Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors Studies on α-glucosidase inhibitors development: magic molecules for the treatment of carbohydrate mediated diseases Newer insights into the drug delivery approaches of α-glucosidase inhibitors Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors Synthesis of andrographolide derivatives: a new family of α-glucosidase inhibitors Rapid screening and identification of α‐glucosidase inhibitors from mulberry leaves using enzyme‐immobilized magnetic beads coupled with HPLC/MS and NMR Interaction of antidiabetic α‐glucosidase inhibitors and gut bacteria α‐glucosidase Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges α-Glucosidase inhibitors prevent diet-induced increases in intestinal sugar transport in diabetic mice Discovery of novel α-glucosidase inhibitors based on the virtual screening with the homology-modeled protein structure Oxindole based oxadiazole hybrid analogs: Novel α-glucosidase inhibitors Polyoxomolybdates as α-glucosidase inhibitors: Kinetic and molecular modeling studies α-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton First Identification of α-Glucosidase Inhibitors from Okra (Abelmoschus Esculentus) Seeds Synthesis and bioevaluation of glycosyl ureas as α-glucosidase inhibitors and their effect on mycobacterium α-Glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum Mini-Special Issue paper Management of diabetic patients with hypoglycemic agents α-Glucosidase inhibitors and their use in clinical practice Antioxidants and α-glucosidase inhibitors from Ipomoea batatas leaves identified by bioassay-guided approach and structure-activity relationships Triazoloquinazolines as a new class of potent α-glucosidase inhibitors: in vitro evaluation and docking study Thielavins A, J and K: α-Glucosidase inhibitors from MEXU 27095, an endophytic fungus from Hintonia latiflora New novel α–glucosidase inhibitors produced by microbial conversion A Determination of Potential α-Glucosidase Inhibitors from Azuki Beans (Vigna angularis) α-Glucosidase Inhibitors from a Xylaria feejeensis Associated with Hintonia latiflora Acylated flavonol monorhamnosides, α-glucosidase inhibitors, from Machilus philippinensis α-Glucosidase Inhibitors from Vauquelinia corymbosa α-Glucosidase Inhibitors from Clove (Syzgium aromaticum) Discovery of novel oxindole derivatives as potent α-glucosidase inhibitors Fruit by-products: The potential natural sources of antioxidants and α-glucosidase inhibitors Microbial α-glucosidase inhibitors: chemistry, biochemistry, and therapeutic potential α-Glucosidase inhibitors from Commelina communis Five-membered iminocyclitol α-glucosidase inhibitors: synthetic, biological screening and in silico studies α-Glucosidase inhibitors from brown rice bound phenolics extracts (BRBPE): Identification and mechanism New α-glucosidase inhibitors from the resins of Boswellia species with structure–glucosidase activity and molecular docking studies Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors Triterpenes as α-glucosidase inhibitors from Fagus hayatae Effect of two α-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors Comparative study of dietary flavonoids with different structures as α-glucosidase inhibitors and insulin sensitizers Hetarylcoumarins: synthesis and biological evaluation as potent α-glucosidase inhibitors Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC …
Comparative review of dipeptidyl peptidase‐4 inhibitors and sulphonylureas Pharmacology of dipeptidyl peptidase-4 inhibitors: similarities and differences Dipeptidyl peptidase‐4 (DPP‐4) inhibitors for type 2 diabetes mellitus Safety of dipeptidyl peptidase 4 inhibitors: a perspective review Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors Dipeptidyl peptidase‐4 inhibitors in the treatment of type 2 diabetes: a comparative review Whey proteins as source of dipeptidyl dipeptidase IV (dipeptidyl peptidase-4) inhibitors Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4) Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions Comparative clinical pharmacokinetics of dipeptidyl peptidase-4 inhibitors The nonglycemic actions of dipeptidyl peptidase-4 inhibitors Dipeptidyl peptidase-4 (DPP-4) inhibitors in the management of diabetes Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus A review of dipeptidyl peptidase‐4 inhibitors. Hot topics from randomized controlled trials Dipeptidyl peptidase-4 inhibitors and bone fractures: a meta-analysis of randomized clinical trials Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes Dipeptidyl peptidase-4 inhibitors: Novel mechanism of actions Tolerability of dipeptidyl peptidase-4 inhibitors: a review Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes Dipeptidyl peptidase-4 inhibitors: 3 years of experience Efficacy and safety of dipeptidyl peptidase-4 inhibitors in type 2 diabetes: meta-analysis Dipeptidyl peptidase‐4 inhibitors for the treatment of type 2 diabetes mellitus Dipeptidyl peptidase-4 inhibitors and heart failure: a meta-analysis of randomized clinical trials Predictors of response to dipeptidyl peptidase‐4 inhibitors: evidence from randomized clinical trials Emerging role of dipeptidyl peptidase-4 inhibitors in the management of type 2 diabetes Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety Dipeptidyl peptidase‐4 inhibitors and cardiovascular risk: a meta‐analysis of randomized clinical trials Overview of the gliptin class (dipeptidyl peptidase-4 inhibitors) in clinical practice Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus Dipeptidyl peptidase‐4 inhibitors for the treatment of type 2 diabetes: focus on sitagliptin Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes Dipeptidyl peptidase‐4 inhibitors and cardiovascular outcomes: meta‐analysis of randomized clinical trials with 55,141 participants Cardiovascular effects of dipeptidyl peptidase-4 inhibitors in diabetic patients: a meta-analysis Dipeptidyl‐peptidase‐4 inhibitors and pancreatic cancer: a cohort study Exposure to dipeptidyl‐peptidase‐4 inhibitors and COVID‐19 among people with type 2 diabetes: a case‐control study Differences in the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors between Asians and non-Asians: a systematic review and meta-analysis Role of dipeptidyl peptidase 4 inhibitors in antidiabetic treatment Effects on lipid profile of dipeptidyl peptidase 4 inhibitors, pioglitazone, acarbose, and sulfonylureas: meta-analysis of placebo-controlled trials Clinical implications of cardiovascular preventing pleiotropic effects of dipeptidyl peptidase-4 inhibitors Longer term safety of dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes mellitus: systematic review and meta‐analysis Dipeptidyl peptidase-4 inhibitors cause bullous pemphigoid in diabetic patients: report of two cases The incretin
Nutrient-sensing mechanisms and pathways Nutrient sensing and signaling: NPKS Nutrient-sensing mechanisms across evolution Perspective: hexosamines and nutrient sensing Nutrient sensing and inflammation in metabolic diseases Structure of the nutrient-sensing hub GATOR2 Nutrient sensing and metabolic decisions Nutrient sensing, metabolism, and cell growth control Nutrient sensing in plant meristems Hexosamines as mediators of nutrient sensing and regulation in diabetes TOR signaling and nutrient sensing Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae Regulation of tissue growth through nutrient sensing The unfolded protein response in nutrient sensing and differentiation Neuronal regulation of homeostasis by nutrient sensing The metabolic impact of small intestinal nutrient sensing Nutrient sensing in the gut: new roads to therapeutics? Nutrient sensing and the oxidative stress response Hypothalamic nutrient sensing in the control of energy homeostasis Minireview: nutrient sensing and the regulation of insulin action and energy balance The TOR kinases link nutrient sensing to cell growth The “Real-Time” revolution for in situ soil nutrient sensing Regulation of reproduction and longevity by nutrient-sensing pathways Nutrient sensing and TOR signaling in yeast and mammals Role of placental nutrient sensing in developmental programming Nutrient sensing and signalling in plants: potassium and phosphorus Nutrient sensing in cancer The eukaryotic plasma membrane as a nutrient-sensing device Nutrient sensing, autophagy, and diabetic nephropathy Nutrient-sensing pathways and metabolic regulation in stem cells Nutrient sensing and signalling by the gut Nutrient-sensing nuclear receptors coordinate autophagy A nutrient-sensing pathway regulates leptin gene expression in muscle and fat With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging Nutrient sensing and the circadian clock AMPK and TOR: the yin and yang of cellular nutrient sensing and growth control Molecular disruption of hypothalamic nutrient sensing induces obesity Gut microbiota, nutrient sensing and energy balance Integration of nutrient sensing in fish hypothalamus Nutrient sensing: another chemosensitivity of the olfactory system Nutrient sensing, signal transduction and immune responses The role of placental nutrient sensing in maternal-fetal resource allocation Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy Control of YAP/TAZ activity by metabolic and nutrient-sensing pathways Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals p62 is a key regulator of nutrient sensing in the mTORC1 pathway γδ T cells regulate the intestinal response to nutrient sensing The emerging role of mTORC1 signaling in placental nutrient-sensing mTOR couples cellular nutrient sensing to organismal metabolic homeostasis Nutrient sensing modulates malaria parasite virulence eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy Autophagy-nutrient sensing pathways in diabetic complications Nutrient sensing: what can we learn from different tastes about the nutrient contents in today's foods? Nutrient-sensing mechanisms in the gut as therapeutic targets for diabetes Nutrient sensing systems in fish: impact on food intake regulation and energy homeostasis Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing Modeling metabolic homeostasis and nutrient sensing in Drosophila: implications for aging and metabolic diseases Nutrient sensing, growth and senescence
Thiazolidinediones Nonhypoglycemic effects of thiazolidinediones Thiazolidinediones Thiazolidinediones: an update The mode of action of thiazolidinediones Metabolic and additional vascular effects of thiazolidinediones Thiazolidinediones in the treatment of insulin resistance and type II diabetes How safe is the use of thiazolidinediones in clinical practice? Unraveling the mechanism of action of thiazolidinediones Insulin resistance and its treatment by thiazolidinediones. A meta-analysis comparing the effect of thiazolidinediones on cardiovascular risk factors Use of thiazolidinediones and fracture risk Thiazolidinediones as anti-cancer agents Thiazolidinediones in type 2 diabetes mellitus: current clinical evidence Effect of thiazolidinediones on body weight in patients with diabetes mellitus Thiazolidinediones and fractures in men and women Thiazolidinediones: a new class of antidiabetic drugs Thiazolidinediones and liver toxicity. Protection of the kidney by thiazolidinediones: an assessment from bench to bedside Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis Thiazolidinediones: a 2010 perspective Thiazolidinediones: effects on insulin resistance and the cardiovascular system Thiazolidinediones and cardiovascular outcomes in older patients with diabetes Pleiotropic effects of thiazolidinediones The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones Hepatotoxicity with thiazolidinediones: is it a class effect? Hepatotoxicity of the thiazolidinediones Thiazolidinediones-mechanisms of action Thiazolidinediones and blood lipids in type 2 diabetes Thiazolidinediones and heart failure: a teleo-analysis Thiazolidinediones: metabolic actions in vitro Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects Thiazolidinediones and inflammation Mechanisms by which thiazolidinediones enhance insulin action Comparative cardiovascular effects of thiazolidinediones: systematic review and meta-analysis of observational studies The safety of thiazolidinediones Considerations for management of fluid dynamic issues associated with thiazolidinediones Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study Hepatotoxicity of thiazolidinediones Thiazolidinediones and the risk of edema: a meta-analysis Thiazolidinediones: a comparative review of approved uses Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells Thiazolidinediones, peripheral edema, and type 2 diabetes: incidence, pathophysiology, and clinical implications Thiazolidinediones improve β-cell function in type 2 diabetic patients The effect of thiazolidinediones on BMD and osteoporosis Thiazolidinediones for the treatment of type 2 diabetes Visfatin is an adipokine, but it is not regulated by thiazolidinediones Pharmacokinetic interactions with thiazolidinediones Thiazolidinediones and fractures: evidence from translating research into action for diabetes Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling. Thiazolidinediones as anti‐inflammatory and anti‐atherogenic agents Thiazolidinediones: the case for early use PPARγ-independent antitumor effects of thiazolidinediones The role of thiazolidinediones in non-alcoholic steatohepatitis–a systematic review and meta analysis New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications Thiazolidinediones–some recent developments Thiazolidinediones, insulin resistance and obesity: finding a balance Pleiotropic effects of thiazolidinediones: taking a look beyond antidiabetic activity Thiazolidinediones can
Antilipolytic effect of insulin in isolated fat cells of the rat The Antilipolytic action of insulin in obese subjects with resistance to its glucoregulatory action Effect of cell size on lipolysis and Antilipolytic action of insulin in human fat cells Antilipolytic action of insulin on fat cells Systemic resistance to the Antilipolytic effect of insulin in black and white women with visceral obesity Various phosphodiesterase subtypes mediate the in vivo Antilipolytic effect of insulin on adipose tissue and skeletal muscle in man Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the Antilipolytic action of insulin in isolated rat adipocytes Antilipolytic action of insulin: role of cAMP phosphodiesterase activation The Antilipolytic effect of insulin in human adipose tissue in obesity, diabetes mellitus, hyperinsulinemia, and starvation Adipose tissue lipolysis revisited (again!): lactate involvement in insulin Antilipolytic action Insensitivity of large rat adipocytes to the Antilipolytic effects of insulin Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the Antilipolytic action of insulin Pro12Ala Polymorphism in the Peroxisome Proliferator–Activated Receptor-γ2 Gene Is Associated With Increased Antilipolytic insulin Sensitivity insulin receptor down-regulation and impaired Antilipolytic action of insulin in diabetic patients after pancreas/kidney transplantation Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms A longitudinal study of the Antilipolytic effect of insulin in women following bariatric surgery Antilipolytic effects of insulin and adenylate cyclase inhibitors on isolated human fat cells. Effect of the Antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes … Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and Antilipolytic agents. Role of phosphodiesterase III in the Antilipolytic effect of insulin in vivo Influence of obesity on the Antilipolytic effect of insulin in isolated human fat cells obtained before and after glucose ingestion. insulin-mimetic compound hexaquis (benzylammonium) decavanadate is Antilipolytic in human fat cells Glucocorticoids antagonize tumor necrosis factor-α-stimulated lipolysis and resistance to the Antilipolytic effect of insulin in human adipocytes Evidence for marked sensitivity to the Antilipolytic action of insulin in obese maturity-onset diabetics The Antilipolytic effects of insulin and epidermal growth factor in rat adipocytes are mediated by different mechanisms Molecular mechanisms involved in the Antilipolytic action of insulin: phosphorylation and activation of a particulate adipocyte cAMP phosphodiesterase Antilipolytic actions of insulin on basal and hormone-induced lipolysis in rat adipocytes Overactivation of the endocannabinoid system alters the Antilipolytic action of insulin in mouse adipose tissue Comparative studies of the Antilipolytic effect of insulin and adenosine in the perifused isolated fat cell The Antilipolytic effect of insulin in human adipocytes requires activation of the phosphodiesterase Lowering of triglycerides by gemfibrozil affects neither the glucoregulatory nor Antilipolytic effect of insulin in type 2 (non-insulin-dependent) diabetic patients Glucose stimulation of the Antilipolytic effect of insulin in humans Resistance to the Antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but
Hormone-sensitive lipase (HSL) is an important enzyme in the process of lipolysis, which breaks down stored fats into free fatty acids and glycerol in fat cells. It helps release energy by acting on fats stored in the body, particularly during times when energy is needed, like fasting or exercise. HSL is activated by hormones such as adrenaline, which signal the body to start breaking down fat. This enzyme plays a vital role not only in providing energy but also in maintaining overall metabolic health, and it is involved in other processes like hormone production. Its proper function is crucial for energy balance and can impact conditions like obesity and diabetes. Hormone-sensitive lipase Hormone-sensitive lipase-new roles for an old enzyme Molecular mechanisms regulating Hormone-sensitive lipase and lipolysis Molecular mechanisms regulating Hormone-sensitive lipase and lipolysis Hormone-sensitive lipase knockouts Adipose triglyceride lipase and Hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state Hormone-sensitive lipase: sixty years later Hormone-sensitive lipase-a multipurpose enzyme in lipid metabolism. Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, Hormone-sensitive lipase, and diacylglycerol-O-acyltransferases Letting lipids go: Hormone-sensitive lipase Adipose triglyceride lipase and Hormone-sensitive lipase are the major enzymes in adipose tissue triacylglycerol catabolism Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13. 3 Contribution of adipose triglyceride lipase and Hormone-sensitive lipase to lipolysis in hMADS adipocytes The adipose tissue phenotype of Hormone‐sensitive lipase deficiency in mice Perilipin A is essential for the translocation of Hormone-sensitive lipase during lipolytic activation Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis Comparative studies of the role of Hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis Phosphorylation of bovine Hormone‐sensitive lipase by the AMP‐activated protein kinase: A possible antilipolytic mechanism Structure–function relationships of Hormone‐sensitive lipase Identification and role of the basal phosphorylation site on Hormone‐sensitive lipase Interaction of rat Hormone-sensitive lipase with adipocyte lipid-binding protein Hormonal regulation of Hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. Lipoprotein lipase and Hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy Expression of Hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle Null mutation in Hormone-sensitive lipase gene and risk of type 2 diabetes Phosphorylation of Hormone-sensitive lipase by cyclic AMP-dependent protein kinase. Domain-structure analysis of recombinant rat Hormone-sensitive lipase A novel lipase belonging to the Hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis Coordinated regulation of Hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat … Decreased expression and function of adipocyte Hormone-sensitive lipase in subcutaneous fat cells of obese subjects Mechanism of Hormone-stimulated lipolysis in adipocytes: translocation of Hormone-sensitive lipase to the lipid storage droplet. A role for Hormone-sensitive lipase in glucose-stimulated insulin secretion: a study in Hormone-sensitive lipase-deficient mice Inhibition of Hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituents
NAD+ kinase—a review A methanol/dioxygen biofuel cell that uses NAD+-dependent dehydrogenases as catalysts: application of an electro-enzymatic method to regenerate nicotinamide … Glyceraldehyde-3-phosphate Dehydrogenase Selectively Binds AU-rich RNA in the NAD+-binding Region (Rossmann Fold)(∗) Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates Structural determination of a cyclic metabolite of NAD+ with intracellular Ca2+-mobilizing activity ADP-ribosyl cyclase: an enzyme that cyclizes NAD+ into a calcium-mobilizing metabolite. Control of the shift from homolactic acid to mixed-acid fermentation in Lactococcus lactis: predominant role of the NADH/NAD+ ratio Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues Inhibitor and NAD+ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling, The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation … NAD+-Dependent Enzyme Electrodes: Electrical Contact of Cofactor-Dependent Enzymes and Electrodes Prostaglandin-Metabolizing Enzymes During Pregnancy: Characterization of NAD+-Dependent Prostaglandin Dehydrogenase, Carbonyl Reductase, and … Roles of glycerol and glycerol-3-phosphate dehydrogenase (NAD+) in acquired osmotolerance of Saccharomyces cerevisiae A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer … Electroreduction of NAD+ to enzymatically active NADH at poly (neutral red) modified electrodes … of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by … A molecular mechanics force field for NAD+ NADH, and the pyrophosphate groups of nucleotides Causes and elimination of erratic blanks in enzymatic metabolite assays involving the use of NAD+ in alkaline hydrazine buffers: improved conditions for the assay of … … dismutase, catalase, glutathione reductase, inorganic peroxides, TBA-reactive material, GSH/GSSG, NADPH/NADP+ and NADH/NAD+ in Drosophila melanogaster Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with … Purification and properties of the NAD+-dependent (type D) and O2-dependent (type O) forms of rat liver xanthine dehydrogenase A gene encoding sn‐glycerol 3‐phosphate dehydrogenase (NAD+) complements an osmosensitive mutant of Saccharomyces cerevisiae Purification and properties of the NAD+-xylitol-dehydrogenase from the yeast Pichia stipitis Osmoregulation in Saccharomyces cerevisiae studies on the osmotic induction of glycerol production and glycerol 3-phosphate dehydrogenase (NAD+) The mechanism of conversion of rat liver xanthine dehydrogenase from an NAD+-dependent form (type D) to an O2-dependent form (type O) Utilization of Glycerol as a Hydrogen Acceptor by Lactobacillus reuteri: Purification of 1,3-Propanediol:NAD+ Oxidoreductase NAD+ ‐dependent malic enzyme of Rhizobium meliloti is required for symbiotic nitrogen fixation Nicotinamide adenine dinucleotide (NAD+) and related compounds. Electrochemical redox pattern and allied chemical behavior Cloning and characterization of GPD2, a second gene encoding sn‐glycerol 3‐phosphate dehydrogenase (NAD+) in Saccharomyces cerevisiae, and its comparison … Structures of horse liver alcohol dehydrogenase complexed with NAD+ and substituted benzyl alcohols Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly (ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic … The effect of growth conditions on NAD+ and NADH concentrations
Molecular physiology of amylin The role of amylin in the control of energy homeostasis Amylin: history and overview Dose-response for glucagonostatic effect of amylin in rats Polymorphic fibrillar assembly of human amylin Amylin: a novel action in the brain to reduce body weight Analysis of amylin cleavage products provides new insights into the amyloidogenic region of human amylin Amylin decreases meal size in rats Clinical implications of amylin and amylin deficiency Amylin agonists: a novel approach in the treatment of diabetes Missense mutation of amylin gene (S20G) in Japanese NIDDM patients Amylin, food intake, and obesity Subdiaphragmatic vagotomy does not influence the anorectic effect of amylin Degradation of amylin by insulin-degrading enzyme In vitro autoradiographic localization of amylin binding sites in rat brain The role of amylin in the physiology of glycemic control Anorexia following the intrahypothalamic administration of amylin Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans S20G mutant amylin exhibits increased in vitro amyloidogenicity and increased intracellular cytotoxicity compared to wild-type amylin Permeability of the blood-brain barrier to amylin Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus High affinity amylin binding sites in rat brain. Stable and metastable states of human amylin in solution Mechanisms of amylin/leptin synergy in rodent models Roles of amylin in diabetes and in regulation of nutrient load. Expression of the rat amylin (IAPP/DAP) gene. Preclinical pharmacology of pramlintide in the rat: comparisons with human and rat amylin Structure and biology of amylin Full-length rat amylin forms fibrils following substitution of single residues from human amylin Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus. The physiology of amylin and insulin Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin (∗) Atomic structure of the cross‐β spine of islet amyloid polypeptide (amylin) Amylin decreases food intake in mice Central amylin expression and its induction in rat dams Pancreatic amylin as a centrally acting satiating hormone The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin Amyloid fibril formation from full-length and fragments of amylin Dynamic α-helix structure of micelle-bound human amylin Reduction of food intake in rats by intraperitoneal injection of low doses of amylin Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment. Amylin receptors: molecular composition and pharmacology Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight Differential permeability of the blood–brain barrier to two pancreatic peptides: insulin and amylin Pancreatic signals controlling food intake; insulin, glucagon and amylin Amylin deposition in the kidney of patients with diabetic nephropathy An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell … Copper (II)
Adapting proteostasis for disease intervention Biological and chemical approaches to diseases of proteostasis deficiency Proteostasis and aging The proteostasis network and its decline in ageing The biology of proteostasis in aging and disease Pathways of cellular proteostasis in aging and disease Aging as an event of proteostasis collapse Proteostasis impairment in protein-misfolding and-aggregation diseases Quality control of mitochondrial proteostasis Proteostasis control by the unfolded protein response Proteostasis, oxidative stress and aging Molecular chaperones in protein folding and proteostasis Proteostasis in cardiac health and disease Proteostasis and longevity: when does aging really begin? Proteostasis and the aging proteome in health and disease Proteostasis impairment in ALS FoldEco: a model for proteostasis in E. coli Molecular chaperone functions in protein folding and proteostasis Cellular proteostasis in neurodegeneration Protein folding and mechanisms of proteostasis Proteostasis and aging of stem cells Walking the tightrope: proteostasis and neurodegenerative disease Small-molecule proteostasis regulators for protein conformational diseases Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity Proteostasis in complex dendrites Small molecules to improve ER proteostasis in disease Insulin regulation of proteostasis and clinical implications Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging The endolysosomal system and proteostasis: from development to degeneration Endoplasmic reticulum proteostasis impairment in aging Immunoproteasomes are important for proteostasis in immune responses Less is more: improving proteostasis by translation slow down Shaping proteostasis at the cellular, tissue, and organismal level Modeling general proteostasis: proteome balance in health and disease A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease Dysfunction of cellular proteostasis in Parkinson's disease The UFMylation system in proteostasis and beyond Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases–progress and prognosis The contribution of the 20S proteasome to proteostasis The proteostasis boundary in misfolding diseases of membrane traffic Diversity in the origins of proteostasis networks—a driver for protein function in evolution A ribosomal perspective on proteostasis and aging Tailoring of proteostasis networks with heat shock factors Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit Extracellular chaperones and proteostasis Targeting defective proteostasis in the collagenopathies Proteostasis and REDOX state in the heart Endoplasmic reticulum proteostasis in hepatic steatosis HSF1: guardian of proteostasis in cancer Mitochondrial proteostasis in the control of aging and longevity The nascent polypeptide‐associated complex is a key regulator of proteostasis A cellular perspective on conformational disease: the role of genetic background and proteostasis networks A genetic screening strategy identifies novel regulators of the proteostasis network Nutrient‐driven O‐GlcNAc in proteostasis and neurodegeneration Systemic stress signalling: understanding the cell non-autonomous control of proteostasis Molecular chaperones and neuronal proteostasis Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy Regulation of organismal proteostasis by transcellular chaperone signaling Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments Happily (n) ever after: Aging in the context of oxidative stress, proteostasis
AMPK activation: a therapeutic target for type 2 diabetes? AMPK activators–potential therapeutics for metabolic and other diseases AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure Choreography of AMPK activation Use of cells expressing γ subunit variants to identify diverse mechanisms of AMPK activation Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Effect of AMPK activation on muscle glucose metabolism in conscious rats AMP as a low-energy charge signal autonomously initiates assembly of AXIN-AMPK-LKB1 complex for AMPK activation A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma Antileukemic effects of AMPK activators on BCR-ABL–expressing cells Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation A small molecule AMPK activator protects the heart against ischemia–reperfusion injury SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth Berberine suppresses proinflammatory responses through AMPK activation in macrophages Activation of autophagy in human skeletal muscle is dependent on exercise intensity and AMPK activation Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation Predominant α2/β2/γ3 AMPK activation during exercise in human skeletal muscle Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy Berberine-induced apoptotic and autophagic death of HepG2 cells requires AMPK activation Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation Structural basis of AMPK regulation by small molecule activators Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation AICAR, an AMPK activator, has protective effects on alcohol‐induced fatty liver in rats AMPK activation—protean potential for boosting healthspan Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect AMPK activation regulates neuronal structure in developing hippocampal neurons AMPK activation of muscle autophagy prevents fasting-induced hypoglycemia and myopathy during aging AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes AMPK activators suppress cervical cancer cell growth through inhibition of DVL3 mediated Wnt/β-catenin signaling activity Berberine-induced AMPK activation