AUTOPHAGY ACTIVATOR

The Most Powerful Science Based Autophagy Activating Formula on the Planet!

MEGA APPETITE SUPPRESSANT! Read the reviews! 

The ULTIMATE fasting companion.

100g bag = 300 1/8 tsp servings.

2-deoxy-d-glucose (2-DG) • 8-Prenylnaringenin • Albatrellus confluens • Alisol B isolated from Alisma orientale • Allicin • Amorphophallus konjac tubor • Anthocyanin extract from black soybean (Glycine max L.) • Apigenin • Apios americana Medik flowers extract • Areca nut • Artemisia vulgaris (mugwort) • Azuki bean (Vigna angularis) extract • Bacopa monnieri • Benzoin gum (Styrax benzoin) • Berberine • Betanin‐Enriched Red Beetroot (Beta vulgaris L.) • Bitter Melon Extract Saponins30% • Brunfelsia grandiflora • Butea monosperma (Lam.) flowers • Buxus sempervirens • Carnosic acid (CA), a polyphenolic diterpene isolated from Rosemary (Rosemarinus officinalis) • Carnosol • Catechin • Celastrol (tripterine) isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) • Celastrus orbiculatus • Cepharanthine (CEP) a biscoclaurine alkaloid extracted from Stephania cepharantha • Chaihu (Radix bupleuri), • Chebulagic acid from Terminalia chebula • Chuan xiong (Rhizoma chuanxiong) • Cichorium intybus Linn. Extract • Clionamine B Isolated from Cliona celata • convallatoxin isolated from Antiaris toxicaria, • Cordycepin • Corynoxine B , isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese), • Cucurbita moschata, variety “long of Naples,” • Curcumin • Dandelion root • Dihydromyricetin (Ampelopsin) • Dimethyl cardamonin isolated from Syzygium samarangense • Dioscin • Docosahexaenoic acid (DHA) • Donglingcao (Rabdosia rubesens), • EGb 761 from Ginkgo biloba extract • Emblica officinalis extract • Evodiamine, an alkaloid isolated from Evodia rutaecarpa • Fenugreek • Fisetin • Fragaria vesca leaves • Fucoidan • Fucoxanthin from Laminaria japonica • Galangin • Ganoderma lucidum • Genistein • Ginger (Zingiber officinale Roscoe) • Gingerol • Ginsenoside 20 (S)-Rg3 • Glucosamine • Glutathione • Gynura formosana Kitam. leaves • Hibiscus sabdariffa Leaf • Honokiol from Magnolia officinalis • Hou po (Cortex magnoliae officinalis) • Hu Zhang (Rhizoma polygoni cuspidati), • Huaier extract • Isorhamnetin from sea buckthorn (Hippophae rhamnoides L.) • Isorhynchophylline (IsoRhy) from Uncaria rhynchophylla • Kaempferol • Luteolin • Matrine • Mung bean (Vigna Radiata) • Muscadine grape skin extract • Myrtillin • Naringin • oblongifolin C from Garcinia yunnanensis Hu • Old Man’s Beard (Usnea barbata) • Oleanolic acid • Onjisaponin B derived from Radix Polygalae • Oridonin • Paclitaxel from pacific yew tree • Panax ginseng • Parthenolide from Feverfew • Phellinus Linteus Extract • Pimenta dioica berries (Allspice) • Piperine • Piperlongumine (PL), from fruit of Long pepper (Piper longum) • Pluchea indica root extract • Plumbagin from Plumbago zeylanica L, Juglans regia, J. cinerea, and J. nigra • Polygonatum cyrtonema Hua • Quercetin • Resveratrol • Rhodiola rosea • Rottlerin from Mallotus philippinensis • Safflower extract • Salidroside • Sarsaparilla (Smilax glabra rhizome) extract • Saussurea lappa extract • Schisandrin A. (Schisandra chinensis fructus) • Silibinin • Tanshinone IIA from the root of Salvia miltiorrhiza Bunge, • Theobroma cacao L • Triptolide (TPL) from Tripterygium wilfordii, • Ursolic acid • Vitamin D3 • Vitamin K2 (MK4) • Vitexin • Wogonin from Scutellaria baicalensis

Click on studies below to learn more:

2-deoxy-d-glucose (2-DG)

1. The wonders of 2‐deoxy‐d‐glucose
2. 2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
3. Mitofusin 2-Deficiency Suppresses Cell Proliferation through Disturbance of autophagy
4. 2-Deoxy-d-glucose enhances TRAIL-induced apoptosis in human gastric cancer cells through downregulating JNK-mediated cytoprotective autophagy
5. Synergy of 2-deoxy-d-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis
6. Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo
7. Synergistic increase in efficacy of a combination of 2-deoxy-d-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis
8. 2‐deoxy‐D‐glucose augments photodynamic therapy induced mitochondrial caspase‐independent apoptosis and energy‐mediated autophagy
9. Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy
10. Differential effects of the glycolysis inhibitor 2‐deoxy‐D‐glucose on the activity of pro‐apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response
11. Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through autophagy and EDC3 Protein in Insulinoma INS-1E Cells
12. 2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells
13. Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death
14. FF when combined with 2-DG lowers ATP levels and inhibits autophagy
15. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
16. Glucosamine induces autophagy via an mtor-independent pathway
17. Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats
18. Deconvoluting the role of reactive oxygen species and autophagy in human diseases
19. Hexokinase-II Positively Regulates Glucose Starvation-Induced autophagy through TORC1 Inhibition
20. Inhibition of autophagy by 3‑MA enhances endoplasmic reticulum stress‑induced apoptosis in human nasopharyngeal carcinoma cells
21. 2-DG led to a higher expression of Beclin-1, a crucial component of the autophagy pathway
22. Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism
23. Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC
24. autophagy induced by 2-deoxy-D-glucose suppresses intracellular multiplication of Legionella pneumophila in A/J mouse macrophages
25. The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells
26. Abstract 1044: A combination of cisplatin and 2-deoxy-d-glucose results in synergistic cell death in both normoxia and hypoxia by the attenuation of autophagy
27. Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-d-Glucose against Human Glioma Cells through Blunting of autophagy
28. autophagy and reversed 2‐DG‐mediated suppression
29. Adipokinetic hormone-induced lipolysis in the fat body of an insect, Manduca sexta: synthesis of sn-1, 2-diacylglycerols.
30. The differential effects of these stresses on the rise in glycerol as an index of lipolysis implies that the sympathetic circuitry was par- tially disabled vis-a-vis the response to 2-DG,
31. It is concluded that 2-DG-induced thermogenesis and lipolysis are primarily dependent on P-adrenergic stimulation
32. In conclusion, unlike the vertebrate system in which lipolysis is regulated solely by the cAMP system, in the insect fat body, both cAMP and calcium are relevant messengers in the stimulation of sn-1,2-DG production.
33. hyperphagia and in the day-time a low rate of glucose utilization, lipolysis and hypophagia, it might be suspected that 2-DG
34. These data therefore support a defect in glucose sensing as a possible initiator of obesity and type 2 diabetes … 50 For instance, glucagon secretion can be induced by the direct injection of 2-deoxy-D-glucose (2-DG)
35. in as much as mice deficient in either protein did not develop obesity (Flier, 2004 … chain fatty acid has been found to inhibit food intake (Obici et al., 2002), whereas central administration of 2-deoxyglucose (2-DG
36. 2–DG-lnduced eating and that serotoninergic and dopaminerglc anorectic drugs modulate the eating responses of rats to cerebral glucoprivatlon induced by insulin or by 2–DG differently suggesting that glucose dysmetabollsm in obesity
37. Early response evaluation of therapy with AP23573 (an mtor inhibitor) in sarcoma using [18F]2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan
38. Intrinsically lower AKT, mtor and HIF activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines
39. Abstract 4081: Sensitivity of gastric cancer cell lines against 2-deoxy-D-glucose is independent of PI3K/mtor inhibition
40. The Relevance of mtor and Hypoxia Inducible Factor to 2-Deoxy-D-Glucose Toxicity in Lung Cancer Cell Lines Under Hypoxia
41. Inhibition of mtor increases cytotoxicity of 2-deoxy-D-glucose in small cell lung cancer under hypoxia
42. Abstract 1422: Dietary 2-deoxy-D-glucose (2-DG) reduces TLR-4 induced acute inflammation and prevents chronic inflammation driven carcinogenesis
43. Contribution of oxidative stress to radiosensitization by a combination of 2-DG and 6-AN in human cancer cell line

8-PRENYLNARINGENIN (FROM HOPS EXTRACT)

1. Flavonoid-induced autophagy in hormone sensitive breast cancer cells
2. Treatment of PC‐3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase‐independent form of cell death
3. Prenylated chalcones and flavonoids for the prevention and treatment of cancer
4. Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (−) MDA-MB-231 human breast cancer cells
5. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells
6. Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo
7. New Insights into the Benefits of Polyphenols in Chronic Diseases
8. Dietary supplementation with shiikuwasha extract attenuates dexamethasone-induced skeletal muscle atrophy in aged rats
9. Pharmaceutical composition
10. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes
11. Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability
12. Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis
13. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model
14. Several epidemiologic studies suggest that a polyphenol-enriched diet is an important strategy to prevent obesity and related chronic diseases, namely, T2DM. Both xanthohumol (XN) and 8-prenylnaringenin
15. 8-prenylnaringenin from hop) [10, 12, 13 … The prolonged lack of estrogen can cause cardiovascular disease, osteoporosis, os- teoarthritis, degenerative disc disease, obesity,
16. Effect of xanthohumol and 8‐prenylnaringenin on MCF‐7 breast cancer cells oxidative stress and mitochondrial complexes expression
17. Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes–associated oxidative stress by downregulating galectin-3

Albatrellus confluens

1. Grifolin induces autophagic cell death by inhibiting the Akt/mtor/S6K pathway in human ovarian cancer cells
2. The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review)
3. Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets
4. Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production
5. Inactivation of Ras and Changes of Mitochondrial Membrane Potential Contribute to Oridonin-Induced autophagy in A431 Cells
6. Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
7. Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
8. Elaborating the Role of Natural Products-Induced autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art
9. Natural products as modulator of autophagy with potential clinical prospects
10. Biosynthesis of Antroquinonol and 4-Acetylantroquinonol B via a Polyketide Pathway Using Orsellinic Acid as a Ring Precursor in Antrodia cinnamomea
11. Relevance of necroptosis in cancer
12. LOW-MOLECULAR-WEIGHT COMPOUNDS WITH ANTICANCER ACTIVITY OF MUSHROOM ORIGIN
13. Grifolic acid induces mitochondrial membrane potential loss and cell death of RAW264.7 macrophages
14. Targeting Cancer Cell Death with Small Molecule Agents for Potential Therapeutics
15. Chinese Herbs Interfering with Cancer Reprogramming Metabolism
16. Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment
17. Roles of PI3‐K/Akt pathways in nanoparticle realgar powders‐induced apoptosis in U937 cells
18. Expression and Characterization of Protein Latcripin-3, an Antioxidant and Antitumor Molecule from Lentinula edodesC91-3
19. Evaluating DAPK as a therapeutic target
20. NA selectively inhibits proliferation and induces apoptosis and autophagy in cancer cells.
21. Albatrellus ovinus (sheep … Several other activities have been reported including hypoglycaemic effect [14], effect against obesity

Alisol B isolated (from Alisma orientale)

1. Alisol A 24-Acetate and Alisol B 23-Acetate Induced autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells
2. Alisol B 23-acetate induces autophagic-dependent apoptosis in human colon cancer cells via ROS generation and JNK activation
3. Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mtor pathway
4. Alisol B 23-acetate-induced HepG2 hepatoma cell death through mtor signaling-initiated G1 cell cycle arrest and apoptosis: A quantitative proteomic study
5. Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces autophagy, Endoplasmic Reticulum Stress, and Apoptosis
6. Potential Agents for Cancer and obesity Treatment with Herbal Medicines from the Green Garden 1071 cological studies has been conducted using this compound [30,56]. Interestingly, alisol B
7. NAFLD has been associated with obesity, type 2 diabetes mellitus, hyperlipidemia, hypertension, fibrosis, and hepatocellular carcinoma [6 … Ten potential compounds, that is, gallic acid, chrysophanol, rhein, emodin, physcion, alisol C monoacetate, alisol B
8. Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from Rhizoma alismatis, which is a medicinal plant that has … the gene expression of CPT1α, ACADS and PPARα, which are involved in fatty acid β-oxidation (B). AB23A also increased the lipolysis
9. Alisol B 23‑acetate inhibits the viability and induces apoptosis of non‑small cell lung cancer cells via PI3K/AKT/mtor signal pathway

allicin (From Garlic Extract)

1. Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mtor and MAPK/ERK/mtor signaling pathways
2. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice
3. Therefore the in vivo effects of tolbutamide and insulin on lipolysis and lipid levels may not be similar. Such a difference is also seen in the effect of allicin
4. The aim of the research was to study the mechanism of intermolecular interaction of allicin and lecithin with pancreatic lipase, and developing the composition, contributing to the inactivation process of lipolysis,
5. behavioral modifications for the treatment of obesity and likely with more success than caloric restriction alone. Based in part on its spectrum of activity in other cell types, we tested ajoene, a stable derivative of allicin
6. Our data suggest that allicin potentially prevents obesity and associated metabolic disorders such as type 2 diabetes mellitus by enhancing the expression of brown adipocyte-specific genes
7. Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis
8. Allicin Alleviates inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells
9. Allicin Attenuates inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice
10. Attenuation of oxidative stress, inflammation, and endothelial dysfunction in hypercholesterolemic rabbits by allicin
11. Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions
12. Comparative Study of Alliin and Allicin Inhibit Tumor Necrosis Factor-α Induced inflammation
13. Allicin Attenuates Myocardial Ischemia Reperfusion Injury in Rats by Inhibition of inflammation and oxidative stress
14. The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
15. The liver-protective effects of allicin against alcoholic fatty liver disease and liver inflammation.
16. Allicin Protects PC12 Cells Against 6-OHDA-Induced oxidative stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
17. Allicin prevents H2O2-induced apoptosis of HUVECs by inhibiting an oxidative stress pathway
18. Allicin prevents oxidized low-density lipoprotein-induced endothelial cell injury by inhibiting apoptosis and oxidative stress pathway
19. Allicin inhibits oxidative stress-induced mitochondrial dysfunction and apoptosis by promoting PI3K/AKT and CREB/ERK signaling in osteoblast cells
20. Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic
21. Protective effect of allicin on high glucose/hypoxia-induced aortic endothelial cells via reduction of oxidative stress
22. In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression
23. Allicin ameliorates cognitive impairment in APP/PS1 mice via Suppressing oxidative stress by Blocking JNK Signaling Pathways
24. Protective effect of allicin against oxidative stress and hepatocyte autophagy in iron-overloaded rats

amorphophallus konjac tubor

1. Suppression of gastric cancer by extract from the tuber of amorphophallus konjac via induction of apoptosis and autophagy
2. Amorphophallus koniac Koch (Araceae), obesity, lipid and glucose metabolism alterations.
3. Amorphophallus konjac … KGM has recently been marketed in capsule form, as a drink mix and in food products (Brown, 2000, Talbott, 2003) and has been touted for its potential in the treatment of obesity
4. obesity has reached alarming levels in the United States … in the colon,* Glucomannan is a water-soluble, fermentable dietary fiber extracted from the tuber or root ofthe elephant yam, also known as konjac {Amorphophallus
5. Therefore using natural products that contain glucomannan to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac.
6. Amorphophallus Konjac … When stored body fat is broken down and used, lipase enzymes hydrolyze triglycerides into glycerol and free fatty acids during the breakdown of fat, called lipolysis

The tuber of amorphophallus konjac (TuAK) is an antitumor herb used in traditional Chinese medicine. The present study investigated the inhibitory effect of TuAK against gastric cancer and the underlying mechanisms associated with two programmed cell death pathways, apoptosis and autophagy. TuAK was extracted by organic solvents including ethanol and ligarine. The extract of TuAK, shortened as TuAKe, significantly inhibited the growth of cultured gastric cancer cell lines SGC-7901 and AGS, with IC50 of 35-45 µg/ml. TuAKe could increase cell apoptosis and induce cell cycle arrest. For the apoptosis-associated proteins, expressions of survivin and Bcl-2 were decreased by treatment of TuAKe, and the expression of Bax and caspase-9 was increased. Furthermore, TuAKe could promote autophagy, and the antitumor efficacy of TuAKe was significantly hampered by targeted suppression of autophagy, suggesting that autophagy contributed to TuAKe-induced cell death. Furthermore, patients with gastric cancer who received TuAK-based medicinal decoction achieved improved scores in assessment of life quality compared with those without TuAK treatment. This study demonstrated the antitumor activity of TuAKe against gastric cancer, and is the first report to show that the underlying mechanism is associated with induction of autophagy. Our data provided support of the clinical use of amorphophallus konjac-based medication in combination with classical chemotherapy to achieve optimized outcome for gastric cancer.

Anthocyanin extract (from black soybean Glycine max L.)

1. [Study on Mulberry Anthocyanins Induced autophagy and Apoptosis of Human Gastric Cancer SGC-7901 Cell autophagy].
2. Anthocyanins Regulate NAFLD by Promoting autophagy Pathway
3. Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death
4. Mulberry Anthocyanins Induce Leukemia WEHI-3 Cells Apoptosis, autophagy, Differentiation and prolong leukemic mice survival.
5. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple
6. Protective effect of anthocyanin on alcohol-induced liver fibrosis is due to the regulation on AMPK/mtor/autophagy pathway and energy status
7. Protective Effect of Purple Tomato Anthocyanidin on Chromium(VI)-Induced autophagy in LMH Cells by Inhibiting Endoplasmic Reticulum Stress
8. autophagy is required for tolerance of drought and salt stress in plants
9. Apoptosis and rotator cuff tears: scientificevidence from basic science to clinical findings
10. We investigated the effects of anthocyanins on cell growth, differentiation, and lipolysis in 3T3-L1 cells to test our hypothesis that anthocyanins could reduce adipose tissue mass by acting directly on adipocytes.
11. These observation provides the first evidence that anthocyanin directly inhibits lipolysis in adipocytes during hyperglycemia, suggesting that this could be a potential mechanism involved in the insulin-sensitizing properties of anthocyanins
12. it is possible that the effects of anthocyanins on TG accumulation may not only be achieved by the down-regulation of lipogenic transcription factors, but also by regulating lipolysis pathway(s)
13. Effects of Anthocyanin-rich Extract from Black Rice on Rats with High Fat Diets-induced obesity
14. Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism
15. The main beneficial effect of roselle (Hibiscus sabdariffa) on obesity is not only related to its anthocyanin content
16. Anthocyanin-rich Black Elderberry Extract improves Inflammatory Markers and Insulin Resistance in a High-Fat Diet-Induced obesity Model of Mice
17. Dietary anthocyanin prevents obesity and ameliorates hyperglycemia in mice: PO0790
18. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism
19. Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis
20. Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet‐induced obese mice
21. Inhibitory effect of anthocyanin-rich black soybean testa (Glycine max (L.) Merr.) on the inflammation-induced adipogenesis in a DIO mouse model
22. Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
23. Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
24. Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular inflammation in Endothelial Cells and Apo E−/− Mice
25. Cyanidin 3-Rutinoside, an Anthocyanin Pigment of Schisandra chinensis Baill, Inhibits Allergic inflammation
26. Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis
27. A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin–Maqui Berry Extract (Delphinol®) on oxidative stress Biomarkers
28. An anthocyanin-rich strawberry extract protects against oxidative stress damage and improves mitochondrial functionality in human dermal fibroblasts exposed to an oxidizing agent
29. Anthocyanin‐rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet
30. Overexpression of R2R3-MYB gene leads to accumulation of anthocyanin and enhanced resistance to chilling and oxidative stress
31. Anthocyanin-Rich Juice Lowers Serum Cholesterol, leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats

Apigenin (From Celery Extract)

1. Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and autophagy
2. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating inflammation, oxidative stress, and autophagy
3. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
4. Inhibition of PI3K/Akt/mtor pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells
5. Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and autophagy as a Mechanism of Action
6. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis
7. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
8. α-Mangostin and apigenin induced the necrotic death of BT474 breast cancer cells with autophagy and inflammation
9. Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation
10. Apigenin Combined With Gefitinib Blocks autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells
11. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
12. Apigenin Ameliorates the obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of obese Mice
13. Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates obesity-Related inflammation Via Regulation of Macrophage Polarization
14. Several in vitro and in vivo studies have reported the anti-inflammatory, anti-diabetic and anti-obesity effects of the flavonoid apigenin.
15. Background and purpose Apigenin can exert beneficial actions in the prevention of obesity. However, its putative action on obesity-associated bowel motor dysfunctions is unknown.
16. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mtor Pathway
17. Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mtor, JNK, and p38-MAPK
18. Apigenin inhibits proliferation and migratory properties of Barrett’s esophageal adenocarcinoma cells by targeting PI3K/Akt/mtor pathway
19. The antidepressant effects of apigenin are associated with the promotion of autophagy via the mtor/AMPK/ULK1 pathway
20. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects
21. Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells
22. Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
23. Protective role of apigenin on rotenone induced rat model of Parkinson’s disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis
24. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage
25. Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling
26. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression
27. Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4′-dimethyl ether isolated from Piper longum L
28. Topical Apigenin Alleviates Cutaneous inflammation in Murine Models
29. Apigenin Protects Endothelial Cells from Lipopolysaccharide (LPS)-Induced inflammation by Decreasing Caspase-3 Activation and Modulating Mitochondrial Function
30. Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK‐3β/NF‐κB signaling cascade
31. Apigenin Attenuates inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury
32. Apigenin-7-O-β-d-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock
33. Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet
34. Anti-inflammation and anti-fibrosis with PEGylated, apigenin loaded PLGA nanoparticles in chronic pancreatitis disease
35. Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
36. Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing inflammation
37. Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway
38. Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line
39. Counteracting effects of apigenin and leptin on lung adenocarcinoma cells.
40. leptin and Apigenin: Antagonists in the Apoptotic Pathway of Lung Adenocarcinoma Cell Line

Apios americana Medik flowers extract

1. Apios americana Medik flowers extract protects PC12 cells against H2O2 induced neurotoxicity via regulating autophagy
2. Apios americana Medikus tuber polysaccharide exerts anti-inflammatory effects by activating autophagy
3. Apios americana Medik flowers polysaccharide (AFP-2) attenuates H2O2 induced neurotoxicity in PC12 cells
4. Effects of C-Glycosides from Apios americana against oxidative stress during Hyperglycemia through Regulating Mitogen-Activated Protein Kinases and Nuclear Factor Erythroid 2-Related Factor 2
5. Anti-Visceral obesity Effect of Apios americana Medikus in Diet-Induced obese Mice
6. Apios americana Medik (hereinafter Apios) has been reported to treat diseases, including cancer, hypertension, obesity, and diabetes
7. Apios could inhibit the proliferation of cancer cells and alleviate obesity, hypertension and diabetes
8. There is some evidence that Apios may cure chronic constipation and exert positive effects on hypertension, disorders before and after childbirth, obesity, and diabetes.
9. Apios americana Medik extract alleviates lung inflammation in influenza virus H1N1-and endotoxin-induced acute lung injury
10. Effects of C-Glycosides from Apios americana Leaves against oxidative stress during Hyperglycemia through Regulating Mitogen-Activated Protein Kinases and Nuclear Factor Erythroid 2-Related Factor 2

Areca nut

1. autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling
2. Mechanistic and compositional studies of the autophagy-inducing areca nut ingredient
3. Impacts of autophagy-Inducing Ingredient of Areca Nut on Tumor Cells
4. autophagy induction by a natural ingredient of areca nut
5. autophagy induction by the 30–100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species
6. Arecoline and the 30–100 kDa fraction of areca nut extract differentially regulate mtor and respectively induce apoptosis and autophagy: a pilot study
7. autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling
8. Molecular and cellular cues of diet‐associated oral carcinogenesis—with an emphasis on areca‐nut‐induced oral cancer development
9. Long‐term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity
10. Impacts of autophagy-Inducing Ingredient of Areca Nut on Tumor Cells
11. Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3β: An Implication for Cytopathic Effects in Betel Quid Chewers
12. Ionizing radiation induces autophagy in human oral squamous cell carcinoma.
13. autophagy mediates oral submucous fibrosis
14. Role of autophagy in head and neck cancer and therapeutic resistance
15. autophagy and its implication in human oral diseases
16. Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma
17. autophagy and Apoptosis Play Opposing Roles in Overall Survival of Esophageal Squamous Cell Carcinoma
18. Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy
19. Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis
20. Clathrin‐mediated endocytosis is required for ANE 30‐100K‐induced autophagy
21. Chapter 16 – Erufosine Induces autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mtor Signaling Pathway
22. Thiamine Deficiency and Neurodegeneration: the Interplay Among oxidative stress, Endoplasmic Reticulum Stress, and autophagy
23. Betel nut (Areca catechu) consumption and induction glucose intolerance in adult CD1 mice and their F1 and F2 offspring … Betel nut chewing is strongly associated with general and central obesity in Chinese male middle-aged adults
24. It is also used in socio-religious practices, in ayurvedic medicines against leucoderma, leprosy, cough, fits, worms anaemia and obesity. Areca tannins from areca nut are found to have inhibitory activities on reverse transcriptase enzyme
25. Areca nut chewing is the fourth most popular substance abuse habit in the world [4]. Previous studies have found that chewing areca nut is associated with obesity, metabolic syndrome, hypertension (HTN),
26. The present invention provides a lipolysis stimulator and a slimming agent, containing as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca.
27. Prevalence of type II diabetes, hyperlipidemia, hypertriglyceridemia and metabolic syndromes are more common in areca nut chewers as its metabolite, arecoline, inhibits adipogenic differentiation, induces lipolysis
28. Areca nut affecting metabolic processes is that arecoline may inhibit the differentiation of adipose tissue, induce adenylyl-cyclase-dependent lipolysis
29. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E 2 , interleukin-6 and TNF-α production of oral epithelial cells by areca nut extract and arecoline
30. Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice
31. Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract
32. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress
33. Role of tumor necrosis factor-α, leptin, and white blood cell count in betel nut chewing–related metabolic derangements

Artemisia vulgaris (mugwort)

1. Herbal extract of Artemisia vulgaris (mugwort) induces antitumor effects in HCT-15 human colon cancer cells via autophagy induction, cell migration suppression and loss of mitochondrial membrane potential.
2. Therapeutic efficacy of Artemisia absinthium against Hymenolepis nana: in vitro and in vivo studies in comparison with the anthelmintic praziquantel
3. The Extracts of Artemisia absinthium L. Suppress the Growth of Hepatocellular Carcinoma Cells through Induction of Apoptosis via Endoplasmic Reticulum Stress and Mitochondrial-Dependent Pathway
4. iTRAQ-Based Proteomics Analysis of autophagy-Mediated Responses against MeJA in Laticifers of Euphorbia kansui L.
5. Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review
6. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice
7. PROMISING BIOLOGICAL ACTIVITIES OF SESQUITERPENE LACTONES
8. SIRT2 Exacerbates MG132-induced Protein Accumulation and Cytotoxicity by Inhibition of autophagy Turnover
9. Accumulation of Indolyl-3-Acetic and Abscisic Acids by “Hairy” Roots of Artemisia vulgaris
10. Antilipogenic and Hypolipidemic Effects of Ethanol Extracts from Two Variants of Artemisia in obese Diabetic Mice
11. Antioxidant and apoptosis modulating effects of Artemisia Vulgaris leaf extracts on in vitro systems subjected to oxidative stress
12. Immunotherapy Of Mugwort Pollen Extract Decreases Airway Hyperresponsiveness And Lung inflammation In A Recombinant Art V1-induced Rat Model Of Allergy
13. 126 Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-specificT-Cell Receptor and HLA-DR1

Ashitaba (Angelica keiskei koidzumi)

1. Soluble fraction of A. keiskei (AK) extracts and its …
   LC3B-I, LC3B-II, and SQSTM1/p62 were gradually reduced as evidence of autophagic flux
2. Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice
3. Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition
4. Antidiabetic Activities of Chalcones Isolated from a Japanese Herb, Angelica keiskei
5. [Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats].
6. Phytonutrient and anti-diabetic functional properties of flavonoid-rich ethanol extract from Angelica Keiskei leaves
7. Effects of Angelica Keiskei Chalcone on Insulin Resistance of SkeletalMuscle Cells of Type 2 Diabetic Rats
8. Anti – diabetic Activities of Ashitaba (Angelica keiskei) : Induction of Adipocyte Differentiation and Enhancement of Glucose Uptake in Adipocyte

Azuki bean (Vigna angularis) extract

1. Azuki bean (Vigna angularis) extract reduces oxidative stress and stimulates autophagy in the kidneys of streptozotocin-induced early diabetic rats
2. Saponins and Flavonoids from Adzuki Bean (Vigna angularis L.) Ameliorate High-Fat Diet-Induced obesity in ICR Mice
3. Suppression of obesity by Black Adzuki Beans (Vigna angularis) in High-fat Diet Fed obese Mouse Model
4. Effects of azuki beans on oxidative stress, hypertriacylglycerolaemia, hypertension, obesity, and diabetes
5. Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats
6. Studies on the changes of oxidative stress and autophagy in the hearts of streptozotocin-induced early diabetes rats, andthe improvement effects by azuki bean (Vigna angularis) extract [an abstract of dissertation and a summary ofdissertation review

Bacopa monnieri

1. Bacopa monnieri‐Induced Protective autophagy Inhibits Benzo[a]pyrene‐Mediated Apoptosis
2. The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis
3. cPKCγ-Modulated autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mtor Pathway
4. Bacopa monnieri-induced protective autophagy inhibits benzo[a]pyrene-mediated apoptosis
5. Bacopa monnieri (Brahmi) induced autophagy Inhibit Benzo[a]pyrene mediated cytotoxicity
6. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy
7. Phytochemicals Bridging autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
8. Plant Extracts Stimulate the autophagy-lysosomal Protein Clearance Pathway and Improve Brain Synapse Markers in an Explant Model of Age-related Protein Accumulation Stress (FS05-04-19)
9. Pharmaceutical composition and drug effect of synthetic Bacopa monnieri L.health promoting agentfrom the perspective of resistance fatigue
10. The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis
11. Virtual Screening of Peptidyl Arginine Deiminase Type 4 Inhibiting Potential of Chosen Flavonoids
12. In vitro cytotoxicity studies of silver nanoparticles with activated folic acid on cancer cell lines.
13. Bacopa monnieri as an Antioxidant Therapy to Reduce oxidative stress in the Aging Brain
14. Renoprotective effect of Bacopa monnieri via inhibition of advanced glycation end products and oxidative stress in STZ-nicotinamide-induced diabetic nephropathy
15. Alterations in Hippocampal oxidative stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
16. Pretreatment with Bacopa monnieri extract offsets 3-nitropropionic acid induced mitochondrial oxidative stress and dysfunctions in the striatum of prepubertal mouse brain
17. Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice
18. Role of Bacopa monnieri in the temporal regulation of oxidative stress in clock mutant (cryb) of Drosophila melanogaster
19. Microbial interference mitigates Meloidogyne incognita mediated oxidative stress and augments bacoside content in Bacopa monnieri L.
20. Extracts of Bacopa monnieri (L) Pennell Down-Regulate the Expression of Leukotriene C4 Synthase mRNA in HL-60 Cells and Suppress OVAInduced inflammation in BALB/c Mice

benzoin gum (Styrax benzoin) ( From Benzoin Tree Bark )

1. Antibacterial, anti-biofilm and anticancer potentials of green synthesized silver nanoparticles using benzoin gum (Styrax benzoin) extract
2. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
3. Styrax benzoin D. (SB) on Brain Physiological Activities Monitored in Real-time
4. Benzoin-like compounds (Figure [1]) have showed high activity towards inhibiting the 11βHSD1 receptor related to diseases such as diabetes, obesity

Berberine ( From Berberis vulgaris )

1. Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes
2. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mtor signaling pathway
3. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
4. Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
5. Berberine induces autophagy in glioblastoma by targeting the AMPK/mtor/ULK1-pathway
6. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
7. Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating Sirt1/FoxO3α induced autophagy
8. Pharmacologic preconditioning with berberine attenuating ischemia-induced apoptosis and promoting autophagy in neuron
9. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement
10. Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis
11. Berberine reduces adipogenic and inflammatory molecules 603 adipocyte reducing effects are caused by lipolysis
12. This result is quite consistent with the previous report that berberine could exhibit significant lipolysis effects in Hep G2 cells
13. TG is the main component of very low-density lipoprotein and increased extracellular TG suggested insulin-mediated inhibition of lipolysis was attenuated. We also observed that berberine reduced extracellular TG accumulation after the stimulation of palmitate
14. However, we previously found that berberine decreased insulin secretion and lipolysis via cAMP/ protein kinase A (PKA) pathway independent of AMPK activation in pancreatic β-cells and adipocytes
15. Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of obesity and Insulin Resistance in High-Fat Diet-Fed Rats
16. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats
17. Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and obesity in High-Fat Diet-Fed C57BL/6J Mice
18. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue inflammation in Mice with Diet-induced obesity
19. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels
20. Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes
21. ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis.
22. Berberine decelerates glucose metabolism via suppression of mtor‑dependent HIF‑1α protein synthesis in colon cancer cells
23. Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mtor signaling
24. Protection of berberine on intestinal mucosa following autologous orthotropic liver transplantation and its correlationship with p-AMPK activation and p-mtor inactivation
25. GW24-e1352 Berberine mitigated cardiac hypoxiareoxygenation injury by Suppressed Autophagy and Reduced Cell Death via inhibition of the activation of AMPK-mtor signalling pathway in rat H9c2 cells
26. Berberine preconditioning protects against hepatic cold ischemia reperfusion injury through the modulation of PI3K/Akt/mtor signaling pathway
27. Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway
28. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
29. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention
30. Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation
31. Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and inflammation in Rats
32. Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated inflammation in Traumatic Brain Injury
33. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling
34. Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-ο-Tetradecanoylphorbol-13-acetate-Induced inflammation in Mice
35. Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction
36. Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin inflammation
37. Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans
38. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose
39. Berberine Ameliorate oxidative stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats
40. Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing oxidative stress and inflammation Response: Role of Silent Information Regulator 1
41. Effects of Berberine on Amelioration of Hyperglycemia and oxidative stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo
42. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
43. Resolution of Liver Fibrosis by Isoquinoline Alkaloid Berberine in CCl4-Intoxicated Mice Is Mediated by Suppression of oxidative stress and Upregulation of MMP-2 Expression
44. Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat
45. The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling

Betanin‐Enriched Red Beetroot (Beta vulgaris L.)

1. Abstract 10893: Dietary Nitrate Supplementation With Beetroot Juice Enhances Cardiac autophagy Markers AMBRA-1 (Activating Molecule in Beclin-1-regulated autophagy) and ATG-5 (autophagy-related Gene 5): Protective Role Against Doxorubicin Cardiotoxicity
2. Betanin‐Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF‐7 Cells
3. POTENTIAL APPLICATION OF BEETROOT IN THERAPY OF obesity
4. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat
5. Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway
6. Betanin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress-myeloperoxidase/low-density lipoprotein in rat
7. Short-Term Betanin Intake Reduces oxidative stress in Wistar Rats
8. Protective Effects of Betanin against oxidative stress in a Peripheral Artery Vasospasm Model in Rat

bitter melon

1. Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death
2. Methanolic Extracts of Bitter Melon Inhibit Colon Cancer Stem Cells by Affecting Energy Homeostasis and autophagy
3. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells
4. Bitter melon: a panacea for inflammation and cancer
5. Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation
6. Altered White Adipose Tissue Protein Profile in C57BL/6J Mice Displaying Delipidative, Inflammatory, and Browning Characteristics after Bitter Melon Seed Oil Treatment
7. Roles of Peroxisome Proliferator-Activated Receptor α in Bitter Melon Seed Oil-Corrected Lipid Disorders and Conversion of α-Eleostearic Acid into Rumenic Acid in C57BL/6J Mice
8. BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells
9. Bitter Melon as a Therapy for Diabetes, inflammation, and Cancer: a Panacea?
10. Bitter gourd (Momordica charantia) as a rich source of bioactive components to combat cancer naturally: Are we on the right track to fully unlock its potential as inhibitor of deregulated signaling pathways
11. Bitter Melon Powder Protects against obesity-associatedFatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced obesity
12. Increased lipolysis in primary human adipocytes, with a concomitant reduction in PPARγ, SREBP-1c, perilipin, and resistin genes expression. These studies are critical as they lay the foundation to identify molecular targets and anti-obesity effects of bitter melon
13. Beneficial Role of Bitter Melon Supplementation in obesity and Related Complications in Metabolic Syndrome
14. Momordica charantia (Bitter Melon) Reduces obesity-Associated Macrophage and Mast Cell Infiltration as well as Inflammatory Cytokine Expression in Adipose Tissues
15. Bitter Melon Powder Protects against obesity-associatedFatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced obesity
16. Anti-obesity effect of bitter melon (Momordica charantia).
17. Momordica charantia (Bitter Melon) Improves Glucose and Lipid Metabolism Disturbance through Reducing obesity-associated inflammation in Mice
18. The Mechanism of Bitter Melon Power Preventing obesity-related inflammation
19. Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats
20. Bitter Melon (Momordica charantia) Reduces Adiposity, Lowers Serum Insulin and Normalizes Glucose Tolerance in Rats Fed a High Fat Diet
21. Bitter melon seed oil may reduce the adiposity through the hypothalamus mtor signaling in mice fed a high fat diet
22. Strawberry, loquat, mulberry, and bitter melon juices exhibit prophylactic effects on LPS-induced inflammation using murine peritoneal macrophages
23. Bitter melon: a panacea for inflammation and cancer
24. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation
25. Inhibitory effects of wild bitter melon leaf extract on Propionibacterium acnes-induced skin inflammation in mice and cytokine production in vitro
26. Bitter Melon as a Therapy for Diabetes, inflammation, and Cancer: a Panacea?
27. Wild Bitter Melon Leaf Extract Inhibits Porphyromonas gingivalis-Induced inflammation: Identification of Active Compounds through Bioassay-Guided Isolation
28. Bitter melon (Momordica charantia) attenuates atherosclerosis in apo-E knock-out mice possibly through reducing triglyceride and anti-inflammation
29. Bitter Melon Improves Glycemic Control and inflammation in Adipose Tissue of Obese and Diabetic Rats
30. Organ inflammation and oxidative damages in fructose-fed adult offspring born of fructose-fed dams: modulation by maternal bitter melon supplementation (1033.6)
31. Regulation of Sphingosine Kinase 1 and Adipose inflammation by Momordica charantia (Bitter Melon) in High-Fat Diet-Fed Mice
32. Supplementation of Bitter Melon to Rats Fed a High-Fructose Diet During Gestation and Lactation Ameliorates Fructose-Induced Dyslipidemia and Hepatic oxidative stress in Male Offspring
33. Supplementation of Bitter Melon to Rats Fed a High-Fructose Diet During Gestation and Lactation Ameliorates Fructose-Induced Dyslipidemia and Hepatic oxidative stress in Male Offspring
34. The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates oxidative stress
35. Testicular oxidative stress in Sprague-Dawley rats treated with bitter melon (<i>Momordica charantia</i>): the effect of antioxidant supplementation
36. Fresh Bitter Melon Fruit (Momordica charantia) Attenuated oxidative stress, Fibrosis and Renal Injury in Carbon Tetrachloride Treated Rats
37. Maternal bitter melon supplementation reduces the risk for metabolic defects later in life: effects on lipidhandling, oxidative stress and inflammation in offspring born to damsfed a high fructose diet
38. Bitter Melon (Momordica charantia) Protects from oxidative stress-Induced Premature Senescence in WI-38 Human Lung Fibroblast Cell
39. The Effect of Bitter Melon Extract (Momordica charantia)in Inhibition of NFkB Activation in leptin treated HUVECS

Brunfelsia grandiflora

1. The Effect of Brunfelsia grandiflora Ethanol Extract on the Induction of autophagy in Human Lung Fibroblasts
2. Inhibition of Cell Proliferation and Induction of Apoptosis by Ethanolic Extract of Lespedeza cuneata G. Don in Human Colorectal Cancer HT-29 cells

Butea monosperma (Lam.) flowers

1. A standardized extract of Butea monosperma (Lam.) flowers suppresses the IL-1β-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes
2. Indian medicinal plant butea monosperma flower extract and its bioactive constituent butein activates autophagy in human oa chondrocytes under pathological conditions
3. BUTEA MONOSPERMA STEM BARK EXTRACT PARTIALLY REVERSES HIGH FAT DIET-INDUCED OBESITY IN RATS
4. BST106 protects against cartilage damage by inhibition of apoptosis and enhancement of autophagy in osteoarthritic rats
5. Butein Activates autophagy Through AMPK/TSC2/ULK1/mtor Pathway to Inhibit IL-6 Expression in IL-1β Stimulated Human Chondrocytes
6. Knockdown of SGK1 alleviates the IL‐1β‐induced chondrocyte anabolic and catabolic imbalance by activating FoxO1‐mediated autophagy in human chondrocytes
7. Deregulation of PI3K/Akt/mtor Signaling Pathways by Isoflavones and its Implication in Cancer Treatment
8. Anti-obese activity of Butea monosperma (Lam) bark extract in experimentally induced obese rats
9. Evaluation of n-butanolic fractions of butea monosperma flowers on dexamethasone induced hyperglycemia and hyperlipidemia in mice
10. (Butea monosperma) Butea has antifungal, antimicrobial, anti inflammatory, anticonvulsive, anti esterogenic, anti fertility, anti … anticonvulsant, sedative, muscle relaxant, antipyretic, anti-inflammatory, antifungal, hepato protective, antimicrobial, antiulcer and lipolytic
11. The plant is known for antioxidant,[5] anti-obesity,[6] anticancer, and chemoprotective[7 … free radical scavenging, anti-oxidative and proapoptotic properties in the flower extracts of Butea monosperma
12. Anti-obese activity of Butea monosperma (Lam) bark extract in experimentally induced obese rats
13. Butea monosperma and Syzygium cumini are used to treat kidney-stones problem and Trigonella foenum-graceum is used as anti-obesity
14. Anti-obese activity of Butea monosperma (Lam) bark extract in experimentally induced obese rats
15. Proanthocyanidins (CLPr) reduced blood glucose levels in obese diabetic mice … and antioxidant attributes of ethanolic extracts of Butea monosperma
16. Protective effect of a Butea monosperma (Lam.) Taub. flowers extract against skin inflammation: Antioxidant, anti-inflammatory and matrix metalloproteinases inhibitory activities
17. Effect of Butea monosperma leaf extracts on cyclophosphamide induced clastogenicity and oxidative stress in mice

Buxus sempervirens

1. Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and autophagy in Breast Cancer Cells
2. Investigation of the laxative, spasmolytic and prokinetic properties of aqueous methanol extract of Buxus sempervirens Linn (Buxaceae)
3. Buxus sempervirens L. Improves Lipid Profile in Diabetic Rats … to insulin resistance, since the same effect on HDL catabolism is observed also in obese
4. Reversal of obesity by targeted … Kupchan and coworkers isolated the first B-ring homosteroid, buxenine G, from Buxus sempervirens and elucidated its structure in 1966

Carnosic acid (CA), a polyphenolic diterpene (from Rosemary)

1. Carnosic acid protects starvation-induced SH-SY5Y cell death through Erk1/2 and Akt pathways, autophagy, and FoxO3a
2. Carnosic Acid Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells by Inducing autophagy Through an Enhanced Interaction of Parkin and Beclin1
3. Carnosic Acid Prevents Beta-Amyloid-Induced Injury in Human Neuroblastoma SH-SY5Y Cells via the Induction of autophagy
4. Carnosic acid potentiates the anticancer effect of temozolomide by inducing apoptosis and autophagy in glioma
5. The protective role of carnosic acid in ischemic/reperfusion injury through regulation of autophagy under T2DM
6. Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy
7. Carnosic acid induces autophagic cell death through inhibition of the Akt/mtor pathway in human hepatoma cells
8. Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
9. Relevance of carnosic acid to the treatment of several health disorders: Molecular targets and mechanisms
10. Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts
11. Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa
12. Compounds with potential health benefits but poorly absorbed, oleoylethanolamide (OEA) and carnosic acid (CA), have been added to the nanoemulsions before lipolysis
13. Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice
14. Carnosic Acid as a Major Bioactive Component in Rosemary Extract Ameliorates High-Fat-Diet-Induced obesity and Metabolic Syndrome in Mice
15. Carnosic acid attenuates obesity‐induced glucose intolerance and hepatic fat accumulation by modulating genes of lipid metabolism in C57BL/6J‐ob/ob mice
16. Rosemary extract enriched in carnosic acid shows anti-obesity and anti-diabetic effects on in vitro and in vivo models
17. Abstract: P1422 CARNOSIC ACID & URSOLIC ACID (ORIGANUM MAJORANA L.) PREVENT ATHEROSCLEROSIS CAUSED BY obesity: SUPPRESSION OF leptin-INDUCED PROLIFERATION IN VASCULAR SMOOTH MUSCLE CELLS
18. Prevention of 4-hydroxynonenal-induced lipolytic activation by carnosic acid is related to the induction of glutathione S-transferase in 3T3-L1 adipocytes
19. Carnosic acid induces autophagic cell death through inhibition of the Akt/mtor pathway in human hepatoma cells
20. The mechanisms of carnosic acid attenuates tumor necrosis factor‐α‐mediated inflammation and insulin resistance in 3T3‐L1 adipocytes
21. Upregulation of Akt/NF-κB-regulated inflammation and Akt/Bad-related apoptosis signaling pathway involved in hepatic carcinoma process: suppression by carnosic acid nanoparticle
22. Carnosic acid (CA) attenuates collagen-induced arthritis in db/db mice via inflammation suppression by regulating ROS-dependent p38 pathway
23. Protective effect of rosmarinic acid and carnosic acid against streptozotocin-induced oxidation, glycation, inflammation and microbiota imbalance in diabetic rats
24. Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast‐like synoviocytes, and collagen‐induced arthritis rats
25. Carnosic acid alleviates brain injury through NF‑κB‑regulated inflammation and Caspase‑3‑associated apoptosis in high fat‑induced mouse models
26. Effects of supercritical fluid extract of rosemary leaf and carnosic acid in inhibiting lipopolysaccharide-induced inflammation in RAW 264.7 macrophage cells.
27. Activated Glutathione Metabolism Participates in Protective Effects of Carnosic Acid against oxidative stress in Neuronal
28. oxidative stress induced by ochratoxin A in LLC-PK1 cell line and the chemoprotective effects of carnosic acid
29. Carnosic Acid, a Natural Diterpene, Attenuates Arsenic-Induced Hepatotoxicity via Reducing oxidative stress, MAPK Activation, and Apoptotic Cell Death Pathway
30. Study of Carnosic acid, Genistein, Quercetin , Taurine, and Melatonin Modulation of AP-1 Gene Regulation in the Human Retinal Pigment Epithelium Under oxidative stress
31. Carnosic acid slows photoreceptor degeneration in Pde6rd10 mice bycontrolling oxidative stress and endoplasmic reticulum stress
32. Abstract: P1422 CARNOSIC ACID & URSOLIC ACID (ORIGANUM MAJORANA L.) PREVENT ATHEROSCLEROSIS CAUSED BY OBESITY: SUPPRESSION OF leptin-INDUCED PROLIFERATION IN VASCULAR SMOOTH MUSCLE CELLS

(Rosemarinus officinalis) Carnosol

1. Carnosol-Induced ROS Inhibits Cell Viability of Human Osteosarcoma by Apoptosis and autophagy
2. Carnosol Induces ROS-Mediated Beclin1-Independent autophagy and Apoptosis in Triple Negative Breast Cancer
3. P0174 Anti-metastatic and anti-tumour growth effects of carnosol on breast cancer through autophagy and apoptosis
4. Mechanistic insight into carnosol-mediated pharmacological effects: Recent trends and advancements
5. Anti-Carcinogenic Effects of Carnosol-An Updated Review
6. Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3
7. Anti-Metastatic and Anti-Tumor growth effects ofcarnosol on breast cancer
8. Carnosic Acid and Carnosol Induced Apoptosis through EP4 Signaling in Human Colon Cancer HCT116 Cells
9. Phytochemicals, withaferin A and carnosol, overcome pancreatic cancer stem cells as c-Met inhibitors
10. The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View
11. Protective effects of carnosol against oxidative stress induced brain damage by chronic stress in rats
12. CARNOSOL ALLEVIATES inflammation AND BACTERIAL TRANSLOCATION IN A RAT MODEL OF INTESTINAL ISCHEMIA-REPERFUSION INJURY

Catechin (From Green Tea Extract)

1. Green Tea Catechin Prevents Hypoxia/Reperfusion-Evoked oxidative stress-Regulated autophagy-Activated Apoptosis and Cell Death in Microglial Cells
2. Achievable Central Nervous System Concentrations of the Green Tea Catechin EGCG Induce Stress in Glioblastoma Cells in Vitro
3. Green tea extract induces protective autophagy in A549 non-small lung cancer cell line
4. Effects of green tea catechin- induced lipolysis on cytosol glycerol content in differenti- ated 3T3-L1 cells
5. Furthermore, procyanidins (oligomers of catechins) exhibited lipolytic effects in 3T3-L1 adipocytes, although the monomers had no effect upon lipolysis
6. Dietary catechin and Spirulina elevated ascorbate levels, increased carnitine synthesis and consequently promoted lipolysis activity in red sea bream
7. Modulation of obesity by a green tea catechin
8. A Catechin‐rich Beverage Improves obesity and Blood Glucose Control in Patients With Type 2 Diabetes
9. Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimming
10. Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate
11. Catechin-Rich Grape Seed Extract Supplementation Attenuates Diet-Induced obesity in C57BL/6J Mice
12. Effects of green tea catechin‐induced lipolysis on cytosol glycerol content in differentiated 3T3‐L1 cells
13. Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes
14. Pro-apoptotic effect of Epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/Akt/mtor signaling in rats with collagen-induced arthritis
15. Catechin and quercetin attenuate adipose inflammation in fructose‐fed rats and 3T3‐L1 adipocytes
16. Different effects of catechin on angiogenesis and inflammation depending on VEGF levels
17. Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice
18. Protective Effects of Catechin against Monosodium Urate-Induced inflammation through the Modulation of NLRP3 Inflammasome Activation
19. Catechin Attenuates Coronary Heart Disease in a Rat Model by Inhibiting inflammation
20. Against NF-κB/thymic stromal lymphopoietin signaling pathway, catechin alleviates the inflammation in allergic rhinitis
21. Catechin modulates inflammation in TNBS induced colitis. (P6238)
22. Modulation effect of catechin in angiogenesis and inflammation
23. Catechin remits the inflammation in allergic asthma mice by suppressing NF-κB-TSLP signal pathway
24. Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats
25. Protective effect of quercetin, EGCG, catechin and betaine against oxidative stress induced by ethanol in vitro
26. The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (–)‐epigallocatechin‐3‐gallate, in oral cells
27. Effect of the Intake of Resveratrol, Resveratrol Phosphate, and Catechin-Rich Grape Seed Extract on Markers of oxidative stress and Gene Expression in Adult Obese Subjects
28. (+)-Catechin protects dermal fibroblasts against oxidative stress-induced apoptosis
29. (+)-Catechin, an Ingredient of Green Tea, Protects Murine Microglia From oxidative stress-Induced DNA Damage and Cell Cycle Arrest
30. Effect of Catechin on Blood leptin Level in C57BL/6 Mice Fed High-fat Diet
31. Effect of Catechin on 3T3-L1 Preadipocytes and Mature Adipocytes in leptin Metabolic Pathway

Celastrol (tripterine) (from the root extracts of Tripterygium wilfordii)

1. Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates inflammation by Promoting Mitochondrial Ubiquitination and autophagy
2. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study
3. autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1
4. Celastrol Induces autophagy by Targeting AR/miR-101 in Prostate Cancer Cells
5. Downregulation of miR-17-92a cluster promotes autophagy induction in response to celastrol treatment in prostate cancer cells
6. Celastrol ameliorates experimental colitis in IL-10 deficient mice via the up-regulation of autophagy
7. Abstract 455: Enhanced autophagy by Celastrol Supplementation Profoundly Increases Angiotensin II-induced Abdominal Aortic Aneurysm Formation in Male and Female Mice
8. Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy
9. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mtor signaling pathways in glioma cells
10. Celastrol protects human retinal pigment epithelial cells against hydrogen peroxide mediated oxidative stress, autophagy, and apoptosis through sirtuin 3 signal pathway
11. Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
12. Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
13. Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
14. Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates inflammation by Promoting Mitochondrial Ubiquitination and autophagy
15. Inhibition of autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models
16. autophagy induction by celastrol augments protection against bleomycin-induced experimental pulmonary fibrosis in rats: Role of adaptor protein p62/ SQSTM1
17. Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy
18. Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells
19. Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol
20. Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
21. Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis
22. Molecular targets of celastrol in cancer: Recent trends and advancements
23. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
24. Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR
25. autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
26. Celastrol and Its Role in Controlling Chronic Diseases
27. Application of white adipose tissue browning irritant to preparation of obesity resisting medicine use of tripterine (celastrol) which is capable of promoting lipolysis, inhibiting fat synthesis,
28. Cascade regulation of PPARγ2 and C/EBPα signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes
29. Treatment of obesity with Celastrol
30. Celastrol Protects against obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis
31. Celastrol suppresses obesity process via increasing antioxidant capacity and improving lipid metabolism
32. Celastrol identified as a leptin sensitizer and potential novel treatment for obesity
33. The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms
34. Celastrol prevents cadmium‐induced neuronal cell death via targeting JNK and PTEN‐Akt/mtor network
35. Celastrol inhibits the HIF-1α pathway by inhibition of mtor/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells
36. Celastrol induces cell cycle arrest by MicroRNA-21-mtor-mediated inhibition p27 protein degradation in gastric cancer
37. Celastrol Attenuates Cadmium‐Induced Neuronal Apoptosis via Inhibiting Ca2+‐CaMKII‐Dependent Akt/mtor Pathway
38. Celastrol Modulates Lipid Synthesis via PI3K/Akt/mtor Signaling Axis to finalize Cell Death Response in Prostate Cancer Cells
39. miR-33a-5p enhances the sensitivity of lung adenocarcinoma cells to celastrol by regulating mtor signaling
40. Celastrol induces ubiquitin-dependent degradation of mtor in breast cancer cells
41. Celastrol prevents cadmium-induced neuronal cell death by blocking mitochondrial ROS inactivation of AMPK and activation of mtor pathway
42. Celastrol Prevents Atherosclerosis via Inhibiting LOX-1 and oxidative stress
43. Anticancer effect of celastrol on human triple negative breast cancer: Possible involvement of oxidative stress, mitochondrial dysfunction, apoptosis and PI3K/Akt pathways
44. Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis
45. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1α-SIRT3 signaling pathway
46. Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo
47. Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ
48. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation
49. Celastrol aggravates LPS-induced inflammation and injuries of liver and kidney in mice
50. Inhibition of inflammation with celastrol fails to improve muscle function in dysferlin-deficient A/J mice
51. Celastrol inhibits IL-1β-induced inflammation in orbital fibroblasts through the suppression of NF-κB activity
52. Celastrol modulates inflammation through inhibition of the catalytic activity of mediators of arachidonic acid pathway: Secretory phospholipase A2 group IIA, 5-lipoxygenase and cyclooxygenase-2
53. Targeting Mast Cells and Basophils with Anti-FcεRIα Fab-Conjugated Celastrol-Loaded Micelles Suppresses Allergic inflammation
54. Celastrol attenuates incision-induced inflammation and pain associated with inhibition of the NF-κB signalling pathway via SARM
55. inflammation-Targeted Delivery of Celastrol via Neutrophil Membrane-Coated Nanoparticles in the Management of Acute Pancreatitis
56. Celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway
57. Celastrol identified as a leptin sensitizer and potential novel treatment for obesity
58. The leptin sensitizer celastrol reduces age‐associated obesity and modulates behavioral rhythms
59. SUN-096 Hypothalamic ATP Has a Crucial Role in the Pathogenesis of leptin Resistance: A Potential Mechanism for the Amelioration of leptin Resistance by Celastrol and Withaferin A
60. leptin sensitizer celastrol, glial calcineurin and hypothalamic glutathione peroxidase 7 – novel entities in weight control and glucose homeostasis

Celastrol (FROm Thunder god vine)

1. Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
2. Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy
3. Inhibition of Autophagy Strengthens Celastrol-Induced Apoptosis in Human Pancreatic Cancer In Vitro and In Vivo Models
4. Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol
5. Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells
6. Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells
7. Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis
8. Autophagy flux inhibition mediated by celastrol sensitized lung cancer cells to TRAIL‑induced apoptosis via regulation of mitochondrial transmembrane potential and reactive oxygen species
9. Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease
10. celastrol administration and leptin, in obese mice with genetically disrupted leptin signalling
11. Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways
12. celastrol has been demonstrated to show effects that control obesity in several mice models
13. celastrol in inflammatory diseases, namely, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, osteoarthritis and allergy, as well as in cancer, neurodegenerative disorders and other diseases, such as diabetes, obesity
14. celastrol on leptin resistance, and further studies are needed to clarify whether celastrol can be used in humans to combat obesity
15. Celastrol was recently identified as a potential novel treatment for obesity
16. celastrol inhibits high fat diet-induced obesity
17. Celastrol suppresses obesity process via increasing antioxidant capacity
18. use of tripterine (celastrol) which is capable of promoting lipolysis
19. Celastrol increased adipocyte differentiation and lipolysis by regulating peroxisome proliferator-activated receptor gamma 2

Celastrus orbiculatus

1. Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mtor inhibition in human colorectal cancer cells
2. A New Sesquiterpene Ester from Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells
3. Cytotoxic constituents from Celastrus paniculatus induce apoptosis and autophagy in breast cancer cells
4. Antiinflammatory Constituents of Celastrus orbiculatus Inhibit the NF-κB Activation and NO Production
5. Interplay between apoptosis and autophagy in colorectal cancer
6. Celastrus Orbiculatus Extract Suppresses Migration and Invasion of Gastric Cancer by Inhibiting Prohibitin and c-Raf/ERK Signaling Pathway
7. Celastrus orbiculatus extracts induce apoptosis in mtor-overexpressed human hepatocellular carcinoma HepG2 cells
8. Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mtor Signaling Pathways
9. lipogenic and lipolytic enzymes in rats fed with methanolic seed extract (50%) of Celastrus paniculatus
10. Celastrus orbiculatus extracts induce apoptosis in mtor-overexpressed human hepatocellular carcinoma HepG2 cells
11. Celastrus Orbiculatus Extracts Inhibit the Metastasis through Attenuating PI3K/Akt/mtor Signaling Pathway in Human Gastric Cance.
12. Celastrus orbiculatus Extracts Inhibit Human Hepatocellular Carcinoma Growth by Targeting mtor Signaling Pathways
13. Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mtor signaling pathway
14. Effects of Celastrus orbiculatus Thunb.Extract on the Overexpression of mtor in Human HepG2 Cells

Cepharanthine (CEP) a biscoclaurine alkaloid (from extracted Stephania)

1. Cepharanthine Induces autophagy, Apoptosis and Cell Cycle Arrest in Breast Cancer Cells
2. Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells
3. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer
4. cepharanthine (1.5mM), tetrandrine (1.5mM) or isotetrandrine (1.5mM), shifted the insulin-re- sponse curve of isoproterenol-induced lipolysis
5. alkaloids such as liensinine, isoliensinine, dauricine and cepharanthine induced AMPK … Autophagy is hence correlated to the degree of obesity,
6. Tetrandrine and cepharanthine induce apoptosis through caspase cascade regulation, cell cycle arrest, MAPK activation and PI3K/Akt/mtor signal modification in glucocorticoid resistant human leukemia Jurkat T cells
7. Biscoclaurine alkaloid cepharanthine protects DNA in TK6 lymphoblastoid cells from constitutive oxidative damage
8. Cepharanthine Exerts Anti-Inflammatory Effects Via NF-κB Inhibition in a LPS-Induced Rat Model of Systemic inflammation
9. Inhibitory effect of cepharanthine and its related compounds on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and inhibition of tumor promotion by cepharanthine in two-stage carcinogenesis in mice
10. Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation
11. Cepharanthine prevents atherosclerosis by attenuation of vascular inflammation and Human Aortic Smooth Muscle Cell proliferation and migration

cepharantha Chaihu (Radix bupleuri),

1. Effect of Chaihu Shugan Powder-Contained Serum on Glutamate-Induced autophagy of Interstitial Cells of Cajal in the Rat Gastric Antrum
2. High Performance Liquid Chromatography Determination and Optimization of the Extraction Process for the Total Alkaloids from Traditional Herb Stephania cepharantha Hayata
3. Cepharanthine Induces autophagy, Apoptosis and Cell Cycle Arrest in Breast Cancer Cells
4. Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells
5. Radix Bupleuri is the saikosaponin a (SSNa) … that SSNa is a novel therapeutic agent against that can be used against obesity‑associated inflammation
6. Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-in High-Fat-Diet-Induced obese Rats
7. Radix Bupleuri regulates lipid disorders via a pathway dependent on peroxisome-proliferator-activated receptor-alpha in high-fat-diet-induced obese rats
8. Radix Bupleuri (thorowax root … resistance is shared by several disorders, including hypertension, diabetes, obesity,
9. Radix Bupleuri, fresh ginger … In the clinical trial, fluoxetine was reported to improve insulin-mediated glucose disposal in obese patients,
10. Radix Bupleuri extracts (RBE) on growth, lipid deposition and metabolism and … than in those fed RBE0 diets, while dietary supplementation with 200–800 mg/kg RBE diets up-regulated lipolysis-related genes

Chebulagic acid (from Terminalia chebula)

1. Neuroprotective Effect of Chebulagic Acid via autophagy Induction in SH-SY5Y Cells
2. Recent advances in autophagy-based neuroprotection
3. Preventive effect of Terminalia bellirica on obesity and metabolic disorders in spontaneously obese type 2 diabetic model mice
4. Chebulagic acid (CA), the major constituent of Terminalia chebula and Phyllanthus emblica, is a benzopyran tannin com pound with various kinds of … Enhanced susceptibility to 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine neurotoxicity in high-fat diet induced obesity
5. Anti-hyperglycemic effect of chebulagic acid from the fruits of Terminalia chebula Retz … Preventive effect of Terminalia bellirica on obesity
6. Chebulagic acid, ellagic and … Prevention effect of Terminalia bellirica on obesity
7. These results clearly indicate that chebulagic acid can be used as an auxiliary in the treatment of obese associated comorbidities and in the control of type 2 diabetes.
8. chebulagic Acid in HT22 and SH-SY5Y Cells … in inflammation and related diseases ㆍHepatic sulfur amino acid metabolism in obese and diabetic
9. chebulagic acid increased the ACTH—induced lipolysis in fat
10. Chebulagic acid (CA) attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW 264.7 macrophages
11. Chebulagic acid reduces inflammation and regulates enteric glial cells in mouse models of dextran sulfate sodium-induced colitis

Chuan xiong (Rhizoma chuanxiong)

1. Chuan xiong (Rhizoma chuanxiong) modulates cancers, neurodegeneration and cardiovascular disease via autophagy.
2. Puerariae Lobatae Radix with chuanxiong Rhizoma for treatment of cerebral ischemic stroke by remodeling gut microbiota to regulate the brain–gut barriers
3. Antioxidative Activity of the Extract from Rhizoma Chuanxiong in Vitro

Cichorium intybus Linn. Extract

1. This study demonstrates the hepatic protective effect of Cichorium intybus L. and active compounds in Cichorium intybus L. The active compounds ameliorate liver injury by acting on Akt-1 and caspase-1, which are related to apoptosis or autophagy.
2. Treatment with EAEC-PDT reduced xenograft tumor size. Further evaluation suggested that activation of the PERK pathway mediates these effects, as the apoptotic rate and autophagy flux increased markedly after EAEC-PDT. EAEC, a natural photosensitizer extracted from Cichorium, displays potential utility in PDT of CRC by targeting the PERK pathway.
3. (Cichorium intybus) and nettle … may be considered as the net result of the balance among dietary absorbed fat, fat synthesis (lipogenesis) and fat catabolism via β-oxidation (lipolysis)
4. Cichorium intybus group (CI … So, if the fat intake and excreted is equal, decreased body fat accumulation could be due to lipolysis or decreased fatty
5. (Cichorium intybus L.) is a medicinal and edible herb that belongs to the Compositae Cichorium family … Polysaccharides promote TG lipolysis
6. Cichorium intybus L. (chicory … 9]. This effect may be due to a decrease in the activity of cholesterol biosynthesis enzymes or decreasing the rate of lipolysis
7. Ameliorating effect of chicory (Cichorium intybus L.)-supplemented diet against nitrosamine precursors-induced liver injury and oxidative stress in male rats
8. Chicory (Cichorium intybus L.) Root Extract Regulates the Oxidative Status and Antioxidant Gene Transcripts in CCl4-Induced Hepatotoxicity
9. Effects of Cichorium Intybus Linn on Blood Glucose, Lipid Constituents and Selected oxidative stress Parameters in Streptozotocin-Induced Diabetic Rats
10. Prevention of oxidative stress-Induced Apoptosis of C2C12 Myoblasts by a Cichorium intybus Root Extract
11. Phenolic compounds, oxidative enzymes and their relationship with discoloration in endive (Cichorium intybus L.).
12. Chicory (Cichorium intybus L.) Root Extract Regulates the Oxidative Status and Antioxidant Gene Transcripts in CCl4-Induced Hepatotoxicity
13. P-302 – Cichorium intybus attenuates streptozotocin induced diabetic cardiomyopathy via inhibition of oxidative stress and inflammatory response in rats
14. Mechanistic evaluation of AMPK/SIRT1/FXR signaling axis, inflammation, and redox status in thioacetamide‐induced liver cirrhosis: The role of Cichorium intybus linn (chicory)‐supplemented diet

Clionamine B ( from Cliona celata )

1. Synthesis, activity and molecular target identification of clionamine B analogues : autophagy stimulating
2. Synthesis of Clionamine B, an autophagy Stimulating Aminosteroid Isolated from the Sponge Cliona celata
3. Highly Efficient and Scalable Synthesis of Clionamine D
4. Clionamine B, an Autophagy Stimulating Aminosteroid Isolated
   from the Sponge Cliona celata. The Journal of Physical Chemistry B … GP-BAR1 is a promising pharmacological target for the treatment of steatohepatitis, type 2 diabetes, and obesity

Convallatoxin ( from Antiaris toxicaria )

1. Convallatoxin, a Dual Inducer of Autophagy and Apoptosis, Inhibits Angiogenesis In Vitro and In Vivo
2. Inhibition of cell proliferation, invasion and migration by the cardenolides digitoxigenin monodigitoxoside and convallatoxin in human lung cancer cell line
3. Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation
4. Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers
5. Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans
6. Plant-derived cardiac glycosides: Role in heart ailments and cancer management
7. obesity and Cardiovascular Disease … CMV protein synthesis has also been shown to decrease in cells treated with the cardiac glycoside convallatoxin

Cordycepin ( From Cordyceps Sinensis )

1. Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado–Joseph disease models
2. Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells
3. Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy
4. Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE-/- mice
5. Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells
6. Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mtor pathway
7. [Effect of cordycepin on apoptosis and autophagy of tongue cancer cells in vitro and the molecular mechanism].
8. AMPK has therefore been proposed as a major
   therapeu- tic target for obesity and obesity-linked metabolic disor- ders such as hyperlipidemia (7). Cordycepin, also known as 3′-deoxyadenosine,
9. Cordycepin, by blocking both adipogenesis
   and lipid accumulation, may have potential as a therapeutic agent for effective treatment of obesity and obesity‐related disorders.
10. Cordycepin regulates body weight by inhibiting lipid droplet formation, promoting lipolysis and recruiting beige adipocytes
11. In this study, we explored the molecular mechanism of the anti-obesity effect of cordycepin.
12. Lipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats
13. Drug effects on the fine structure of Trypanosoma rhodesiense: Puromycin and its aminonucleoside, Cordycepin and Nucleocidin
14. Cordycepin, by blocking both adipogenesis
    and lipid accumulation, may have potential as a therapeutic agent for effective treatment of obesity and obesity‐related disorders.
15. Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-κB through Akt and p38 inhibition in RAW 264.7 macrophage cells
16. Cordycepin (3′-deoxyadenosine) Down-Regulates the Proinflammatory Cytokines in inflammation-Induced Osteoporosis Model
17. Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis
18. the polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis
19. The cordycepin derivative IMM-H007 improves endothelial dysfunction by suppressing vascular inflammation and promoting AMPK-dependent eNOS activation in high-fat diet-fed ApoE knockout mice
20. Cordycepin Inhibits Lipopolysaccharide-Stimulated inflammation in Human Umbilical Vein Endothelial Cells
21. Effect of Manganese oxidative stress on Contents of Cordycepin and Adenosine in Mycelia of Cordyceps militaris
22. Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats
23. Cordycepin prevents oxidative stress-induced inhibition of osteogenesis
24. Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress
25. Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats

Corynoxine B (Cory B), ( from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese) )

1. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells
2. B1 is involved in autophagy inhibition caused by SNCA/a-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B.
3. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression
4. Corynoxine, a Natural autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mtor Pathway
5. Corynoxine isomers decrease levels of amyloid-β peptide and amyloid-β precursor protein by promoting autophagy and lysosome biogenesis

Cucurbita Moschata

1. autophagy flux modulation by a carotenoid-enriched extract from the pumpkin Cucurbita moschata on human chronic lymphocytic leukemia cell line
2. A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model
3. Corrigendum to “A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model”
4. Cucurbita maxima fruit …the C. pepo esterases may have a considerable potential in the lipolysis
5. (Cucurbita pepo L.) var … They were identified by co migration of commercial standards. The triacylglycerol (TAG) spots and their lipolysis
6. Ameliorative effects of squash (Cucurbita moschata Duchesne ex Poiret) leaf extracts on oxidative stress
7. Cytoprotective Effects of Pumpkin (Cucurbita Moschata) Fruit Extract against oxidative stress and Carbonyl Stress
8. Phytochemical Composition And Oxidative Stability Of Cold-Pressed Butternut Squash (Cucurbita Moschata) And Pumpkin (Cucurbita Pepo L.) Seed Oils

Curcumin ( From Tumeric Extract )

1. Curcumin-Loaded Layered Double Hydroxide Nanoparticles-Induced autophagy for Reducing Glioma Cell Migration and Invasion
2. autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas
3. Curcumin regulates proliferation, autophagy, and apoptosis in gastric cancer cells by affecting PI3K and P53 signaling
4. Curcumin: A naturally occurring autophagy modulator
5. Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mtor signaling pathway in human melanoma cells
6. Curcumin Suppresses Proliferation and Migration of MDA-MB-231 Breast Cancer Cells through autophagy-Dependent Akt Degradation
7. Curcumin targets the TFEB-lysosome pathway for induction of autophagy
8. Curcumin hormesis mediates a cross-talk between autophagy and cell death
9. Curcumin inhibits autophagy and apoptosis in hypoxia/reoxygenation-induced myocytes
10. Role of autophagy on Heavy Metal-Induced Renal Damage and the Protective Effects of Curcumin in autophagy and Kidney Preservation
11. Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells
12. Curcumin alleviates isoproterenol-induced cardiac hypertrophy and fibrosis through inhibition of autophagy and activation of mtor
13. Antagonism between curcumin and the topoisomerase II inhibitor etoposide
14. Curcumin as an ROS Scavenger in Amyotrophic Lateral Sclerosis
15. Curcumin alleviates neuronal apoptosis and cerebral mitochondrial dysfunction in septic mice
16. Is Chronic Curcumin Supplementation Neuroprotective Against Ischemia for Antioxidant Activity, Neurological Deficit, or Neuronal Apoptosis in an Experimental Stroke Model?
17. The Polyphenolic Compound Curcumin Conjugation with an Alkyne Moiety in the Process of autophagy
18. Curcumin‐induced autophagy and nucleophagy in Sp
19. Targeting inflammation-Induced obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
20. curcumin-treated adipocytes contained a greater number of small lipid … provide a greater surface area for the actions of water-soluble lipolytic
21. Finally, a recent report has demonstrated that curcumin prevents the lipolytic effects
22. In this study, we used curcumin as a model lipophilic component that could be incorporated into functional food products
23. Curcumin inhibits lipolysis via suppression of ER stress in adipose tissue and prevents hepatic insulin resistance
24. Curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3T3-L1 adipocytes
25. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases
26. Curcumin and obesity: evidence and mechanisms
27. Curcumin and obesity
28. Curcumin Prevents High Fat Diet Induced Insulin Resistance and obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes
29. Curcumin molecular targets in obesity and obesity-related cancers
30. Roles of the Akt/mtor/p70S6K and ERK1/2 Signaling Pathways in Curcumin-Induced Autophagy
31. Curcumin Inhibits Proliferation of Colorectal Carcinoma by Modulating Akt/mtor Signaling
32. Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mtor/p70S6K Signaling and the Recovery of Macroautophagy
33. Curcumin disrupts uterine leiomyosarcoma cells through AKT-mtor pathway inhibition
34. Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt‐mtor and MAPK signaling pathways in human leukemia HL‐60 cells
35. Curcumin inhibited HGF-induced EMT and angiogenesis through regulating c-Met dependent PI3K/Akt/mtor signaling pathways in lung cancer
36. Curcumin inhibits cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mtor/HIF-1α signaling
37. Transient Metals Enhance Cytotoxicity of Curcumin: Potential Involvement of the NF-κB and mtor Signaling Pathways
38. Curcumin sensitizes glioblastoma to temozolomide by simultaneously generating ROS and disrupting AKT/mtor signaling
39. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of mtor inhibition
40. Curcumin attenuates gentamicin-induced renal oxidative damage in rats
41. Curcumin and Especially Tetrahydrocurcumin Ameliorate oxidative stress-Induced Renal Injury in Mice
42. Chemical Studies on Antioxidant Mechanism of Curcumin:  Analysis of Oxidative Coupling Products from Curcumin and Linoleate
43. Curcumin Activates Defensive Genes and Protects Neurons Against oxidative stress
44. Protective Effects of Curcumin against Oxidative Damage on Skin Cells In Vitro: Its Implication for Wound Healing
45. Effect of Curcumin on inflammation and oxidative stress in Cisplatin-Induced Experimental Nephrotoxicity
46. Curcumin suppresses AGEs induced apoptosis in tubular epithelial cells via protective autophagy
47. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys
48. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation
49. Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage
50. Curcumin, inflammation, ageing and age-related diseases
51. Biodegradable microspheres of curcumin for treatment of inflammation.
52. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update
53. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage
54. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis
55. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats
56. Modulation Of Inflammatory Mediators By Ibuprofen And Curcumin Treatment During Chronic inflammation In Rat
57. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide
58. Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation
59. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis
60. Curcumin Eliminates leptin’s Effects on Hepatic Stellate Cell Activation via Interrupting leptin Signaling
61. Inhibition of leptin and leptin Receptor Gene Expression by Silibinin-Curcumin Combination
62. Curcumin Protects Hepatic Stellate Cells against leptin-Induced Activation in Vitro by Accumulating Intracellular Lipids
63. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter‐4 and increasing glucokinase
64. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling
65. Curcumin prevents leptin-induced tight junction dysfunction in intestinal Caco-2 BBe cells
66. Curcumin inhibits leptin gene expression and secretion in breast cancer cells by estrogen receptors
67. [The study of insulin resistance and leptin resistance on the model of simplicity obesity rats by curcumin].
68. Therapeutic effect of curcumin on nonalcoholic fatty liver disease in rats and its influence on the expression of leptin in liver
69. Evaluation of serum cancer antigen 125, resistin, leptin, homocysteine, and total antioxidant capacity in rat model of endometriosis treated with Curcumin
70. Effect of Phytosomal Curcumin on Circulating Levels of Adiponectin and leptin in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
71. Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma
72. 7 Food additives sodium sulfite, sodium benzoate and curcumin inhibit leptin release in murine adipocytes in vitro
73. Preparation and Evaluation of effect Magnetic Nanoparticles Modified with Biodegradable Copolymer PCL-PEG containing Curcumin – Silibinin on leptin Gene Experession in Lung Cancer

dandelion root

1. Selective Induction of Apoptosis and Autophagy Through Treatment With Dandelion Root Extract in Human Pancreatic Cancer Cells

Dihydromyricetin (Ampelopsin) ( From Vine Tea Extract )

1. Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
2. Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway
3. Dihydromyricetin promotes autophagy and apoptosis through ROS-STAT3 signaling in head and neck squamous cell carcinoma
4. Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
5. Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy
6. Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury
7. Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-κB signalling in human melanoma cells
8. Dihydromyricetin inhibits PC12 cell injury induced by 1-methyl-4-phenylpyridinium by up-regulating autophagy activity
9. Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
10. Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mtor and regulating its upstream pathways
11. Dihydromyricetin protects against liver ischemia/reperfusion induced apoptosis via activation of FOXO3a-mediated autophagy
12. Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury
13. Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Mice
14. The Versatile Effects of Dihydromyricetin in Health
15. Dihydromyricetin Enhances the Chemo-Sensitivity of Nedaplatin via Regulation of the p53/Bcl-2 Pathway in Hepatocellular Carcinoma Cells
16. Determination of dihydromyricetin in rat plasma by LC-MS/MS and its application to a pharmacokinetic study
17. Dihydromyricetin protects against lipopolysaccharide‑induced cardiomyocyte injury through the toll‑like receptor‑4/nuclear factor‑κB pathway
18. The in vitro assays detected action of dihydromyricetin on adipogenesis, lipolysis and lipogenesis
19. “Dihydromyricetin prevents obesity-induced slow-twitch-fiber reduction partially via FLCN/FNIP1/AMPK pathway,”
20. Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial
21. Dihydromyricetin[A];[C];2006 … on Seral Lipids in High Fat and Sugar Diet-induced obese
22. Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mtor and regulating its upstream pathways
23. Ampelopsin suppresses breast carcinogenesis by inhibiting the mtor signalling pathway
24. Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells
25. Dihydromyricetin ameliorates oleic acid-induced lipid accumulation in L02 and HepG2 cells by inhibiting lipogenesis and oxidative stress
26. Dihydromyricetin attenuated Ang II induced cardiac fibroblasts proliferation related to inhibitory of oxidative stress
27. Protection of oxidative stress induced apoptosis in osteosarcoma cells by dihydromyricetin through down-regulation of caspase activation and up-regulation of BcL-2
28. Dihydromyricetin Attenuates Myocardial Hypertrophy Induced by Transverse Aortic Constriction via oxidative stress Inhibition and SIRT3 Pathway Enhancement
29. Dihydromyricetin improves type 2 diabetes-induced cognitive impairment via suppressing oxidative stress and enhancing brain-derived neurotrophic factor-mediated neuroprotection in mice
30. Dihydromyricetin Inhibits Lead-Induced Cognitive Impairments and inflammation by the Adenosine 5′-Monophosphate-Activated Protein Kinase Pathway in Mice
31. Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway
32. Dihydromyricetin Inhibits inflammation of Fibroblast-Like Synoviocytes through Regulation of Nuclear Factor-κB Signaling in Rats with Collagen-Induced Arthritis

dimethyl cardamonin (from Syzygium samarangense)

1. Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells
2. Autophagy induced by cardamonin is associated with mtorC1 inhibition in SKOV3 cells
3. Cardamonin Inhibits Metastasis of Lewis Lung Carcinoma Cells by Decreasing mtor Activity
4. mtor inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion
5. Cardamonin Inhibits Angiogenesis by mtor Downregulation in SKOV3 Cells
6. [Antiproliferation of cardamonin associated with mRNA expression of mtor, Raptor and Rictor].
7. Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mtor pathway
8. Anti-inflammatory Effects of Cardamonin in Ovarian Cancer Cells Are Mediated via mtor Suppression
9. Cardamonin attenuates lung carcinoma and promotes autophagy via targeting p53 and regulating mtor.
10. Glycolysis inhibition via mtor suppression is a key step in cardamonin-induced autophagy in SKOV3 cells
11. Cardamonin inhibits the proliferation and metastasis of non-small-cell lung cancer cells by suppressing the PI3K/Akt/mtor pathway
12. Semi-synthesis of novel cardamonin analogues and identification of a highly active Cu(II)-cardamonin complex that inhibits migration and induces apoptosis via inhibition of mtor expression
13. Cardamonin Attenuates Tamoxifen Induced Hepatotoxicity in Rats through Modulation of Inflammatory Mediators, oxidative stress and Apoptosis
14. Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: Impact on NOX-1, inflammation and apoptosis
15. Cardamonin attenuates chronic inflammation and tumorigenesis in colon
16. Cardamonin Alleviates Pressure Overload-induced Cardiac Remodeling and Dysfunction Through Inhibition of oxidative stress
17. Apoptotic cell death via oxidative stress mediated caspase-dependent mechanism in Jurkat T cells by cardamonin and its transition metal Cu (II) and Fe (II) complexes

Dioscin (CAS 19057-60-4) (From Wild Yam Root Extract)

1. Dioscin Alleviates Crystalline Silica-Induced Pulmonary inflammation and Fibrosis through Promoting Alveolar Macrophage autophagy
2. Corrigendum to(autophagy Inhibition Enhances ApoptosisInduced by Dioscin in Huh7 Cells)
3. Potent effects of dioscin against hepatocellular carcinoma through regulating TP53‐induced glycolysis and apoptosis regulator (TIGAR)‐mediated apoptosis, autophagy, and DNA damage
4. Erratum to: Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines
5. Dioscin strengthens the efficiency of adriamycin in MCF-7 and MCF-7/ADR cells through autophagy induction: More than just down-regulation of MDR1
6. Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway
7. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines
8. Diosgenin induces ROS-dependent autophagy and cytotoxicity via mtor signaling pathway in chronic myeloid leukemia cells
9. autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells
10. Diosgenin‑induced autophagy and apoptosis in a human prostate cancer cell line
11. Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells
12. Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating autophagy and Alleviating Apoptosis
13. Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
14. Dioscin, Human pleura[ fluid (HPF) INTRODUCTION Phospholipase A2 (PLA2) is lipolytic enzyme that specifically hydrolyzes the sn-2 position of glyceropho- spholipid.
15. dioscin exerts a protective effect against NAFLD … fed mice prevented fat accumulation in epididymal tissues by stimulating lipolysis and ameliorating
16. dioscin and its aglycone, diosgenin, showed inhibitory potential against fat absorption(12 …Besides, the observed reduction in intracellular lipolytic activity of cultured 3T3-L1 adipocytes may reduce the levels
17. Dioscin ameliorates cardiac hypertrophy through inhibition of the MAPK and Akt/GSK3β/mtor pathways
18. Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins
19. Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation
20. Dioscin Prevents the Mitochondrial Apoptosis and Attenuates oxidative stress in Cardiac H9c2 Cells
21. Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of oxidative stress and inflammation
22. Dioscin Attenuates Hepatic Ischemia-Reperfusion Injury in Rats Through Inhibition of Oxidative-Nitrative Stress, inflammation and Apoptosis
23. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation
24. Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation
25. Potent effects of dioscin against thioacetamide-induced liver fibrosis through attenuating oxidative stress in turn inhibiting inflammation, TGF-β/Smad and MAPK signaling pathways
26. Dioscin Protects ANIT-Induced Intrahepatic Cholestasis Through Regulating Transporters, Apoptosis and oxidative stress
27. Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections
28. Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model
29. Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways
30. Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism
31. Dioscin ameliorates intestinal ischemia/reperfusion injury via adjusting miR-351-5p/MAPK13-mediated inflammation and apoptosis
32. Corrigendum to “Protective effects of dioscin agains doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation” [Toxicology 378 (2017) 53-64].

Docosahexaenoic acid (DHA) ( From Algae )

1. Docosahexaenoic acid (DHA) promotes immunogenic apoptosis in human multiple myeloma cells, induces autophagy and inhibits STAT3 in both tumor and dendritic cells
2. Docosahexaenoic acid enhances M2 macrophage polarization via the p38 signaling pathway and autophagy
3. Docosahexaenoic Acid Attenuated Experimental Chronic Colitis in Interleukin 10–Deficient Mice by Enhancing autophagy Through Inhibition of the mtor Pathway
4. Docosahexaenoic acid, an omega-3 fatty acid, induces autophagy in human breast cancer cells: role of oxidative stress-induced growth inhibitor 1
5. Docosahexaenoic acid induces autophagy through p53/AMPK/mtor signaling and promotes apoptosis in human cancer cells harboring wild-type p53
6. Docosahexaenoic Acid Induces Cell Death in Human Non-Small Cell Lung Cancer Cells by Repressing mtor via AMPK Activation and PI3K/Akt Inhibition
7. Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells
8. Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy
9. Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes
10. Omega‐3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF‐7 breast cancer cells
11. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)
12. Microarray analysis of anti-cancer effects of docosahexaenoic acid on human colon cancer model in nude mice
13. AKT/mtor signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells
14. DHA regulates lipogenesis and lipolysis genes in mice adipose and liver
15. In vitro examination of DHA-edible micro algae: 1. Effect on rumen lipolysis and biohydrogenation of linoleic and linolenic acids
16. The effects of dietary EPA and DHA fortification on lipolysis activity and physiological function in juvenile black sea bream Acanthopagrus schlegeli (Bleeker)
17. The Effect of Insulin, TNFα and DHA on the Proliferation, Differentiation and lipolysis of Preadipocytes Isolated from Large Yellow Croaker (Pseudosciaena Crocea R.)
18. EPA and DHA influenced differently the MRNA expression levels of some lipolysis-related factors in subcutaneous and visceral rabbit ADSCs in vitro
19. Prevention and Reversal of obesity and Glucose Intolerance in Mice by DHA Derivatives
20. The Role of Docosahexaenoic Acid (DHA) in the Control of obesity and Metabolic Derangements in Breast Cancer
21. Effect of DHA supplementation in a very low-calorie ketogenic diet in the treatment of obesity: a randomized clinical trial
22. Frontline Science: A reduction in DHA‐derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody
23. Long-term dietary EPA or DHA supplementation do not ameliorate obesity but improve glucose homeostasis via gut-adipose axis in already obese mice
24. Abstract 2867: Docosahexaenoic acid induces autophagy through p53/AMPK/mtor signaling in human cancer cells
25. Abstract 4654: Docosahexaenoic acid induces autophagy through reactive oxygen species /mtor pathway in p53 mutant cancer
26. 139 Docosahexaenoic Acid-induced Autophagy is Related to Inhibition of mtor by Reactive Oxygen Species in P53 Mutant Cancer Cells
27. Abstract 2274: Docosahexaenoic acid-induced cell death may be related to inhibition of mtor through AMPK activation and PI3K/Akt inhibition in human non-small cell lung cancer cells
28. 138 Inhibition of mtor Through AMPK Activation and PI3K/Akt Inhibition is Important to Docosahexaenoic Acid-induced Cell Death in Human Non-small Cell Lung Cancer Cells
29. 1034 POSTER Docosahexaenoic Acid Induces Autophagy Through p53/AMPK/mtor Signaling in Human Cancer Cells Harboring Wild-type p53
30. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: Evidence for a PPAR-γ–dependent mechanism
31. DHA Supplementation Decreases Serum C-Reactive Protein and Other Markers of inflammation in Hypertriglyceridemic Men
32. Dietary Olive Oil Supplemented with Fish Oil, Rich in EPA and DHA (n-3) Polyunsaturated Fatty Acids, Attenuates Colonic inflammation in Rats with DSS-Induced Colitis
33. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation
34. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation
35. Administration of DHA Reduces Endoplasmic Reticulum Stress-Associated inflammation and Alters Microglial or Macrophage Activation in Traumatic Brain Injury
36. A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study
37. DHA at nutritional doses restores insulin sensitivity in skeletal muscle by preventing lipotoxicity and inflammation
38. Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA supplementation in Wistar rats: Lipidomic biomarkers of oxidative stress and inflammation
39. Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells
40. DHA-induced stress response in human colon cancer cells – Focus on oxidative stress and autophagy
41. The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells
42. Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae
43. Selenium inclusion decreases oxidative stress indicators and muscle injuries in sea bass larvae fed high-DHA microdiets
44. Vitamin C Enhances Vitamin E Status and Reduces oxidative stress Indicators in Sea Bass Larvae Fed High DHA Microdiets
45. PUFA and oxidative stress. Differential modulation of the cell response by DHA
46. Membrane Lipid Modification by Docosahexaenoic Acid (DHA) Promotes the Formation of α-Synuclein Inclusion Bodies Immunopositive for SUMO-1 in Oligodendroglial Cells After oxidative stress
47. Tumor and non-tumor tissues differential oxidative stress response to supplemental DHA and chemotherapy in rats
48. Increased Uncoupling Protein2 mRNA in White Adipose Tissue, and Decrease in leptin, Visceral Fat, Blood Glucose, and Cholesterol in KK-AyMice Fed with Eicosapentaenoic and Docosahexaenoic Acids in Addition to Linolenic Acid
49. leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation
50. A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet

Donglingcao (From Rabdosia rubesens)

1. Donglingcao (Rabdosia rubesens) modulates cancers, neurodegeneration and cardiovascular disease via autophagy.
2. Donglingcao (Rabdosia rubesens … is frequently lost in patients enduring metabolic syndromes such as obesity

EGb 761 (from Ginkgo biloba extract)

1. Ginkgo biloba Extract EGb 761 and Its Specific Components Elicit Protective Protein Clearance Through the autophagy-Lysosomal Pathway in Tau-Transgenic Mice and Cultured Neurons
2. Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease
3. The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation
4. EGb761 improves the cognitive function of elderly db/db−/− diabetic mice by regulating the beclin-1 and NF-κB signaling pathways
5. Role of EGB 761 as a Possible Aromatase Inhibitor for Breast Cancer Therapy
6. EGB 761 Reduces Tumor Growth in Postmenopausal Xenograft Models Implanted MCF-7 AROM Breast Cancer Cells
7. Influence of Standardized Extract Ginkgo biloba EGb761® Towards Quality of Life Indicators in Patients with Diabetes Mellitus Type 2
8. EGb 761 (5) may counteract this process … of the glu- cose- and fatty acid metabolism in diabetes leading to high levels of free fatty acids in the blood and to in-creasing synthesis of triglicerides accompanied by in- hibition of lipolysis
9. EGb 761 may prevent LDL lipoperoxidation in both lipolytic and hydrophylic phases and may be useful in the prevention of atherosclerosis
10. EGb 761 has a broad spectrum of beneficial effects in several disease states, but the primary interest of this laboratory is to … the insulin resistance syndrome (also called syndrome X). The insulin resistance syndrome includes metabolic defects such as obesity,
11. adipogenesis involved in obesity (Naaz et al., 2002). Therefore, the present results suggest that the potency of EGb 761 on the ER-mediated reproductive actions
12. Ginkgo biloba exocarp extracts induces autophagy in Lewis lung cancer cells involving AMPK / mtor / p70S6k signaling pathway
13. Ginkgo Biloba Leaf Extract Attenuates Atherosclerosis in Streptozotocin-Induced Diabetic ApoE-/- Mice by Inhibiting Endoplasmic Reticulum Stress via Restoration of Autophagy through the mtor Signaling Pathway
14. Central and Local Administration of Gingko Biloba Extract EGb 761® Inhibits Thermal Hyperalgesia and inflammation in the Rat Carrageenan Model
15. Ginkgo biloba (EGb 761): An anti-dementia drug with inflammation inhibiting and cardiovascular effects
16. Central and local administration of Gingko biloba extract EGb 761® inhibits thermal hyperalgesia and inflammation in the rat carrageenan model
17. Ginkgo biloba Extract (EGb 761) Pretreatment Limits Free Radical oxidative stress in Patients Undergoing Coronary Bypass Surgery
18. Ginkgo biloba extract (EGb 761) attenuates lung injury induced by intestinal ischemia/reperfusion in rats: Roles of oxidative stress and nitric oxide
19. Effect of the antioxidant action of Ginkgo biloba extract (EGb 761) on aging and oxidative stress
20. Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-κB-dependent matrix metalloproteinase-9 pathway
21. Ginkgo biloba extract (EGb 761) attenuates oxidative stress induction in erythrocytes of sickle cell disease patients
22. The Effect of Ginkgo biloba extract (EGb 761) on parameters of oxidative stress in different regions of aging rat brains after acute hypoxia
23. Suppressive effect ofGinkgo bilobaextract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino rats
24. Antioxidant effect of EGb 761 on aging and oxidative stress

Emblica officinalis extract

1. Emblica officinalis Extract Induces Autophagy and Inhibits Human Ovarian Cancer Cell Proliferation, Angiogenesis, Growth of Mouse Xenograft Tumors
2. Emblica officinalis Gaertn. Attentuates N-Nitrosodiethylamine-Induced Apoptosis, Autophagy, and inflammation in Rat Livers
3. (Emblica officinalis Gartn.) is … as an antidiabetic and anti- atherogenic adipokine.37 Serum adiponectin levels are de- creased under the conditions of obesity,
4. Emblica officinalis Non-obese type 2 diabetes β-Cell function Antioxidant Ellagic acid Insulin secretion.
5. (Emblica officinalis Gaertn.), at 10 … High-fructose diets have been used in animal models to induce the metabolic syndrome, including abdominal obesity
6. Anti-obesity effects of Emblica officinalis (Amla) are associated with inhibition of nuclear transcription factor, peroxisome proliferator-activated receptor gamma (PPARγ)
7. Emblica officinalis – Anti-obesity activity
8. Emblica officinalis in non-diabetic control and diabetic rats … These may be due to inhibition of lipolysis in adipose tissue by insulin sensitizing or insulin mimetic effect of polyphenolic fraction
9. Emblica officinalis (family: Euphorbiaceae), also known as Indian gooseberry or amla … A) High-fat-fed animals showed decreased hepatic lipolytic enzyme ie CPT
10. Emblica officinalis in our study hypothesizes that a possible inhibition of lipolysis in adipose tissue due to insulin sensitizing or insulin mimetic effect of polyphenolic compound
11. Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process
12. Amla (Emblica officinalis Gaertn.) Extracts Reduce oxidative stress in Streptozotocin-Induced Diabetic Rats
13. Emblica officinalis causes myocardial adaptation and protects against oxidative stress in ischemic‐reperfusion injury in rats
14. Amla (Emblica officinalis Gaertn.) Attenuates Age-Related Renal Dysfunction by oxidative stress
15. Supplementation of Emblica Officinalis (Amla) Extract Reduces oxidative stress in Uremic Patients
16. Studies on effects of Emblica officinalis (Amla) on oxidative stress and cholinergic function in scopolamine induced amnesia in mice.
17. A Pilot clinical study to evaluate the effect of Emblica officinalis extract (Amlamax™) on markers of systemic inflammation and dyslipidemia
18. Emblica officinalis Gaertn. Attentuates N-Nitrosodiethylamine-Induced Apoptosis, Autophagy, and inflammation in Rat Livers
19. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic inflammation: Involvement of Possible Mechanisms
20. Protective effect of Emblica-officinalis in arsenic induced biochemical alteration and inflammation in mice
21. Rutin rich Emblica officinalis Geart. fruit extract ameliorates inflammation in the pancreas of rats subjected to alcohol and cerulein administration
22. Amelioration of Aluminum Maltolate-Induced inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model

Evodiamine, an alkaloid ( from Evodia rutaecarpa )

1. Corrigendum to “Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells”
2. WZY‑321, a novel evodiamine analog, inhibits glioma cell growth in an autophagy‑associated manner
3. oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer
4. Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells
5. Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells
6. A Drug Screening Method Based on the autophagy Pathway and Studies of the Mechanism of Evodiamine against Influenza A Virus
7. Evodiamine Induces Transient Receptor Potential Vanilloid-1-Mediated Protective autophagy in U87-MG Astrocytes
8. Anti-Proliferative Effects of Evodiamine in Human Lung Cancer Cells
9. The effects of evodiamine on autophagy in human colon adenocarcinoma Lovo cells
10. Evodiamine Induces Cell Growth Arrest, Apoptosis and Suppresses Tumorigenesis in Human Urothelial Cell Carcinoma Cells
11. Evodiamine and Its Role in Chronic Diseases
12. Reported a capsaicin‐like anti‐obese activity of evodiamine
13. Evodiamine Improves Diet-Induced obesity in a Uncoupling Protein-1-Independent Manner: Involvement of Antiadipogenic Mechanism and Extracellularly Regulated Kinase/Mitogen-Activated Protein Kinase Signaling
14. Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes
15. Dietary supplementation with evodiamine prevents obesity and improves insulin resistance in ageing mice
16. Capsaicin-Like Anti-obese Activities of Evodiamine from Fruits of Evodia rutaecarpa, a Vanilloid Receptor Agonist
17. Effect of evodiamine on the mRNA expression of lipolytic enzymes Given the results described above,
18. Long-term effects of evodiamine on expressions of lipogenesis and lipolysis genes in mouse adipose and liver tissues
19. Evodiamine had on hemodynamics, energy expenditure, and markers … Epinephrine strongly enhances the rate of glycogenolysis and of lipolysis and appearance of free fatty acids
20. Evodiamine from fruits of … alba) is provided for increasing individual’s natural adipose lipolytic metabolism via adipose metabolism by way of lipolysis or lipolytic metabolism.
21. Evodiamine, and hordenine, all of which have been shown to play a role in enhancing lipolysis and increasing ener- gy expenditure
22. Evodiamine Induces Apoptosis and Enhances TRAIL-Induced Apoptosis in Human Bladder Cancer Cells through mtor/S6K1-Mediated Downregulation of Mcl-1
23. [Effect of evodiamine in inducing apoptosis of gastric cancer SGC-7901 cells through mtor signal pathway].
24. The molecular mechanism of apoptosis in human gastric cancer SGC-7901 cells induced by evodiamine inhibition mtor signal pathway
25. Evodiamine Inhibits Zymosan-Induced inflammation In Vitro and In Vivo: Inactivation of NF-κB by Inhibiting IκBα Phosphorylation
26. Protective Effects of Evodiamine against LPS-Induced Acute Kidney Injury through Regulation of ROS-NF-κB-Mediated inflammation
27. Evodiamine ameliorates paclitaxel-induced neuropathic pain by inhibiting inflammation and maintaining mitochondrial anti-oxidant functions
28. Inhibitory effects of evodiamine on zymosan-induced inflammation: inactivation of NF-κB by inhibiting IκBα phosphorylation
29. Nitric oxide activated by p38 and NF-κB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells
30. Evodiamine inhibits PDGF‑BB‑induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress
31. The Effect of Evodiamine Against Intestinal Tissue Injury Induced By Mesenteric Ischemia-Reperfusion: Role of oxidative stress

Fenugreek

1. Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells
2. Fenugreek alkaloids have also been shown to stimulate the hepatic lipogenic enzymes . During [43] diabetes, lipogenesis is decreased while lipolysis
3. Fenugreek may be due, at least in part, to intestinal glucosidase inhibition … Measurement of adrenaline-induced lipolysis
4. Hypolipidemic Effect of Fenugreek Seeds Is Mediated Through Inhibition of Fat Accumulation and Upregulation of LDL Receptor.
5. Fenugreek hypolipidemic action may be an outcome of the achievement of normal glucose level which may reduce degradation of already accumulated lipids and inhibit lipolysis
6. Effects of fenugreek seeds on adipogenesis and lipolysis in normal and diabetic rats.
7. 4-Hydroxyisoleucine from Fenugreek (Trigonella foenum-graecum): Effects on Insulin Resistance Associated with obesity
8. Efficacy of Fenugreek-based bionanocomposite on renal dysfunction and endogenous intoxication in high-calorie diet-induced obesity rat model—comparative study
9. Low molecular weight galactomannans-based standardized fenugreek seed extract ameliorates high-fat diet-induced obesity in mice via modulation of FASn, IL-6, leptin, and TRIP-Br2†
10. Treatment Effects of Fenugreek (Trigonella foenum-graecum) Seed Powder against High Calorie Diet Indused obesity in Rats
11. Protein based product from fenugreek seeds that regulates dyslipidemia and obesity, and a process for the preparation thereof
12. Supplementation of Fenugreek Leaves Reduces oxidative stress in Streptozotocin-Induced Diabetic Rats
13. Effect of trigonelline and ethanol extract of Iraqi Fenugreek seeds on oxidative stress in alloxan diabetic rabbits
14. A Mechanism-based Pharmacological Evaluation of Efficacy of Trigonella foenum graecum (Fenugreek) Seeds in Regulation of Dyslipidemia and oxidative stress in Hyperlipidemic Rats
15. Amelioration of oxidative stress by dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats
16. Effect of Aqueous Extract of Fenugreek (Trigonella foenum-graecum L.) On Selected Biochemical and oxidative stress Biomarkers in Rats Intoxicated with Carbon Tetrachloride
17. Alleviation of oxidative stress-mediated nephropathy by dietary fenugreek (Trigonella foenum-graecum) seeds and onion (Allium cepa) in streptozotocin-induced diabetic rats
18. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues
19. Does fenugreek (Trigonella foenum-graecum) seed improve inflammation, and oxidative stress in patients with type 2 diabetes mellitus? A parallel group randomized clinical trial
20. Dietary Fenugreek Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis: Role of inflammation
21. Mol Nutr Food Res: Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues
22. Fenugreek alleviates airway eosinophilic inflammation of allergic asthma in OVA-induced mouse model
23. Fenugreek, A Potent Hypoglycaemic Herb Can Cause Central Hypothyroidism Via leptin – A Threat To Diabetes Phytotherapy
24. Low molecular weight galactomannans-based standardized fenugreek seed extract ameliorates high-fat diet-induced obesity in mice via modulation of FASn, IL-6, leptin, and TRIP-Br2

fisetin (From Cotinus Coggygria Extract)

1. Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
2. Crosstalk between Fisetin-induced Apoptosis and autophagy in Human Oral Squamous Cell Carcinoma
3. Fisetin regulates obesity by targeting mtorC1
4. Fisetin at low concentration that does not affect Akt/mtorC1 signaling inhibited adipocyte differentiation, which does not compromise the fisetin’s potential of anti-obesity
5. Fisetin regulates obesity by targeting mtorC1 signaling
6. Potentiation of β-adrenoceptor agonist-mediated lipolysis by quercetin and fisetin in isolated rat adipocytes
7. Another possible mechanism by which fisetin may regulate obesity pathogenesis is by reducing hepatic lipogenesis
8. fisetin act synergistically with epinephrine on β-adrenergic receptor (4), while genistein inhibits … Hormonal short-term modulation of lipolysis is mainly driven by cAMP-dependent protein kinase A
9. Fisetin has also been reported as a potent inhibitor of the human P-form phenolsulfonyl transferase, which reflects its role as chemo-preventive agent in carcinogenesis induced by sulfation [12]. It increases lipolysis
10. Fisetin shows a dose- and time-dependent increase in lipolysis,
11. fisetin exhibited the most effective lipolysis
12. Fisetin modulates adipogenesis and lipolysis in steatotic hepatocytes
13. Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mtor: Findings from 3-D melanoma skin equivalents and computational modeling
14. Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mtor and ERK1/2 signaling pathways
15. Fisetin Suppresses Lipid Accumulation in Mouse Adipocytic 3T3-L1 Cells by Repressing GLUT4-Mediated Glucose Uptake through Inhibition of mtor-C/EBPα Signaling
16. Promising tumor inhibiting potentials of Fisetin through PI3K/AKT/mTOR pathway
17. Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mtor pathway: In vitro and in vivo studies
18. Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models
19. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-κB
20. Fisetin Enhances Behavioral Performances and Attenuates Reactive Gliosis and inflammation During Aluminum Chloride-Induced Neurotoxicity
21. Fisetin Inhibits UVB‐induced Cutaneous inflammation and Activation of PI3K/AKT/NFκB Signaling Pathways in SKH‐1 Hairless Mice
22. Fisetin inhibits high-glucose-induced vascular inflammation in vitro and in vivo
23. Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway
24. Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy
25. Fisetin Regulates Nrf2 Expression and the inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice
26. Activated TNF-α/RIPK3 signaling is involved in prolonged high fat diet-stimulated hepatic inflammation and lipid accumulation: inhibition by dietary fisetin intervention
27. Abstract 216: The Effect of Fisetin on Lipopolysccharide-induced inflammation and MMP Activity in Mouse Peritoneal Macrophages
28. Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats
29. Fisetin averts oxidative stress in pancreatic tissues of streptozotocin-induced diabetic rats
30. Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress
31. Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway
32. Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial oxidative stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity
33. Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress

Fragaria vesca leaves

1. Bioactivity of Fragaria vesca leaves through inflammation, proteasome and autophagy modulation

Fucoidan ( From Seaweed Extract )

1. Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
2. Real-time tracking of the autophagy process in living cells using plasmonically enhanced Raman spectroscopy of fucoidan-coated gold nanoparticles
3. Effect of fucoidan on autophagy, migration and invasion of U266 cells
4. fucoidan can be useful for the prevention or treatment of obesity
5. Fucoidan administration reduced circulating lipopolysaccharide and ameliorated systematic inflammation in HFD-induced obese mice
6. The present study was undertaken to investigate the potential effects of fucoidan on obesity through an in vitro study by determining the effects of fucoidan on preadipocyte differentiation into adipocytes
7. Fucoidan Prevents High‐Fat Diet‐Induced obesity in Animals by Suppression of Fat Accumulation
8. Effect of Fucoidan Administration on Insulin Secretion and Insulin Resistance in Overweight or obese Adults
9. Lipolytic regulation. Here, we examined the biological response of fucoidan on the protein level of lipolysis pathway
10. fucoidan inhibited the fat accumulation in 3T3-L1 adipocytes via regulation of lipolysis
11. Fucoidan, a sulfated polysaccharide derived from brown seaweeds, has been shown to reduce blood glucose levels and improve insulin sensitivity in mice. We investigated the effects of fucoidan on lipid accumulation, lipolysis
12. Fucoidan inhibits leukocyte recruitment in a model peritonial inflammation in rat and blocks interaction of P‐selectin with its carbohydrate ligand
13. Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia–reperfusion injury in rats via regulating the inflammation response
14. Fucoidan from the sporophyll of Undaria pinnatifida suppresses adipocyte differentiation by inhibition of inflammation-related cytokines in 3T3-L1 cells
15. Different Suppressive Effects of Fucoidan and Lentinan on IL-8 mRNA Expression in in Vitro Gut inflammation
16. Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases and oxidative stress in RAW264.7 cells
17. Fucoidan inhibits LPS-induced inflammation in vitro and during the acute response in vivo
18. Low molecular weight fucoidan ameliorates the inflammation and glomerular filtration function of diabetic nephropathy
19. Attenuation of inflammation by marine algae Turbinaria ornata in cotton pellet induced granuloma mediated by fucoidan like sulphated polysaccharide
20. Fucoidan from Acaudina molpadioides protects pancreatic islet against cell apoptosis via inhibition of inflammation in type 2 diabetic mice
21. Fucoidan attenuates atherosclerosis in LDLR-/- mice through inhibition of inflammation and oxidative stress
22. Suppression by Fucoidan of Liver Fibrogenesis via the TGF-β/Smad Pathway in Protecting against oxidative stress
23. Fucoidan protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in a murine hindlimb ischemia model
24. Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease
25. Low Molecular Weight Fucoidan Alleviates Cardiac Dysfunction in Diabetic Goto-Kakizaki Rats by Reducing oxidative stress and Cardiomyocyte Apoptosis
26. Fucoidan protects ARPE-19 cells from oxidative stress via normalization of reactive oxygen species generation through the Ca2+-dependent ERK signaling pathway
27. Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells
28. Fucoidan-Vitamin C complex suppresses tumor invasion through the basement membrane, with scarce injuries to normal or tumor cells, via decreases in oxidative stress and matrix metalloproteinases

Fucoxanthin (from Laminaria japonica)

1. Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways
2. Fucoxanthin, the constituent of Laminaria japonica, triggers AMPK-mediated cytoprotection and autophagy in hepatocytes under oxidative stress
3. Effects of fucoxanthin on autophagy and apoptosis in SGC‐7901cells and the mechanism
4. Study on the Mechanism of autophagy of HeLa Cells in Human Cervical Cancer Induced by Fucoxanthin
5. Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model
6. Anti-obesity Activity of the Marine Carotenoid Fucoxanthin
7. Nutraceutical Effects of Fucoxanthin for obesity and Diabetes Therapy: A Review
8. Petalonia binghamiae Extract and Its Constituent Fucoxanthin Ameliorate High-Fat Diet-Induced obesity by Activating AMP-Activated Protein Kinase
9. We next examined whether fucoxanthin stimulated lipolysis in mature 3T3-L1 adipocytes by measuring levels of glycerol in culture supernatants.
10. These data indicate that fucoxanthin suppresses lipid accumulation and reduces lipolysis; lipolytic enzyme activity was also inhibited in the NAC positive control group
11. The effect of fucoxanthin on lipolysis-related protein
12. Fucoxanthin-supplemented group with a high-fat diet; FCH, 0.167 mg/kg/bw fucoxanthin-supplemented group
13. Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mtor Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells
14. Fucoxanthin restrains oxidative stress induced by retinol deficiency through modulation of Na+K+-ATPase and antioxidant enzyme activities in rats
15. Neuroprotective effects of fucoxanthin and its derivative fucoxanthinol from the phaeophyte Undaria pinnatifida attenuate oxidative stress in hippocampal neurons
16. The protective effect of fucoxanthin isolated from Ishige okamurae on oxidative stress induced by high glucose in human umbilical vein endothelial cells and zebrafish model
17. Assessment of therapeutic effects of Fucoxanthin by attenuates the inflammation in ovalbumin induced asthma in experimental animal model
18. Undaria pinnatifidaand Fucoxanthin AmeliorateLipogenesis and Markers of Both inflammation andCardiovascular Dysfunction in an Animal Model ofDiet-Induced Obesity
19. Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated inflammation
20. Down‐Regulation of Hepatic Stearoyl‐CoA Desaturase‐1 Expression by Fucoxanthin via leptin Signaling in Diabetic/Obese KK‐Ay Mice

galangin ( From Galangal Root Extract )

1. Galangin Induces autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells
2. Galangin decreases p‑tau, Aβ42 and β‑secretase levels, and suppresses autophagy in okadaic acid‑induced PC12 cells via an Akt/GSK3β/mtor signaling‑dependent mechanism
3. Galangin Induces autophagy through Upregulation of p53 in HepG2 Cells
4. Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway
5. Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner
6. Ethanolic Extract of Algerian Propolis and Galangin Decreased Murine Melanoma T
7. Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation
8. Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells
9. Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells
10. Protection by Naringin and Some Other Flavonoids of Hepatocytic autophagy and Endocytosis against Inhibition by Okadaic Acid
11. Cytoprotective effect of flavonoid‐induced autophagy on bisphosphonate mediated cell death in osteoblast
12. Galangin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Mitochondrial Pathway and Phosphatidylinositol 3-Kinase/Akt Inhibition
13. Algerian ethanolic extract of Propolis and galangin decreased melanoma tumour progression in C57BL6 mice
14. Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-κB Phosphorylation
15. This mechanism is believed to be active in preventing obesity, although the activity of galangin in animal models was not investigated
16. Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats
17. Galangin and primers for RT-PCR analysis were purchased from Sigma–Aldrich Pvt … that TGF-β1 gene expression is elevated in the adipose tissue from genetically obese mice
18. Anti-obesity effects of galangin
19. Galangin induced antitumor effects in human kidney tumor cells mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting PI3K/ AKT/mtor signalling pathway.
20. Galangin attenuates mast cell-mediated allergic inflammation
21. Galangin Abrogates Ovalbumin-Induced Airway inflammation via Negative Regulation of NF-B
22. Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling
23. Galangin ameliorates cisplatin induced nephrotoxicity in vivo by modulation of oxidative stress, apoptosis and inflammation through interplay of MAPK signaling cascade
24. Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity
25. D31 NOVEL MECHANISMS OF ALLERGY AND AIRWAY inflammation: Galangin Attenuates Airway Remodeling By Inhibiting Tgf-[Beta]1-Mediated Ros Generation And Mapk/akt Phosphorylation In Asthma
26. Galangin Suppresses Renal inflammation via the Inhibition of NF-κB, PI3K/AKT and NLRP3 in Uric Acid Treated NRK-52E Tubular Epithelial Cells

Ganoderma lucidum

1. A Ribonuclease Isolated from Wild Ganoderma Lucidum Suppressed autophagy and Triggered Apoptosis in Colorectal Cancer Cells
2. Methanolic Extract of Ganoderma lucidum Induces autophagy of AGS Human Gastric Tumor Cells
3. Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mtor Signaling Pathway
4. Triterpenes From Ganoderma Lucidum Induce autophagy in Colon Cancer Through the Inhibition of p38 Mitogen-Activated Kinase (p38 MAPK)
5. Anti-cancer properties of triterpenoids isolated from Ganoderma lucidum – a review
6. A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle
7. Biologic Activity of Spores and Dried Powder from Ganoderma lucidum for the Inhibition of Highly Invasive Human Breast and Prostate Cancer Cells
8. Ganoderma lucidum (Reishi) Inhibits Cancer Cell Growth and Expression of Key Molecules in Inflammatory Breast Cancer
9. Active lipids of Ganoderma lucidum spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K pathways
10. GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via autophagy in Lung Cancer Cells
11. Total triterpenoids from Ganoderma Lucidum suppresses prostate cancer cell growth by inducing growth arrest and apoptosis
12. GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells
13. Ganoderma lucidum triterpenoid extract induces apoptosis in human colon carcinoma cells (Caco-2)
14. A supercritical-CO2 extract of Ganoderma lucidum spores inhibits cholangiocarcinoma cell migration by reversing the epithelial–mesenchymal transition
15. Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1β Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice
16. Studying Ganoderma lucidum as a source of molecular inducers of autophagy
17. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
18. Anti-obesity Effect Of Mushroom (Ganoderma Lucidum) On Experimentally Induced obese Rats
19. Method to prepare Ganoderma lucidum polysaccharides possessing anti-obesity properties
20. Sporoderm-broken spores of Ganoderma lucidum water extract (BSGLWE) inhibits high-fat diet induced obesity through regulating gut microbiota in mice
21. The Effects of Ganoderma Lucidum Pharmacopuncture and Moxibustion (Wang-tteum) on Abdominal obesity: Case Report
22. The Mechanism of Ganoderma lucidum Specific microRNA glu-miR-01Regulation of Target Genes on PI3K/AKT/mtor Signaling Pathway
23. Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
24. Ganoderma Lucidum Polysaccharide Accelerates Refractory Wound Healing by Inhibition of Mitochondrial oxidative stress in Type 1 Diabetes
25. Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3
26. Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress
27. Ganoderma lucidum protects liver mitochondrial oxidative stress and improves the activity of electron transport chain in carbon tetrachloride intoxicated rats
28. Laccase isozymes from Ganoderma lucidum MDU-7: Isolation, characterization, catalytic properties and differential role during oxidative stress
29. Neuroprotective effects of ganoderma lucidum polysaccharides against oxidative stress-induced neuronal apoptosis
30. Effects of Selenium-Enriched Protein from Ganoderma lucidum on the Levels of IL-1β and TNF-α, oxidative stress, and NF-κB Activation in Ovalbumin-Induced Asthmatic Mice
31. Effectiveness of Dp2 nasal therapy for Dp2- induced airwayinflammation in mice: using oral Ganoderma lucidum as animmunomodulator
32. Ganoderma lucidum beta 1,3/1,6 glucan as an immunomodulator in inflammation induced by a high-cholesterol diet
33. Ganoderma lucidum repress injury of ethanol-induced steatohepatitis via anti-inflammation, anti-oxidation and reducing hepatic lipid in C57BL/6J mice
34. Le Ganoderma lucidum: accompagnement cancérologique, lutte antivirale, lutte contre l’inflammation ou contre le syndrome métabolique
35. LBPS 01–05 GANODERMA LUCIDUM POLYSACCHARIDE PEPTIDES AS ANTIOXIDANT, ANTI-inflammation, ANTI-HYPERTENSION AND ANTI-LIPID IN HIGH-RISK PATIENTS OF ATHEROSCLEROSIS
36. A Study on the Controlling Effect of Ganoderma lucidum Mycelium Extract on the Respiratory System inflammation of the Mice
37. Ganoderma lucidum suppresses colon carcinogenesis and inflammation
38. PS 02-02 Effect Ganoderma lucidum Polysaccharide Peptides as Anti-hypertension, Anti-lipid, Anti-oxidant, Anti-inflammation in High Risk Patients of Atherosclerosis
39. A study on the controlling effect of Ganoderma lucidum mycelium extract on the respiratory system inflammation of the mice

Genistein (From Genista Extract)

1. autophagy plays a role in genistein inhibiting proliferation of cervical cancer cells
2. Genistein-induced LKB1–AMPK activation inhibits senescence of VSMC through autophagy induction
3. Correction of Huntington’s Disease Phenotype by Genistein-Induced autophagy in the Cellular Model
4. A High Concentration of Genistein Induces Cell Death in Human Uterine Leiomyoma Cells by autophagy
5. Genistein and Myd88 Activate autophagy in High Glucose-Induced Renal Podocytes In Vitro
6. autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer’s disease
7. Genistein protects against rat hippocampus amyloid-β1-42 neurotoxicity through p-mtor-dependent autophagy
8. Genistein protects against ox-LDL-induced senescence through enhancing SIRT1/LKB1/AMPK-mediated autophagy flux in HUVECs
9. L11 A novel approach for treatment of huntington’s disease by genistein-mediated stimulation of autophagy
10. [Role of PPAR-γ-regulated autophagy in genistein-induced inhibition of hepatic stellate cell activation].
11. Genistein affects lipogenesis and lipolysis in isolated rat adipocytes
12. Genistein and daidzein repress adipogenic differentiation of human adipose tissue‐derived mesenchymal stem cells via Wnt/β‐catenin signalling or lipolysis
13. Genistein inhibits adipogenesis and increases lipolysis in primary human adipocytes
14. Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from obesity by Modifying the Fetal Epigenome
15. Genistein: A promising therapeutic agent for obesity and diabetes treatment
16. Hepatic Gene Expression Profiles Are Altered by Genistein Supplementation in Mice with Diet-Induced obesity
17. Effect of Genistein with Carnitine Administration on Lipid Parameters and obesity in C57Bl/6J Mice Fed a High-Fat Diet
18. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity
19. Genistein Exposure During the Early Postnatal Period Favors the Development of obesity in Female, But Not Male Rats
20. Modulation of Adipocyte Differentiation and Proadipogenic Gene Expression by Sulforaphane, Genistein, and Docosahexaenoic Acid as a First Step to Counteract obesity
21. Sensitization of Cervical Cancer Cells to Cisplatin by Genistein: The Role of NF B and Akt/mtor Signaling Pathways
22. Novasoy and genistein inhibit endometrial cancer cell proliferation through disruption of the AKT/mtor and MAPK signaling pathways
23. Genistein protects against rat hippocampus amyloid-β1-42 neurotoxicity through p-mtor-dependent autophagy
24. Genistein and Gut inflammation: Role of Nitric Oxide
25. Estradiol or genistein prevent Alzheimer’s disease-associated inflammation correlating with an increase PPARγ expression in cultured astrocytes
26. Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation
27. Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice
28. Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis
29. Genistein inhibits TNF-α-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL/6 mice
30. Genistein modulates NF-κB-associated renal inflammation, fibrosis and podocyte abnormalities in fructose-fed rats
31. Genistein ameliorates cardiac inflammation and oxidative stress in streptozotocin-induced diabetic cardiomyopathy in rats
32. Genistein Prevents Hyperglycemia-Induced Monocyte Adhesion to Human Aortic Endothelial Cells through Preservation of the cAMP Signaling Pathway and Ameliorates Vascular inflammation in Obese Diabetic Mice
33. Soy isoflavones (daidzein & genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice
34. Genistein attenuates oxidative stress and neuronal damage following transient global cerebral ischemia in rat hippocampus
35. The Soy Isoflavone, Genistein, Protects Human Cortical Neuronal Cells from oxidative stress
36. Suppressive Effects of Genistein on oxidative stress and NFκB Activation in RAW 264.7 Macrophages
37. Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress
38. Genistein reduced the neural apoptosis in the brain of ovariectomised rats by modulating mitochondrial oxidative stress
39. Dietary genistein and equol (4′, 7 isoflavandiol) reduce oxidative stress and protect rats against focal cerebral ischemia
40. Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury
41. Genistein modulates oxidative stress in breast cancer cell lines according to ERα/ERβ ratio: Effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes
42. Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes
43. Genistein restricts leptin secretion from rat adipocytes
44. Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts
45. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle
46. Effects of estradiol, estrogen receptor subtype-selective agonists and genistein on glucose metabolism in leptin resistant female Zucker diabetic fatty (ZDF) rats
47. Effect of the genistein metabolite on leptin secretion in murine adipocytes in vitro
48. Genistein suppresses leptin‐induced proliferation and migration of vascular smooth muscle cells and neointima formation
49. Genistein Precipitated Hypothyroidism, Altered leptin and C-Reactive Protein Synthesis in Pregnant Rats
50. The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats
51. Hypothyroidism, altered leptin and c-reactive protein synthesis characterised pregnancy exposed to genistein
52. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle
53. Impact of estradiol, estrogen receptor subtype specific agonists and genistein on food intake, body weight, and glucose metabolism in leptin resistant ovariectomized Zucker diabetic fatty rats
54. Genistein Combined with Exercise Improves Lipid Profiles and leptin Levels in C57BL/6J Mice Fed a High Fat Diet

ginger (Zingiber officinale Roscoe)

1. Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult
2. Genetic and Histopathological Responses to Cadmium Toxicity in Rabbit’s Kidney and Liver: Protection by Ginger (Zingiber officinale)
3. Ginger was reported that it could stimulate the lipolysis activity
4. Zingiber officinale, has shown therapeutic role in health management since … reported to be effective in enhancing basal lipolysis
5. Beneficial effects of Zingiber officinale on goldthioglucose induced obesity
6. Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review.
7. Mioga (Zingiber mioga Rosc.) Extract Prevents 3T3-L1 Differentiation into Adipocytes and obesity in Mice
8. A systematic review of the anti‐obesity and weight lowering effect of ginger (Zingiber officinale Roscoe) and its mechanisms of action
9. Effect of Zingiber officinale Supplementation on obesity Management with Respect to the Uncoupling Protein 1 ‐3826A>G and ß3‐adrenergic Receptor Trp64Arg Polymorphism
10. Ginger (Zingiber officinale) has been used as a medicinal spice for a long time.21, 22 It … zingerone at the concentration of 1000 μM increases basal lipolysis
11. Mechanism of Chemoprevention against Colon Cancer Cells Using Combined Gelam Honey and Ginger Extract via mTOR and Wnt/β-catenin Pathways.
12. Influence of dietary ginger (Zingiber officinales Rosc) on oxidative stress induced by malathion in rats
13. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin–nicotinamide diabetic rats
14. 6-Shogaol (Alkanone from Ginger) Induces Apoptotic Cell Death of Human Hepatoma p53 Mutant Mahlavu Subline via an oxidative stress-Mediated Caspase-Dependent Mechanism
15. Ginger Pharmacopuncture Improves Cognitive Impairment and oxidative stress Following Cerebral Ischemia
16. Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, oxidative stress, and inflammation in Type 2 Diabetes Patients
17. Effect of Ginger and Cinnamon Intake on oxidative stress and Exercise Performance and Body Composition in Iranian Female Athletes
18. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice
19. Ginger, micro-inflammation and kidney disease
20. Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation
21. Influence of Ginger and Cinnamon Intake on inflammation and Muscle Soreness Endued by Exercise in Iranian Female Athletes
22. Dried Ginger (Zingiber officinalis) Inhibits inflammation in a Lipopolysaccharide-Induced Mouse Model
23. Protective effects of ginger‐turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis
24. inflammation reducing action of synergistic mixtures of bisabolol and ginger extracts
25. Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients
26. Standardized ginger (Zingiber officinale) extract reduces bacterial load and suppresses acute and chronic inflammation in Mongolian gerbils infected with cagA+ Helicobacter pylori
27. Effects of clove and fermented ginger on blood glucose, leptin, insulin and insulin receptor levels in high fat diet- induced type 2 diabetic rabbits
28. Effect of ginger (Zingiber officinale Roscoe) supplementation on nutritional status and circulating level of some adipocytokines in obese women with regard to genetic polymorphism of leptin, adiponectin, UCP-1 and beta 3 adrenergic receptors

Gingerol (From Zingiber Officinale)

1. 6-Gingerol induces autophagy to protect HUVECs survival from apoptosis
2. autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells
3. Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death
4. A Bioactive Constituent of Ginger, 6‐Shogaol, Prevents Adipogenesis and Stimulates lipolysis in 3T3‐L1 Adipocytes
5. Anti‐obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high‐fat diet
6. Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia
7. Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats
8. 6-Gingerol Inhibits Lipid Accumulation and obesity-Induced Inflammatory Responses In 3T3-L1 adipocytes and RAW264.7 Macrophages.
9. Mechanisms for antidiabetic effect of gingerol in cultured cells and obese diabetic model mice
10. 6-Gingerol Suppresses Adipocyte-Derived Mediators of inflammation In Vitro and in High-Fat Diet-Induced obese Zebra Fish
11. A study on 6-gingerol attenuate vascular smooth muscle cells senescence through inhibition of mtor pathway molecular
12. 6-Gingerol Protects against Nutritional Steatohepatitis by Regulating Key Genes Related to inflammation and Lipid Metabolism
13. [6]-Gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis
14. 6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced inflammation via the PI3K/Akt-Dependent Mechanism in Rats
15. 6-Gingerol mitigates nutritional steatohepatitis through regulating key genes related to oxidative stress, inflammation and fibrogenesis
16. The Natural Product 6-Gingerol Inhibits inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E2 Levels
17. Corrigendum to(6-Gingerol Protects Heart by SuppressingMyocardial Ischemia/Reperfusion Induced inflammation viathe PI3K/Akt-Dependent Mechanism in Rats)
18. Chapter 24 – The Phenolic Gingerols and Gingerol-Derived Shogaols: Features and Properties Related to the Prevention and Treatment of Cancer and Chronic inflammation
19. 6-gingerol ameliorates gentamicin induced renal cortex oxidative stress and apoptosis in adult male albino rats
20. Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach
21. 6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction
22. Anti‐obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high‐fat diet

Ginsenoside 20 (S)-Rg3 ( From Ginseng Root Extact )

1. Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer
2. 20(S)-Ginsenoside Rh2 Induce the Apoptosis and autophagy in U937 and K562 Cells
3. Stereoisomer-Specific Anticancer Activities of Ginsenoside Rg3 and Rh2 in HepG2 Cells: Disparity in Cytotoxicity and autophagy-Inducing Effects Due to 20(S)-Epimers
4. Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells
5. 20(S)-ginsenoside Rg3 sensitizes human non-small cell lung cancer cells to icotinib through inhibition of autophagy
6. 20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin
7. The Ginsenoside 20-O-β-D-Glucopyranosyl-20(S)-Protopanaxadiol Induces autophagy and Apoptosis in Human Melanoma via AMPK/JNK Phosphorylation
8. Ginsenoside 20(S)-Rg3 induced autophagy to inhibit migration and invasion of ovarian cancer
9. Ginsenoside Rg5 Inhibits Succinate-Associated lipolysis in Adipose Tissue and Prevents Muscle Insulin Resistance
10. Ginsenoside Rb_1 facilitates adipocyte differentiation and inhibits lipolysis in 3T3-L1 adipocytes
11. Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor-dependent lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice
12. Anti-obesity effects of ginsenoside Rh2 are associated with the activation of AMPK signaling pathway in 3T3-L1 adipocyte
13. Ginsenoside Rh1 Ameliorates High Fat Diet-Induced obesity in Mice by Inhibiting Adipocyte Differentiation
14. Ginsenoside F2 possesses anti-obesity activity via binding with PPARγ and inhibiting adipocyte differentiation in the 3T3-L1 cell line
15. Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
16. Anti-obesity Effects of Ginsenoside Rd via AMPK and PPAR Gamma
17. Ginsenoside Rg5: Rk1 Exerts an Anti-obesity Effect on 3T3-L1 Cell Line by the Downregulation of PPARγ and CEBPα
18. Saponin from sea cucumber exhibited more significant effects than ginsenoside on ameliorating high fat diet-induced obesity in C57BL/6 mice
19. Stereoisomer-specific ginsenoside 20(S)-Rg3 reverses replicative senescence of human diploid fibroblasts via Akt-mtor-Sirtuin signaling
20. 20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mtor signal pathway
21. Central Inflammation and leptin Resistance Are Attenuated by Ginsenoside Rb1 Treatment in Obese Mice Fed a High-Fat Diet
22. Ginsenoside Rb1 improves leptin sensitivity in the prefrontal cortex in obese mice
23. Ginsenoside Rb1 exerts antidiabetic action on C2C12 muscle cells by leptin receptor signaling pathway

Glucosamine ( From Crab and Shrimp SHells )

1. Glucosamine Activates autophagy In Vitro and In Vivo
2. Glucosamine induces autophagy via an mtor-independent pathway
3. Glucosamine protects nucleus pulposus cells and induces autophagy via the mtor‐dependent pathway
4. Glucosamine promotes osteoblast proliferation by modulating autophagy via the mammalian target of rapamycin pathway
5. Glucosamine extends the lifespan of Caenorhabditis elegans via autophagy induction
6. Glucosamine-Induced autophagy through AMPK–mtor Pathway Attenuates Lipofuscin-Like Autofluorescence in Human Retinal Pigment Epithelial Cells In Vitro
7. Glucosamine regulates autophagy in vitro and in vivo
8. O-LINKED N-ACETYL GLUCOSAMINE (O-GLCNAC) REGULATES autophagy AND APOPTOSIS IN CARDIOMYOCYTES: A DOUBLE-EDGED SWORD IN INTERMITTENT HYPOXIA-INDUCED CARDIAC REMODELING
9. Glucosamine induces autophagic cell death through the stimulation of ER stress in human glioma cancer cells
10. Glucosamine protects nucleus pulposus cells and induces autophagy via the mtor‐dependent pathway
11. autophagy in osteoarthritis
12. autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
13. Post-translational protein modification by O-linked N-acetyl-glucosamine: Its role in mediating the adverse effects of diabetes on the heart
14. Effects of Lipofectamine 2000/siRNA Complexes on autophagy in Hepatoma Cells
15. Beneficial reward-to-risk action of glucosamine during pathogenesis of osteoarthritis
16. Molecular mechanisms of anticancer effects of Glucosamine
17. autophagy Modulation for Alzheimer’s Disease Therapy
18. Glucosamine: an ingredient with skin and other benefits
19. Cytotoxic Effects of d-Glucosamine on the Ultrastructures of Normal and Neoplastic Tissues in Vivo
20. Anti-obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced obese Rats
21. glucosamine (glucosamine-6-phosphate, PGlc) was synthesized using methanesulfonic acid, phosphorus … genes and proteins associated with adipogenesis and lipolysis
22. glucosamine and inositol monophosphate, whereas the insulin effects on 3-0-methylglucose, cyclic AMP and lipolysis were unaffected
23. Glucosamine induces insulin … identification of phosphorylation sites and effects on the phosphorylation by lipolytic hormones
24. Anti-obesity effect of sulfated glucosamine by AMPK signal pathway in 3T3-L1 adipocytes
25. Glucosamine Enhances Body Weight Gain and Reduces Insulin Response in Mice Fed Chow Diet but Mitigates obesity, Insulin Resistance and Impaired Glucose Tolerance in Mice High-Fat Diet
26. Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocytes
27. Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or obese Subjects
28. Anti-obese Effect of Glucosamine and Chitosan Oligosaccharide in High-Fat Diet-Induced obese Rats
29. Increased number of subjects with elevated levels of blood glucose (HbA1c) after prolonged glucosamine usage among overweight and obese women
30. An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells
31. Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22Phox and iNOS expression
32. Comparison of effect of chitin, chitosan, chitosan oligosaccharide and N-acetyl-d-glucosamine on growth performance, antioxidant defenses and oxidative stress status of Penaeus monodon
33. Protective Effects of Glucosamine on Oxidative-Stress and Ischemia/Reperfusion-Induced Retinal Injury
34. Randomized Trial of Glucosamine and Chondroitin Supplementation on inflammation and oxidative stress Biomarkers and Plasma Proteomics Profiles in Healthy Humans
35. Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats
36. Evaluation of antigenotoxic effects of Glucosamine and N-acetylglucosamine on human peripheral lymphocytes exposed to oxidative stress
37. Combined effect of celecoxib and glucosamine sulfate on inflammatory factors and oxidative stress indicators in patients with knee osteoarthritis
38. Inflammatory and oxidative stress in the Airway Epithelium Are Mediated Through O-Linked N-Acetyl-Glucosamine Modification and Regulated by FGF23
39. Effects of Chondroitin and Glucosamine Sulfate in a Dietary Bar Formulation on inflammation, Interleukin-1β, Matrix Metalloprotease-9, and Cartilage Damage in Arthritis
40. Joint inflammation increases glucosamine levels attained in synovial fluid following oral administration of glucosamine hydrochloride
41. Glucosamine attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling
42. Attenuation of LPS-Induced Lung inflammation by Glucosamine in Rats
43. Effect of a high dose of glucosamine on systemic and tissue inflammation in an experimental model of atherosclerosis aggravated by chronic arthritis
44. Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats
45. Effects of dietary supplementation of glucosamine sulfate on intestinal inflammation in a mouse model of experimental colitis
46. Glucosamine and egg for reducing inflammation
47. Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic inflammation
48. Effects of glucosamine sulfate and exercise therapy on serum leptin levels in patients with knee osteoarthritis: preliminary results of randomized controlled clinical trial
49. Glucosamine attenuates increases of intraabdominal fat, serum leptin levels, and insulin resistance induced by a high-fat diet in rats
50. Effect of oral glucosamine sulfate on serum leptin levels in human subjects

Glutathione (From Glutamic Acid, Cysteine and Glycine)

1. Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells
2. Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation
3. Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
4. Intracellular Glutathione Regulates Sesquiterpene Lactone-induced Conversion of autophagy to Apoptosis in Human Leukemia HL60 Cells
5. Glutathione Depletion Induces Spermatogonial Cell autophagy
6. Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis
7. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans
8. Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis–autophagy crosstalk in macrophages
9. Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy
10. Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
11. Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells
12. Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation
13. Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
14. Sodium nitroprusside induces autophagic cell death in glutathione-depleted osteoblasts
15. Glutathione Participates in the Regulation of Mitophagy in Yeast
16. Ascorbate induces autophagy in pancreatic cancer
17. Chirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots
18. Glutathione in Cancer Cell Death
19. Glutathione: new roles in redox signaling for an old antioxidant
20. Glutathione Efflux and Cell Death
21. Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer
22. Glutathione peroxidase activity is neuroprotective in models of Huntington’s disease
23. Cellular glutathione peroxidase in human brain: cellular distribution, and its potential role in the degradation of Lewy bodies in Parkinson’s disease and dementia with Lewy bodies
24. Effect of Alloxan on Spontaneous lipolysis and Glutathione System in Isolated Rat Adipocytes
25. Effect of insulin, the glutathione system, and superoxide anion radical in modulation of lipolysis in adipocytes of rats with experimental diabetes
26. Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase
27. Glutathione-S-Transferase M1, obesity, Statins, and Autonomic Effects of Particles
28. Glutathione S-Transferase Polymorphisms, Passive Smoking, obesity, and Heart Rate Variability in Nonsmokers
29. Cytochrome P450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes
30. Glutathione Depletion Prevents Diet‐Induced obesity and Enhances Insulin Sensitivity
31. Hepatic Expression of Adiponectin Receptors Increases with Non-alcoholic Fatty Liver Disease Progression in Morbid obesity in Correlation with Glutathione Peroxidase 1
32. Serum Selenium and Glutathione Peroxidase in Patients with Obesity and Metabolic Syndrome
33. Mutant Type Glutathione S-transferase Theta 1 Gene Homologue to mtor in Myelodysplastic Syndrome: Possible Clinical Application of Rapamycin
34. P663 Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mtor.
35. Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mtor signaling in the cerebellum
36. Glutathione, Stress Responses, and Redox Signaling in Lung inflammation
37. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches
38. Environmental toxicity, redox signaling and lung inflammation: The role of glutathione
39. High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis
40. Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer
41. Role of glutathione in immunity and inflammation in the lung
42. Regulation of glutathione in inflammation and chronic lung diseases
43. Glutathione Redox Regulates Airway Hyperresponsiveness and Airway inflammation in Mice
44. Protein-Deficient Pigs Cannot Maintain Reduced Glutathione Homeostasis When Subjected to the Stress of inflammation
45. Polymorphisms at the glutathione S‐transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation
46. Glutathione, oxidative stress and neurodegeneration
47. Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
48. Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress
49. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.
50. Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death
51. Tissue glutathione, nutrition, and oxidative stress
52. Glutathione Depletion Due to Copper-Induced Phytochelatin Synthesis Causes oxidative stress in Silene cucubalus
53. Glutathione depletion and oxidative stress
54. Renal antioxidant enzymes and glutathione redox status in leptin-induced hypertension
55. Wound tissue malondialdehyde and glutathione levels in leptin treated healthy and diabetic rats.
56. [Effects of glutathione on oxidative stress, leptin and adiponectin in patients with obstructive sleep apnea complicated with metabolic syndrome].
57. leptin sensitizer celastrol, glial calcineurin and hypothalamic glutathione peroxidase 7 – novel entities in weight control and glucose homeostasis

Grifolin, a secondary metabolic product isolated from the mushroom Albatrellus confluence

1. Grifolin induces autophagic cell death by inhibiting the Akt/mtor/S6K pathway in human ovarian cancer cells
2. Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells
3. Grifolin, a potent antitumour natural product inhibits the growth and invasion of gastric cancer cells in vitro

Gynura formosana Kitam. leaves

1. The Ethyl Acetate Extract of Gynura formosana Kitam. Leaves Inhibited Cervical Cancer Cell Proliferation via Induction of autophagy
2. Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication
3. First record of Phytophthora drechsleri on Gynura formosana
4. Antioxidant Capacity, Cytotoxicity, and Acute Oral Toxicity of Gynura bicolor
5. Gynura procumbens modulates the microtubules integrity and enhances distinct mechanism on doxorubicin and 5-flurouracil-induced breast cancer cell death
6. Effects of light quality on growth, secondary metabolites, and oxidative stress tolerance of Gynura bicolor.
7. Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice

Hibiscus sabdariffa Leaf

1. Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and autophagy
2. Delphinidin-rich extracts of Hibiscus sabdariffa L. trigger mitochondria-derived autophagy and necrosis through reactive oxygen species in human breast cancer cells
3. Autophagic effects of Hibiscus sabdariffa leaf polyphenols and epicatechin gallate (ECG) against oxidized LDL-induced injury of human endothelial cells
4. Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans
5. Effect of Hibiscus sabdariffa extract on high fat diet–induced obesity and liver damage in hamsters
6. Potential use of dietary fibre from Hibiscus sabdariffa and Agave tequilana in obesity management
7. Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to obesity
8. Postweaning Consumption of Aqueous Extract of Hibiscus sabdariffa May Predispose Rats to Obesity
9. Antidiabetic properties of Hibiscus rosa sinensis L. leaf extract fractions on non-obese diabetic (NOD) mouse
10. Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice
11. Effect of Hibiscus sabdariffa Calices on Dyslipidemia in obese Adolescents: A Triple-masked Randomized Controlled Trial
12. Effect of Hibiscus sabdariffa Supplementation on Renal Function and Lipidic Profile in obese Rats
13. Effect of different fractions of Hibiscus rosa sinensis leaf extract on islets of Langerhans and antioxidant activity in non-obese diabetic (NOD) mouse
14. Polyphenols Extracted from Hibiscus sabdariffa L. Inhibited Lipopolysaccharide-Induced inflammation by Improving Antioxidative Conditions and Regulating Cyclooxygenase-2 Expression
15. Anti-inflammatory Activity of Methanolic Extract ofHibiscus sabdariffaon CarrageenanInduced inflammation in Wistar Rat
16. Exploring the effect and mechanism of Hibiscus sabdariffa on urinary tract infection and experimental renal inflammation
17. Aqueous extract of Hibiscus sabdariffa L. decelerates acetaminophen‐induced acute liver damage by reducing cell death and oxidative stress in mouse experimental models
18. The protective effect of aqueous extracts of roselle (Hibiscus sabdariffa L. UKMR-2) against red blood cell membrane oxidative stress in rats with streptozotocin-induced diabetes
19. Anthocyanin – Rich Red Dye of Hibiscus Sabdariffa Calyx Modulates Cisplatin-induced Nephrotoxicity and oxidative stress in Rats
20. Hibiscus sabdariffa ethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits.
21. The Effect of Green Tea and Sour Tea (Hibiscus sabdariffa L.) Supplementation on oxidative stress and Muscle Damage in Athletes
22. Infusion of Hibiscus sabdariffa L. Modulates oxidative stress in Patients with Marfan Syndrome
23. Efficacy of Hibiscus sabdariffa and Telfairia occidentalis in the attenuation of CCl4-mediated oxidative stress
24. Evaluation of the effects of roselle (Hibiscus sabdariffa L.) on oxidative stress and serum levels of lipids, insulin and hs-CRP in adult patients with metabolic syndrome: a double-blind placebo-controlled clinical trial
25. Modulation of oxidative stress in Fatty Liver of Rat with Metabolic Syndrome by Hibiscus Sabdariffa
26. oxidative stress Attenuation in Hiv/Aids Patients on Antiretroviral Drugs by Calyx Juice of Hibiscus sabdariffa Linn (Malvaceae)
27. Anthocyanin–Rich Red Dye of Hibiscus sabdariffa L. Calyx Modulates CdCl2- Induced Hypochromic Microcytic Anaemia and oxidative stress in Rat Red Blood Cells

honokiol (from Magnolia officinalis)

1. Honokiol‑induced apoptosis and autophagy in glioblastoma multiforme cells
2. Honokiol activates reactive oxygen species‐mediated cytoprotective autophagy in human prostate cancer cells
3. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mtor and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration
4. Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas
5. Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cell
6. Honokiol Induces Apoptosis, G1 Arrest, and autophagy in KRAS Mutant Lung Cancer Cells
7. Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
8. Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells
9. Data analyses of honokiol-induced autophagy of human glioma cells in vitro and in vivo
10. Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells
11. Honokiol‑induced apoptosis and autophagy in glioblastoma multiforme cells
12. Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent
13. Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mtor and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration
14. Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mtor signaling pathway
15. Honokiol inhibits melanoma stem cells by targeting notch signaling
16. Honokiol triggers the activation of the LKB1–AMPK signaling pathway, thereby leading to the induction of lipolysis
17. We next evaluated the effect of honokiol on lipolysis by Western blotting and confirmed enhanced expression of p-HSL and p-PLIN
18. Honokiol (molecular weight: 266.33; 99.8% purity)36 was provided by Jack Arbiser’s Laboratory, Department of Dermatology, Emory University Medical School … In vitro studies show that solar radiation produces TNF‐α, IL‐1α, IL‐11, and IL‐6, inducing lipolysis and decreasing
19. honokiol in an effective amount to increase lipolysis in mature adipocytes
20. Honokiol, magnolol, and a combination of both compounds improve glucose metabolism in high-fat diet-induced obese mice
21. Growth Inhibitory Activity of Honokiol through Cell-cycle Arrest, Apoptosis and Suppression of Akt/mtor Signaling in Human Hepatocellular Carcinoma Cells
22. Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mtor signaling pathway
23. Honokiol Inhibits Vascular Vessel Formation of Mouse Embryonic Stem Cell-Derived Endothelial Cells via the Suppression of PECAM and MAPK/mtor Signaling Pathway
24. Honokiol induces autophagy and apoptosis of osteosarcoma through PI3K/Akt/mtor signaling pathway
25. mtor signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis
26. Honokiol induces apoptosis and suppresses migration and invasion of ovarian carcinoma cells via AMPK/mtor signaling pathway
27. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis
28. Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA
29. Honokiol protects rat hearts against myocardial ischemia reperfusion injury by reducing oxidative stress and inflammation
30. Honokiol protects against renal ischemia/reperfusion injury via the suppression of oxidative stress, iNOS, inflammation and STAT3 in rats
31. Honokiol Reduces oxidative stress, c-jun-NH2-Termial Kinase Phosphorylation and Protects against Glycochenodeoxycholic Acid-Induced Apoptosis in Primary Cultured Rat Hepatocytes
32. Honokiol Alleviates oxidative stress-Induced Neurotoxicity via Activation of Nrf2
33. Honokiol Ameliorates Myocardial Ischemia/Reperfusion Injury in Type 1 Diabetic Rats by Reducing oxidative stress and Apoptosis through Activating the SIRT1-Nrf2 Signaling Pathway
34. Long‐term supplementation of honokiol and magnolol ameliorates body fat accumulation, insulin resistance, and adipose inflammation in high‐fat fed mice
35. Honokiol Downregulates Kruppel-Like Factor 4 Expression, Attenuates inflammation, and Reduces Histopathology After Spinal Cord Injury in Rats
36. Honokiol inhibits ultraviolet radiation-induced immunosuppression through inhibition of ultraviolet-induced inflammation and DNA hypermethylation in mouse skin
37. Honokiol Attenuates Sepsis-Associated Acute Kidney Injury via the Inhibition of oxidative stress and inflammation
38. Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage
39. Honokiol improved chondrogenesis and suppressed inflammation in human umbilical cord derived mesenchymal stem cells via blocking nuclear factor-κB pathway
40. Oral administration of honokiol attenuates airway inflammation in asthmatic mouse model.
41. Effects of Honokiol on airway inflammation in asthmatic mice exposed to PM2.5 and its mechanism
42. Administration of synergistic amounts of modified citrus pectin and honokiol to treat inflammation and anti-oxidant needs
43. Effects of particulate matter (PM 2.5) exposure on airway inflammation in asthmatic mice and intervention effect of Honokiol
44. Honokiol abrogates leptin-induced tumor progression by inhibiting Wnt1-MTA1-β-catenin signaling axis in a microRNA-34a dependent manner
45. Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

Hou po (Cortex magnoliae officinalis)

1. Autophagy triggered by magnolol derivative negatively regulates angiogenesis
2. Magnolol-lnduced H460 cells deathvia autophagy but not apoptosis
3. Tiron and trolox potentiate the autophagic cell death induced by magnolol analog Ery5 by activation of Bax in HL-60 cells
4. Magnolol derivative 002C-3 protects brain against ischemia–reperfusion injury via inhibiting apoptosis and autophagy
5. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways

Hu Zhang (Rhizoma polygoni cuspidati)

1. Hu Zhang (Rhizoma polygoni cuspidati) modulates cancers, neurodegeneration and cardiovascular disease via autophagy

Huaier extract (From Auricularia on Sophora Japonica)

1. Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells
2. Huaier suppresses proliferative and metastatic potential of prostate cancer PC3 cells via downregulation of Lamin B1 and induction of autophagy
3. [Huaier aqueous extract inhibits proliferation of human hepatoma SK-HEP-1 cells through up-regulation of autophagy].
4. Huaier Extract Induces Autophagic Cell Death by Inhibiting the mtor/S6K Pathway in Breast Cancer Cells
5. Huaier extract synergizes with tamoxifen to induce autophagy and apoptosis in ER-positive breast cancer cells
6. Huaier Extract Inhibits Breast Cancer Progression Through a LncRNA-H19/MiR-675-5p Pathway
7. Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation
8. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK
9. Huaier extract restrains the proliferative potential of endocrine-resistant breast cancer cells through increased ATM by suppressing miR-203
10. Huaier extract enhances the treatment efficacy of paclitaxel in breast cancer cells via the NF-κB/IκBα pathway
11. Huaier aqueous extract inhibits cervical cancer cell proliferation via JNK/p38 pathway
12. A Randomized, Double-Blind, Controlled Clinical Study on the Curative Effect of Huaier on Mild-to-Moderate Psoriasis and an Experimental Study on the Proliferation of Hacat Cells
13. A polysaccharide from Huaier ameliorates cisplatin nephrotoxicity by decreasing oxidative stress and apoptosis via PI3K/AKT signaling

Isorhamnetin (from sea buckthorn / Hippophae rhamnoides L.)

1. Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells
2. Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice
3. Isorhamnetin Inhibits Liver Fibrosis by Reducing autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
4. Antiviral Effect of Methylated Flavonol Isorhamnetin against Influenza
5. 7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells
6. Isorhamnetin‐3‐O‐Glucuronide Suppresses JNK and p38 Activation and Increases Heme‐Oxygenase‐1 in Lipopolysaccharide‐Challenged RAW264.7 Cells
7. FRI0531 THE ARTICULAR PROTECTION EFFECT OF ISORHAMNETIN IN THE RATS OF MONOSODIUM IODOACETATE-INDUCED OSTEOARTHRITIS
8. Water Dropwort, Hyperoside and Isorhamnetin, Regulates the Inflammasome Activation
9. Induction of HO-1 by Isorhamnetin Inhibits COX-2 Expression in Response to inflammation
10. Isorhamnetin glycoside isolated from Opuntia ficus-indica (L.) MilI induces apoptosis in human colon cancer cells through mitochondrial damage
11. isorhamnetin may be beneficial to obesity and steatosis prevention
12. The effect of isorhamnetin glycosides extracted from Opuntia ficus-indica in a mouse model of diet induced obesity
13. Dietary Isorhamnetin Reduces obesity-induced Hepatic Steatosis in Mice Fed a High-fat Diet
14. Isorhamnetin (ISOR), known as 3-O-methylquercetin (Figure 1a), a metabolite of quercetin, is a … Dietary quercetin, ameliorated high fat diet-induced obesity
15. Isorhamnetin revealed that isorhamnetin suppresses the … In vivo studies to observe the effects of SL extract on obesity
16. lipolysis and the … inhibitors of adipose differentiation have been identified, including isorhamnetin
17. Isorhamnetin reduced the mRNA levels of C/EBP α and … expression may impair the barrier function of the protein, thereby leading to enhanced lipolysis
18. Isorhamnetin-3-O … hepatic lipid metabolism is controlled by a balance between lipogenesis and lipolysis processes
19. Isorhamnetin (ISOR), known as 3-O-methylquercetin (Figure 1a), a metabolite of quercetin, is a naturally occurring flavonoid in … essential for maintaining metabolic homeostasis in white adipose tissue because, they are involved in adipogenesis, lipogenesis, lipolysis
20. Isorhamnetin-3-O … Studies found H. fulva plant extract to be a novel lipolysis-promoting material that sensitized the lipolytic response
21. Isorhamnetin suppresses colon cancer cell growth through the PI3K‑Akt‑mtor pathway
22. O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation
23. The Antioxidant Effects of Isorhamnetin Contribute to Inhibit COX-2 Expression in Response to inflammation: A Potential Role of HO-1
24. Protective effects of isorhamnetin on apoptosis and inflammation in TNF-α-induced HUVECs injury
25. Induction of HO-1 by Isorhamnetin Inhibits COX-2 Expression in Response to inflammation
26. Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes
27. AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction
28. Isorhamnetin-3-glucoside alleviates oxidative stress and opacification in selenite cataract in vitro
29. Isorhamnetin attenuates liver fibrosis by inhibiting TGF-β/Smad signaling and relieving oxidative stress
30. Isorhamnetin attenuates collagen-induced arthritis via modulating cytokines and oxidative stress in mice
31. The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation.
32. Protective effect of isorhamnetin on H9 C2 cell line against oxidative stress
33. Isorhamnetin protects against hypoxia/reoxygenation-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes
34. O-Methylated Flavonoid Isorhamnetin Protects against oxidative stress via Activation of Nrf2 and Target Gene Expression
35. Dietary component isorhamnetin is a PPARγ antagonist and ameliorates metabolic disorders induced by diet or leptin deficiency

Isorhynchophylline (IsoRhy) (from Uncaria rhynchophylla)

1. Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy
2. Isorhynchophylline, a natural alkaloid, promotes the degradation of α-synuclein in neuronal cells via inducing autophagy. autophagy 2012; 8:98–108
3. Isorhynchophylline: A plant alkaloid with therapeutic potential for cardiovascular and central nervous system diseases
4. Isorhynchophylline, a natural alkaloid, promotes the degradation of α-synuclein in neuronal cells via inducing autophagy
5. Aberrant autophagy and Parkinsonism: Does Correction Rescue from Disease Progression?
6. Isorhynchophylline improves learning and memory impairments induced by D-galactose in mice
7. Isorhynchophylline Attenuates MPP+-Induced Apoptosis Through Endoplasmic Reticulum Stress- and Mitochondria-Dependent Pathways in PC12 Cells: Involvement of Antioxidant Activity
8. Isorhynchophylline Treatment Improves the Amyloid-β-Induced Cognitive Impairment in Rats via Inhibition of Neuronal Apoptosis and Tau Protein Hyperphosphorylation
9. Stereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes
10. Isorhynchophylline, a Potent Plant Alkaloid, Induces Apoptotic and Anti-Metastatic Effects in Human Hepatocellular Carcinoma Cells through the Modulation of Diverse Cell Signaling Cascades

kaempferol (From Sophora Japonica Extract)

1. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson’s disease
2. Carcinoma cells activate AMP-activated protein kinase-dependent autophagy as survival response to kaempferol-mediated energetic impairment
3. Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells
4. The role of kaempferol-induced autophagy on differentiation and mineralization of osteoblastic MC3T3-E1 cells
5. Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mtor signaling pathway
6. Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mtor pathway in human endothelial cells
7. Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
8. Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells
9. The Effects of Kaempferol-Inhibited autophagy on Osteoclast Formation
10. Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis
11. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson’s disease
12. Kaempferol induces autophagic cell deathvia IRE1-JNK-CHOP pathway and inhibitionof G9a in gastric cancer cells
13. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention
14. Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling
15. Succinate-induced neuronal mitochondrial fission and hexokinase II malfunction in ischemic stroke: Therapeutical effects of kaempferol
16. Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells
17. kaempferol has antioxidative [17], antimicrobial [15], anti-inflammatory [18], lipolytic [19]
18. Anti-obesity effects of kaempferol by inhibiting adipogenesis and increasing lipolysis in 3T3-L1 cells
19. Kaempferol Prevents obesity through Inhibiting Adipogenesis of 3T3-L1 Cells
20. effect of kaempferol on lipolysis, it is unlikely that kaempferol increases lipolysis
21. kaempferol only inhibits the early stage. Regarding mature adipocytes, the three compounds reduce TG accumulation by activating, at least in part, lipolysis,
22. kaempferol increased lipolysis and restored chronic high fatty acid-impaired glucose uptake
23. Kaempferol alleviates palmitic acid-induced lipid stores, endoplasmic reticulum stress and pancreatic β-cell dysfunction through AMPK/mtor-mediated lipophagy
24. Kaempferol Inhibits Angiogenesis by Suppressing HIF-1α and VEGFR2 Activation via ERK/p38 MAPK and PI3K/Akt/mtor Signaling Pathways in Endothelial Cells
25. A Novel C-Glucosides of Kaempferol Isolated From the Steam-Bark of Ulmus Walli
26. Kaempferol Inhibits Angiogenesis through the Suppression of HIF-1α and VEGFR2 Expression via ERK/p38 MAPK-Dependent and PI3K/AKT/mtor Signaling Pathways in Endothelial Cells.
27. Effects of Phenol-Depleted and Phenol-Rich Diets on Blood Markers of oxidative stress, and Urinary Excretion of Quercetin and Kaempferol in Healthy Volunteers
28. Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis
29. Kaempferol Derivatives Prevent oxidative stress–Induced Cell Death in a DJ-1–Dependent Manner
30. Effects of Parsley (Petroselinum crispum) and its Flavonol Constituents, Kaempferol and Quercetin, on Serum Uric Acid Levels, Biomarkers of oxidative stress and Liver Xanthine Oxidoreductase Aactivity inOxonate-Induced Hyperuricemic Rats
31. Kaempferol Attenuates Cardiac Hypertrophy via Regulation of ASK1/MAPK Signaling Pathway and oxidative stress
32. Kaempferol attenuates hyperglycemia-induced cardiac injuries by inhibiting inflammatory responses and oxidative stress
33. Kaempferol protects against propacetamol-induced acute liver injury through CYP2E1 inactivation, UGT1A1 activation, and attenuation of oxidative stress, inflammation and apoptosis in mice
34. Kaempferol and inflammation: From chemistry to medicine
35. Kaempferol Suppresses Eosionphil Infiltration and Airway inflammation in Airway Epithelial Cells and in Mice with Allergic Asthma
36. Quercetin and kaempferol suppress immunoglobulin E-mediated allergic inflammation in RBL-2H3 and Caco-2 cells
37. Kaempferol Alleviates the Interleukin-1β-Induced inflammation in Rat Osteoarthritis Chondrocytes via Suppression of NF-κB
38. Blockade of Airway inflammation by Kaempferol via Disturbing Tyk-STAT Signaling in Airway Epithelial Cells and in Asthmatic Mice
39. Inhibitory effects of kaempferol-3-O-rhamnoside on ovalbumin-induced lung inflammation in a mouse model of allergic asthma
40. Enzymatic Synthesis of a Novel Kaempferol-3-O-β-d-glucopyranosyl-(1→4)-O-α-d-glucopyranoside Using Cyclodextrin Glucanotransferase and Its Inhibitory Effects on Aldose Reductase, inflammation, and oxidative stress
41. Anti-inflammatory effects of Kaempferol on Helicobacter pylori-induced inflammation
42. Kaempferol inhibits chemokine expression and attenuates airway inflammation by suppressing STAT/JAK and NF-kB activity in human airway epithelial cells

luteolin (Peanut Shell Extract)

1. autophagy Inhibitor Chloroquine Enhanced the Cell Death Inducing Effect of the Flavonoid Luteolin in Metastatic Squamous Cell Carcinoma Cells
2. Induction of endoplasmic reticulum stress-mediated apoptosis and non-canonical autophagy by luteolin in NCI-H460 lung carcinoma cells
3. Posttraumatic administration of luteolin protects mice from traumatic brain injury: Implication of autophagy and inflammation
4. Luteolin alleviates post‐infarction cardiac dysfunction by up‐regulating autophagy through Mst1 inhibition
5. Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo
6. Luteolin Attenuates Foam Cell Formation and Apoptosis in Ox-LDL-Stimulated Macrophages by Enhancing autophagy
7. Luteolin Promotes Cell Apoptosis by Inducing autophagy in Hepatocellular Carcinoma
8. The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates autophagy in Parkinson’s Disease Model
9. The Association of Palmitoylethanolamide with Luteolin Decreases autophagy in Spinal Cord Injury
10. Luteolin decreases the UVA‑induced autophagy of human skin fibroblasts by scavenging ROS
11. Anti-tumor activities of luteolin and silibinin in glioblastoma cells: overexpression of miR-7-1-3p augmented luteolin and silibinin to inhibit autophagy and induce apoptosis in glioblastoma in vivo
12. Molecular targets of luteolin in cancer
13. The flavonoid luteolin enhances doxorubicin-induced autophagy in human osteosarcoma U2OS cells
14. Luteolin promotes the sensitivity of cisplatin in ovarian cancer by decreasing PRPA1-medicated autophagy.
15. Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms
16. Luteolin and Apigenin Attenuate 4-Hydroxy-2-Nonenal-Mediated Cell Death through Modulation of UPR, Nrf2-ARE and MAPK Pathways in PC12 Cells
17. Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells
18. Caspase Activation and Extracellular Signal‐Regulated Kinase/Akt Inhibition Were Involved in Luteolin‐Induced Apoptosis in Lewis Lung Carcinoma Cells
19. Luteolin Induces Apoptosis and autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway
20. RECENT UPDATES ON NEUROPHARMACOLOGICAL EFFECTS OF LUTEOLIN
21. Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells
22. Luteolin exerts an anticancer effect on NCI-H460 human non-small cell lung cancer cells through the induction of Sirt1-mediated apoptosis
23. luteolin suppressed adipogenic and lipogenic genes in the cells, while lipolytic genes
24. Luteolin can maintain fasting blood glucose in normal levels and thus prevent lipolysis.
25. Luteolin protects against high fat diet-induced cognitive deficits in obesity mice
26. Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin
27. Luteolin Attenuates Hepatic Steatosis and Insulin Resistance Through the Interplay Between the Liver and Adipose Tissue in Mice with Diet-Induced obesity
28. Low‐dose diet supplement of a natural flavonoid, luteolin, ameliorates diet‐induced obesity and insulin resistance in mice
29. Luteolin reduces obesity-associated insulin resistance in mice by activating AMPKα1 signalling in adipose tissue macrophages
30. Luteolin Prevents Cardiometabolic Alterations and Vascular Dysfunction in Mice With HFD-Induced obesity
31. Luteolin-Enriched Artichoke Leaf Extract Alleviates the Metabolic Syndrome in Mice with High-Fat Diet-Induced obesity
32. Modulating effect of luteolin on ethanol and cerulein induced inflammation— In silico and in vivo studies using rat model of pancreatitis
33. Combination of curcumin and Luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice
34. Investigating the Effect of Luteolin on Interleukin-1β and Tumor Necrosis Factor-α in inflammation Induced by Lipopolysaccharide in Male Rats
35. Luteolin Ameliorates Gut inflammation by Inhibition of NF-?B Activation in in vivo and in vitro inflammation Models
36. Effects of luteolin on inflammation and immune function
37. [The inhibitory effect of luteolin on inflammation in LPS-induced microglia].
38. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells
39. Brain “fog,” inflammation and obesity: key aspects of neuropsychiatric disorders improved by luteolin
40. Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney
41. LUTEOLIN REDUCES CARDIAC DYSFUNCTIONS AND MITOCHONDRIAL oxidative stress IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
42. Luteolin Ameliorates Endothelial Dysfunction Induced by oxidative stress
43. Luteolin extracted from Platycodon grandiflorum protects retinal pigment epithelial cells from oxidative stress-induced caspase-3 dependent apoptosis
44. LUTEOLIN HAS THERAPEUTIC POTENTIAL THROUGH THE REGULATION OF oxidative stress IN CASTRATION-RESISTANT PROSTATE CANCER: MP84-17
45. Flavonoids as protective agents against oxidative stress induced by gentamicin in systemic circulation. Potent protective activity and microbial synergism of luteolin
46. Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
47. Luteolin attenuate the d-galactose-induced renal damage by attenuation of oxidative stress and inflammation
48. Luteolin rescues pentylenetetrazole-induced cognitive impairment in epileptic rats by reducing oxidative stress and activating PKA/CREB/BDNF signaling

Matrine (From Sophora Flavescens Extract)

1. Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy
2. Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases
3. JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced autophagy and Apoptosis via Interplay with Beclin 1
4. Matrine induces Akt/mtor signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells
5. Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells
6. autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells
7. Matrine‑induced autophagy counteracts cell apoptosis via the ERK signaling pathway in osteosarcoma cells
8. Involvement of β‑catenin in matrine‑induced autophagy and apoptosis in WB‑F344 cells
9. Matrine suppresses KRAS‐driven pancreatic cancer growth by inhibiting autophagy‐mediated energy metabolism
10. [Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mtor pathway].
11. Blocking Autophagic Flux Enhances Matrine-Induced Apoptosis in Human Hepatoma Cells
12. Protective role of autophagy in matrine‑induced gastric cancer cell death
13. JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced autophagy and Apoptosis via Interplay with Beclin 1
14. Matrine induces Akt/mtor signalling inhibition‐mediated autophagy and apoptosis in acute myeloid leukaemia cells
15. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells
16. Matrine‑induced autophagy counteracts cell apoptosis via the ERK signaling pathway in osteosarcoma cells
17. Involvement of β‑catenin in matrine‑induced autophagy and apoptosis in WB‑F344 cells
18. Autophagic death induced by matrine in BEL-7402 cells
19. Anticancer Advances of Matrine and Its Derivatives
20. Potentiation of resveratrol-induced apoptosis by matrine in human hepatoma HepG2 cells
21. Effect of matrine on transforming growth factor β1 and hepatocyte growth factor in rat liver fibrosis model
22. Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents
23. Anti-tumor effect of matrine combined with cisplatin on rat models of cervical cancer
24. The effect of matrine on adriamycin-induced podocyte injury and the function of mtor signaling pathway
25. Matrine Exerts Antidepressant-Like Effects on Mice: Role of the Hippocampal PI3K/Akt/mtor Signaling
26. Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mtor signaling pathway
27. [Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mtor pathway].
28. Matrine Protects Against MCD-Induced Development of NASH via Upregulating HSP72 and Downregulating mtor in a Manner Distinctive From Metformin
29. Matrine improves skeletal muscle atrophy by inhibiting E3 ubiquitin ligases and activating the Akt/mtor/FoxO3α signaling pathway in C2C12 myotubes and mice
30. Impact of matrine on inflammation related factors in rat intestinal microvascular endothelial cells
31. Matrine attenuates allergic airway inflammation and eosinophil infiltration by suppressing eotaxin and Th2 cytokine production in asthmatic mice
32. Matrine protects neuro-axon from CNS inflammation-induced injury
33. Prevention of ocular inflammation by matrine, prednisolone, and cyclooxygenase and lipoxygenase inhibitors.
34. Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice
35. [Effect of matrine on NO and ADMA metabolism pathways in serum and tissues of mice with lipopolysaccharide-induced intestine tissue inflammation].
36. [Effects of matrine on airway inflammation and early airway remodeling in asthmatic mice].
37. The Matrine Derivate MASM Prolongs Survival, Attenuates inflammation, and Reduces Organ Injury in Murine Established Lethal Sepsis
38. Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis.
39. Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress
40. Matrine attenuates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via maintaining AMPKα/UCP2 pathway
41. Matrine Attenuates D-Galactose-Induced Aging-Related Behavior in Mice via Inhibition of Cellular Senescence and oxidative stress

Mung bean (Vigna Radiata)

1. Cotyledon cells of Vigna mungo seedlings use at least two distinct autophagic machineries for degradation of starch granules and cellular components
2. Connections between dictyosomes, ER and GERL in cotyledons of mung bean (Vigna radiata L.)
3. Chemistry and technology of green gram (Vigna radiata [L.] Wilczek)
4. Protein bodies of mung bean cotyledons as autophagic organelles
5. Role of Reactive Oxygen Species in Cotyledon Senescence During Early Seedling Stage of Mung Bean [Vigna radiata (L.) Wilczek]
6. Involvement of carboxypeptidase in the degradation of the mung bean (Vigna radiata) trypsin inhibitor during germination and early seedling growth
7. Relationship between loss of desiccation tolerance and programmed cell death (PCD) in mung bean (Vigna radiata) seeds
8. Ameliorative effect of melatonin on meristematic cells of chilled and re-warmed Vigna radiata roots
9. The first possibility is that MBT may activate AMPK-induced lipolysis. AMPK is a critical regulator of leptin-induced fatty acid metabolism and glucose uptake in skeletal muscle. 12–14 Even though vitexin in mung bean extracts increased AMPK protein expression
10. Effects of Mung-Bean and Black-Bean ethanol extracts on inflammation related to obesity in the high fat induced obesity model
11. Mung Bean-Derived Protein Protects Against Neurodegeneration and Memory Impairment in Animal Model of Menopause with obesity
12. Physiological Effects of Mung Bean Starch RS-3 on the obesity Index and Adipose Cell Profile of Sprague-Dawley Rats
13. lipolytic activity of the mung bean lipase
14. Mung bean protein hydrolysates … hypocaloric diets: effects on weight loss and mitochondrial oxidation in obese
15. mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults.
16. mung bean hulls have high potential as a new feedstock for xylitol production. In addressing the current concerns of obesity
17. mung bean coat (MBC … db/db Mice are leptin receptor-deficient and are considered to be an animal model of type 2 diabetes because mice are obese,
18. mung bean can be quite beneficial for planning the diets of diabetic, obese and patients
19. Arsenic-induced root growth inhibition in mung bean (Phaseolus aureus Roxb.) is due to oxidative stress resulting from enhanced lipid peroxidation
20. Changes in oxidative stress defense system in wheat (Triticum aestivum L.) and mung bean (Vigna radiata L.) cultivars grown with and without mineral nutrients and irradiated by supplemental ultraviolet-B
21. Cadmium causes oxidative stress in mung bean by affecting the antioxidant enzyme system and ascorbate-glutathione cycle metabolism
22. Mobile phone radiation inhibits Vigna radiata (mung bean) root growth by inducing oxidative stress
23. oxidative stress and antioxidant defense mechanism in mung bean seedlings after lead and cadmium treatments
24. Caffeic acid inhibits in vitro rooting in mung bean [Vigna radiata (L.) Wilczek] hypocotyls by inducing oxidative stress
25. Dimethoate modifies enhanced UV-B effects on growth, photosynthesis and oxidative stress in mung bean (Vigna radiata L.) seedlings: Implication of salicylic acid
26. Protective role of mannitol against the oxidative stress induced by H2O2 in mung bean (Vigna radiata L.): Changes in antioxidant defense systems
27. Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease
28. Fermented composition of mung bean hulls, method for forming thereof, and anti-oxidation and anti-inflammation composition using the same

Muscadine grape skin extract

1. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis
2. Attenuation of obesity by tocotrienol and application of muscadine grape seed oil as its food based delivery system
3. muscadine grapes … rice bran oil and may offer an alternative solution to attenuate high fat diet-mediated obesity
4. Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented obesity-Associated Metabolic Complications in C57BL/6J Mice
5. Nutraceutical Values of Muscadine against obesity and Metabolic Complications in-vivo
6. Correction to Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented obesity Associated Metabolic Complications in C57BL/6J Mice
7. Attenuation of obesity by tocotrienol and application of muscadine grape seed oil as its food based delivery system
8. Muscadine Juice, Wine and Dealcoholized wine 125 … Thus under normal conditions, insulin suppresses glycogenolysis and gluconeogenesis in the liver, and inhibits lipolysis
9. muscadine or peppervine … increase heart rate, release energy from glucose and glycogen, increase muscle readiness and induce lipolysis
10. muscadine extracts being more effective … The spoilage microorganisms including yeasts and moulds and lipolytic
11. muscadine or peppervine …Zucker rats are known to have reduced response to stimulators of lipolysis,
12. muscadine grape poly … are maintained in abdominally obese men through a reduction in lipolytic
13. Muscadine Grape Extract Prevents Proliferation of HER2 Positive Breast Cancer Cells in Association with a Decrease in Phosphorylation of AKT and mtor
14. Polyphenolics from Açaí (Euterpe oleracea Mart.) and Red Muscadine Grape (Vitis rotundifolia) Protect Human Umbilical Vascular Endothelial Cells (HUVEC) from Glucose- and Lipopolysaccharide (LPS)-Induced inflammation and Target MicroRNA-126
15. Topical Anti-Inflammatory Activities of Vitis rotundifolia (Muscadine Grape) Extracts in the Tetradecanoylphorbol Acetate Model of Ear inflammation
16. Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation
17. Muscadine grape pomace in the treatment of intestinal inflammation
18. Muscadine Grape (Vitis rotundifolia) or Wine Phytochemicals Reduce Intestinal inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis
19. Muscadine Skin Nutraceutical Extract Is Highly Anti-Inflammatory In The TPA Model Of Topical inflammation
20. Muscadine Grape (Vitis rotundifolia) or Wine Supplement Alleviates Intestinal inflammation in a Chronic Colitis Mice Model
21. Identification and Characterization of Tocotrienols in Muscadine Grape Seed Oil and their Inhibitory Effects on Adipogenesis and inflammation
22. Ocular endoplasmic reticulum stress and inflammation is attenuated by supplementation with muscadine grape polyphenols in vitro and in vivo (1045.2)
23. Abstract P3052: A Muscadine Grape Extract Improves Hypertension-Induced Aortic Damage in Conjunction With a Reduction in Fibrosis, oxidative stress, and inflammation
24. Abstract P2007: Muscadine Grape Extract Prevents Cardiac Cell Cytotoxicity Due to oxidative stress by Enhancing Mitochondrial Function
25. Muscadine Grape Extract Improves Exercise Capacity and Reduces oxidative stress in Aging Transgenic (mRen2)27 Hypertensive Female Rats

Myrtillin (From Commiphora Myrrha Extract)

1. Myrrh induces apoptosis and autophagy and enhances the activity of cisplatin in vitro.
2. Polyphenol content influences the course of obesity disease, Aqueous extract … myrtillus L. Ericaceae, Lowering blood glucose levels (active component: myrtillin
3. Most important of these is reduction of obesity by low calorie diets … The extract was given the name myrtillin (Myrtomel Squibb)
4. myrtillin, soon discredited because of their … As with insulin, these drugs might find misapplication in the obese
5. Myrtillin, Glucosone etc., etc. 7. Use of insulin in non -diabetic conditions … From these figures Joslin concludes that diab- etes is largely a penalty of obesity

Naringin (From Grapefruit Extract)

1. Protection by Naringin and Some Other Flavonoids of Hepatocytic autophagy and Endocytosis against Inhibition by Okadaic Acid
2. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mtor cascade via activation of MAPK pathways in AGS cancer cells
3. Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy, and DNA damage
4. Naringin-sensitive protein phosphorylation pathways in the regulation of hepatocytic autophagy
5. Therapeutic Potential of Naringin for Intervertebral Disc Degeneration: Involvement of autophagy Against oxidative stress-Induced Apoptosis in Nucleus Pulposus Cells
6. Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo
7. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects
8. Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti‐fibrosis effect by inhibition of mammalian target of rapamycin
9. Therapeutic effects of silymarin and naringin on methotrexate‐induced nephrotoxicity in rats: Biochemical evaluation of anti‐inflammatory, antiapoptotic, and antiautophagic properties
10. Naringin attenuates granule cell dispersion in the dentate gyrus in a mouse model of temporal lobe epilepsy
11. Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes
12. A spectroscopic study of the interaction of the antioxidant naringin with bovine serum albumin
13. Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation
14. Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice
15. naringin in acute … food consisting of Salacia Reticula has shown a significant lipolytic effect
16. Naringin Improves Diet-Induced Cardiovascular Dysfunction and obesity in High Carbohydrate, High Fat Diet-Fed Rats
17. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced obese Mice
18. Naringin Activates AMPK Resulting in Altered Expression of SREBPs, PCSK9, and LDLR To Reduce Body Weight in obese C57BL/6J Mice
19. Combination effect naringin and pravastatin in lipid profile and glucose in obese rats
20. Naringin inhibits lipopolysaccharide-induced damage in human umbilical vein endothelial cells via attenuation of inflammation, apoptosis and MAPK pathways
21. [Research progress on Drynaria fortunei naringin on inflammation and bone activity].
22. Protective effect of naringin against ankylosing spondylitis via ossification, inflammation and oxidative stress in mice
23. Naringin regulates cholesterol homeostasis and inhibits inflammation via modulating NF-κB and ERK signaling pathways in vitro
24. Natural dietary compound naringin prevents azoxymethane/dextran sodium sulfate-induced chronic colorectal inflammation and carcinogenesis in mice
25. Naringin at a nutritional dose modulates expression of genes related to lipid metabolism and inflammation in liver of mice fed a high-fat diet
26. Naringin protects acrolein-induced pulmonary injuries through modulating apoptotic signaling and inflammation signaling pathways in mice
27. Naringin As Natural Fruit Product And Bitter Taste Agonist Induces Relaxation Of Airway SmoothMuscle Cells Via Intracellular Calcium Signaling
28. P18. Treatment of osteoporotic vertebral fractures/defect in rats by naringin/hydroxyapatite/silk fibroin composite scaffolds in regulation of osteogenic differentiation, angiogenesis and inflammation
29. Protective Effects of Rutin and Naringin in Testicular Ischemia-Reperfusion Induced oxidative stress in Rats
30. Naringin Reduces Hyperglycemia-Induced Cardiac Fibrosis by Relieving oxidative stress
31. Preconditioning L6 Muscle Cells with Naringin Ameliorates oxidative stress and Increases Glucose Uptake
32. Naringin ameliorates cognitive deficits via oxidative stress, proinflammatory factors and the PPARγ signaling pathway in a type 2 diabetic rat model
33. Naringin alleviates early brain injury after experimental subarachnoid hemorrhage by reducing oxidative stress and inhibiting apoptosis
34. Naringin Reverses Hepatocyte Apoptosis and oxidative stress Associated with HIV-1 Nucleotide Reverse Transcriptase Inhibitors-Induced Metabolic Complications
35. Inhibition of the leptin-induced activation of the p38 MAPK pathway contributes to the protective effects of naringin against high glucose-induced injury in H9c2

Old Man’s Beard (Usnea barbata)

1. Usnic Acid Induces Cycle Arrest, Apoptosis, and Autophagy in Gastric Cancer Cells In Vitro and In Vivo
2. The Role of Autophagy in Usnic Acid-Induced Toxicity in Hepatic Cells
3. The role of usnic acid-induced apoptosis and autophagy in hepatocellular carcinoma
4. 869 The lichen compound usnic acid disturbs mitochondrial function and induces autophagy in cancer cells
5. Usnea barbata toxicity INTRODUCTION …Subsequently, 2,4- dinitrophenol was formulated into an anti-obesity drug

Oleanolic acid (From Olive Leaf Extract)

1. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mtor pathways
2. Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells
3. Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy
4. SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells
5. SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells
6. The dual induction of apoptosis and autophagy by SZC014, a synthetic oleanolic acid derivative, in gastric cancer cells via NF-κB pathway
7. AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells
8. Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS‐dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells
9. Oleanolic acid but not ursolic acid induces cell death in HepG2 cells under starvation-induced autophagy
10. Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and autophagy
11. Oleanolic acid induces protective autophagy in cancer cells through the JNK and mtor pathways
12. Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mtor and ROS-dependent pathway
13. Oleanolic acid induces autophagic death in human gastric cancer cells in vitro and in vivo
14. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis
15. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
16. Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mtor/S6K and ERK1/2 signaling
17. Synthesis and proapoptotic activity of oleanolic acid derived amides
18. ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway
19. Oleanolic acid induces mitochondrial-dependent apoptosis and G0/G1 phase arrest in gallbladder cancer cells
20. 3-O-[N-(p-fluorobenzenesulfonyl)-carbamoyl]-oleanolic acid, a semisynthetic analog of oleanolic acid, induces apoptosis in breast cancer cells
21. Caveolin-1 plays a key role in the oleanolic acid-induced apoptosis of HL-60 cells
22. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet
23. Oleanolic acid improves diet-induced obesity by modulating fat preference and inflammation in mice
24. The therapeutic effects of an oleanolic acid derivative in diet induced obesity
25. 2030-P: BS-016, a Novel Oleanolic Acid Derivative, Exerts Antidiabetic and Anti-obesity Effects in Preclinical Studies
26. Pomace Olive Oil Enriched In Oleanolic Acid Improves Diet-Induced obesity And Exerts Protective Effects In Vascular Dysfunction And Metabolic Parameters
27. [Oleanolic acid-stimulated lipolysis in primary adipocytes and its mechanisms].
28. Inhibition of mtor signaling by oleanolic acid contributes to its anti‐tumor activity in osteosarcoma cells†
29. Oleanolic acid suppresses the proliferation of human bladder cancer by Akt/mtor/S6K and ERK1/2 signaling
30. Oleanolic acid induced autophagic cell death in hepatocellular carcinoma cells via PI3K/Akt/mtor and ROS-dependent pathway
31. Protosappanin‐A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT‐mtor signaling
32. Inhibition of mtor signaling by oleanolic acid contribute to its anti-tumor activity in osteosarcoma cells
33. Oleanolic acid and N-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model
34. Identification of a novel oxidative stress induced cell death by Sorafenib and oleanolic acid in human hepatocellular carcinoma cells
35. Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats
36. Oleanolic acid protects against oxidative stress‑induced human umbilical vein endothelial cell injury by activating AKT/eNOS signaling
37. Oleanolic acid controls oxidative stress and expression of the anti-inflammatory protein netrin-1 to protect against autoimmune encephalomyelitis
38. Effect of Oleanolic Acid on Complement in Adjuvant‐ and Carrageenan‐induced inflammation in Rats
39. Anti-inflammatory Effects of Oleanolic Acid on LPS-Induced inflammation In Vitro and In Vivo
40. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring
41. Antioxidant inflammation modulators: C-17 homologated oleanolic acid derivatives
42. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
43. Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at C-17
44. Oleanolic acid suppresses ovalbumin-induced airway inflammation and Th2-mediated allergic asthma by modulating the transcription factors T-bet, GATA-3, RORγt and Foxp3 in asthmatic mice