacterial chitosan films modified with N-halamine for biomedical application
- Qualitative Determination of the Secondary Metabolites and Evaluation of the antimicrobial Activity of Leaf Extracts from Different Plant Families (Boraginaceae …
- Screening the UV-blocking and antimicrobial properties of herbal nanoparticles prepared from Aloe vera leaves for textile applications
- Secondary metabolites from the Actinomycete Acrocarpospora punica
- Selective antimicrobial activity of maggots against pathogenic bacteria
- Solid lipid nanoparticles containing copaiba oil and allantoin: development and role of nanoencapsulation on the antifungal activity
- Stability, antibacterial ability, and inhibition of “zinc burning” of amitrole as thermal stabilizer for transparent poly (vinyl chloride)
- STUDY OF antimicrobial AND HAIR REGROWTH ACTIVITY OF TRIDAX PROCUMBENS FOR SCALP DISORDER
- Study on Synthesis of Diazolidinyl Urea as Preservative [J]
- Supramolecular Hydrogels Based on Cellulose for Sustained Release of Therapeutic Substances with antimicrobial and Wound Healing Properties
- Survey of the antimicrobial Activity of Commercially Available Australian Tea Tree (Melaleuca alternifolia) Essential Oil Products In Vitro
- The effects of a topical gel containing chitosan, 0, 2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower …
- The identification and quantification of bioactive compounds from the aqueous extract of comfrey root by UHPLC-DAD-HESI-MS method and its microbial activity
- The identification and quantification of bioactive compounds from the aqueous extract of comfrey root by…
- The pharmacology of Anchusa italica and Anchusa strigosa–A review
- The physical properties, antioxidant and antimicrobial activity of chitosan–gelatin edible films incorporated with the extract from hop plant
- Urate Oxidase produced by Lucilia sericata medical maggots is localized in Malpighian tubes and facilitates allantoin production
Alphitonia philippinensis stems
(Alphitonia philippinensis Braid)Three new flavonol glycosides, namely, isorhamnetin 3-O-(6″-O-(Z)-p-coumaroyl)-β-d-glucopyranoside, quercetin 3-O-α-l-rhamnopyranosyl(1-2)-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, and quercetin 3-O-α-l-arabinopyranosyl(1-2)-α-l-rhamnopyranoside, were isolated from the stems of Alphitonia philippinensis collected from Hainan Island, China. Some of the isolated triterpenoids and flavonoid glycosides showed cytotoxicity against human PC-3 cells and hepatoma HA22T cells, and the inhibition of replication on HSV-1 (131). Viral diseases, especially of skin, can be treated with a virucide encapsulated in multilamellar phospholipid liposomes. Rosmarinic acid (70), incorporated in phospholipid mixture demonstrated effectiveness in humans afflicted with HSV (132). Flavonol glycosides (from quercetin and isorhamnetin) derived from the stems of Alphitonia philippinensis have been reported to inhibit the replication of HSV-1.
- Evaluation Of Antioxidant Activity And Phytochemical Screening Of Leaves, Barks, Stems And Fruits Of Alphitonia Philippinensis (Rhamnaceae) From Brunei …
- Triterpenoids With A Five-Membered A-Ring: Distribution In Nature, Transformations, Synthesis, And Biological Activity
- Antiviral activity of phytochemicals: a current perspective
- Gastroprotective activity of the hydroethanolic extract and ethyl acetate fraction from Kalanchoe pinnata (Lam.) Pers.
- Medicinal uses of selected fruit trees and woody perennials
Amygdalin
(Semen Armeniacae Amarum Extract)Contribution of traditional Chinese medicine to the treatment of COVID-19
Amygdalin could Inhibit IFN-γ, NF-κB and NLRP3 signaling pathways so as to reduce the inflammatory response (Paoletti et al., 2013; Zhang et al., 2017). These reports provided the scientific ground of integrating TCM therapy from the aspects of their compositions’ potential targeting proteins and signaling pathways in the treatment of COVID-19.
- A Network Analysis Of The Chinese Medicine Lianhua-Qingwen Formula To Identify Its Main Effective Components
- Antitussive, Anti-Pyretic And Toxicological Evaluation Of Ma-Xing-Gan-Shi-Tang In Rodents
- Anti-virus Effect Of Traditional Chinese Medicine Yi-Fu-Qing Granule On Acute Respiratory Tract Infections.
- Chinese Herbal Medicine For Coronavirus Disease 2019: A Systematic Review And Meta-Analysis
- Determination Of Amygdalin In Maxing Shigan Decoction By Hpce
- Determination The Active Compounds Of Herbal Preparation By Uhplc–Ms/Ms And Its Application On The Preclinical Pharmacokinetics Of Pure Ephedrine, Single Herbal …
- Effect Of Compatibility On Content Of Amygdalin In Sanao Decoction
- Effects Of Different Principles Of Traditional Chinese Medicine Treatment On Tlr7/Nf-Κb Signaling Pathway In Influenza virus Infected Mice
- Ma Xing Shi Gan Decoction Attenuates Pm2. 5 Induced Lung Injury Via Inhibiting Hmgb1/Tlr4/Nfκb Signal Pathway In Rat
- Yidu-Toxicity Blocking Lung Decoction Ameliorates Inflammation In Severe Pneumonia Of Sars-Cov-2 Patients With Yidu-Toxicity Blocking Lung Syndrome By …
Anemarrhena asphodeloides extract
(Anemarrhena asphodeloides Bunge)Two known steroidal saponins, timosaponin A-III (1) and anemarsaponin B (2) were isolated from the BuOH fraction of the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae) together with the xanthone derivatives, mangiferin (3) and neomangiferin (4). Structures of the isolates were identified using 1D and 2D NMR techniques and by comparison with the published values. Timosaponin A-III (1) exhibited potent inhibitory effects on the respiratory syncytial virus (RSV), with an IC50 value of 1.00 µM.
- (-)-Nyasol (Cis-Hinokiresinol), A Norneolignan From The Rhizomes Of Anemarrhena Asphodeloides, Is A Broad Spectrum Inhibitor Of Eicosanoid And Nitric Oxide …
- A Fructan From Anemarrhena Asphodeloides Bunge Showing Neuroprotective And Immunoregulatory Effects
- A Metabolomic Approach To Determine The Geographical Origins Of Anemarrhena Asphodeloides By Using Uplc–Qtof Ms
- Anemarrhenae Asphodeloides Rhizoma Extract Enriched In Mangiferin Protects Pc12 Cells Against A Neurotoxic Agent-3-Nitropropionic Acid
- Anti-Inflammatory Effect Of Anemarsaponin B Isolated From The Rhizomes Of Anemarrhena Asphodeloides In Lps-Induced Raw 264.7 Macrophages Is Mediated By …
- Anti-Inflammatory Effect Of Win-34B, A New Herbal Formula For Osteoarthritis Composed Of Lonicera Japonica Thunb And Anemarrhena Asphodeloides Bunge In …
- Anti-Respiratory Syncytial virus (Rsv) Activity Of Timosaponin A-Iii From The Rhizomes Of Anemarrhena Asphodeloides
- Identification Of Nyasol And Structurally Related Compounds As The Active Principles From Anemarrhena Asphodeloides Against Respiratory Syncytial virus (Rsv)
- The Genus Anemarrhena Bunge: A Review On Ethnopharmacology, Phytochemistry And Pharmacology
Angelica sinensis
(Angelica sinensis (Oliv.) Diels)
Increased oxidative stress and disturbed glutathione redox system play an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. Depletion in intracellular levels of reduced glutathione (GSH) contributes to an increment in tumor necrosis factor α (TNF-α)-stimulated-HIV-1-transcription, activation of HIV-1-replication, sensitivity to TNF-α-induced cell death, and impairment of CD4+ cell function and survival. Therefore, several studies have investigated the effect of GSH-enhancer agents such as N-acetyl cystein in the treatment of patients with HIV infection. With regard to the beneficial effects of Angelica sinensis, a Chinese medicinal herb, on GSH redox system and the pathogenic role of GSH depletion in HIV infection and the immunomodulator effects of active ingredients of this herb, we postulated that Angelica sinensis may be of value in the treatment of HIV-infected patients.
- Angelica Sinensis Polysaccharide Attenuates Concanavalin A-Induced Liver Injury In Mice
- Antiviral Activity Of Guiqi Polysaccharides Against Enterovirus 71 In Vitro
- Biotransformation Of Neuro-Inflammation Inhibitor Kellerin Using Angelica Sinensis (Oliv.) Diels Callus
- Dong Quai (Angelica Sinensis [Oliv.] Diels), Chinese Angelica
- Lowering Sugar Effect And Mechanism Of Angelica Polysaccharide To Wister Diabetic Rats Induced By Stz [J]
- Macrophage Activation By An Acidic Polysaccharide Isolated From Angelica Sinensis (Oliv.) Diels
- Pharmacological Action And Toxicity Of Angelica Sinensis
- Radix Angelica Sinensis Soup Production By Decocting Process Using High Pressure
- Therapeutic Effect Of Qigui Tangtong Ning Granules On Diabetic Peripheral Neuropathy In Rats
- Use Of A Magnetic Ultrafiltration Membrane For The Separation Of Angelica Sinensis Root Polysaccharides [J]
Apigenin
(celery extract)Targeting SARS-CoV-2 Spike Protein of COVID-19 with Naturally Occurring Phytochemicals
Apigenin has shown potent antiviral activity against hepatitis B virus, adenoviruses, african swine fever virus and some RNA viruses in vitro.
- Anti‐Obesity Effects Of Enzyme‐Treated Celery Extract In Mice Fed With High‐Fat Diet
- Apigenin Inhibits African Swine Fever virus Infection In Vitro
- Botanical Therapeutics: Phytochemical Screening And Biological Assessment Of Chamomile, Parsley And Celery Extracts Against A375 Human Melanoma …
- Inhibition Of Epstein-Barr virus Reactivation By The Flavonoid Apigenin
- Potency Of Herbal Plants Formulation As Anticholesterole Agent: In Vitro Studies
- Role Of Phenolic Compounds In Peptic Ulcer: An Overview
- The Expected Protective Role Of Celery Oil On Induced Toxic Effects Of Acrylamide On The Testis Of Adult Albino Rat: A Morphological, Morphometric And …
- The Flavonoid Apigenin Inhibits Hepatitis C virus Replication By Decreasing Mature Microrna122 Levels
arctigeNin, arctin
(Burdock extract (Arctium Lappa))Arctiin and its aglucone, arctigenin from the fruits of Arctium lappa L. showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). Based on the data from time-of-addition experiments and on release tests of progeny viruses, arctigenin was assumed to interfere with early event(s) of viral replication after viral penetration into cells, and to suppress the release of progeny viruses from the host cells. Arctiin was orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice, being less effective as compared with oseltamivir. Noticeably, arctiin produced a larger amount of virus-specific antibody than those of control and oseltamivir in sera collected from 5-FU-treated mice. Furthermore, oral treatment of 5-FU-treated mice with arctiin did not induce any resistant viruses, although the same treatment with oseltamivir induced resistant viruses at a 50% frequency. When the combination of arctiin and oseltamivir was administered to normal mice infected with IFV, the virus yields in both bronchoalveolar lavage fluids and lungs were significantly reduced relative to those in the mice treated with arctiin or oseltamivir alone. Thus, monotherapy of arctiin or combined therapy of arctiin with oseltamivir would be another treatment option for influenza.
- Therapeutic effect of arctiin and arctigenin in immunocompetent and immunocompromised mice infected with influenza A virus
- Evaluation on the antiviral activity of arctigenin against spring viraemia of carp virus
- Synthesis and in vitro activities evaluation of arctigenin derivatives against spring viraemia of carp virus
- Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase
- Synthesis and antiviral activity of a new arctigenin derivative against IHNV (infectious hematopoietic necrosis virus) in vitro and in vivo
- Antioxidants: potential antiviral agents for Japanese encephalitis virus infection
- Antiviral activity of Arctigenin against Newcastle Disease virus in vitro
- Evaluation on antiviral activity of a novel arctigenin derivative against multiple rhabdoviruses in aquaculture
- Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection
artemisinin
(Artemisia annua extract)Discuss about the application of Artemisia annua prescriptions in the treatment of COVID-19
The applications of traditional Chinese medicine (TCM) have been playing an important role in treating the epidemics of Coronavirus Disease 2019 (COVID-19), which is now prevalent all over the world. Exploring the mechanisms of TCM compound prescriptions might be difficult though, pharmacological studies on elucidating the effective components of TCM could serve as the experimental basis in the application of TCM compound prescription in treating COVID-19. As the critical active ingredients of Qinghao (Artemisia annua), artemisinin was initially used as antimalaria drug. Artemisia annua prescriptions take significant effect against pneumonia. Sharing similarities in pharmacology with artemisinin, chloroquine has been confirmed effective in inhibiting Severe Acute Respiratory Syndrome coronavirus 2 (SARS-Cov-2) both in vitro and practically. In this context, we discussed the application of Artemisia annua prescriptions against COVID-19 along with the antiviral effect of chloroquine.
Conclusion
With similar pharmacological effects between chloroquine and artemisinin in treating infectious diseases, this paper discusses the modern scientific basis for the application of Artemisia annua prescriptions in COVID-19. Except for antimalarial, most of the other pharmacological studies on artemisinin and its derivatives are still on the bench or at animal level, with only a few in clinical trials. Artemisinin treatment on COVID-19 has not been reported yet. As a treasure of TCM, compound prescription has played an important role in plagues in history. The main cause of COVID-19 in Wuhan is damp-heat according to TCM theory. The prescription for clearing heat and eliminating dampness based on Artemisia annua is widely used in this epidemic. Based on the antiviral and anti-inflammatory effects of artemisinin and its derivatives, Artemisia annua prescriptions have great value to dig into and are promising to be used in more infectious diseases. But more in vitro experiments need to be carried out to provide more evidence, such as the influence of Artemisia or Artemisia annua prescriptions on inflammatory factors express
- Access To New Highly Potent Antileukemia, Antiviral And Antimalarial Agents Via Hybridization Of Natural Products (Homo) Egonol, Thymoquinone And Artemisinin
- Antiviral Effect Of Artemisinin From Artemisia Annua Against A Model Member Of The Flaviviridae Family, The Bovine viral Diarrhoea virus (Bvdv)
- Artemisia Annua (Sweet Annie), Other Artemisia Species, Artemisinin, Artemisinin Derivatives, And Malaria
- Artemisia Annua: Trials Are Needed For Covid‐19
- Artemisinin Analogues As Potent Inhibitors Of In Vitro Hepatitis C virus Replication
- Crystallization Of Artemisinin From Chromatography Fractions Of Artemisia Annua Extract
- Delayed Clearance Of Plasmodium Falciparum In Patients With Human Immunodeficiency virus Co-Infection Treated With Artemisinin
- Effect Of Artemisinin/Artesunate As Inhibitors Of Hepatitis B virus Production In An “In Vitro” Replicative System
- Frontispiece: Synthesis Of Artemisinin‐Derived Dimers, Trimers And Dendrimers: Investigation Of Their Antimalarial And Antiviral Activities Including Putative …
- Hemin Potentiates The Anti-Hepatitis C virus Activity Of The Antimalarial Drug Artemisinin
- Highly Potent Artemisinin-Derived Dimers And Trimers: Synthesis And Evaluation Of Their Antimalarial, Antileukemia And Antiviral Activities
- Stability And Antiviral Activity Against Human Cytomegalovirus Of Artemisinin Derivatives
- Synthesis And In Vitro Anti-Human Immunodeficiency virus Activity Of Artemisinin (Qinghaosu)-Related Trioxanes
- Synthesis Of Artemisinin‐Derived Dimers, Trimers And Dendrimers: Investigation Of Their Antimalarial And Antiviral Activities Including Putative Mechanisms Of Action
- Synthesis Of Thymoquinone–Artemisinin Hybrids: New Potent Antileukemia, Antiviral, And Antimalarial Agents
- The Antiviral Activities Of Artemisinin And Artesunate
aspalathin
(ROOIBOS tea)Aspalathus Linearis (Burm.f.) R. Dahlrgen (Rooibos)
Aspalathin and nothofagin extracted from Rooibos have been shown to effectively inhibit LPS-induced release of HMGB1, and suppressed HMGB1-mediated septic responses, such as hyperpermeability, adhesion and migration of leukocytes, and expression of cell adhesion molecules [124]. These molecules, as part of ethanol and alkaline extracts of the Rooibos plant, have also been shown to reduce Influenza A viral load at a late stage of the infection in vitro [125].- A Kinetic And Equilibrium Study Of Rooibos Tea Infusions.
- A Review Of The Bioactivity Of South African Herbal Teas: Rooibos (Aspalathus Linearis) And Honeybush (Cyclopia Intermedia)
- Antioxidant Properties Of Rooibos (Aspalathus Linearis)–In Vitro And In Vivo Evidence
- Antioxidants Of Rooibos Tea-A Possible Explanation For Its Health Promoting Properties?
- Antiviral Activity Of Aspalathus Linearis Against Human Influenza virus
- Aspalathin A Unique Phytochemical From The South African Rooibos Plant (Aspalathus Linearis): A Mini Review
- Commercially Important Medicinal Plants Of South Africa: A Review
- Concise Total Syntheses Of Aspalathin And Nothofagin
- Development Of A Sensory Lexicon And Sensory Wheel For Rooibos (Aspalathus Linearis) And The Role Of Its Phenolic Composition On Taste And Mouthfeel.
- Effect Of Rooibos (Aspalathus Linearis) On Growth Control Of Clostridium Perfringens And Lipid Oxidation Of Ready‐To‐Eat Jokbal (Pig’S Trotters)
- Hepatotoxicity Due To Red Bush Tea Consumption: A Case Report
- Identification Of Phenolic Compounds In Aqueous And Ethanolic Rooibos Extracts (Aspalathus Linearis) By Hplc-Esi-Ms (Tof/It)
- Rooibos Tea As A Likely Health Food Supplement
- Rooibos Tea Extracts Inhibit Osteoclast Formation And Activity Through The Attenuation Of Nf-Κb Activity In Raw264. 7 Murine Macrophages
- Rooibos Tea: New Research Documents Antioxidant And Anticancer Properties
- Rooibos Tea: Research Into Antioxidant And Antimutagenic Properties
- Rooibos-The New” White Tea” For Hair And Skin Care
- Selective Bronchodilatory Effect Of Rooibos Tea (Aspalathus Linearis) And Its Flavonoid, Chrysoeriol
- Tea And Bone Health: Findings From Human Studies, Potential Mechanisms, And Identification Of Knowledge Gaps
- The Transport Of The Rooibos Tea Flavonoid Aspalathin Across The Skin And The Intestinal Epithelium
