Within Traditional Chinese medicine the fruits from this plant contain a very cooling nature and can serve to reduce swelling and bleeding. It has long been utilized as a treatment for fever and restlessness as well as insomnia.
It is said if you use the powder and mix it with an egg white it can be used to treat traumatic injuries, sprains, and bruises.
The effects of the geniposide and gardenia yellow obtained on sleep latency period and sleep time of mice were investigated to evaluate their sedative activities.
These results demonstrate that the gardenia yellow from Cape Jasmine Fruit possesses potent sedative activity.
Regulate Metabolism - This study is aimed at analyzing how exercise and gardenia affect hormones that regulate energy metabolism by having middle aged, obese women exercise and take gardenia simultaneously.
The obtained conclusion is as follows: The %fat and WHR has decreased further in the gardenia+exercise group and the exercise group as compared with the control group.
As a result of this study, all the treatment groups were found to have an improvement effect of research variables in general; therefore, the single treatment and complex treatment for the middle-aged obese women were found to have a positive impact on body composition, adjusting factors for energy metabolism.
In particular, in the case of visceral fat area that is the major risk factor for metabolic disease of middle-aged obese women, it was found to have decreased further in the complex treatment group than the gardenia group; therefore, the complex treatment was found to be more advantageous.
Anxiety Relief - Ethanol extract of Yueju pill, a Traditional Chinese Medicine herbal formula widely used to treat mood disorders, demonstrates rapid antidepressant effects similar to ketamine, likely via instant enhancement of brain-derived neurotrophic factor (BDNF) expression in the hippocampus.
The antidepressant response started at 2 hours after GJ administration. Similar to Yueju and ketamine, a single administration of GJ significantly reduced the number of escape failures in the learned helplessness test.
These findings suggest that GJ has rapid antidepressant effects, which are associated with the elevated expression of BDNF in the hippocampus. In Yueju formula, Yue represents GJ, as this study demonstrates the primary role of GJ in rapid antidepressant efficacy of Yueju.
The GJE extract, ursolic acid and genipin showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effects on the growth of Helicobacter pylori (H. pylori), which are almost equivalent to positive control compounds.
Taken together, GJE extract and its constituents might have antigastritic activities, associated with the antioxidant activities, acid-neutralizing capacities, and anti-H. pylori action.
The present study provided a new approach to enhance the stability of protein-emulsified nanoemulsions and to control the lipase digestibility of lipid droplets through spontaneous cross-linking of the interfacial layer with genipin, a functional ingredient isolated from the fruit of Gardenia jasminoides E.
Interestingly, the intestinal digestibility of lipid droplets was delayed very significantly (p < 0.01) after cross-linking the interfacial casein layer with genipin, which was enhanced by the increase in genipin/casein mass ratio and cross-linking time.
Pain Relief - Neuropathic pain is a severe health problem for which there is a lack of effective therapy. Ozone and Gardenia fruits have been used separately in pain relief for many years; however, their underlying mechanisms remain unclear.
To investigate the pain‑relieving effects of combined ozone and Gardenia, a chronic constriction sciatic nerve injury (CCI) rat model was constructed and treated with ozone and gardenoside (Ozo&Gar), which is a compound found in Gardenia fruits.
These results indicated that the mechanism underlying the pain‑relieving effects of ozone and gardenoside may be mediated by inhibition of P2X3 and P2X7 purine receptors in the DRG.
This finding suggested that ozone and gardenoside may be considered potential drug candidates that target P2X3 and P2X7 purine receptors.