ACB: PI3K/AKT/mTOR/Sonic Hedgehog Pathway Inhibitor

“PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit cancer and tumor growth.”

“Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals”

“Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment”

“Inhibition of PI3K/Akt/mTOR Signaling by Natural Products”

“mTOR Inhibition: From Aging to Autism and Beyond“

From wiki: “The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3Kactivation phosphorylates and activates AKT, localizing it in the plasma membrane.^[1] AKT can have a number of downstream effects such as activating CREB,^[2] inhibiting p27,^[3] localizing FOXO in the cytoplasm,^[3] activating PtdIns-3ps,^[4] and activating mTOR^[3] which can affect transcription of p70 or 4EBP1.^[3] There are many known factors that enhance the PI3K/AKT pathway including EGF,^[5]shh,^[2] IGF-1,^[2] insulin,^[3] and CaM.^[4] The pathway is antagonized by various factors including PTEN,^[6]GSK3B,^[2] and HB9.^[5] In many cancers, this pathway is overactive, thus reducing apoptosis and allowing proliferation.”

”The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.^[1]

FEATURING: •Aegle marmelos Correa • Agaricus blazei Murill • Aloe emodin • American ginseng extract • Andrographolide • Angelica archangelica • Angelica sinensis extract • Bilberry extract Anthocyanin • Antrodia cinnamomea • Artemisinin Artemisia annua L. (Huanghuahao) • Artepillin C (Brazilian propolis) • Ashwagandha • Astragalus membranaceus extract • Belamcanda chinensis • Berberine (Cortidis rhizoma) • Camellia sinensis • Carnosine • Carnosol • Cat’s Claw (Uncaria tomentosa) • Catharantus roseus • Celastrol (derived from Trypterygium wilfordii) • Celastrus Orbiculatus • Chenopodium ambrosioides L • Cinnamomum cassia • Commiphora myrrha • Coprinus comatus • Corchorus olitorius • Cordycepin • Cordyceps militaris • Crocus sativus (Saffron) • Curcuma wenyujin • Curcumin • Cycloastragenol • Cynara cardunculus • Dalbergia odorifera • EGCG • Eleutherococcus senticosus • Emblica officinalis • Epimedium koreanum • Euonymus alatus • Flammulina velutipes (enokitake) • Fomes fomentarius • Frankincense (Boswellia carteri) • Fucus vesiculosus (seaweed) • Gambogic acid (Garcinia hanburyi) • Ganoderma lucidum • Ganoderma tsugae • Genistein • Ginkgo Biloba • Ginseng extract• ginsenoside Rh • Glycyrrhiza glabra • Grape Seed Extract • Grifola frondosa — Maitake • Gynostemma pentaphylla extract • Hedyotis Diffusa Willd extract • Hericium erinaceus — Lions mane • Hibiscus sabdariffa • Honokiol • Humulone • Icariin • Inonotus obliquus — Chaga • Lactarius flavidulus • Lapacho (Tabebuia impetiginosa) • Lithospermum erythrorhizon • Livistona chinensis • Lupeol • Luteolin • Lycium barbarum—Wolfberry (goji) • Lycopene • Magnolia officinalis (Chinese magnolia tree) • Mangiferin (Mangifera indica) • Momordica cochinchinensis Spreng • Moringa oleifera • Noni (Morinda citrifolia) • Ocimum gratissimum oil • Oldenlandia diffusa • Oleanolic acid • Oleuropein • Orthosiphon Stamineus • Osthol (Cnidium monnieri) • Oyster extract • Panax notoginseng extract • Patrinia scabiosaefolia • Pfaffia paniculata —Brazilian Ginseng (Suma) • Phellinus linteus • Phycocyanin • Phyllanthus urinaria • Pleurotus ostreatus • Pleurotus pulmonarius • Plumbago zeylanica L • Podophyllotoxin (Podophyllyum emodi) • Polygonum cuspidatum • Polyozellus multiplex • Poria cocos • Prunella vulgaris extract • Punica granatum (pomegranate) • Punicalagin (from pomegranate extract) • Quercetin • Rabdosia rubescens • Reineckia carnea (RCE ) • Resveratrol • Rhodiola rosea • Rhus verniciflua • Russula lepida • Salvia miltiorrhiza extract • Salvia officinalis • Schizophyllum commune • Scrophularia ningpoensis • Scutellaria baicalensis Georgi • Scutellaria barbata • Sea Cucumber (Cucumaria frondos) • Shiitake— Lentinula edodes mycelia extract • Silymarin• a flavonolignan from milk thistle (Silybum marianum) • Strychnos nux vomica L extract • Thymoquinone (Nigella sativa) • Trifolium pratense L. • Turkey tail mushroom —Trametesversicolor orCoriolusversicolor • Ursolic acid • Wedelia chinensis • Wogonin (Scutellariae radix) • Xanthohumol • Zerumbone (From Zingiber zerumbet) • Zingiber officinale Roscoe • Zizyphus mauritiana

WARNING: As with any supplement, consult your medical practitioner prior to using this product if you are pregnant, may become pregnant, breastfeeding, taking medication, other dietary supplements or have a medical condition.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

*Daily Value has not been established

ACB 

200:1 CONCENTRATION

”It’s like firing 125 arrows at the bullseye—one is bound to hit the mark.” 

100g = 300 1/8 tsp servings

In stock and shipping now!

Aegle marmelos yCorrea

1. In vitro antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Aegle marmelos Correa
2. Antioxidant and hepatoprotective potential of Aegle marmelos Correa. against CCl4-induced oxidative stress and early tumor events
3. Taxol, an anticancer drug produced by an endophytic fungus Bartalinia robillardoides Tassi, isolated from a medicinal plant, Aegle marmelos Correa ex Roxb.
4. Radioprotective Effects of Aegle marmelos (L.) Correa (Bael): A Concise Review
5. A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats
6. Fruit extract of Aegle marmelos protects mice against radiation-induced lethality
7. Hepatoprotective effect of the pulp/seed of Aegle marmelos correa ex Roxb against carbon tetrachloride induced liver damage in rats
8. Aegle marmelos (L.) Correa (Bael) and Its Phytochemicals in the Treatment and Prevention of Cancer
9. Healing effects of Aegle marmelos (L.) Correa fruit extract on experimental colitis
10. Effect of Aegle marmelos Correa. (Bael) fruit extract on tissue antioxidants in streptozotocin diabetic rats
11. Antioxidant, anticancer, antibacterial activities and GC-MS analysis of aqueous extract of pulps of Aegle marmelos (L.) Correa
12. Evaluation of Aegle marmelos L. Fruit Extract in Reduction of Mobile Phone Induced Oxidative Stress in Mice, Mus musculus
13. Aegle marmelos (L.) CORREA Inhibits the Proliferation of Transplanted Ehrlich Ascites Carcinoma in Mice
14. Aegle marmelos and Emblica officinalis, used in traditional Asian medicine in the treatment of tissue inflammation and cancer. To this aim, we evaluated the potential of the selected plant extracts to affect proliferation and differentiation of ERα-negative MDA-MB-231 breast cancer cells,
15. Therapeutic potential of Aegle marmelos (L.)-An overview
16. Aegle marmelos (L.) Correa (Bael) and Its Phytochemicals in the Treatment and Prevention of Cancer
17. Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial dependent apoptosis against pancreatic cancer cells
18. Effect of Aegle marmelos leaf extract on N-methyl N-nitrosourea-induced hepatocarcinogensis in Balb/c mice
19. Pharmacognostic standardisation and antiproliferative activity of Aegle marmelos (L.) Correa leaves in various human cancer cell lines
20. Aegle Marmelos In this work the extraction of the Aegeline is taken up along with the separation of its enantiomers, its crystal structure
    and activity of individual isomers on cervical cancer
21. Aegle marmelos … to treat cancer) has been shown to increase the
    level and function of natural killer cells in cervical cancer patients undergoing
22. (Aegle marmelos) leaves and … The nanoparticles were tested for cytotoxicity
    on two human cancer cell lines, HeLa (human cervical cancer)

Agaricus blazei Murill

1. Tumor-specific cytocidal and immunopotentiating effects of relatively low molecular weight products derived from the basidiomycete, Agaricus blazei Murill.
2. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action
3. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis
4. Quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy
5. Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer
6. Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro
7. Secretion of TNF-α, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro
8. Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis
9. Isolation of an anti‐angiogenic substance from Agaricus blazei Murill: Its antitumor and antimetastatic actions
10. The mushroom Agaricus blazei Murill elicits medicinal effects on tumor, infection, allergy, and inflammation
11. The Polar High Molecular Weight Fraction of the Agaricus blazei Murill Extract, AndoSan™, Reduces the Activity of the Tumor-Associated Protease
12. Influences of the Extract of Agaricus Blazei Murill on Hepatitis, Cancer and Immunity
13. Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo
14. An Alternative Medicine, Agaricus blazei, May Have Induced Severe Hepatic Dysfunction in Cancer Patients
15. Measuring perceived effects of drinking an extract of basidiomycetes Agaricus blazei murill: a survey of Japanese consumers with cancer
16. A novel medicinal mushroom blend which consists of a blend of mushroom mycelia from the species Agaricus blazei, demonstrates cytostatic effects through the inhibition of cell proliferation and cell cycle arrest at the G2/M phase of highly invasive human breast cancer cells
17. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) “Himematsutake” and its mechanisms in tumor-bearing mice.
18. Medicinal Properties and Clinical Effects of Culinary-Medicinal Mushroom Agaricus blazei Murrill (Agaricomycetideae) (Review)
19. Effect of water-soluble proteoglycan isolated from Agaricus blazei on the maturation of murine bone marrow-derived dendritic cells
20. The effects of dietary supplementation with Agaricales mushrooms and other medicinal fungi on breast cancer: evidence-based medicine
21. Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells
22. Anti-cancer Property of Aegle marmelos Leaves: Finding the Facts Against Hepatocellular Carcinoma HepG2 cell.
23. Nontargeted analysis and cancer cells cytotoxicity of Aegle marmelos Correa Ex Roxb.
24. ANTI-MICROBIAL AND ANTI-CANCER ACTIVITY OF AEGLE MARMELOS AND GAS CHROMATOGRAPHY COUPLED SPECTROMETRY ANALYSIS OF THEIR CHEMICAL CONSTITUENTS
25. A xylorhamnoarabinogalactan I from Bael (Aegle marmelos L.) modulates UV/DMBA induced skin cancer via galectin-3 & gut microbiota
26. Anticancer ability of Jamur Dewa Extract (Agaricus blazei Murill) On Cervical
    Cancer cells as a Reading Material For Traditional Medicine.
27. which included 61 cervical cancer patients, stages Ia–IIIb, received either carboplatin and etoposide or carboplatin and Taxol every 3 weeks with or without oral Agaricus blazei (as Agaricus blazei Murill
28. Immunomodulatory Effects of the Agaricus blazei Murrill-Based Mushroom Extract AndoSan in Patients with Multiple Myeloma Undergoing High Dose Chemotherapy and Autologous Stem Cell Transplantation: A Randomized, Double Blinded Clinical Study
29. The Agaricus blazei-based mushroom extract, AndosanTM, has immuno-suppressive and anti-inflammatory effects when used as supplement to multiple myeloma patients receiving high-dose chemotherapy and autologous bone marrow transplantation
30. Antitumor and immunomodulating effects of the mushroom product AndosanTM, based on the Basidiomycetes mushroom Agaricus blazei Murill, with special focus on multiple myeloma

Aloe emodin

1. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma
2. Protein kinase C involvement in aloe‐emodin‐and emodin‐induced apoptosis in lung carcinoma cell
3. Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma
4. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors
5. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
6. Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells
7. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
8. The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line
9. Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells
10. Evaluation of the anti-angiogenic effect of aloe-emodin
11. Suppressed Transformation and Induced Differentiation of HER-2/neu-overexpressing Breast Cancer Cells by Emodin
12. Tyrosine Kinase Inhibitor Emodin Suppresses Growth of HER-2/neu-overexpressing Breast Cancer Cells in Athymic Mice and Sensitizes These Cells to the Inhibitory Effect of Paclitaxel
13. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ERα Inhibition
14. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells
15. Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a
16. Emodin Down-Regulates Androgen Receptor and Inhibits Prostate Cancer Cell Growth
17. Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: The mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1
18. Emodin induces apoptosis in human prostate cancer cell LNCaP
19. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2
20. Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4
21. Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3
22. Erratum to “Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3”
23. Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (ΛΨm)
24. Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis
25. Protein Kinase C Delta-mediated Cytoskeleton Remodeling Is Involved in Aloe-emodin-induced Photokilling of Human lung cancer Cells
26. Abstract 133: Aloe-emodin as a potential lead targets lung cancer stem cells
27. P-052 Aloe-emodin inhibit n-acetyltransferase activity and geneexpression in human lung cancer cell line (NCI-H209)
28. Glycosylated Aloe Emodin Inhibits the Growth of Human lung cancer Cells in vitro and in vivo
29. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB
30. Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human colon cancer Cells
31. The Effect of Aloe-emodin on Multiplication Cycle and Apoptosis of Colon Carcinoma Cancer Cell SW480
32. Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in colorectal cancer Cells
33. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells
34. Aloe-emodin inhibited N-acetylation and DNA adduct of 2-aminofluorene and arylamine N-acetyltransferase gene expression in mouse leukemia L 1210 cells
35. Aloe-emodin as antiproliferative and differentiating agent on human U937 monoblastic leukemia cells
36. Studies of the interaction between Aloe-emodin and DNA and preparation of DNA biosensor for detection of PML-RARα fusion gene in acute promyelocytic leukemia
37. Pro-apoptic effect of Aloe emodin on human thyroid cancer cell K1.
38. Emodin impairs radioresistance of human osteosarcoma cells by suppressing sonic Hedgehog signaling
39. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation
40. Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
41. Curcumin and Emodin Down-Regulate TGF-β Signaling Pathway in Human Cervical Cancer Cells
42. Combination of aloe-emodin with radiation enhances radiation effects and improves differentiation in human cervical cancer cells
43. Emodin Induces Apoptosis of Human Tongue Squamous Cancer SCC-4 Cells through Reactive Oxygen Species and Mitochondria-dependent Pathways
44. Anticancer potential of emodin
45. Emodin, Aloe-emodin and Rhein Induced DNA Damage and Inhibited DNA Repair Gene Expression in SCC-4 Human Tongue Cancer Cells
46. The distinct mechanisms of the antitumor activity of emodin in different types of cancer (Review)
47. [Inhibitory effect of emodin on the growth of cervical cancer in tumor-transplanted mice and underlying mechanism].
48. Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9
49. Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma
50. Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma
51. Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo
52. [Effect of emodin on proliferation and cell cycle of human oral squamous carcinoma Tca8113 cells in vitro].
53. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines
54. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
55. [Inhibitory and Inducing Effects of Emodin Derivative E11 on Proliferation and Apoptosis of Multiple Myeloma Cells].

American ginseng extract

1. American ginseng: potential structure–function relationship in cancer chemoprevention
2. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA
3. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots
4. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF‐7 breast cancer cell growth
5. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line
6. Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs.
7. Cisplatin’s tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng
8. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells
9. Extraction-dependent effects of American ginseng (Panax quinquefolium) on human breast cancer cell proliferation and estrogen receptor activation
10. Panax ginseng—a non-organ-specific cancer preventive?
11. Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell
12. Rh2 from Ginseng Synergistically Enhances Paclitaxel or Mitoxantrone in Prostate Cancer Models
13. Generation of ginsenosides Rg3 and Rh2 from North American ginseng
14. Experimental therapy of prostate cancer with novel natural product anti‐cancer ginsenosides
15. Protective Effects of Asian Dietary Items on Cancers – Soyand Ginseng
16. Extraction-Dependent Effects of American Ginseng (Panax quinquefolium) on Human Breast Cancer Cell Proliferation and Estrogen Receptor Activation
17. American Ginseng Transcriptionally Activates p21mRNA in BreastCancer Cell Lines
18. American Ginseng Inhibits Induced COX-2 and NFKB Activation in Breast Cancer Cells
19. Chemical and pharmacological studies of saponins with a focus on American ginseng
20. The influence of lead and arsenite on the inhibition of human breast cancer MCF-7 cell proliferation by American ginseng root (Panax quinquefolius L.)
21. Uses of north american ginseng fractions for treating leukemia
22. American ginseng and its interactions with Imatinib mesylate (Gleevec) on K562 chronic myeloid leukemia cells
23. The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells
24. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR
25. Role of cyclin inhibitor protein p21 in the inhibition of HCT116 human colon cancer cell proliferation by American ginseng (Panax quinquefolius) and its constituents
26. A Key Role of microRNA-29b for the Suppression of colon cancer Cell Migration by American Ginseng
27. Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis
28. A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated colon cancer: Anti-inflammatory and Proapoptotic Mechanisms
29. Metabonomic Profiling Reveals Cancer Chemopreventive Effects of American Ginseng on Colon Carcinogenesis in ApcMin/+ Mice
30. Role of intestinal microbiome in American ginseng-mediated colon cancer protection in high fat diet-fed AOM/DSS mice
31. Hexane Fraction of American Ginseng Suppresses Colitis and colon cancer—Letter
32. Red American ginseng enhances the effect of fluorouracil on human colon cancer cells via both paraptosis and apoptosis pathways
33. Hexane Fraction of American Ginseng Suppresses Colitis and colon cancer—Response
34. Abstract 1248: Gut microbiome and metabolomic profiling reveal preventive effects of American ginseng on inflammation-associated colon cancer
35. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells
36. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells
37. American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells
38. [Progress in anti-cancer research of American ginseng: with an example of colorectal cancer].
39. Abstract B28: Chemoprevention of colorectal cancer: Does American ginseng play a role?
40. Abstract LB-168: A hexane fraction of American ginseng suppresses colon cancer associated with colitis
41. Ginseng and cancer
42. Effect of sun ginseng potentiation on epirubicin and paclitaxel-induced apoptosis in human cervical cancer cells
43. Functional role of ginseng-derived compounds in cancer
44. Potential Anti-Cancer Activities of Furanodiene, A Sesquiterpene from Curcuma wenyujin
45. Improved anticancer effect of ginseng extract by microwave-assisted processing through the generation of ginsenosides Rg3, Rg5 and Rk1
46. Ginseng nanoparticles: a budding tool for cancer treatment
47. Determination of Ginsenosides Content in Korean Ginseng Seeds and Roots by High Performance Liquid Chromatography
48. Notoginsenoside R7 suppresses cervical cancer via PI3K/PTEN/Akt/mTOR signaling
49. Ginsenoside‑Rg5 induces apoptosis and DNA damage in human cervical cancer cells
50. Ginseng: A medical Enigma

Andrographolide

1. Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway
2. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata
3. Apoptosis inducing effect of andrographolide on TF-47 human breast cancer cell line
4. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
5. DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells
6. Andrographolide, an herbal medicine, inhibits interleukin-6 expression and suppresses prostate cancer cell growth
7. The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma
8. Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis
9. Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression
10. Andrographolide down-regulates hypoxia-inducible factor-1α in human non-small cell lung cancer A549 cells
11. Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells
12. Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth
13. Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G1 arrest and apoptosis
14. Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line
15. Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
16. Andrographolide, an Herbal Medicine, Inhibits Interleukin-6 Expression and Suppresses Prostate Cancer Cell Growth
17. Andrographolide Targets Androgen Receptor Pathway in Castration-Resistant Prostate Cancer
18. Taxifolin Enhances Andrographolide-Induced Mitotic Arrest and Apoptosis in Human Prostate Cancer Cells via Spindle Assembly Checkpoint Activation
19. Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells
20. Morphological and Biochemical Changes of Andrographolide-induced Cell Death in Human Prostatic Adenocarcinoma PC-3 Cells
21. Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer
22. The HLJ1 -targeting drug screening identified Chinese herb andrographolide that can suppress tumour growth and invasion in non-small-cell lung cancer
23. Andrographolide inhibits the activation of NF‑κB and MMP‑9 activity in H3255 lung cancer cells
24. SRS06, a New Semisynthetic Andrographolide Derivative with Improved Anticancer Potency and Selectivity, Inhibits Nuclear Factor-κB Nuclear Binding in the A549 Non-Small Cell lung cancer Cell Line
25. Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells through blockade of autophagy
26. Effect of Andrographolide on Human lung cancer Cells Proliferation and Invasion-associated Molecular Expression
27. Molecular mechanism of Andrographolide on MMP-9 expression in human lung cancer cells
28. Endoplasmic reticulum stress and IRE-1 signaling cause apoptosis in colon cancer cells in response to andrographolide treatment
29. Andrographolide Exhibits Anti-Invasive Activity against colon cancer Cells via Inhibition of MMP2 Activity
30. Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells
31. Andrographolide suppresses proliferation of human colon cancer SW620 cells through the TLR4/NF‑κB/MMP‑9 signaling pathway
32. In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog
33. Andrographolide Exhibits Anticancer Potential Against Human colon cancer Cells by Inducing Cell Cycle Arrest and Programmed Cell Death via Augmentation of Intracellular Reactive Oxygen Species Level
34. A silyl andrographolide analogue suppresses Wnt/β-catenin signaling pathway in colon cancer
35. Cytotoxic activity of andrographolide in colon cancer through inhibition cox-2 by in silico study
36. Induction of G1 arrest and apoptosis by new benzylidene derivatives of andrographolide in breast and colon cancer cells
37. Effect of andrographolide in inhibition of human colon cancer SW1116 cell.
38. Anticancer Activity of A Silyl Andrographolide Analogue Mediated Through Wnt/β-Catenin Signaling In colon cancer Cells
39. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression
40. Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
41. The anti-cancer activity of an andrographolide analogue functions through a GSK-3β-independent Wnt/β-catenin signaling pathway in colorectal cancer cells
42. Andrographolide Antagonizes TNF-α-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-κB and Src/MAPKs/AP-1 Axis in Human colorectal cancer HCT116 Cells
43. An open-label, randomized, controlled clinical trial to explore the curative effects between the treatment of capecitabine and andrographolide and the single capecitabine in the patients with pathological and/or histologic diagnosed unresectable, advanced, recurrent, and metastatic colorectal cancer.
44. Folate-Functionalized Amphiphilic Chitosan Polymeric Micelles Containing Andrographolide Analogue (3A.1) for colorectal cancer
45. Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemia Jurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways
46. Andrographolide potentiates the antitumor effect of topotecan in acute myeloid leukemia cells through an intrinsic apoptotic pathway
47. Andrographolide pre-treatment enhances the anti-tumor activity of topotecan on acute myeloid leukemia cells in vitro
48. Andrographolide from Andrographis paniculata shows anti-proliferative activity and anti-inflammatory effects in human monocytic leukemia cells
49. Andrographolide and its potent derivative exhibit anticancer effects against imatinib-resistant chronic myeloid leukemia cells by downregulating the Bcr-Abl oncoprotein
50. Abstract 717: The diterpenoid lactone andrographolide (andro) induces apoptosis in all- trans-retinoic-acid (ATRA) resistant acute promyelocytic leukemia (APL) cell lines: Potential therapeutic implications
51. Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore
52. In vivo inhibitory activity of andrographolide derivative ADN-9 against liver cancer and its mechanisms involved in inhibition of tumor angiogenesis
53. Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy
54. Anti-proliferative and Pro-apoptotic Effects from Sequenced Combinations of Andrographolide and Cisplatin on ovarian cancer Cell Lines
55. Effects of andrographolide on invasion and apoptosis of ovarian cancer SKOV-3 cells
56. A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP
57. Andrographolide stimulates osteoblastogenesis and bone formation by inhibiting nuclear factor kappa-Β signaling both in vivo and in vitro
58. Effects of rapeseed meal, terramycin, berberine hydrochloride and andrographolide on thyroid function in fattening swine
59. Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells
60. Inhibition of the JAK-STAT3 pathway by andrographolide enhances chemosensitivity of cancer cells to doxorubicin
61. Activity of Andrographolide and Its Derivatives on HPV16 Pseudovirus Infection and Viral Oncogene Expression in Cervical Carcinoma Cells
62. Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation
63. Broad-spectrum antiviral properties of andrographolide
64. The effect of andrographolide on Human papillomavirus type 16 (HPV16) positive cervical cancer cells (SiHa)
65. Nanoparticle Engineering Enhances Anticancer Efficacy of Andrographolide in MCF-7 Cells and Mice Bearing EAC
66. Synthesis and evaluation of anticancer activity of novel andrographolide derivatives†
67. Andrographolide: A New Plant-Derived Antineoplastic Entity on Horizon
68. Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer

Angelica archangelica

1. The cytotoxic effect of two chemotypes of essential oils from the fruits of Angelica archangelica L.
2. Antitumour activity of Angelica archangelica leaf extract
3. Antiproliferative effect of Angelica archangelica fruits
4. Antioxidant and flavor properties of Angelica sinensis extracts as affected by processing
5. Study of the antimutagenic properties of Angelica archangelica by the micronucleus test
6. An Update on Antitumor Activity of Angelica Species
7. Antitumour activity of Angelica archangelica leaf extract. – NCBI
8. Antitumour activity of Angelica archangelica leaf extract – ResearchGate
9. Antiproliferative Effect of Angelica archangelica Fruits
10. Antitumour Activity of Angelica archangelica Leaf Extract
11. Enhanced accumulation of decursin and decursinol angelate in root cultures and intact roots of Angelica gigas Nakai following elicitation
12. Angelicin inhibits the malignant behaviours of human cervical cancer potentially via inhibiting autophagy
13. Complementary and Alternative Approach to Heal Cancer: A Review
14. Imperatorin efficiently blocks TNF-α-mediated activation of ROS/PI3K/Akt/NF-κB pathway

Angelica sinensis extract

1. Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis
2. Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells
3. Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis
4. Effect of polysaccharides from Angelica sinensis on gastric ulcer healing
5. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
6. The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo
7. Structure of an anti-tumor polysaccharide from Angelica sinensis (Oliv.) Diels
8. The natural compound n‐butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo3
9. Characterizations and anti-tumor activities of three acidic polysaccharides from Angelica sinensis (Oliv.) Diels
10. The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo
11. Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells
12. Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: is it appropriate?
13. Among the top 10 most frequently prescribed CHP for treating breast cancer, seven contained dang qui (Angelica sinensis-radix) and six contained ren shen (Panax ginseng-radix), which are reported to have potential beneficial synergistic effects on breast cancer cells.
14. Estrogenic activity of standardized extract of Angelica sinensis
15. Angelicae sinensis are traditional Chinese herbs, all of which have proven immunomodulatory functions in laboratory‐based research.
16. Epigenetic Reactivation of Nrf2 in Murine Prostate Cancer TRAMP C1 Cells by Natural Phytochemicals Z-Ligustilide and Radix Angelica Sinensis via Promoter CpG Demethylation
17. Angelica sinensis suppresses human lung adenocarcinoma A549 cell metastasis by regulating MMPs/TIMPs and TGF-β1
18. Angelica sinensis (also called danggui in Chinese) is one of the most commonly used traditional herbs in China. It is recommended as a tonic, hemopoetic, spasmolytic, and analgesic drug in clinical practice [4]. In our previous study, n-butylidenephthalide (BP), a compound isolated from Angelica sinensis chloroform extract, exhibits growth inhibitory activity on various human cancer cell lines, including brain, lung and liver cancer cells.
19. Inhibitory effect of Angelica sinensis extract in the presence of 2-hydroxypropyl-β-cyclodextrin
20. Oral administration of Angelica sinensis polysaccharide protects against pancreatic islets failure in type 2 diabetic mice: Pancreatic β-cell apoptosis inhibition
21. [colorectal cancer preventive effect of combined administration of phenolic acids and supercritical extracts from Angelica sinensis].
22. Senescence Effects of Angelica sinensis Polysaccharides on Human Acute Myelogenous leukemia Stem and Progenitor Cells
23. Angelica sinensis polysaccharide induces erythroid differentiation of human chronic myelogenous leukemia k562 cells.
24. [Experimental study on aging effect of Angelica sinensis polysaccharides combined with cytarabine on human leukemia KG1alpha cell lines].
25. Structure characterization and anti-leukemia activity of a novel polysaccharide from Angelica sinensis (Oliv.) Diels
26. [Biological mechanisms of human-derived leukemia stem cells senescence regulated by Angelica sinensis polysaccharide].
27. Effects of combined injection of Angelica sinensis polysaccharide and cytarabine on bone marrow mononuclear cells of transplanted human leukemia mice
28. Angelica sinensis polysaccharide nanoparticles as a targeted drug delivery system for enhanced therapy of liver cancer
29. Angelica sinensis: A Chinese herb for brain cancer therapy
30. A novel polysaccharide, isolated from Angelica sinensis (Oliv.) Diels induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
31. Anti-Cancer Effect of Angelica Sinensis on Women’s Reproductive Cancer
32. Natural Products Reported as Potential Inhibitorsof Uterine Cervical Neoplasia
33. The effects of polysaccharides from the root of Angelica sinensis on tumor growth and iron metabolism in H22-bearing mice
34. Angelica sinensis: A Chinese herb for brain cancer therapy
35. The anticancer effects of ferulic acid is associated with induction of cell cycle arrest and autophagy in cervical cancer cells
36. Medical composition for inhibiting the growth of cancer stem cells

antroquinonol

1. Antroquinonol blocks Ras and Rho signaling via the inhibition of protein isoprenyltransferase activity in cancer cells

Bilberry extract Anthocyanin

1. Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth
2. Anthocyanin-rich extracts inhibit multiple biomarkers of colon cancer in rats
3. Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo
4. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula
5. Structure− function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth
6. Anticancer activities of an anthocyanin-rich extract from black rice against breast cancer cells in vitro and in vivo
7. Antitumor effect of hydrolyzed anthocyanin from grape rinds and red rice
8. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways
9. Anthocyanins and their role in cancer prevention
10. Cranberry and blueberry: evidence for protective effects against cancer and vascular diseases
11. Anthocyanin Extracted from Black Soybean Reduces Prostate Weight and Promotes Apoptosis in the Prostatic Hyperplasia-Induced Rat Model
12. Anthocyanins: Targeting of Signaling Networks in Cancer Cells
13. Anthocyanin Induces Apoptosis of DU-145 Cells In Vitro and Inhibits Xenograft Growth of Prostate Cancer
14. Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma
15. Evaluation of Antiproliferative Activity of Red Sorghum Bran Anthocyanin on a Human Breast Cancer Cell Line (MCF-7)
16. Cytotoxic Effects of Bilberry Extract on MCF7-GFP-Tubulin Breast Cancer Cells
17. Isolation of bioactive constituents from Vaccinium myrtillus (bilberry) fruits and cell cultures β-Sitosterol and the carotenoids lutein and zeaxanthin were identified as components of the active hexane extract, which also exhibited a growth suppressing effect against two human breast cancer cell lines MCF-7 and BT-20.
18. [Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats].
19. Protective effect of anthocyanin-rich extract from bilberry (Vaccinium myrtillus L.) against myelotoxicity induced by 5-fluorouracil
20. Anthocyanins extract from bilberry enhances the therapeutic effect of pollen of Brassica napus L. on stress-provoked benign prostatic hyperplasia in restrained mice
21. Antioxidative efficiency of an anthocyanin rich bilberry extract in the human colon tumor cell lines Caco-2 and HT-29
22. Inhibition of pancreatic cancer cell migration by plasma anthocyanins isolated from healthy volunteers receiving an anthocyanin-rich berry juice
23. Abstract 1615: Anthocyanin-rich black raspberry extract negatively regulates stem cell related molecules, EMT, and pluripotency of pancreatic cancer stem cells
24. Anthocyanin from Mulberry Extract Protects Hyperglycemia-Induced Pancreatic β-cell Apoptosis
25. Bilberry extract (Antho 50) selectively induces redox-sensitive caspase 3-related apoptosis in chronic lymphocytic leukemia cells by targeting the Bcl-2/Bad pathway
26. Anthocyanin-rich bilberry extract induces apoptosis in acute lymphoblastic leukemia cells via redox-sensitive epigenetic modifications
27. Evaluation of anthocyanin levels after consumption of bilberry extract in patients with colorectal cancer and liver metastases
28. Influence of bilberry-derived anthocyanidins on key regulators of colorectal cancer development.
29. Prevention and treatment of familial adenomatous polyposis and colorectal cancer by bilberry-derived anthocyanidins.
30. Antiproliferative and Antioxidant Properties of Anthocyanin Rich Extracts from Blueberry and Blackcurrant Juice
31. Antioxidant Activities of Chokeberry Extracts and the Cytotoxic Action of Their Anthocyanin Fraction on HeLa Human Cervical Tumor Cells
32. Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells
33. Berry Extracts Exert Different Antiproliferative Effects against Cervical and Colon Cancer Cells Grown in Vitro
34. Beyond Conventional Medicine – a Look at Blueberry, a Cancer-Fighting Superfruit
35. Blueberry as a Potential Radiosensitizer for Treating Cervical Cancer
36. Health benefits of anthocyanins and molecular mechanisms: Update from recent decade
37. Cancer prevention with freeze-dried berries and berry components
38. Anthocyanins and Cancer Prevention
39. The studies of cyanidin 3-glucoside-induced apoptosis in human cervical cancer Hela cells and its mechanism

Antrodia cinnamomea

1. Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer
2. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action
3. Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights
4. Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells
5. Review of pharmacological effects of Antrodia camphorata and its bioactive compounds
6. Anti-inflammatory effects of methanol extract of Antrodia cinnamomea mycelia both in vitro and in vivo
7. Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines
8. Antioxidant Properties of Antrodia camphorata in Submerged Culture
9. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
10. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata
11. Inhibition of growth, migration and invasion of human bladder cancer cells by antrocin, a sesquiterpene lactone isolated from Antrodia cinnamomea, and its molecular
12. Ethanol Extracts of Fruiting Bodies of Antrodia cinnamomea Suppress CL1-5 Human Lung Adenocarcinoma Cells Migration by Inhibiting Matrix Metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt Signaling Pathways
13. Ethanol extracts of fruiting bodies of Antrodia cinnamomea exhibit anti-migration action in human adenocarcinoma CL1-0 cells through the MAPK and PI3K/AKT signaling pathways
14. Unique Formosan Mushroom Antrodia camphorata Differentially Inhibits Androgen-Responsive LNCaP and -Independent PC-3 Prostate Cancer Cells
15. Antrodan, A β-glucan obtained from Antrodia cinnamomea mycelia, is beneficial to benign prostate hyperplasia
16. Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model
17. Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
18. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata
19. Novel effect and the mechanistic insights of fruiting body extract of medicinal fungus Antrodia cinnamomea against T47D breast cancer
20. Inhibition of cyclooxygenase-2 and induction of apoptosis in estrogen-nonresponsive breast cancer cells by Antrodia camphorata
21. Identification of Antrocin from Antrodia camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells
22. Anticancer effects on human pancreatic cancer cells of triterpenoids, polysaccharides and 1,3-β-d-glucan derived from the fruiting body of Antrodia camphorata†
23. Inhibition of the survival of pancreatic cancer by cyclohexenone compounds from Antrodia camphorata
24. Antrodia cinnamomea induces autophagic cell death via the CHOP/TRB3/Akt/mTOR pathway in colorectal cancer cells
25. Molecular mechanism of Antrodia cinnamomea sulfated polysaccharide on the suppression of lung cancer cell growth and migration via induction of transforming growth factor β receptor degradation
26. Coenzyme Q0 from Antrodia cinnamomea in Submerged Cultures Induces Reactive Oxygen Species-Mediated Apoptosis in A549 Human lung cancer Cells
27. Antrodia cinnamomea induces anti-tumor activity by inhibiting the STAT3 signaling pathway in lung cancer cells
28. Suppression of Cell Growth, Migration and Drug Resistance by Ethanolic Extract of Antrodia cinnamomea in Human lung cancer A549 Cells and C57BL/6J Allograft Tumor Model
29. Antrodia Cinnamomea Prolongs Survival in a Patient with Small Cell lung cancer
30. Method of preparing bioactive compound from solid-state cultivated Antrodia cinnamomea mycelium for anti-metastasis against lung cancer cells
31. A sulfated glucan from Antrodia cinnamomea reduces Slug expression through regulation of TGFβ/AKT/GSK3β axis in lung cancer
32. 4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells
33. Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor κB pathway.
34. Cytotoxic Effect and Induction of Apoptosis in Human Cervical Cancer Cells by Antrodia camphorata
35. Pinicolol B from Antrodia cinnamomea induces apoptosis of nasopharyngeal carcinoma cells
36. A polysaccharide from Antrodia cinnamomea mycelia exerts antitumor activity through blocking of TOP1/TDP1-mediated DNA repair pathway

Artemisinin Artemisia annua L. (Huanghuahao)

1. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer
2. Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines
3. Inhibitory effect of jaceosidin isolated from Artemisia argyi on the function of E6 and E7 oncoproteins of HPV 16
4. Eupatilin, a Pharmacologically Active Flavone Derived from Artemisia Plants, Induces Apoptosis in Human Gastric Cancer (AGS) Cells
5. Composition and anti-oxidant, anti-cancer and anti-inflammatory activities of Artemisia herba-alba, Ruta chalpensis L. and Peganum harmala L.
6. Anti-inflammatory and immunosuppressive effect of flavones isolated from Artemisia vestita
7. Study ontoxic effects of Artemisisa spp. fractions from Iran on human cancer cell lines
8. Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells
9. Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells
10. Oral artemisinin prevents and delays the development of 7, 12-dimethylbenz [a] anthracene (DMBA)-induced breast cancer in the rat
11. Synthetic Derivatives of Artemisinin and Cancer
12. Ethnopharmacology of Artemisia annua L.: A Review Research studies also report that artemisinin is effective for killing human breast cancer cells.
13. Artemisia Species in Small Ruminant Production: their PotentialAntioxidant and Anthelmintic Effects.
14. Nanocarriers for Delivery of Herbal Based Drugs in Breast Cancer – An Overview
15. An Overview of the Current Development of Phytoremedies for Breast Cancer
16. Role of angiogenic factors of herbal origin in regulation of molecular pathways that control tumor angiogenesis
17. Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients
18. Evaluation of the anticancer activities of pomegranate (Punica granatum) and harmal (Rhazya stricta) plants grown in Saudi arabia
19. Artemisinin as a Chinese medicine, selectively induces apoptosis in pancreatic tumor cell line
20. Potent anticancer activity of the second generation artemisinin-derived trioxane dimers on pancreatic cancer cells.
21. Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for ovarian cancer
22. Artemisinin derivatives inhibit epithelial ovarian cancer cells via autophagy-mediated cell cycle arrest
23. Abstract 470: Artemisinin derivatives synergize with paclitaxel by targeting FOXM1 through Raf/MEK/MAPK signaling pathway in ovarian cancer
24. Artemisinin induced reversal of EMT affects the molecular biological activity of ovarian cancer SKOV3 cell lines
25. Artemisinin inhibits the proliferation, migration, and inflammatory reaction induced by tumor necrosis factor-α in vascular smooth muscle cells through nuclear factor kappa B pathway
26. Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo
27. Use of artemisinin and its derivatives to treat HPV-infected/transformed cells and cervical cancer: a review
28. Selective Radiosensitization of Human Cervical Cancer Cells and Normal Cells by Artemisinin Through the Abrogation of Radiation-Induced G2 Block
29. Study on the radiosensitizing effect of artemisinin on human cervical cancer and corresponding mechanisms.
30. Synthesis of Artemisinin–Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer
31. Molecular alterations induced by artemisinin in HPV-39 infected human cervical cancer cells
32. Artemisinin derivative artesunate induces radiosensitivity in cervical cancer cells in vitro and in vivo