From wiki: “The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3Kactivation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. There are many known factors that enhance the PI3K/AKT pathway including EGF,shh, IGF-1, insulin, and CaM. The pathway is antagonized by various factors including PTEN,GSK3B, and HB9. In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation.”
”The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.
The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila; fruit fly larva lacking the Hh gene are said to resemble hedgehogs. Hh is one of Drosophila’s segment polarity gene products, involved in establishing the basis of the fly body plan. Larvae without Hh, are short and spiny, resembling the hedgehog animal. The molecule remains important during later stages of embryogenesis and metamorphosis.
Mammals have three Hedgehog homologues, Desert (DHH), Indian (IHH), and Sonic (SHH), of which Sonic is the best studied. The pathway is equally important during vertebrate embryonic development and is therefore of interest in evolutionary developmental biology. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.”
FEATURING: •Aegle marmelos Correa • Agaricus blazei Murill • Aloe emodin • American ginseng extract • Andrographolide • Angelica archangelica • Angelica sinensis extract • Bilberry extract Anthocyanin • Antrodia cinnamomea • Artemisinin Artemisia annua L. (Huanghuahao) • Artepillin C (Brazilian propolis) • Ashwagandha • Astragalus membranaceus extract • Belamcanda chinensis • Berberine (Cortidis rhizoma) • Camellia sinensis • Carnosine • Carnosol • Cat’s Claw (Uncaria tomentosa) • Catharantus roseus • Celastrol (derived from Trypterygium wilfordii) • Celastrus Orbiculatus • Chenopodium ambrosioides L • Cinnamomum cassia • Commiphora myrrha • Coprinus comatus • Corchorus olitorius • Cordycepin • Cordyceps militaris • Crocus sativus (Saffron) • Curcuma wenyujin • Curcumin • Cycloastragenol • Cynara cardunculus • Dalbergia odorifera • EGCG • Eleutherococcus senticosus • Emblica officinalis • Epimedium koreanum • Euonymus alatus • Flammulina velutipes (enokitake) • Fomes fomentarius • Frankincense (Boswellia carteri) • Fucus vesiculosus (seaweed) • Gambogic acid (Garcinia hanburyi) • Ganoderma lucidum • Ganoderma tsugae • Genistein • Ginkgo Biloba • Ginseng extract• ginsenoside Rh • Glycyrrhiza glabra • Grape Seed Extract • Grifola frondosa — Maitake • Gynostemma pentaphylla extract • Hedyotis Diffusa Willd extract • Hericium erinaceus — Lions mane • Hibiscus sabdariffa • Honokiol • Humulone • Icariin • Inonotus obliquus — Chaga • Lactarius flavidulus • Lapacho (Tabebuia impetiginosa) • Lithospermum erythrorhizon • Livistona chinensis • Lupeol • Luteolin • Lycium barbarum—Wolfberry (goji) • Lycopene • Magnolia officinalis (Chinese magnolia tree) • Mangiferin (Mangifera indica) • Momordica cochinchinensis Spreng • Moringa oleifera • Noni (Morinda citrifolia) • Ocimum gratissimum oil • Oldenlandia diffusa • Oleanolic acid • Oleuropein • Orthosiphon Stamineus • Osthol (Cnidium monnieri) • Oyster extract • Panax notoginseng extract • Patrinia scabiosaefolia • Pfaffia paniculata —Brazilian Ginseng (Suma) • Phellinus linteus • Phycocyanin • Phyllanthus urinaria • Pleurotus ostreatus • Pleurotus pulmonarius • Plumbago zeylanica L • Podophyllotoxin (Podophyllyum emodi) • Polygonum cuspidatum • Polyozellus multiplex • Poria cocos • Prunella vulgaris extract • Punica granatum (pomegranate) • Punicalagin (from pomegranate extract) • Quercetin • Rabdosia rubescens • Reineckia carnea (RCE ) • Resveratrol • Rhodiola rosea • Rhus verniciflua • Russula lepida • Salvia miltiorrhiza extract • Salvia officinalis • Schizophyllum commune • Scrophularia ningpoensis • Scutellaria baicalensis Georgi • Scutellaria barbata • Sea Cucumber (Cucumaria frondos) • Shiitake— Lentinula edodes mycelia extract • Silymarin• a flavonolignan from milk thistle (Silybum marianum) • Strychnos nux vomica L extract • Thymoquinone (Nigella sativa) • Trifolium pratense L. • Turkey tail mushroom —Trametesversicolor orCoriolusversicolor • Ursolic acid • Wedelia chinensis • Wogonin (Scutellariae radix) • Xanthohumol • Zerumbone (From Zingiber zerumbet) • Zingiber officinale Roscoe • Zizyphus mauritiana
WARNING: As with any supplement, consult your medical practitioner prior to using this product if you are pregnant, may become pregnant, breastfeeding, taking medication, other dietary supplements or have a medical condition.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
*Daily Value has not been established
”It’s like firing 125 arrows at the bullseye—one is bound to hit the mark.”
100g = 300 1/8 tsp servings
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Aegle marmelos yCorrea
Agaricus blazei Murill
American ginseng extract
Angelica sinensis extract