Adipose tissue, often referred to as fat, plays a crucial role in our health by storing energy, regulating hormones, and insulating our bodies. However, as we age or experience obesity, adipose tissue undergoes a complex change known as senescence. This process creates senescent cells that release a harmful cocktail of molecules called the Senescence-Associated Secretory Phenotype (SASP). SASP disrupts the healthy functioning of adipose tissue. It promotes inflammation, hinders the formation of new fat cells,and disrupts the body's ability to regulate blood sugar. This dysfunction contributes to a cascade of age-related diseases including type 2 diabetes, heart disease, and even Alzheimer's. Understanding how SASP and adipose tissue senescence interact is a promising avenue for researchers seeking to develop interventions to promote healthy aging and combat chronic diseases. Exercise prevents diet-induced cellular senescence in adipose tissue Physiological aging: links among adipose tissue dysfunction, diabetes, and frailty Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses Aging and adipose tissue: potential interventions for diabetes and regenerative medicine Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities The emerging role of senescent cells in tissue homeostasis and pathophysiology Cellular senescence and the senescent secretory phenotype in age-related chronic diseases JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice Aging-related inflammation in osteoarthritis Cellular senescence in type 2 diabetes: a therapeutic opportunity The fat cell senescence hypothesis: a mechanism responsible for abrogating the resolution of inflammation in chronic disease Feast and famine: adipose tissue adaptations for healthy aging Macrophages in age-related chronic inflammatory diseases Proposed metabolic vicious circle in patients with large myocardial infarcts and high plasma-free-fatty-acid concentrations Perspective: targeting the JAK/STAT pathway to fight age-related dysfunction Effect of low-dose rapamycin on senescence markers and physical functioning in older adults with coronary artery disease: results of a pilot study. Systemic DNA damage response and metabolic syndrome as a premalignant state Stem cell senescence and regenerative paradigms Cellular senescence in ageing, age-related disease and longevity Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic Cellular senescence in aging and age-related disease: from mechanisms to therapy Deleted in B reast C ancer 1 regulates cellular senescence during obesity Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues Mitochondrial dysfunction induces senescence with a distinct secretory phenotype Impact of growth hormone on regulation of adipose tissue Senescence-associated secretory phenotype (SASP) involvement in the development of cancer, aging, and age related diseases Clearance of p16Ink4a-positive senescent

The ketogenic diet is a high-fat, adequate-protein, low-carbohydrate diet that in medicine is used primarily to treat difficult-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates. Normally, the carbohydrates contained in food are converted into glucose, which is then transported around the body and is particularly important in fueling brain function. However, if little carbohydrate remains in the diet, the liver converts fat into fatty acids and ketone bodies. The ketone bodies pass into the brain and replace glucose as an energy source. An elevated level of ketone bodies in the blood, a state known as ketosis, leads to a reduction in the frequency of epileptic seizures.[1] Around half of children and young people with epilepsy who have tried some form of this diet saw the number of seizures drop by at least half, and the effect persists even after discontinuing the diet.[2] Some evidence indicates that adults with epilepsy may benefit from the diet, and that a less strict regimen, such as a modified Atkins diet, is similarly effective.[1] Potential side effects may include constipation, high cholesterol, growth slowing, acidosis, and kidney stones.[3] The original therapeutic diet for paediatric epilepsy provides just enough protein for body growth and repair, and sufficient calories[Note 1] to maintain the correct weight for age and height. The classic therapeutic ketogenic diet was developed for treatment of paediatric epilepsy in the 1920s and was widely used into the next decade, but its popularity waned with the introduction of effective anticonvulsant medications. This classic ketogenic diet contains a 4:1 ratio by weight of fat to combined protein and carbohydrate. This is achieved by excluding high-carbohydrate foods such as starchy fruits and vegetables, bread, pasta, grains, and sugar, while increasing the consumption of foods high in fat such as nuts, cream, and butter.[1] Most dietary fat is made of molecules called long-chain triglycerides (LCTs). However, medium-chain triglycerides (MCTs)—made from fatty acids with shorter carbon chains than LCTs—are more ketogenic. A variant of the classic diet known as the MCT ketogenic diet uses a form of coconut oil, which is rich in MCTs, to provide around half the calories. As less overall fat is needed in this variant of the diet, a greater proportion of carbohydrate and protein can be consumed, allowing a greater variety of food choices.[4][5] In 1994, Hollywood producer Jim Abrahams, whose son's severe epilepsy was effectively controlled by the diet, created the Charlie Foundation for Ketogenic Therapies to further promote diet therapy. Publicity included an appearance on NBC's Dateline program and ...First Do No Harm (1997), a made-for-television film starring Meryl Streep. The foundation sponsored a research study, the results of which—announced in 1996—marked the beginning of renewed scientific interest in the diet.[1] Possible therapeutic uses for the ketogenic diet have been studied for many additional neurological disorders, some of which include: Alzheimer's disease, amyotrophic lateral sclerosis, headache, neurotrauma, pain, Parkinson's disease, and sleep disorders.[6] - wiki SCIENTIFIC STUDIES 10 Graphs That Show The Power Of A Ketogenic Diet 10 Patients, 10 Years–Long Term Follow-Up Of Cardiovascular Risk Factors In Glut1 Deficiency Treated With Ketogenic Diet Therapies: A Prospective, Multicenter … 10 Questions About The Ketogenic Diet 113 Ketogenic Diet Services At Children'S Hospital Across The United Kingdom 31P-Nmr Study Of Brain Metabolism In The Rat Model Of The Ketogenic Diet 3T

Urolithin A is a natural molecule that has been found to downregulate androgen receptor activation and suppress the growth of prostate cancer. It is a metabolite derived from ellagic acid, which is found in various fruits and nuts. Some of the top foods and herbs that contain ellagic acid and can potentially produce urolithin A include: 1. Pomegranates: Pomegranate juice and seeds are rich sources of ellagic acid, which can be metabolized into urolithin A in the gut. 2. Raspberries: Raspberries are another fruit that contains ellagic acid and can potentially produce urolithin A. 3. Walnuts: Walnuts are a type of nut that contains ellagic acid and can contribute to the production of urolithin A. 4. Strawberries: Strawberries are known to contain ellagic acid, which can be converted into urolithin A. 5. Blackberries: Blackberries are also a good source of ellagic acid and can potentially produce urolithin A. The health benefits of urolithin A include: 1. Anti-cancer properties: Urolithin A has been shown to inhibit cell proliferation and induce apoptosis in various cancer cell lines, including prostate cancer cells. It targets the androgen receptor signaling axis, which is crucial for the growth and progression of prostate cancer. 2. Anti-inflammatory effects: Urolithin A has been found to possess anti-inflammatory properties, which can help reduce inflammation in the body and potentially protect against chronic diseases associated with inflammation. 3. Antioxidant activity: Urolithin A exhibits antioxidant activity, which can help neutralize harmful free radicals and protect cells from oxidative damage. 4. Gut health benefits: Urolithin A is produced by the gut microbiota through the metabolism of ellagic acid. It has been shown to have beneficial effects on gut health by promoting the growth of beneficial bacteria and reducing inflammation in the gut. … emblica L.) Fruits Ameliorate Vascular Smooth Muscle Cell Dysfunction in Hyperglycemia: An Underlying Mechanism Involved in Ellagitannin Metabolite Urolithin A A natural molecule, Urolithin A, downregulates androgen receptor activation and suppresses growth of prostate cancer A Novel Candidate for Prevention and Treatment of Atherosclerosis: Urolithin B Decreases Lipid Plaque Deposition in apoE−/− Mice and Increases Early Stages of … Activation of the miR-34a-Mediated SIRT1/mTOR Signalling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice An increased autophagic flux contributes to the anti-inflammatory potential of Urolithin A in macrophages Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism Antiaging Effects of Urolithin A on Replicative Senescent Human Skin Fibroblasts Antimelanogenic effect of Urolithin A and urolithin B, the colonic metabolites of ellagic acid, in B16 melanoma cells Antiproliferative activity of the ellagic acid-derived gut microbiota isoUrolithin A and comparison with its Urolithin A isomer: the role of cell metabolism Antiproliferative activity of the ellagic acid-derived gut microbiota isoUrolithin A and comparison with its Urolithin A isomer: the role of cell metabolism Antiproliferative effect of Urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2. 2.15 cells by targeting Lin28a/let-7a axis Bioactivity screening for xylopic

Zerumbone Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid Zerumbone Studies in sesquiterpenes—XVI: Zerumbone, a monocyclic sesquiterpene ketone Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice Anti-inflammatory effect of Zerumbone on acute and chronic inflammation models in mice Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary Zerumbone isolated from Zingiber zerumbet Zerumbone induces apoptosis in T-acute lymphoblastic leukemia cells In vitro ultramorphological assessment of apoptosis induced by Zerumbone on (HeLa) Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect Zerumbone, an HIV-inhibitory and cytotoxic sesquiterpene of Zingiber aromaticum and Z. zerumbet Anticancer and antimicrobial activities of Zerumbone from Characterization of the inclusion complex of Zerumbone with hydroxypropyl-β-cyclodextrin Chemistry of Zerumbone. 2. Regulation of ring bond cleavage and unique antibacterial activities of Zerumbone derivatives Preliminary analysis of the antinociceptive activity of Zerumbone Zerumbone abolishes NF-κB and IκBα kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis … Antitumor effects of Zerumbone from Zingiber zerumbet in P-388D1 cells in vitro and in vivo Attractive reactivity of a natural product, Zerumbone Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation … Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells Suppression of dextran sodium sulfate-induced colitis in mice by Zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive … Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas‐and mitochondria‐mediated pathway Key cell signaling pathways modulated by Zerumbone: role in the prevention and treatment of cancer Nuclear magnetic resonance spectroscopy. The conformational mobility of humulene and Zerumbone In vitro covalent binding proteins of Zerumbone, a chemopreventive food factor Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer Chemistry of Zerumbone. 1. Simplified isolation, conjugate addition reactions, and a unique ring contracting transannular reaction of its dibromide Zerumbone inhibits interleukin-6 and induces apoptosis and cell cycle arrest in ovarian and cervical cancer cells Zerumbone abolishes RANKL-induced NF-κB activation, inhibits osteoclastogenesis, and suppresses human breast cancer–induced bone loss in athymic nude mice Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by Zerumbone from the rhizomes of the … Zerumbone, a Southeast Asian ginger sesquiterpene, induced apoptosis of pancreatic carcinoma cells through p53 signaling pathway Anticancer activity of natural compound (Zerumbone) extracted from Zingiber zerumbet in human HeLa cervical cancer cells The chemistry of Zerumbone. Part 5: Structural transformation of the dimethylamine derivatives Antibacterial and antimutagenic activities of novel Zerumbone analogues Zerumbone, an anti‐inflammatory phytochemical, induces expression of proinflammatory cytokine genes in human colon adenocarcinoma cell

  Ursolic Acid 23-Hydroxy Ursolic acid Protects Atherosclerosis-Prone Mice From Monocyte Dysfunction 27-O-(E)-P-Coumaric Acyl Ursolic acid Via Jnk/Sapk Signal Pathway Regulates Apoptosis Of Human Breast Cancer Mda-Mb-231 Cell Line 27-P-Cumaroxy-Ursolsäure, Ein Neuer Inhaltsstoff Von Ilex Aquifolium L.[1]/27-P-Cumaroxy Ursolic acid-A New Constituent Of Ilex Aquifolium L.[1] 2D Raman Spectroscopy As An Alternative Technique For Distinguishing Oleanoic Acid And Ursolic acid 3D-Qsar And Docking Studies On Ursolic acid Derivatives For Anticancer Activity Based On Bladder Cell Line T24 Targeting Nf-Kb Pathway Inhibition 858. Triterpenoids From New Zealand Plants. Isolation Of Ursolic acid From Gaultheria Subcorymbosa Col. A Bioinformatic And Mechanistic Study Elicits The Antifibrotic Effect Of Ursolic acid Through The Attenuation Of Oxidative Stress With The Involvement Of Erk, Pi3K … A Comparative Study For The Extraction Methods And Solvent Selection For Isolation, Quantitative Estimation And Validation Of Ursolic acid In The Leaves Of … A Comparative Study Of The Separation Of Oleanolic Acid And Ursolic acid In Prunella Vulgaris By High-Performance Liquid Chromatography And Cyclodextrin-Modified … A Comparative Study On The Isolation And Cerium (Iv) Ammonium Nitrate Mediated Oxidative Transformation Of Oleanolic Acid And Ursolic acid A Comparison Of The Effects Of Ursolic acid And L-Leucine Supplementation On Igf-1 Receptor And Akt-Mtor Signaling In Response To Resistance Exercise In Trained … A Convenient Separation Of Ursolic And Oleanolic Acid A functionalized multi-walled carbon nanotube-based composite monolith as a solid-phase extraction adsorbent for on-line purification and enrichment of Ursolic acid in medicinal plants A High Content Drug Screen Identifies Ursolic acid As An Inhibitor Of Amyloid Β Protein Interactions With Its Receptor Cd36 A Hydrophilic Conjugate Approach Toward The Design And Synthesis Of Ursolic acid Derivatives As Potential Antidiabetic Agent A Metal Organic Framework Polymer Monolithic Column As A Novel Adsorbent For On-Line Solid Phase Extraction And Determination Of Ursolic acid In Chinese Herbal … A Myrtus Communis Extract Enriched In Myrtucummulones And Ursolic acid Reduces Resistance Of Propionibacterium Acnes Biofilms To Antibiotics Used In Acne … A New Synthetic Ursolic acid Derivative Iua With Anti-Tumor Efficacy Against Osteosarcoma Cells Via Inhibition Of Jnk Signaling Pathway A Novel Co-Drug Of Aspirin And Ursolic acid Interrupts Adhesion, Invasion And Migration Of Cancer Cells To Vascular Endothelium Via Regulating Emt And Egfr … A Novel Form Of Melanoma Apoptosis Resistance: Melanogenesis Up-Regulation In Apoptotic B16-F0 Cells Delays Ursolic acid-Triggered Cell Death A Novel Synthetic Ursolic acid Derivative Inhibits Growth And Induces Apoptosis In Breast Cancer Cell Lines A Pentacyclic Triterpene Natural Product, Ursolic acid And Its Prodrug Us597 Inhibit Targets Within Cell Adhesion Pathway And Prevent Cancer Metastasis A Phase I Pharmacokinetic Study Of Ursolic acid Nanoliposomes In Healthy Volunteers And Patients With Advanced Solid Tumors A Phase I Trial To Evaluate The Multiple-Dose Safety And Antitumor Activity Of Ursolic acid Liposomes In Subjects With Advanced Solid Tumors A Preliminary Investigation Of Ursolic acid In Cell Suspension Culture Of Salvia Officinalis A Rapid Tandem Mass Spectrometric Assay For Determination Of Ursolic acid–Application To Analysis Of Ursolic acid In Four Species Of Staphylea L. And