SIRT-1: Longevity Gene Activator – Starts Shipping November 19th 2024!

INTRODUCING

INTERSTELLAR BLEND™

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SIRT-1

LONGEVITY GENE ACTIVATOR

200:1 Concentration

HEALTH BENEFITS

Explaining SIRT1 in Layman’s Terms

SIRT1 is a vital protein in our bodies, acting like a multitasking superhero to keep us healthy.

1. DNA Fixer: Imagine DNA as a long instruction manual that tells our body how to work. Sometimes, this manual gets damaged. SIRT1 is like a careful proofreader, fixing these mistakes to keep our body’s instructions accurate.

2. Energy Manager: Our body needs energy to function, and SIRT1 helps manage how we use it. It’s like a smart thermostat, adjusting our energy use based on our needs.

3. Guardian of Cell Powerhouses: Our cells have tiny powerhouses called mitochondria. SIRT1 ensures these powerhouses are working well and even helps create new ones when needed.

4. Disease Fighter: Acting as a bodyguard, SIRT1 helps protect us from various diseases, including cancer, heart disease, and brain disorders.

5. Brain Protector: SIRT1 acts like a shield for our brain, protecting it from damage and keeping it functioning well.

6. Fat Controller: SIRT1 helps manage fats in our body, especially when we haven’t eaten for a while. It’s like a traffic controller, directing where fats should go and how they should be used.

In simple terms, SIRT1 is a crucial protein that plays multiple roles in maintaining our health. By repairing DNA, regulating energy, safeguarding mitochondria, fighting diseases, protecting the brain, and controlling fats, SIRT1 keeps our bodies functioning smoothly. Understanding the importance of SIRT1 highlights how essential it is for our overall well-being and longevity.

IMPORTANCE OF SIRT1 ACTIVATION

Sirtuin 1 (SIRT1) is a protein that plays a crucial role in various biological processes. Its activation is associated with several benefits:

1. Gene Expression and DNA Repair: SIRT1 plays an important role in controlling gene expression and DNA repair. It helps in maintaining the integrity of the genetic material and proper functioning of the cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426493/

2. Metabolism and Oxidative Stress Response: SIRT1 is involved in metabolism regulation and the oxidative stress response. It helps the body to efficiently use energy and protect cells from damage caused by reactive oxygen species. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426493/

3. Mitochondrial Function and Biogenesis: SIRT1 is also crucial for the proper functioning of mitochondria, the powerhouses of the cell. It helps in the creation of new mitochondria and ensures that existing ones function optimally. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426493/

4. Disease Prevention: Activation of SIRT1 has been associated with the prevention of several human pathologies, including cancer, neurodegeneration, and cardiovascular disease. It’s also been linked to improved energy homeostasis and the reprogramming of liver cancer metabolism. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04440-9

5. Neurological Health: SIRT1 activation has been linked to improved neurological health. It’s been suggested that increasing SIRT1 could help with cognitive problems, mood imbalances, and serious inflammation. Furthermore, SIRT1-activating molecules have shown therapeutic benefits and neuroprotective effects against age-dependent neurodegenerative diseases.

6. Lipid Homeostasis: SIRT1 is an important regulator of lipid homeostasis in response to nutrient availability. It positively regulates peroxisome proliferators-activated receptor (PPAR), a nuclear receptor that mediates the adaptive response to fasting and starvation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103488/

SIRT-1 AND OBESITY

Activation of SIRT1 can prevent obesity through multiple mechanisms. SIRT1 regulates energy metabolism by promoting energy expenditure, enhancing fat oxidation, and improving mitochondrial function. It controls lipid metabolism by inhibiting lipogenesis and promoting lipolysis. Additionally, SIRT1 improves insulin sensitivity, regulates appetite and food intake, reduces inflammation, and influences fat storage and distribution in the body. These combined effects help prevent excess fat accumulation and the development of obesity.

Natural ways to activate SIRT1 include:

1. Caloric Restriction: Reducing calorie intake without malnutrition increases SIRT1 activity and promotes longevity.

2. Exercise: Regular physical activity, including aerobic exercises and resistance training, activates SIRT1 and enhances metabolic health.

3. Resveratrol: Found in grapes, red wine, berries, and peanuts, resveratrol is a potent SIRT1 activator with significant health benefits.

4. Intermittent Fasting: Fasting increases NAD+ levels, leading to SIRT1 activation and improved cellular homeostasis.

5. Polyphenol-Rich Foods: Consuming polyphenols and plant-derived compounds in foods like onions, apples, berries, green tea, and turmeric activates SIRT1 and offers health advantages.

By naturally activating SIRT1 through these methods, one can enhance energy metabolism, improve insulin sensitivity, reduce inflammation, and prevent obesity. Incorporating these practices into daily life promotes overall well-being and aids in weight management.

SIRT1 Regulation in Ageing and Obesity

Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples. The downstream effects of SIRT1 activity have been thoroughly explored, and their research is still in expanse. SIRT1 activation has been shown to regulate pathways with beneficiary effects on:

1. Ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-II diabetes with.

2. Chronic inflammatory processes such as arthritis, atherosclerosis and emphysema.

3. DNA damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers.

This knowledge intensified the interest in uncovering the mechanisms regulating the expression and activity of SIRT1. This review focuses on the upstream regulatory mechanisms controlling SIRT1, and how this knowledge could potentially contribute to the development of therapeutic interventions.

INGREDIENTS & STUDIES

alpha-lipoic acid

Alpha-lipoic acid (ALA) is a powerful antioxidant that enhances SIRT1 activity, improving lipid metabolism and cellular energy. By increasing the NAD/NADH ratio, ALA promotes mitochondrial function, fatty acid oxidation, and insulin sensitivity. Its neuroprotective and anti-inflammatory properties make ALA beneficial for metabolic disorders and overall cellular health.

Alpha-lipoic acid activates SIRT1-PGC-1α, protecting brain from ischemia.

Alpha-lipoic acid (ALA) enhances SIRT1 and PGC-1α, reduces infarct volume and brain edema in ischemic mice, improving neurological outcomes—suggesting potential stroke recovery benefits.

Acer Truncatum seed extract Nervonic acid

SIRT1 activation is vital for metabolic health and cognitive enhancement, making it a focus in aging research. Acer Truncatum seed extract, rich in nervonic acid, supports brain health and memory. Incorporating this oil may boost SIRT1 activity, promoting healthy aging and cognitive function. Discover the benefits for optimal brain wellness.

Nervonic acid limits weight gain in a mouse model of diet-induced obesity

Nicotinic acid supplementation enhances PPARα, PGC-1α, and SIRT1 in high-fat diet mice, promoting fatty acid oxidation, reducing triglycerides, and improving glucose and insulin tolerance.

Acetylcysteine

SIRT1 is crucial for regulating inflammation, apoptosis, and DNA repair, essential for overall health. Its activation promotes anti-inflammatory effects, aiding chronic disease management and longevity. Acetylcysteine, an antioxidant, enhances SIRT1’s benefits by reducing oxidative stress. Together, they support metabolic health and cognitive function, promoting healthy aging and vitality.

N-Acetyl cysteine protects liver from lead via SIRT1 and LXR.

Sb treatment induces apoptosis by downregulating SIRT1 in BEAS-2b cells. Resveratrol and NAC increase SIRT1 levels, inhibiting ERK and JNK activation, suggesting ROS involvement.

Allicin

SIRT1 regulates metabolism, inflammation, and stress responses, promoting longevity and metabolic health. Allicin, found in garlic, complements SIRT1 with antioxidant and anti-inflammatory effects. Together, they enhance cardiovascular health and immunity. Consuming allicin-rich foods like garlic may boost SIRT1 activation, supporting wellness and disease prevention for a healthier, longer life.

Allicin activates SIRT1, alleviating acrylamide-induced kidney mitochondrial dysfunction.

Allicin restores mitochondrial function and enhances SIRT1 expression, preventing AA-induced mitochondrial apoptosis and nephrotoxicity by inhibiting p53 acetylation and reducing caspase expression.

Ampelopsin

Ampelopsin enhances SIRT1 activity, promoting metabolic health, longevity, and anti-inflammatory effects. It supports cardiovascular function, improves insulin sensitivity, and protects against oxidative stress. Research indicates Ampelopsin’s potential in mitigating age-related diseases and promoting neuroprotection, making it a valuable compound for overall health and wellness enhancement.

Ampelopsin attenuates liver fibrosis via SIRT1/TGF-β1/Smad3 autophagy.

Amp reduces liver fibrosis by inhibiting HSC activation, modulating SIRT1/TGF-β1/Smad3 and autophagy pathways, decreasing fibrosis markers, and increasing MMPs and autophagy proteins.

Angelica Extract Polysaccharides

Angelica extract polysaccharides enhance SIRT1 activity, promoting metabolic regulation, anti-inflammatory effects, and improved immune function. Research suggests they support cardiovascular health, enhance antioxidant defenses, and protect against neurodegenerative diseases. These benefits make Angelica extract polysaccharides a promising natural compound for promoting overall health and longevity through SIRT1 modulation.

Angelica sinensis polysaccharide improves fatty liver via SIRT1 activation.

ASP reduces liver lipid accumulation and hepatic steatosis in high-fat diet mice by activating PPARγ, adiponectin-SIRT1-AMPK signaling, and improving insulin resistance, offering metabolic syndrome support.

Apigenin8-C-glucoside

Apigenin 8-C-glucoside (Vitexin) enhances SIRT1 activity, promoting metabolic health, anti-inflammatory effects, and neuroprotection. Research indicates it supports cardiovascular health, reduces oxidative stress, and improves insulin sensitivity. By modulating SIRT1, Apigenin 8-C-glucoside offers potential benefits for longevity and prevention of age-related diseases, making it a valuable dietary compound for wellness.

Vitexin Protects Against Ethanol-Induced Liver Damage via Sirt1/p53 Pathway

Vitexin protects against ethanol-induced liver damage by inhibiting apoptosis through the Sirt1/p53 pathway, restoring cell viability and reducing oxidative stress and inflammation.

Astaxanthin

Astaxanthin enhances SIRT1 activity, promoting antioxidant effects, reducing oxidative stress, and supporting cardiovascular health. It aids in improving metabolic function, protecting against neurodegeneration, and reducing inflammation. Research highlights astaxanthin’s potential in extending lifespan and combating age-related diseases, making it a powerful natural compound for overall health and wellness.

Nutraceutical activation of Sirt1: a review

Studies show astaxanthin enhances SIRT1 expression, activating sirtuin 1 for anti-aging benefits. This science-backed antioxidant supports cellular health and longevity.

Astragaloside IV

Astragaloside IV activates SIRT1, promoting antioxidant effects, enhancing metabolic health, and reducing inflammation. It supports cardiovascular function, improves insulin sensitivity, and may protect against age-related diseases. Research suggests that Astragaloside IV could be a beneficial natural compound for enhancing longevity and overall health through SIRT1 modulation.

Astragaloside IV activates SIRT1, protects diabetic kidneys via autophagy.

Astragaloside IV enhances autophagy and protects against podocyte injury in diabetes by activating SIRT1 and inhibiting NF-κB acetylation, supporting kidney health under hyperglycemic conditions.

Astragalus membranaceus extract

Astragalus membranaceus activates SIRT1, promoting antioxidant activity, reducing inflammation, and enhancing metabolic health. It supports cardiovascular function, boosts immune response, and may protect against age-related diseases. Research indicates its potential in prolonging lifespan and improving overall wellness through SIRT1 modulation and its bioactive compounds, offering significant health benefits.

Astragalus polysaccharide activates SIRT1/FoxO1, protecting diabetic kidneys.

APS mitigates diabetic nephropathy by activating the SIRT1/FoxO1 autophagy pathway, enhancing podocyte viability, reducing apoptosis, and alleviating oxidative stress and inflammation in hyperglycemic conditions.

Atractylodes chinensis

Atractylodes chinensis activates SIRT1, promoting antioxidant effects and reducing inflammation. It supports metabolic health, enhances immune function, and may protect against age-related diseases. Research suggests its potential in improving overall wellness and longevity through SIRT1 modulation, making it a valuable herbal remedy for various health conditions.

Atractylodes chinensis Water Extract Reduces Obesity via SIRT1/AMPK.

Atractylodes chinensis reduces obesity by decreasing body weight, enhancing fatty acid oxidation, and upregulating SIRT1 and AMPK expression in high-fat diet-induced obese mice.

Berberine

Berberine activates SIRT1, promoting metabolic health, enhancing insulin sensitivity, and reducing inflammation. It supports weight loss, lowers cholesterol, and may protect against type 2 diabetes and cardiovascular diseases. Research highlights its potential in regulating lipid metabolism and improving overall health through SIRT1 activation and other beneficial pathways.

Berberine Enhances Adipose Remodeling and Thermogenesis via AMPK/SIRT1.

Berberine reduces body weight and insulin resistance by enhancing AMPK/SIRT1 activation, promoting brown adipose tissue thermogenesis and remodeling, offering a novel approach for obesity treatment.

Bergamot

Bergamot enhances SIRT1 activation, promoting metabolic health and reducing cholesterol levels. Its antioxidant properties support cardiovascular health and may aid in weight management. Research indicates bergamot’s potential in regulating glucose levels and improving overall wellness, making it a promising natural supplement for metabolic and cardiovascular disorders.

Citrus bergamia Juice Enhances AMPK/SIRT1 Axis: A Study.

Bergamot extract enhances SIRT1 activity via the AMPK pathway, showing potential in treating related pathologies, as demonstrated in THP-1 cells exposed to LPS.

Butein

Butein, a flavonoid found in plants, enhances SIRT1 activity, promoting longevity and metabolic health. Research indicates it may improve cardiovascular function, reduce inflammation, and support neuroprotection. By activating SIRT1, butein contributes to cellular resilience, potentially aiding in age-related diseases and overall wellness. Discover the science-backed benefits of butein today!

Butein Activates SIRT1 to Inhibit Arecoline-Induced Mitochondrial Dysfunction.

Butein enhances SIRT1 activity, promoting mitochondrial health in oral cancer cells by regulating PGC1α and MTP18, reducing dysfunction and mitigating carcinogenesis risk.

Carnosic acid (CA)

Carnosic acid, a potent compound from rosemary, activates SIRT1, enhancing cellular health and longevity. Research shows it may improve neuroprotection, reduce inflammation, and support metabolic health. Additionally, carnosic acid’s antioxidant properties contribute to its role in preventing chronic diseases, making it a promising supplement for overall wellness.

Carnosic acid attenuates acute ethanol-induced liver injury via a SIRT1/p66Shc-mediated mitochondrial pathway

Carnosic acid protects against ethanol-induced liver injury by enhancing SIRT1 expression, inhibiting p66Shc, and reducing mitochondrial apoptosis through a SIRT1/p66Shc pathway.

Carnosol

Carnosol, a bioactive compound from sage, activates SIRT1, promoting longevity and cellular health. Research indicates it enhances antioxidant defenses, reduces inflammation, and protects against neurodegeneration. By modulating metabolic processes, carnosol supports heart health and may aid in cancer prevention, making it a valuable addition to a health-conscious diet.

SIRT1 Activation by Rosemary Diterpenes: Anti-Inflammatory Mechanisms Explained.

Rosemary’s carnosic acid and carnosol offer antioxidant and anti-inflammatory benefits by modulating NF-κB, MAPK, Nrf2 pathways, reducing ROS and pro-inflammatory cytokines like TNF-α, IL-1, IL-6.

Catalpol

Catalpol, a natural compound derived from Rehmannia glutinosa, activates SIRT1, a key regulator of cellular health. Research shows it enhances metabolism, promotes neuroprotection, and may improve longevity by mimicking caloric restriction. Catalpol’s antioxidant properties further support cardiovascular health, making it a promising candidate for age-related disease prevention.

Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease

Catalpol from Rehmannia glutinosa enhances SIRT1 expression, reducing inflammation and apoptosis in kidney damage, highlighting its potential as a protective agent against adriamycin toxicity.

Celastrol

Celastrol, a natural compound from Tripterygium wilfordii, activates SIRT1, promoting metabolic health and longevity. Research demonstrates its anti-inflammatory, antioxidant, and neuroprotective effects, enhancing glucose metabolism and reducing obesity-related complications. Celastrol’s SIRT1 modulation offers promising therapeutic potential for age-related diseases and metabolic disorders.

Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1

Celastrol enhances SIRT1 expression, improving antioxidant and anti-inflammatory responses in HFD-fed WT mice, while aggravating liver damage in LKO mice by disrupting AMPKα and NFκB pathways.

Chicory extrACT

Chicory extract, rich in inulin and polyphenols, supports metabolic health by improving glycemic control, reducing inflammation, and enhancing antioxidant defenses. While direct effects on SIRT1 aren’t fully established, chicory’s benefits may influence longevity pathways associated with SIRT1, offering potential against age-related metabolic disorders.

Chicory Enhances SIRT1 Signaling and Reduces Inflammation in Liver Cirrhosis.

Cichorium intybus (chicory) protects against TAA-induced liver cirrhosis by enhancing pAMPK/SIRT1 levels, reducing inflammation, and improving liver function through FXR signaling and oxidative stress relief.

Chrysanthemum Flower Extract

Chrysanthemum flower extract is rich in flavonoids and antioxidants, promoting cardiovascular health and anti-inflammatory effects. Research suggests it may activate SIRT1, enhancing metabolic regulation and cellular health, potentially offering protective benefits against age-related diseases and oxidative stress, making it a valuable addition to health-promoting diets.

Chrysanthemum morifolium Extract Activates SIRT1 to Inhibit Adipogenesis.

Chrysanthemum flower extract (HCF) inhibits adipogenesis in 3T3-L1 cells by reducing lipid accumulation and activating AMPK/SIRT1, suggesting potential for obesity prevention.

Chrysin

Chrysin, a natural flavonoid found in passionflower and honey, activates SIRT1, enhancing antioxidant defenses and reducing inflammation. Research shows it supports metabolic health, promotes neuroprotection, and may inhibit cancer cell growth. By modulating SIRT1, chrysin offers potential therapeutic benefits against age-related diseases and oxidative stress.

Chrysin Activates SIRT1/NRF2 Pathway to Reduce Lung Injury and Pleurisy.

Chrysin activates SIRT1/NRF2 pathway, inhibiting neutrophil activation and oxidative stress, attenuating lung injury in rats, suggesting potential therapeutic benefits against carrageenan-induced lung damage.

Codonopsis pilosula extract

Codonopsis pilosula extract activates SIRT1, enhancing antioxidant defenses and reducing oxidative stress. Research shows it may protect liver and hippocampal tissues, promoting anti-aging effects via the SIRT1/Nrf2 pathway, making it a promising natural remedy for age-related diseases and improving cellular health.

Codonopsis Polysaccharides Activate SIRT1 to Alleviate Energy Dysmetabolism.

Codonopsis pilosula polysaccharides activate SIRT1/SIRT3, increase NAD+ and ATP levels, reduce oxidative stress, and improve mitochondrial function in Aβ1-40-treated cells, suggesting neuroprotective effects.

Coenzyme Q10

Coenzyme Q10 (CoQ10) enhances SIRT1 activity, promoting mitochondrial function and energy production. Research shows CoQ10’s antioxidant properties reduce oxidative stress, improve heart health, and support cognitive function, potentially offering protective benefits against age-related diseases and metabolic disorders by activating SIRT1, a key regulator of cellular health and longevity.

Coenzyme Q10 deficiency can be expected to compromise Sirt1 activity

CoQ10 supplementation may enhance SIRT1/SIRT3 activity, offering clinical benefits for heart failure, hypertension, non-alcoholic fatty liver disease, metabolic syndrome, and periodontal disease management.

Conjugated linoleic acid

Conjugated linoleic acid (CLA) is linked to reduced body fat, improved metabolic health, and anti-inflammatory effects. While CLA influences fat metabolism, its direct interaction with SIRT1—a key regulator of energy balance and longevity—is not fully established, and further research is needed to confirm any direct relationship.

Cross regulation of sirtuin 1, AMPK, and PPARγ in conjugated linoleic acid treated adipocytes

CLA enhances triglyceride loss in 3T3-L1 adipocytes via SIRT1 activation, impacting AMPK and PPARγ pathways, highlighting their cross-regulatory roles in lipid metabolism.

CordycepIN

Cordycepin, a bioactive compound from Cordyceps, enhances SIRT1 activity, promoting cellular health and longevity. Research indicates it may improve metabolic function, reduce oxidative stress, and exhibit anti-inflammatory effects, making it a promising candidate for age-related diseases and overall health enhancement through SIRT1 modulation.

Cordycepin Enhances SIRT1 Expression and Maintains Stemness of Human Mesenchymal Stem Cells

Cordycepin enhances SIRT1 expression in MSCs, promoting stemness, delaying aging, and boosting autophagy for potential anti-aging applications.

Crocin

Crocin, a key component of saffron, enhances SIRT1 expression, promoting neuroprotection and anti-aging effects. It activates the AMPK-SIRT1 pathway, improving cellular health, reducing oxidative stress, and potentially mitigating age-related disorders, making it a promising natural compound for longevity and cognitive function enhancement.

Crocin enhances SIRT1, AMPK; lowers LOX1, NF-κB in heart disease.

Crocin enhances SIRT1 and AMPK expression while reducing LOX1, NF-κB, ox-LDL, and MCP-1 levels, suggesting cardiovascular benefits for coronary artery disease patients.

Curcumin

Curcumin, a bioactive compound in turmeric, enhances SIRT1 activity, promoting cellular health. Research indicates that curcumin’s anti-inflammatory and antioxidant properties may improve metabolic functions, support weight management, and protect against neurodegenerative diseases. This synergy suggests potential benefits for longevity and overall wellness through SIRT1 modulation.

Curcumin activates SIRT1, blocking amyloid-β neurotoxicity.

Curcumin protects cortical neurons from Aβ25–35 toxicity by enhancing SIRT1 expression, improving mitochondrial function, reducing ROS, and inhibiting apoptosis, highlighting its neuroprotective effects.

Danshen Extract

Danshen extract, derived from Salvia miltiorrhiza, activates SIRT1, promoting cardiovascular health and neuroprotection. Research shows it enhances endothelial function, reduces oxidative stress, and may improve metabolic disorders, highlighting its potential in aging and chronic disease management through SIRT1 modulation.

Salvianolic acid A activates AMPK-SIRT1, protecting against NAFLD.

Salvianolic acid A activates AMPK-mediated SIRT1 upregulation, protecting against lipotoxicity and NAFLD by attenuating liver injury, revealing a novel hepatoprotective mechanism.

Delphinidin-3-glucoside

Delphinidin-3-glucoside, an anthocyanin found in berries, exhibits potent antioxidant and anti-inflammatory effects. Research indicates it may modulate SIRT1 pathways, enhancing metabolic health, reducing oxidative stress, and providing neuroprotective benefits, potentially contributing to chronic disease prevention by promoting cellular health through SIRT1 activation.

Delphinidin-3-glucoside protects endothelial cells via AMPK/SIRT1 autophagy.

Delphinidin-3-glucoside protects endothelial cells from oxLDL-induced injury via AMPK/SIRT1-mediated autophagy, highlighting potential for atherosclerosis prevention and therapy.

Dihydromyricetin

Dihydromyricetin (DHM) activates SIRT1, offering antioxidant, anti-inflammatory, and neuroprotective effects. Scientific studies suggest DHM enhances SIRT1 pathways, potentially inhibiting aging processes, improving metabolic health, protecting against neurodegenerative diseases, and reducing liver damage, making it a promising compound for health promotion.

Dihydromyricetin reduces doxorubicin cardiotoxicity via SIRT1-mediated NLRP3 inhibition.

Dihydromyricetin from Hovenia dulcis protects against doxorubicin cardiotoxicity by inhibiting NLRP3 inflammasome via SIRT1 activation, improving heart function and reducing inflammation.

Dioscorea nipponica extract

Dioscorea nipponica extract activates SIRT1, offering anti-inflammatory, antioxidant, and cardioprotective effects. Scientific evidence shows it modulates SIRT1 pathways, reducing inflammation and oxidative stress, improving metabolic health, and benefiting conditions like arthritis, cardiovascular diseases, and metabolic disorders.

Dioscorea nipponica, SIRT1 in CKD: Composition and Pharmacology Review

Dioscin from Dioscorea nipponica lowers lipids via SIRT1/AMPK activation, inhibiting SREBPs, reducing cholesterol, triglycerides, fatty acids, and improving liver fat in mouse models.

Diospyros kaki extract

Diospyros kaki (Japanese persimmon) extract activates SIRT1, offering antioxidant, anti-inflammatory, and metabolic benefits. Studies show it modulates SIRT1 pathways, enhancing anti-aging effects, improving glucose metabolism, reducing oxidative stress, and protecting against chronic diseases like diabetes and cardiovascular disorders.

Panax ginseng, Diospyros kaki activate AMPK/SIRT1 to inhibit adipogenesis.

Panax ginseng and Diospyros kaki leaf extracts synergistically inhibit adipogenesis and promote adipocyte browning via AMPK/SIRT1 activation, offering a promising obesity management strategy.

Docosahexaenoic Acid

Docosahexaenoic Acid (DHA) activates SIRT1, providing neuroprotective, anti-inflammatory, and metabolic benefits. Scientific studies show DHA upregulates SIRT1, enhancing brain function, reducing oxidative stress, improving insulin sensitivity, and promoting longevity—beneficial for cognitive health, cardiovascular health, and metabolic disorders.

DHA activates SIRT1, protects against hepatic steatosis in NAFLD.

DHA activates SIRT1, reversing hepatic steatosis by increasing fatty acid oxidation, reducing lipid accumulation and inflammation in high-fat diet-induced NAFLD models.

Ecklonia cava extract

Ecklonia cava extract, rich in antioxidant phlorotannins, has been shown to activate SIRT1—a protein linked to longevity and metabolic regulation. Evidence suggests it offers neuroprotective effects, improves insulin sensitivity, reduces inflammation, and supports cardiovascular health, highlighting its potential in promoting healthy aging and overall wellness.

Ecklonia cava extract activates SIRT1, reducing liver fat and inflammation.

Ecklonia cava polyphenol extract activates AMPK and SIRT1, reducing obesity, inflammation, and oxidative stress in high-fat diet-induced obese mice, improving fat metabolism and antioxidant defenses.

EGCG

EGCG, a potent antioxidant found in green tea, activates SIRT1—a protein associated with longevity and metabolic regulation. Scientific studies show that EGCG enhances cell survival, reduces inflammation, improves metabolic health, and may protect against neurodegenerative diseases by modulating SIRT1 pathways, promoting overall wellness and healthy aging.

EGCG modulates SIRT1 to reduce CPP crystal-induced inflammation.

EGCG activates SIRT1, inhibiting NF-κB-mediated IL-8 and IL-1β production in CPP crystal-induced inflammation, reducing proinflammatory cytokines and suggesting anti-inflammatory effects via SIRT1 modulation.

Ellagic acid

Ellagic acid, a natural antioxidant found in berries and pomegranates, has been shown in scientific studies to enhance SIRT1 activity—a protein associated with longevity and metabolic regulation. Research indicates that ellagic acid provides anti-inflammatory effects, improves metabolic health, offers neuroprotection, and has potential anti-aging benefits, promoting overall wellness.

Ellagic acid activates SIRT1 and AMPK, reducing liver lipids in aging rats.

Ellagic acid activates SIRT1 and AMPK, reduces hepatic triglycerides and cholesterol, lowers SREBP-1c, improving lipid metabolism and liver health in aged rats.

Equisetum arvense L. (Horsetail)

Equisetum arvense (Horsetail), rich in phenolic compounds and antioxidants, supports bone health, hair growth, and acts as a diuretic. Studies show Horsetail extract activates SIRT1, providing cardioprotection by reducing oxidative stress, inflammation, and apoptosis in diabetic models, indicating potential benefits for metabolic and cardiovascular health via SIRT1 modulation.

Equisetum arvense activates SIRT1, enhancing insulin sensitivity in diabetic rats.

Equisetum arvense (Horsetail) extract enhances SIRT1 activation, improving insulin sensitivity and reducing blood glucose levels in streptozotocin-induced diabetic rats, suggesting potential cardioprotective effects against diabetes-related complications.

Ferulic Acid

Ferulic acid enhances SIRT1 activity, promoting cellular health by reducing oxidative stress and inflammation. Research indicates it may improve metabolic function, support cardiovascular health, and exhibit anti-aging properties through its role in activating sirtuins, crucial for longevity and cellular repair mechanisms.

Maize extract prevents obesity by modulating SIRT1, AMPK, IL-6.

Maize extract rich in ferulic acid and anthocyanins prevents obesity by modulating SIRT1, AMPK, and IL-6, reducing adipogenesis and inflammation while promoting energy expenditure.

Fisetin

Fisetin activates SIRT1, promoting cellular health by enhancing antioxidant defenses and reducing inflammation. Evidence suggests it may improve metabolic function, support neuroprotection, and exhibit anti-aging effects, making it a promising compound for longevity and overall wellness through its modulation of key signaling pathways.
Fisetin protects against hepatic steatosis via SIRT1 and AMPK regulation.

Fisetin reduces body weight and liver steatosis in NAFLD mice by activating the SIRT1/AMPK pathway, enhancing fatty acid β-oxidation and improving hepatic lipid metabolism.

Formononetin

Formononetin activates SIRT, enhancing cellular metabolism and promoting anti-inflammatory effects. Research indicates it may improve insulin sensitivity, support cardiovascular health, and exhibit neuroprotective properties. By modulating key signaling pathways, formononetin shows promise as a natural compound for combating obesity, metabolic disorders, and aging-related diseases.

Formononetin restores SIRT1 and NAD+ metabolism, improving renal disease outcomes.

Formononetin, an isoflavone from plants, enhances kidney function by improving SIRT1 expression, reducing oxidative stress, and lowering urinary albumin, potentially delaying diabetic kidney disease progression.

Ganoderma lucidum extract

Ganoderma lucidum extract enhances SIRT1 activity, promoting longevity and metabolic health. Its bioactive compounds exhibit antioxidant, anti-inflammatory, and immunomodulatory effects, potentially improving cardiovascular health and reducing oxidative stress. Regular consumption may support overall well-being and longevity, making it a valuable addition to health regimens.

Ganoderma lucidum polysaccharides activate SIRT1, protecting against sepsis-induced cardiac dysfunction.

Ganoderma lucidum polysaccharides enhance SIRT1 expression, reduce inflammatory factors, inhibit apoptosis, and promote myocardial proliferation, offering a novel treatment strategy for sepsis-induced cardiac dysfunction.

Gastrodin

Gastrodin activates SIRT1, promoting neuroprotection, anti-inflammatory effects, and improved cognitive function. Research shows it enhances mitochondrial function, reduces oxidative stress, and may aid in neurodegenerative disease prevention. Its ability to modulate SIRT1 underscores its potential as a therapeutic agent for enhancing brain health and overall longevity.

Gastrodin inhibits ferroptosis, alleviating cisplatin nephrotoxicity via SIRT1 signaling.

Gastrodin alleviates cisplatin-induced acute kidney injury by inhibiting ferroptosis through the SIRT1/FOXO3A/GPX4 pathway, offering potential for new anti-AKI therapies from traditional Chinese medicine.

Genistein

Genistein activates SIRT1, promoting anti-inflammatory, antioxidant, and neuroprotective effects. Research indicates it enhances metabolic health, reduces oxidative stress, and may prevent neurodegeneration. By modulating SIRT1 activity, genistein offers potential therapeutic benefits for age-related diseases, making it a promising compound in functional food and nutraceutical development.

Polyphenols like genistein restore SIRT1 and NAD+ metabolism in renal disease.

Genistein enhances SIRT1 activity, reducing renal injury from ischemia/reperfusion by decreasing apoptosis and promoting cell proliferation, highlighting its protective effects in kidney health.

Ginkgo Biloba Extract ginkgolide

Ginkgo biloba extract, rich in ginkgolides, stimulates SIRT1 activity, promoting neuroprotection and enhancing cognitive function. Research shows it improves blood circulation, reduces oxidative stress, and may alleviate symptoms of anxiety and depression, positioning ginkgo biloba as a promising natural remedy for age-related cognitive decline and vascular health.

Ginkgo biloba lactone activates AMPK-SIRT1 pathway, preventing osteoarthritis..

Ginkgo biloba extract BB enhances cartilage health by activating the AMPK-SIRT1 pathway, preventing osteoarthritis through increased anabolic proteins and reduced ECM degradation.

Ginsenoside F1

Ginsenoside F1 activates SIRT1, promoting cellular health and longevity. Research indicates it enhances antioxidative defense, reduces inflammation, and improves metabolic function, potentially mitigating age-related diseases. Ginsenoside F1’s modulation of SIRT1 signaling positions it as a promising therapeutic agent for conditions like diabetes, neurodegeneration, and cardiovascular diseases.

Screening medicinal plants, including Ginsenoside F1, for SIRT1 activators.

Four compounds, including ginsenoside Rb2 and F1, activate SIRT1, enhancing mitochondrial function and reducing oxidative damage in H9c2 cardiomyocytes exposed to t-BHP, suggesting protective effects against oxidative stress.

Ginsenoside Rb2

Ginsenoside Rb2, a saponin from ginseng, activates SIRT1, enhancing metabolic health. It promotes autophagy and reduces hepatic lipid accumulation, aiding in managing hyperglycemia and hyperlipidemia. Additionally, Rb2 modulates inflammation and oxidative stress, highlighting its potential therapeutic effects for metabolic regulation and longevity in health research.

Ginsenoside Rb2 and SIRT1 activators combat oxidative damage in mitochondria.

Ginsenoside Rb2, F1, Rc, and schisandrin A activate SIRT1, enhancing mitochondrial function and protecting H9c2 cardiomyocytes from oxidative damage induced by tert-butyl hydroperoxide.

Ginsenoside Rc

Ginsenoside Rc, a bioactive compound from ginseng, activates SIRT1, promoting metabolic health and cellular longevity. Research indicates it enhances mitochondrial function, reduces oxidative stress, and improves insulin sensitivity. By modulating inflammation and promoting autophagy, Ginsenoside Rc supports cardiovascular health and metabolic regulation, making it a promising therapeutic agent.

Ginsenoside Rc activates SIRT1, protecting mitochondria from oxidative damage.

Ginsenoside Rc, a potent SIRT1 activator, enhances mitochondrial function, increases ATP, and reduces oxidative damage in H9c2 cardiomyocytes exposed to tert-butyl hydroperoxide.

Ginsenoside Rh1

Ginsenoside Rh1, a bioactive saponin from ginseng, activates SIRT1, promoting cellular health and longevity. Research shows it enhances mitochondrial function, reduces oxidative stress, and improves glucose metabolism. By modulating inflammation and promoting autophagy, Ginsenoside Rh1 supports cardiovascular health and metabolic regulation, highlighting its therapeutic potential in health applications.

Ginsenoside Rc activates SIRT1, boosting energy metabolism in cardiomyocytes and neurons.

Ginsenoside Rc activates SIRT1, enhancing mitochondrial biogenesis, ATP production, and glucose metabolism, providing neuroprotective and cardioprotective effects under physiological and ischemia/reperfusion injury conditions.

Grape seed extract

Grape seed extract (GSE) activates SIRT1, promoting cellular health and longevity. Studies show it enhances mitochondrial function, reduces oxidative stress, and improves metabolic profiles. GSE also supports cardiovascular health by lowering blood pressure and cholesterol levels, while its anti-inflammatory properties further contribute to its potential as a therapeutic agent for metabolic disorders.

Grape seed extract moderates retinal cell senescence via NAMPT/SIRT1.

Grape seed proanthocyanidin extract (GSPE) alleviates retinal pigment epithelium senescence via the NAMPT/SIRT1/NLRP3 pathway, enhancing NAD+ levels and reducing cellular aging effects.

Green Tea extract Polyphenols

Green tea extract polyphenols, particularly EGCG, activate SIRT1, promoting cellular health and longevity. Research shows they enhance metabolism, support cardiovascular health, reduce inflammation, and improve cognitive function. These compounds demonstrate potential in combating obesity and age-related diseases, making green tea a powerful ally in health and wellness.

Green tea extract enhances heart function in diabetic rats via SIRT1

Green tea extract restores heart function in diabetic rats via SIRT1 activation, enhancing mitochondrial function and calcium regulation, potentially preventing diabetic cardiomyopathy.

Gynostemma pentaphyllum extract

Gynostemma pentaphyllum extract enhances health by upregulating SIRT1, promoting anti-obesity effects, reducing inflammation, and improving metabolic disorders like type 2 diabetes and dyslipidemia. Its bioactive compounds, including gypenosides, contribute to cardiovascular health and exhibit potential anti-cancer properties, making it a versatile herbal remedy.

Gynostemma pentaphyllum extract reduces obesity by upregulating SIRT1 effectively.

Gynostemma pentaphyllum extract mitigates obesity in mice by enhancing AMPK activation and SIRT1 expression, reducing fat accumulation, and regulating genes involved in lipid metabolism.

Hesperetin

Hesperetin activates SIRT1, promoting anti-inflammatory effects, improving insulin sensitivity, and enhancing lipid metabolism. This flavonoid also exhibits antioxidant properties, protecting against oxidative stress, potentially reducing obesity-related complications and cardiovascular diseases, making it a promising candidate for metabolic health interventions and overall wellness support.

Hesperetin activates SIRT1-AMPK pathway, enhancing metabolism in HepG2 cells.

Hesperetin activates SIRT1 and AMPK in HepG2 cells, enhancing protein expression and phosphorylation, suggesting its potential as a novel therapeutic agent for metabolic regulation.

Humulus japonicus extract

Humulus japonicus extract exhibits antioxidative and anti-aging properties by modulating the AMPK-SIRT1 pathway. Scientific evidence suggests it alleviates oxidative stress, enhances neuroprotection, and demonstrates anti-inflammatory effects, positioning it as a promising candidate for health improvement and disease prevention.

Humulus japonicus extract promotes anti-aging through AMPK-SIRT1 pathway modulation.

Ethanol extracts from H. japonicus leaves enhance lifespan in yeast and human fibroblast cells by upregulating sirtuin 1 and AMPK, while effectively scavenging reactive oxygen species, indicating strong antioxidative potential and promising anti-aging properties.

Hyperoside

Hyperoside, a flavonoid found in various plants, enhances SIRT1 activity, promoting longevity and metabolic health. Research indicates it may improve cardiovascular function, reduce inflammation, and support neuroprotection. Its antioxidant properties further contribute to cellular health, making hyperoside a promising compound for age-related diseases and overall well-being.

Hyperoside reduces inflammation in HT22 cells by upregulating SIRT1.

Hyperoside protects against neuroinflammation by upregulating SIRT1, activating Wnt/β-catenin and sonic hedgehog pathways, enhancing cell survival and reducing oxidative stress.

Isoliquiritigenin

Isoliquiritigenin, a flavonoid derived from licorice, exhibits various health benefits, including anti-inflammatory, antioxidant, and neuroprotective effects. It enhances SIRT1 activity, promoting cellular health, longevity, and metabolic regulation, while potentially mitigating neurodegenerative diseases and improving cognitive function through its modulation of oxidative stress and inflammation pathways.
Isoliquiritigenin activates SIRT1, reducing oxidative damage in diabetic neuropathy.

ILQ enhances SIRT1 activation, boosting mitochondrial biogenesis and autophagy, improving nerve conduction and reducing oxidative stress in diabetic neuropathy models through antioxidant signaling.

Kaempferia parviflora

Kaempferia parviflora, an herbal plant, enhances SIRT1 activity, promoting antioxidant defense, anti-inflammatory effects, and neuroprotection. Its bioactive compounds support metabolic health, improve cognitive function, and may aid in age-related disorders by mimicking calorie restriction effects, thereby boosting mitochondrial function and cellular resilience against stress.

Polymethoxyflavonoids from Kaempferia parviflora stimulate SIRT1 and combat glycation.

Kaempferia parviflora extract significantly enhances SIRT1 activity and exhibits potent anti-glycation effects, outperforming resveratrol and aminoguanidine with its main polymethoxyflavonoids.

kaempferol

Kaempferol, a flavonoid found in various plants, activates SIRT1, promoting anti-inflammatory, antioxidant, and neuroprotective effects. Its activation of SIRT1 enhances cellular metabolism, supports mitochondrial function, reduces oxidative stress, and may contribute to improved cognitive health and longevity, making it beneficial for age-related diseases and metabolic disorders.

Kaempferol activates SIRT1, reducing liver damage from acetaminophen toxicity.

Kaempferol reduces acetaminophen-induced liver damage by lowering inflammatory markers, enhancing antioxidant levels, and modulating SIRT1 activity, promoting anti-inflammatory and anti-apoptotic effects in rats.

L-Aspartic acid

L-Aspartic acid, an amino acid, activates SIRT1, promoting metabolic health and enhancing mitochondrial function. Its role in regulating energy metabolism, reducing oxidative stress, and supporting cognitive function demonstrates potential benefits for age-related diseases, metabolic disorders, and overall cellular resilience, making it a key compound in nutritional science.

L-Ergothioneine

L-Ergothioneine (EGT) is a potent antioxidant derived from mushrooms, known for its anti-inflammatory properties and potential to mitigate chronic diseases associated with aging. It enhances SIRT1 activity, promoting cellular health and longevity, making it a promising dietary component for improving overall well-being and combating oxidative stress.

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6

L-Ergothioneine (EGT) upregulates SIRT1 and SIRT6 while downregulating p66Shc and NF-κB, protecting against high-glucose-induced endothelial senescence linked to type 2 diabetes.

Luteolin

Luteolin, a flavonoid, enhances SIRT1 activity, promoting cellular health and longevity. Evidence suggests it possesses anti-inflammatory, antioxidant, and neuroprotective properties, potentially aiding in metabolic disorders and age-related diseases. Its role in modulating SIRT1 may contribute to improved cardiovascular health and cognitive function, highlighting its therapeutic potential.

Luteolin boosts SIRT1, enhancing cellular health and longevity.

Luteolin may enhance Nrf2 production in mouse liver by activating SIRT1 signaling or directly influencing the Nrf2-Keap1 complex, despite miRNA-146a’s inhibition.

Lycium barbarum polysaccharide (LBP)

Lycium barbarum polysaccharides (LBP) enhance SIRT1 expression, promoting metabolic health by mitigating high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) and oxidative stress. LBP’s ability to regulate SIRT1 contributes to its protective effects against diabetes-related complications, supporting overall cellular health and longevity.

Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract

Lycium barbarum polysaccharide (LBP) enhances cell viability by upregulating SIRT1 and Bcl-2, while suppressing apoptosis-related proteins, benefiting diabetic cataract and overall metabolic health.

Lycopene

Lycopene, a potent antioxidant found in red fruits and vegetables, activates SIRT1, enhancing insulin sensitivity and muscle capillary density. This action mitigates oxidative stress and supports skin health, potentially reducing aging effects and chronic disease risks associated with insulin resistance.

Phenolic Plant Extracts Induce Sirt1 Activity and Increase Antioxidant Levels in the Rabbit’s Heart and Liver

VB extract boosts SIRT1 activity in heart and liver, enhancing glycemic and lipid profiles through antioxidant effects, suggesting its potential for improving metabolic health.

Myricetin

Myricetin, a flavonoid found in various fruits and vegetables, activates SIRT1, promoting antioxidant defense and reducing inflammation. This action improves metabolic health, enhances insulin sensitivity, and may protect against age-related diseases, making myricetin a promising dietary component for longevity and overall well-being.

Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway

Myricetin enhances SIRT1, inhibiting TNF-α-induced NF-κB activation in A549 cells, reducing inflammatory responses and offering potential therapeutic insights for inflammation-related diseases like asthma.

Neochlorogenic acid

Neochlorogenic acid, a phenolic compound, exhibits antioxidant and anti-inflammatory properties while enhancing SIRT1 activity. This modulation supports lipid metabolism and may protect against metabolic disorders, making it a promising candidate for functional foods aimed at improving overall health and reducing inflammation-related conditions.

Nutraceutical activation of Sirt1: a review

Neochlorogenic acid enhances SIRT1 synthesis, promoting antioxidant effects and metabolic health. Other nutraceuticals like ferulic acid and melatonin also support SIRT1 activity, contributing to overall wellness.

Nicotinamide riboside

Nicotinamide riboside (NR), a vitamin B3 derivative, enhances NAD+ levels, promoting health benefits such as improved mitochondrial function, reduced inflammation, and potential neuroprotection. It activates SIRT1, a key regulator of cellular health, and may mitigate age-related diseases, obesity, and liver injuries.

Nicotinamide riboside, an NAD+ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages

Nicotinamide riboside (NR) activates SIRT1, reducing inflammation and oxidative stress in macrophages exposed to ethanol, while normalizing NAD+ levels and metabolic disruptions, promoting cellular health.

NMN （β-Nicotinamide Mononucleotide）

Nicotinamide mononucleotide (NMN) boosts NAD+ levels, activating SIRT1, a crucial regulator of metabolism and cellular health. Research indicates NMN enhances mitochondrial function, reduces inflammation, and may protect against age-related diseases, neurodegeneration, and metabolic disorders, promoting overall longevity and vitality.

β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice

Nicotinamide mononucleotide (NMN) protects against sepsis-induced memory dysfunction and neuroinflammation via the NAD+/SIRT1 pathway, improving hippocampal health and cognitive performance.

Oleanolic acid

Oleanolic acid, a natural triterpenoid, activates SIRT1, enhancing cellular health and exhibiting anti-inflammatory, antioxidant, and neuroprotective effects. Research suggests it may aid in treating chronic diseases, including neurodegenerative disorders, by modulating key signaling pathways and reducing oxidative stress and inflammation.

Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation

Oleanolic acid activates SIRT1, reduces HMGB1 acetylation, and decreases neuronal apoptosis, demonstrating anti-inflammatory effects that alleviate early brain injury after subarachnoid hemorrhage.

Oryzanol

Gamma oryzanol, derived from rice bran, may enhance SIRT1 activity, promoting anti-inflammatory effects and improving lipid metabolism. Research suggests it supports muscle strength and reduces oxidative stress, potentially benefiting metabolic health and neuroprotection, making it a promising supplement for overall wellness.

Effectiveness of Gamma Oryzanol on prevention of surgical induced endometriosis development in rat model

Gamma oryzanol significantly increases SIRT1 expression in rats, enhancing antioxidant activity. Western blot analysis shows reduced HO-1 levels in vitamin C groups, indicating its potential in modulating protein expressions related to oxidative stress and inflammation.

Panax notoginseng 

Panax notoginseng saponins (PNS) enhance SIRT1 expression, promoting antioxidant activity and reducing inflammation. Research indicates PNS may protect against diabetes-related kidney damage and alleviate apoptosis in endothelial cells, highlighting its potential in treating metabolic and cardiovascular diseases through SIRT1 modulation.

Combination of Panax ginseng and Diospyros kaki Leaf Inhibits White Adipocyte Differentiation and Browning Process through AMP-Activated Protein Kinase (AMPK) Activation In Vitro and In Vivo

Panax notoginseng saponins boost SIRT1, enhancing antioxidant effects and reducing inflammation, potentially protecting against diabetes-related kidney damage and supporting cardiovascular health.

Phellopterin

Phellopterin, a natural compound from Phellodendron amurense, activates SIRT1, promoting anti-inflammatory and antioxidant effects. Research suggests it may protect against oxidative stress, enhance metabolic health, and improve neuroprotection, highlighting its potential in treating chronic diseases and supporting overall well-being through SIRT1 modulation.

Phellopterin cream exerts an anti-inflammatory effect that facilitates diabetes-associated cutaneous wound healing via SIRT1

Phellopterin promotes healing in diabetic ulcers by upregulating SIRT1 and downregulating ICAM-1, reducing inflammation and enhancing re-epithelialization, though SIRT1 inhibition negates these benefits.

Piceatannol

Piceatannol, a natural stilbene, activates SIRT1, enhancing antioxidant defenses and exhibiting anti-inflammatory properties. Research indicates it may improve metabolic health, protect against obesity-related complications, and promote cardiovascular health, showcasing its potential as a therapeutic agent for chronic diseases through SIRT1 modulation.

Piceatannol promotes hepatic and renal AMPK/SIRT1/PGC-1α mitochondrial pathway in rats exposed to reserpine or gamma-radiation

Piceatannol reduces inflammatory and apoptotic markers while enhancing SIRT1 and PGC-1α levels, offering potential protective effects against oxidative stress and apoptosis in diabetic conditions.

Pinocembrin

Pinocembrin, a flavonoid from propolis, enhances SIRT1 activity, promoting antioxidant and anti-inflammatory effects. Research shows it may protect against neurodegenerative diseases, improve cardiac function, and support metabolic health, highlighting its therapeutic potential in managing chronic inflammatory conditions through SIRT1 modulation and related pathways.

Pinocembrin ameliorates acute liver failure via activating the Sirt1/PPARα pathway in vitro and in vivo

Pinocembrin, a natural flavonoid, exhibits anti-inflammatory and antioxidant effects, reducing hepatocyte apoptosis and inflammation in acute liver failure via the SIRT1/PPARα signaling pathway.

Platycodon grandiflorum

Platycodon grandiflorum, a traditional herbal remedy, contains saponins and flavonoids that enhance SIRT1 activity. Research indicates it may reduce inflammation, protect against oxidative stress, and improve metabolic health, suggesting its potential as a therapeutic agent for chronic diseases through SIRT1 modulation and related pathways.

Saponins from Platycodon grandiflorum inhibit hepatic lipogenesis through induction of SIRT1 and activation of AMP-activated protein kinase in high-glucose-induced HepG2 cells

Changkil saponins from Platycodon grandiflorum prevent lipid accumulation in HepG2 cells by activating AMPK and SIRT1, inhibiting SREBP-1c and FAS expression, thereby showcasing hepatoprotective properties and potential therapeutic benefits against liver diseases.

Polydatin

Polydatin, a natural compound derived from the root of Rheum palmatum, activates SIRT1, promoting antioxidant and anti-inflammatory effects. Research shows it may improve insulin sensitivity, protect against neurodegenerative diseases, and enhance cardiovascular health, highlighting its therapeutic potential in managing chronic conditions through SIRT1 modulation and related pathways.

SIRT1 Activation by Polydatin Alleviates Oxidative Damage and Elevates Mitochondrial Biogenesis in Experimental Diabetic Neuropathy

Polydatin improves hyperalgesia and nerve function in diabetic rats by activating SIRT1 and Nrf2, enhancing mitochondrial biogenesis and antioxidant signaling in high-glucose conditions.

Pterostilbene

Pterostilbene, a natural compound found in blueberries, activates SIRT1, enhancing antioxidant defenses and promoting metabolic health. Research indicates it may improve cognitive function, protect against neurodegenerative diseases, and alleviate liver conditions, showcasing its potential as a therapeutic agent through SIRT1 modulation and related pathways.

Pterostilbene Enhances Thermogenesis and Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α/SIRT3 Pathway to Prevent Western Diet-Induced Obesity

Pterostilbene (PSB) outperforms pinostilbene (PIN) in reducing obesity, enhancing thermogenesis, and promoting gut health through SIRT1 activation and microbial metabolite production.

Puerarin

Puerarin, an isoflavone from kudzu, activates SIRT1, promoting metabolic health. Research shows it enhances glucose metabolism, reduces oxidative stress, improves cardiovascular function, and exhibits anti-inflammatory properties. Puerarin’s role in SIRT1 activation may contribute to longevity and weight management, highlighting its potential as a therapeutic agent for metabolic disorders.

Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease

Puerarin, an isoflavonoid from Radix puerariae, enhances kidney health by reducing damage in diabetic kidney disease, upregulating SIRT1, FOXO1, and PGC1α expressions.

Quercetin

Quercetin, a flavonoid found in fruits and vegetables, activates SIRT1, promoting longevity and metabolic health. Research indicates it enhances antioxidant defense, reduces inflammation, supports cardiovascular function, and improves glucose metabolism, demonstrating potential benefits for aging, obesity, and chronic diseases through SIRT1-mediated pathways in various tissues.

Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1

Quercetin 3,5,7,3′,4′-pentamethyl ether (KPMF-8) from Kaempferia parviflora directly activates SIRT1, enhancing its binding affinity with Ac-p53 peptide and promoting intracellular deacetylase activity more effectively than resveratrol.

Raphanus sativus extract

Raphanus sativus extract, derived from radishes, exhibits potential health benefits by activating SIRT1. Studies show it enhances antioxidant activity, reduces inflammation, and improves metabolic functions, contributing to weight management and cardiovascular health. Its SIRT1 activation may play a crucial role in combating age-related diseases and promoting overall wellness.

Resveratrol

Resveratrol, a natural polyphenol found in grapes and berries, activates SIRT1, promoting longevity and health. Research indicates it enhances cardiovascular function, reduces inflammation, improves metabolic health, and exhibits neuroprotective effects. Its ability to modulate SIRT1 pathways may offer therapeutic potential for age-related diseases and chronic conditions.

The Sirtuin System: The Holy Grail of Resveratrol?

Resveratrol, a polyphenol in red wine, activates SIRT1, mediating antioxidant, anti-inflammatory, and anti-proliferative effects, and has traditional uses in East Asian and South American medicine.

Rheum palmatum extract

Rheum palmatum extract, known for its traditional medicinal uses, activates SIRT1, promoting antioxidant and anti-inflammatory effects. Research indicates it may enhance metabolic health and exhibit potential anti-cancer properties, suggesting its role in regulating cellular processes and improving overall health through SIRT1-mediated pathways.

Rhodiola Rosea (Salidroside)

Rhodiola rosea, particularly its active compound salidroside, activates SIRT1, promoting antioxidant and anti-inflammatory effects. Research suggests it enhances physical and mental performance, reduces fatigue, and supports metabolic health, potentially offering protective benefits against stress-related conditions and age-related diseases through SIRT1-mediated pathways.

Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention

Salidroside from Rhodiola rosea exhibits anti-inflammatory effects by inhibiting pro-inflammatory cytokines and pathways, enhancing SIRT1 expression, and improving vascular function, thus promoting overall health and metabolic balance.

Rutin

Rutin, a flavonoid found in fruits and vegetables, activates SIRT1, providing antioxidant and anti-inflammatory benefits. Research indicates it improves cardiovascular health, enhances glucose metabolism, and exhibits neuroprotective effects. By modulating SIRT1 pathways, rutin may play a significant role in preventing age-related diseases and promoting overall wellness.

Rutin and Gallic Acid Regulates Mitochondrial Functions via the SIRT1 Pathway in C2C12 Myotubes

Gallic acid and rutin enhance mitochondrial dynamics by regulating the SIRT1 pathway in C2C12 myotubes, improving mitochondrial DNA expression, enzymatic activities, and ATP levels, thus promoting metabolic health.

Saikogenin A

Saikogenin A, a natural compound derived from various plants, activates SIRT1, promoting antioxidant and anti-inflammatory effects. Research suggests it enhances metabolic health, improves insulin sensitivity, and exhibits neuroprotective properties, potentially offering therapeutic benefits against age-related diseases and metabolic disorders through SIRT1-mediated mechanisms.

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Saikosaponin A from Radix Bupleuri exhibits hepatoprotective effects by modulating SIRT1 activity, enhancing antioxidant and anti-inflammatory responses, and regulating mTOR and PPAR-α pathways, suggesting its potential as a therapeutic agent for alcoholic liver disease and other liver-related conditions.

Salvianolic acid A AND b

Salvianolic acids A and B, derived from Salvia miltiorrhiza, activate SIRT1, offering antioxidant and anti-inflammatory benefits. Research indicates they improve cardiovascular health, enhance neuroprotection, and regulate glucose metabolism. Their modulation of SIRT1 pathways suggests potential therapeutic applications in age-related diseases and metabolic disorders, promoting overall health and longevity.

Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice

Salvianolic acid A (Sal A) protects against lipotoxicity by activating AMPK and SIRT1, reducing liver injury and steatosis in high-fat diet mice and HepG2 cells.

Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease

Salvianolic acid B (SalB) protects against NAFLD by enhancing SIRT1 activity, inhibiting HMGB1 release, and reducing liver inflammation and steatosis from high-fat diets.

Schisandrin A

Schisandrin A enhances SIRT1 activity, promoting cellular health and longevity. It exhibits antioxidant, anti-inflammatory, and hepatoprotective effects, improves metabolic functions, and may prevent neurodegenerative diseases. Research suggests Schisandrin A’s potential in combating obesity, diabetes, and liver disorders through SIRT1-mediated pathways, making it a promising therapeutic agent for various health conditions.

Screening SIRT1 Activators from Medicinal Plants as Bioactive Compounds against Oxidative Damage in Mitochondrial Function

Ginsenoside Rb2, F1, Rc, and schisandrin A activate SIRT1, enhancing mitochondrial function and reducing oxidative damage in H9c2 cardiomyocytes exposed to tert-butyl hydroperoxide, promoting cellular health and resilience against oxidative stress.

Shikonin

Shikonin activates SIRT1, offering protective effects against oxidative stress and inflammation. It enhances mitochondrial function, promotes cell survival, and exhibits potential anti-cancer properties. Research indicates shikonin’s role in improving metabolic health and reducing neurodegenerative risks, highlighting its therapeutic potential through SIRT1 modulation in various health conditions.

Shikonin Ameliorates LPS-Induced Cardiac Dysfunction by SIRT1-Dependent Inhibition of NLRP3 Inflammasome

Shikonin ameliorates lipopolysaccharide-induced cardiac dysfunction by enhancing SIRT1 expression, inhibiting NLRP3 inflammasome activation, and reducing inflammation and apoptosis, offering potential therapeutic benefits for myocardial injury.

Siberian Ginseng extract

Siberian Ginseng extract activates SIRT1, promoting anti-aging effects and enhancing metabolic health. Research indicates it improves endurance, reduces fatigue, and exhibits neuroprotective properties. By modulating inflammation and oxidative stress, Siberian Ginseng extract supports cardiovascular health and cognitive function, highlighting its potential as a natural therapeutic agent for various health conditions.

Silibinin

Silibinin activates SIRT1, providing protective effects against oxidative stress and inflammation. It promotes liver health, enhances metabolic function, and exhibits anti-cancer properties. Research suggests silibinin’s role in improving insulin sensitivity and reducing fatty liver disease, making it a promising therapeutic agent for various metabolic disorders and liver conditions.

Activation of SIRT1 by silibinin improved mitochondrial health and alleviated the oxidative damage in experimental diabetic neuropathy and high glucose-mediated neurotoxicity

Two-week SBN treatment enhances neurobehavioural symptoms and activates SIRT1, promoting mitophagy and antioxidant defense in diabetic peripheral neuropathy through upregulation of key protective proteins..

Strawberry Extract

Strawberry extract activates SIRT1, offering antioxidant and anti-inflammatory effects. It enhances metabolic health, supports weight management, and improves cardiovascular function. Research shows that strawberry extract’s polyphenols promote cellular longevity and protect against oxidative stress, highlighting its potential as a natural therapeutic agent for various health conditions and age-related diseases.

Effects of strawberry dried methanolic extract on p-AMPK, AMPK, Sirt1, and LKB1 expression.

Strawberry dried methanolic extract enhances p-AMPK, AMPK, SIRT1, and LKB1 expression in HepG2 cells, promoting metabolic health and antioxidant defense, crucial for cellular function and protection against oxidative stress.

Syringaresinol

Syringaresinol activates SIRT1, exhibiting anti-inflammatory and antioxidant properties. Research indicates its potential in enhancing cellular longevity, improving metabolic health, and protecting against oxidative stress. By modulating SIRT1 pathways, syringaresinol supports cardiovascular health and may offer therapeutic benefits for age-related diseases and metabolic disorders, highlighting its significance in health promotion.

Enantioselective induction of SIRT1 gene by syringaresinol from Panax ginseng berry and Acanthopanax senticosus Harms stem

(+)-Syringaresinol upregulates SIRT1 gene expression, enhancing its biological activity compared to (-)-syringaresinol. Panax ginseng berries, rich in (+)-syringaresinol, demonstrate superior SIRT1 induction, emphasizing the significance of enantiomer configuration in health benefits.

Syzygium aromaticum

Syzygium aromaticum, or clove, enhances SIRT1 activity, demonstrating antioxidant and anti-inflammatory properties. Research indicates its potential in improving metabolic health, supporting cardiovascular function, and protecting against neurodegenerative diseases. By modulating SIRT1 pathways, Syzygium aromaticum may promote longevity and overall health, highlighting its significance in traditional and modern medicine.

Neuroprotection by ethanolic extract of Syzygium aromaticum in Alzheimer’s disease like pathology via maintaining oxidative balance through SIRT1 pathway

Syzygium aromaticum enhances SIRT1 activity, scavenges ROS, and boosts antioxidant enzymes, showing potential for Alzheimer’s disease management by regulating oxidative stress and γ-secretase levels.

Tetrahydrocurcumin

Tetrahydrocurcumin activates SIRT1, providing antioxidant and anti-inflammatory benefits. Research shows it enhances metabolic health, promotes neuroprotection, and supports cardiovascular function. By modulating SIRT1 pathways, tetrahydrocurcumin may improve insulin sensitivity and protect against oxidative stress, highlighting its potential as a therapeutic agent for age-related diseases and metabolic disorders.

Nutraceutical activation of Sirt1: a review

Tetrahydrocurcumin enhances SIRT1 synthesis and activity, promoting antioxidant effects and metabolic health. This potent nutraceutical, along with others, supports cellular function and longevity by increasing NAD+ availability, making it a valuable component in strategies for age-related disease management.

Trans-3,4’,5-trihydroxistilbene

Trans-3,4’,5-trihydroxystilbene, a potent SIRT1 activator, enhances cellular health by regulating inflammation, aging, and fat storage. Scientific evidence suggests it may improve metabolic health, promote neuroprotection, and support longevity, making it a promising compound for combating age-related diseases and enhancing overall well-being.

Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

THSG effectively delays vascular senescence and enhances blood flow in hypertensive rats, promoting SIRT1 activation, eNOS expression, and reducing cellular aging markers compared to resveratrol.

Trans-chalcone

Trans-chalcone activates SIRT1, contributing to improved metabolic health and anti-inflammatory effects. Research suggests it enhances insulin sensitivity, protects against oxidative stress, and promotes cardiovascular health, making it a promising compound for managing age-related diseases and metabolic disorders while supporting overall wellness and longevity.

Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway

Trans-chalcone reduces food intake, body weight, and serum glucose while enhancing SIRT1 levels and inhibiting hepatic miR-34a expression, acting as an insulin-sensitizing agent through the miR-34a/SIRT1 pathway in male rats.

Urolithin A

Urolithin A, a gut-derived metabolite from ellagitannins, activates SIRT1, enhancing mitochondrial function and promoting muscle health. Research indicates its potential to improve endurance, support cardiovascular health, and mitigate age-related decline, making it a promising compound for longevity and overall well-being.

Nutraceutical activation of Sirt1: a review

Urolithin A enhances SIRT1 expression, promoting mitochondrial function and metabolic health. This nutraceutical, derived from ellagitannins, supports longevity by improving muscle health and reducing age-related decline, making it a valuable addition to healthspan-boosting strategies.

Ursolic Acid

Ursolic acid, a natural triterpenoid found in fruits and herbs, activates SIRT1, promoting anti-inflammatory and antioxidant effects. Research indicates its potential to enhance muscle growth, support metabolic health, and combat age-related decline, making it a valuable compound for improving longevity and overall well-being.

Mounting evidence validates Ursolic Acid directly activates SIRT1: A powerful STAC which mimic endogenous activator of SIRT1

Ursolic Acid activates SIRT1, enhancing its catalytic efficiency and binding affinity. This pentacyclic triterpenoid shows promise in regulating aging and longevity through increased SIRT1 activity in vivo.

Verbascoside

Verbascoside, a phenylethanoid glycoside, activates SIRT1, promoting anti-inflammatory and antioxidant effects. Research indicates its potential to enhance metabolic health, improve cardiovascular function, and support neuroprotection, making it a promising compound for combating age-related diseases and promoting overall well-being and longevity.

Phenolic Plant Extracts Induce Sirt1 Activity and Increase Antioxidant Levels in the Rabbit’s Heart and Liver

Verbascoside, Raphanus sativus, and lycopene enhance SIRT1 activity and improve blood lipid and glycemic profiles. Verbascoside shows the most significant antioxidant effects, suggesting its potential in regulating oxidative stress and promoting heart and liver health.

α-Mangostin

α-Mangostin, a polyphenolic xanthone from mangosteen, activates SIRT1, enhancing antioxidant defenses and neuroprotection. It exhibits anti-inflammatory and anticancer properties, potentially improving metabolic health and longevity by regulating oxidative stress and cellular aging, making it a promising compound for various health benefits.

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

α-Mangostin from Garcinia mangostana activates SIRT1, inhibiting p65 acetylation and down-regulating pro-inflammatory genes like COX-2 and iNOS in U937 cells. This suggests its potential in modulating inflammatory responses via the SIRT1/NF-kB signaling pathway.