INTERSTELLAR PEEL (Flavonoid Powerhouse)

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INTERSTELLAR BLEND “SPICE” POLYPHENOL POWERHOUSE (100 Spices in 1)

INTERSTELLAR SPICE (Polyphenol Powerhouse)

Name: INTERSTELLAR SPICE (Polyphenol Powerhouse)
SKU: SPICE-200-100
Availability: InStock
Rating: 5.00 (19 reviews)

Rated 5.00 out of 5 based on 18 customer ratings

(19 customer reviews)

$75.00 – $275.00

SKU: SPICE-200-100 Category: Featured Tag: Featured

introducing

INTERSTELLAR “SPICE”

POLYPHENOL POWERHOUSE

100 SPICES in one

In the heart of nature, a secret thrives,
A tale spun in the loom of life’s archives.
Polyphenols, a legion vast and strong,
In flora’s realm, they quietly belong.

From simple phenols, to chains complex,
Their weight in life, we can’t annex.
Misunderstood, once viewed with disdain,
Their power hidden in a tannin’s reign.

Considered foes, these antinutrients bold,
In protein’s saga, a villain, we were told.
Yet, as the veils of ignorance fell,
A different tale, they began to tell.

Gifts of the earth, in abundance, they rise,
In berries, in wine, in the trees that touch skies.
Their purpose, more profound than ever we knew,
In the dance of life, an essential crew.

They stand on guard, these noble knights,
Against free radicals, they ignite fights.
Metal chelators, in our body’s defence,
Their valor, their strength, immense.

More than guardians, their role unfolds,
In the human saga, their story is told.
Cancer, heart disease, pathologies vast,
Under their watch, become shadows cast.

In the crucible of life, they play their part,
Polyphenols, nature’s work of art.
In their chemistry, a promise penned,
Of life’s ailments, an impending end.

So, let us raise a toast, to these silent heroes,
Battling life’s countless, looming zeros.
In the heart of nature, a secret thrives,
Polyphenols, the essence of countless lives.

Believe it or not the spices in your cupboard have tremendous healing capabilities and this is because of their POLYPHENOL content.

Now you can have them all in one blend!

What are polyphenols?

Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance

“Polyphenols constitute one of the most numerous and ubiquitous groups of plant metabolites and are an integral part of both human and animal diets. Ranging from simple phenolic molecules to highly polymerized compounds with molecular weights of greater than 30,000 Da, the occurrence of this complex group of substances in plant foods is extremely variable. Polyphenols traditionally have been considered antinutrients by animal nutritionists, because of the adverse effect of tannins, one type of polyphenol, on protein digestibility. However, recent interest in food phenolics has increased greatly, owing to their antioxidant capacity (free radical scavenging and metal chelating activities) and their possible beneficial implications in human health, such as in the treatment and prevention of cancer, cardiovascular disease, and other pathologies. ”

polyphenols: a potentiol new strategy for the prevention and treatment of anxiety and depression

Following recent evidence that disturbances in oxidative metabolism are involved in anxiety disorders, high anxiety levels and depression, the use of antioxidants has been proposed as a novel approach for the prevention or treatment of these conditions. Polyphenols are naturally-occurring antioxidant substances which can have pharmacological actions on the central nervous system. This mini-review aims to examine the current evidence for the potential use of dietary polyphenols as neuroprotective agents to reduce anxiety and to manage depression.

I will outline recent findings which demonstrate that polyphenols have anti-anxiety effects at higher doses (300/60/30/20 mg/kg body weight) as well as at lower doses (2-4 mg/kg); this can be compared to conventional anxiolytics, which only have anxiolytic effects at lower doses (1-5 mg/kg). To circumvent problems associated with polyphenols (e.g., quercetin) having difficulty crossing the blood-brain barrier and to effectively reduce the active dose, intranasal administration in the form of liposomes could be an interesting approach. I also suggest that dietary polyphenols could be a new alternative approach to treat depression, because they exhibit antidepressant activity with relatively lower doses (0.3-2 mg/kg) than commonlyused antidepressants such as imipramine (10 mg/kg). The polyphenols discussed in this mini-review are found in vegetables and fruits such as apples, plums, cherries, onions and tea. Therefore, a varied diet that is rich in naturallyoccurring polyphenols could be an effective means to prevent (or delay) anxiety, depression and other diseases linked to oxidative stress.

Polyphenols: antioxidants and beyond

“Research on the effects of dietary polyphenols on human health has developed considerably in the past 10 y. It strongly supports a role for polyphenols in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers. The antioxidant properties of polyphenols have been widely studied, but it has become clear that the mechanisms of action of polyphenols go beyond the modulation of oxidative stress.”

At the interface of antioxidant signalling and cellular function: Key polyphenol effects

“Effects of (poly) phenols on pathways of chronic inflammation leading to prevention of some of the damaging effects associated with the metabolic syndrome. (2) Interaction of (poly)phenols with endothelial cells and smooth muscle cells, leading to effects on blood pressure and endothelial dysfunction, and consequent reduction in cardiovascular disease risk. (3) The inhibition of xanthine oxidoreductase leading to modulation of intracellular superoxide and plasma uric acid, a risk factor for developing type 2 diabetes. “

POLYPHENOLS: Small molecules that regulate lifespan: evidence for xenohormesis

Barring genetic manipulation, the diet known as calorie restriction (CR) is currently the only way to slow down ageing in mammals. The fact that CR works on most species, even microorganisms, implies a conserved underlying mechanism. Recent findings in the yeast Saccharomyces cerevisiae indicate that CR extends lifespan because it is a mild biological stressor that activates Sir2, a key component of yeast longevity and the founding member of the sirtuin family of deacetylases. The sirtuin family appears to have first arisen in primordial eukaryotes, possibly to help them cope with adverse conditions. Today they are found in plants, yeast, and animals and may underlie the remarkable health benefits of CR. Interestingly, a class of POLYPHENOLIC molecules produced by plants in response to stress can activate the sirtuins from yeast and metazoans. At least in the case of yeast, these molecules greatly extend lifespan by mimicking CR. One explanation for this surprising observation is the ‘xenohormesis hypothesis’, the idea that organisms have evolved to respond to stress signalling molecules produced by other species in their environment. In this way, organisms can prepare in advance for a deteriorating environment and/or loss of food supply.

The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in Type 2 diabetes mellitus without complications

“These observations indicated that the polyphenol-rich antioxidant supplement containing pomegranate extract, green tea extract, and ascorbic acid has important antagonizing effects on oxidative stress and lipid peroxidation in patients with Type 2 DM and might be beneficial in preventing cardiovascular complications.”

Natural Polyphenols for Prevention and Treatment of Cancer

There is much epidemiological evidence that a diet rich in fruits and vegetables could lower the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols. Besides, numerous studies have demonstrated that natural polyphenols could be used for the prevention and treatment of cancer. Potential mechanisms included antioxidant, anti-inflammation as well as the modulation of multiple molecular events involved in carcinogenesis. The current review summarized the anticancer efficacy of major polyphenol classes (flavonoids, phenolic acids, lignans and stilbenes) and discussed the potential mechanisms of action, which were based on epidemiological, in vitro, in vivo and clinical studies within the past five years.

Polyphenols and cancer cell growth

Polyphenols constitute an important group of phytochemicals that gained increased research attention since it was found that they could affect cancer cell growth. Initial evidence came from epidemiologic studies suggesting that a diet that includes regular consumption of fruits and vegetables (rich in polyphenols) significantly reduces the risk of many cancers. In the present work we briefly review the effects of polyphenols on cancer cell fate, leading towards growth, differentiation and apoptosis. Their action can be attributed not only to their ability to act as antioxidants but also to their ability to interact with basic cellular mechanisms. Such interactions include interference with membrane and intracellular receptors, modulation of signaling cascades, interaction with the basic enzymes involved in tumor promotion and metastasis, interaction with oncogenes and oncoproteins, and, finally, direct or indirect interactions with nucleic acids and nucleoproteins.

These actions involve almost the whole spectrum of basic cellular machinery–from the cell membrane to signaling cytoplasmic molecules and to the major nuclear components–and provide insights into their beneficial health effects. In addition, the actions justify the scientific interest in this class of compounds, and provide clues about their possible pharmaceutical exploitation in the field of oncology.

Polyphenols and Aging

“These increasingly well-documented results have begun to provide a basis for considering the use of polyphenols in the development of novel therapies for certain human diseases. And while the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases.”

The Anti-Cancer Effect of Polyphenols against Breast Cancer and Cancer Stem Cells: Molecular Mechanisms

The high incidence of breast cancer in developed and developing countries, and its correlation to cancer-related deaths, has prompted concerned scientists to discover novel alternatives to deal with this challenge. In this review, we will provide a brief overview of polyphenol structures and classifications, as well as on the carcinogenic process. The biology of breast cancer cells will also be discussed. The molecular mechanisms involved in the anti-cancer activities of numerous polyphenols, against a wide range of breast cancer cells, in vitro and in vivo, will be explained in detail.

The interplay between autophagy and apoptosis in the anti-cancer activity of polyphenols will also be highlighted. In addition, the potential of polyphenols to target cancer stem cells (CSCs) via various mechanisms will be explained. Recently, the use of natural products as chemotherapeutics and chemopreventive drugs to overcome the side effects and resistance that arise from using chemical-based agents has garnered the attention of the scientific community. Polyphenol research is considered a promising field in the treatment and prevention of breast cancer.

Polyphenol-Rich Foods in the Mediterranean Diet are Associated with Better Cognitive Function in Elderly Subjects at High Cardiovascular Risk

“Increased consumption of antioxidant-rich foods in general and of polyphenols in particular is associated with better cognitive performance in elderly subjects at high cardiovascular risk. The results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline.”

Plant Polyphenol Antioxidants and Oxidative Stress

“Thus, polyphenols probably protect LDL oxidation in vivo with significant consequences in atherosclerosis. and also protect DNA from oxidative damage with important consequences in the age-related development of some cancers.”

Effects of polyphenolic antioxidants on exercise-induced oxidative stress

“However, in response to strenuous exercise, the polyphenol-supplemented test showed a smaller increase in plasma TBARS and CK than the placebo test.”

Polyphenols and Aging

“Our understanding of aging is constantly evolving, but there is great interest in using polyphenol organic compounds to modify or retard the aging process.”

Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects – A review

“Phenolic compounds, ubiquitous in plants, are an essential part of the human diet and are of considerable interest due to their antioxidant properties and potential beneficial health effects.”

Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

“Phenolic compounds including phenolic acids, flavonoids and proanthocyanidins are widely distributed in plants as a protective mechanism against biotic and abiotic stresses.”

Antiglycative and neuroprotective activity of colon‐derived polyphenol catabolites

“Some polyphenolic catabolites, generated in vivo in the colon, were able in vitro to counteract two key features of diabetic complications, i.e. protein glycation and neurodegeneration. These observations could lead to a better control of these events, which are usually correlated with hyperglycemia.”

Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis

“This Review gives answers from a chemical perspective, summarizes the state of the art, and highlights the most significant advances in the field of polyphenol research.”

Polyphenols and Human Health: A Prospectus

“We summarize the recent findings concerning the effects of polyphenols on human health, analyze the current limitations at pitfalls, and propose future directions for research.”

Distinct mechanisms underlie distinct polyphenol‐induced neuroprotection

“In conclusion, polyphenolic compounds inhibit glutamate‐induced toxicity. Each polyphenolic compound, however, exerts its protection by distinctive mechanisms. Combination of these effects might enhance the protective effect and could counter ischemic diseases or neurodegeneration. “

200:1 = 300 1/8 tsp servings

20:1 = 72 1/2 tsp servings

INGREDIENTS & science

Alkanet (Alkanna tinctoria)

Primary Polyphenols / Flavonoids

pulegone (22.27%)

1,8-cineole (13.03%)

α-terpinyl acetate (6.87%)

isophytol (6.83%)

Source:
https://link.springer.com/article/10.1007/s10068-010-0168-x