Thymoquinone Thymoquinone is a potent superoxide anion scavenger Hepatoprotective activity of Thymoquinone in isolated rat hepatocytes Thymoquinone: potential cure for inflammatory disorders and cancer Thymoquinone: a promising anti-cancer drug from natural sources Fixed oil of Nigella sativa and derived Thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation The influence of Thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats Thymoquinone and its therapeutic potentials Thymoquinone protects against carbon tetrachloride hetatotoxicity in mice via an antioxidant mechanism Inhibitory effects of Thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. In vitro toxicological properties of Thymoquinone Antinociceptive effects of Nigella sativa oil and its major component, Thymoquinone, in mice Effects of Thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models Thymoquinone protects against experimental colitis in rats Anticonvulsant effects of Thymoquinone, the major constituent of Nigella sativa seeds, in mice Antitumor activity of gemcitabine and oxaliplatin is augmented by Thymoquinone in pancreatic cancer Acute and subchronic toxicity of Thymoquinone in mice Thymoquinone protects against doxorubicin-induced cardiotoxicity without compromising its antitumor activity. Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by Thymoquinone. In Vitro acetylcholinesterase inhibitory properties of thymol, carvacrol and their derivatives Thymoquinone and thymohydroquinone Review on molecular and therapeutic potential of Thymoquinone in cancer Oral and intraperitoneal LD50 of Thymoquinone, an active principle of Nigella sativa, in mice and rats Improvement of experimental allergic encephalomyelitis (EAE) by Thymoquinone; an oxidative stress inhibitor. Thymoquinone reduces hepatic glucose production in diabetic hamsters In vitro inhibition of growth and induction of apoptosis in cancer cell lines by Thymoquinone Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages Androgen receptor–and E2F-1–targeted Thymoquinone therapy for hormone-refractory prostate cancer Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways Neuroprotective effects of Thymoquinone against transient forebrain ischemia in the rat hippocampus Anti-inflammatory effect of Thymoquinone in a mouse model of allergic lung inflammation Protective effects of Thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity Anti-inflammatory effects of the Nigella sativa seed extract, Thymoquinone, in pancreatic cancer cells Antidermatophyte activity of ether extract of Nigella sativa and its active principle, Thymoquinone Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism Reactive oxygen species mediate Thymoquinone-induced apoptosis and activate ERK and JNK signaling Nigella sativa oil, nigellone and derived Thymoquinone inhibit synthesis of 5-lipoxygenase products in polymorphonuclear leukocytes from rats Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling Effects of alpha-hederin and Thymoquinone, constituents of Nigella sativa, on human cancer cell lines Nonenzymatic reduction of Thymoquinone in physiological conditions Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice Lack of p53 augments Thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells Targeting nuclear factor-κB activation pathway by Thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis Thymoquinone: fifty years of success in the battle against cancer
Sulforaphane Anticarcinogenic activities of Sulforaphane and structurally related synthetic norbornyl isothiocyanates. Multi-targeted prevention of cancer by Sulforaphane Molecular basis for chemoprevention by Sulforaphane: a comprehensive review Identification of Nrf2-regulated genes induced by the chemopreventive agent Sulforaphane by oligonucleotide microarray A novel mechanism of chemoprotection by Sulforaphane: inhibition of histone deacetylase Sulforaphane treatment of autism spectrum disorder (ASD) Nuclear factor κB is a molecular target for Sulforaphane-mediated anti-inflammatory mechanisms Sulforaphane as a promising molecule for fighting cancer Chemoprotection by Sulforaphane: keep one eye beyond Keap1 Protective effect of Sulforaphane against oxidative stress: recent advances Molecular targets of dietary phenethyl isothiocyanate and Sulforaphane for cancer chemoprevention Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells Antimetastatic activity of Sulforaphane Potent induction of phase 2 enzymes in human prostate cells by Sulforaphane Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apcmin mice Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, Sulforaphane and Sulforaphane nitrile Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent Sulforaphane Preclinical and clinical evaluation of Sulforaphane for chemoprevention in the breast Heating decreases epithiospecifier protein activity and increases Sulforaphane formation in broccoli Keap1–nrf2 signaling: a target for cancer prevention by Sulforaphane Dietary Sulforaphane, a histone deacetylase inhibitor for cancer prevention Chemoprevention of colonic aberrant crypt foci in Fischer rats by Sulforaphane and phenethyl isothiocyanate Modification of keap1 cysteine residues by Sulforaphane Sulforaphane induces cell type–specific apoptosis in human breast cancer cell lines Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo [a] pyrene-induced stomach tumors A Sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent Sulforaphane Electrophilic tuning of the chemoprotective natural product Sulforaphane Disposition of glucosinolates and Sulforaphane in humans after ingestion of steamed and fresh broccoli Sulforaphane as a potential protective phytochemical against neurodegenerative diseases Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells Thermal degradation of Sulforaphane in aqueous solution Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines Oral Sulforaphane increases Phase II antioxidant enzymes in the human upper airway Sulforaphane and its glutathione conjugate but not Sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in … Sulforaphane targets pancreatic tumour-initiating cells by NF-κB-induced antiapoptotic signalling Discovery and development of Sulforaphane as a cancer chemopreventive phytochemical1 Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species Sulforaphane improves cognitive function administered following traumatic brain injury Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3
Solidago virgaurea Study of the anti-inflammatory activity of Populus tremula, Solidago virgaurea and Fraxinus excelsior. A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaurea in rats Anti-inflammatory effects of Populus tremula, Fraxinus excelsior, Solidago virgaureaextracts and their combination Phytodolor® in human monocytes … -inflammatory drug: investigations into the cyto-and molecular pharmacology for a better understanding of the anti-inflammatory activity of preparations from Solidago … … and clinical effectiveness of a fixed phytogenic combination trembling poplar (Populus tremula), true goldenrod (Solidago virgaurea) and ash (Fraxinus excelsior) in … … drug: investigations into the cyto-and molecular pharmacology for a better understanding of the anti-inflammatory activity of preparations from Solidago virgaurea. … Korean natural products for anti-adipogenesis properties and isolation of kaempferol-3-O-rutinoside as a potent anti-adipogenetic compound from Solidago virgaurea A Case of Abnormal Flower Structures connected with Reduced Fertility in Solidago virgaurea L. A combination of Populus tremula, Solidago virgaurea and Fraxinus excelsior as an anti-inflammatory and antirheumatic drug. A short review. Abundance and diversity of arbuscular mycorrhizal fungi in invasive Solidago canadensis and indigenous S. virgaurea Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp. gigantea Extracts and … Anti-inflammatory effects of Populus tremula, Fraxinus excelsior, Solidago virgaurea extracts and their combination Phytodolor® in human monocytes Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice … Antibacterial and antimutagenic activity of extracts aboveground parts of three Solidago species: Solidago virgaurea L., Solidago canadensis L. and Solidago … Antibacterial clerodane diterpenes from goldenrod (Solidago virgaurea) Antimicrobial activity of Solidago virgaurea L. from in vitro cultures Antineoplastic activity of Solidago virgaurea on prostatic tumor cells in an SCID mouse model Antioxidant activity of goldenrod (Solidago virgaurea) leaf and stem powder on raw ground pork during chilled storage Antioxidant and antimicrobial activities of Solidago virgaurea extracts Antioxidative properties of Alchemilla xanthochlora, Salvia officinalis and Solidago virgaurea water extracts Antioxidative properties of alcoholic extracts from Fraxinus excelsior, Populus tremula and Solidago virgaurea. Assessment of allelopathic potential of Solidago virgaurea L. on some selected crops. Biochemical effects of Solidago virgaurea extract on experimental cardiotoxicity Biorefining of Bergenia crassifolia L., Fagopyrum esculentum Moench. and Solidago virgaurea L. by high pressure extraction methods and evaluation of obtained … Biorefining of goldenrod (Solidago virgaurea L.) leaves by supercritical fluid and pressurized liquid extraction and evaluation of antioxidant properties and main … Characterizing the Allergens Contained in goldenrod (Solidago virgaurea) Chromatographic fingerprint, antioxidant activity, and colour characteristic of polish goldenrod (Solidago virgaurea L.) honey and flower Competition for resources is ameliorated by niche differentiation between Solidago virgaurea life-history stages in the Arctic Constituents of the essential oil of Solidago virgaurea L. Development and characterization of EST‐SSR markers for the Solidago virgaurea complex (Asteraceae) in the Japanese archipelago Effect of agrotechnical factors on the yield of goldenrod (Solidago
Silybin (Milk Thistle) A comparative study on enzyme kinetics of diastereoisomeric silybin A and silybin B glucuronidation in rat liver microsome A comparative study on the stability of silybin and that in silymarin in buffers and biological fluids. A Comparison of Spray-Drying and Freeze-Drying for the Production of Stable silybin Nanosuspensions A comparison of the diastereoisomers, silybin A and silybin B, on the induction of apoptosis in K562 cells A long-term treatment with silybin in patients with non-alcoholic steatohepatitis stimulates catalase activity in human endothelial cells A new drug nanocrystal self-stabilized Pickering emulsion for oral delivery of silybin A New Pro-Prodrug Aminoacid-Based for Trans-Ferulic Acid and silybin Intestinal Release A new silybin-vitamin E-phospholipid complex improves insulin resistance and liver damage in patients with non-alcoholic fatty liver disease: preliminary observations A novel approach for the efficient extraction of silybin from milk thistle fruits A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients A phase I dose-finding study of silybin phosphatidylcholine (milk thistle) in patients with advanced hepatocellular carcinoma A pilot study on the liver protective effect of silybin-phosphatidylcholine complex (IdB1016) in chronic active hepatitis. A presurgical study of oral silybin-phosphatidylcholine in patients with early breast cancer A randomized multicentre double-blind vs placebo trial: Evaluation of effect of silybin conjugated with phosphatidilcholine and vitamin E on liver damage in patients … A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis A silybin-phospholipids complex counteracts rat fatty liver degeneration and mitochondrial oxidative changes A Simple HPLC Method for the Quantitative Determination of silybin in Rat Plasma: Application to a Comparative Pharmacokinetic Study on Commercial Silymarin … A study of high‐dose oral silybin‐phytosome followed by prostatectomy in patients with localized prostate cancer Ability of silybin and its derivatives to prevent protein oxidation in different model systems Absorption characteristics of silybin-phospholipid complex by rat intestine. Abstract A58: Green tea and silybin for breast cancer: A pilot presurgical study Abstract# 4510: A pilot study of oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer Acetaminophen does not induce oxidative stress in isolated rat hepatocytes: its probable antioxidant effect is potentiated by the flavonoid silybin Activation of sirtuin 3 by silybin attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury ADME/Tox Properties and Biochemical Interactions of silybin Congeners: In silico Study Advances in Chemical Modification of silybin and Its Analogues. Advances in the Researches on Derivatives of silybin [J] Alterations in insulin receptor in injured rats and the effects of dexamethasone and silybin Ameliorative effect of silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures Anti-cancer efficacy of silybin derivatives-a structure-activity relationship Anti-inflammatory effects of silybin and Thioctic acid in lipopolysaccharide (LPS)-induced BV-2 murine microglia Antioxidant activity of silybin and 2, 3-dehydrosilybin from Silybum marianum (L). Gaertn. Fruits Antioxidant activity of silybin in vivo during long-term iron overload in rats Antioxidant and antiviral activities
Sansalvamide A (MArine Fungi Fusarium) A comprehensive study of Sansalvamide A derivatives: The structure–activity relationships of 78 derivatives in two pancreatic cancer cell lines A novel peptide sansalvamide analogue inhibits pancreatic cancer cell growth through G0/G1 cell-cycle arrest A novel sansalvamide analogue inhibits pancreatic cancer cell proliferation via induction of macrophage inhibitory cytokine (MIC-1) Comprehensive study of Sansalvamide A derivatives and their structure–activity relationships against drug-resistant colon cancer cell lines Design and synthesis of Hsp90 inhibitors: exploring the SAR of Sansalvamide A derivatives Design, synthesis, and biological activity of Sansalvamide A derivatives Design, synthesis, and mechanistic studies of Sansalvamide A derivatives as anti-cancer agents Effect of the 4′-substituted phenylalanine moiety of Sansalvamide A peptide on antitumor activity Evaluation of di-Sansalvamide A derivatives: synthesis, structure− activity relationship, and mechanism of action Highly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A High-yielding macrocyclization conditions used in the synthesis of novel Sansalvamide A derivatives Identification of Sansalvamide A analog potent against pancreatic cancer cell lines Ionic‐Liquid‐Supported Total Synthesis of Sansalvamide A Peptide Mechanism of inhibition of a poxvirus topoisomerase by the marine natural product sansalvamide A Mechanistic studies of Sansalvamide A-amide: an allosteric modulator of Hsp90 N-Triethylene glycol (N-TEG) as a surrogate for the N-methyl group: application to Sansalvamide A peptide analogs PANCREATIC CANCER CELL CYCLE ARREST AND APOPTOSIS ARE INDUCED BY A NOVEL DEPSIPEPTIDE SANSALVAMIDE ANALOGUE PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A decapeptide PET imaging of Hsp90 expression in pancreatic cancer using a new 64Cu-labeled dimeric Sansalvamide A derivative Photo-induced synthesis and in vitro biological activity of a Sansalvamide A analog Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic Sansalvamide A using a side-chain-tethered phenylalanine building block Sansalvamide A and heat shock protein 90 biochemical and binding studies Sansalvamide: A new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium Solid-phase, Pd-catalyzed silicon-aryl carbon bond formation. Synthesis of Sansalvamide A peptide Structure-activity of Sansalvamide A derivatives and their apoptotic activity in the pancreatic cancer cell line PL-45 Synthesis and cytotoxicity of novel Sansalvamide A derivatives Synthesis and evaluation of biotinylated Sansalvamide A analogs and their modulation of Hsp90 Synthesis and novel structure–activity relationships of potent Sansalvamide A derivatives Synthesis of Cyclic Pentadepsipeptoids Analogues of Sansalvamide A by Combination of Ugi and Passerini Reactions Synthesis of macrocyclic anticancer agents: Sansalvamide A derivatives and Urukthapelstatin A Synthesis of N-OEG analogs of the Sansalvamide A peptide and evaluation of their biological activity Synthesis of Radioiodinated Antitumor Cyclic Peptide,[125I]-Sansalvamide A Derivative Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29 Synthesis of Sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds Synthesis of second-generation Sansalvamide A derivatives: Novel templates as potential antitumor agents
Rottlerin (Asian tree Mallotus philippensis) … (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn … Receptor Crosstalk: The IL-4-induced Alternate Pathway for BCR Signaling Operates in Parallel with the Classical Pathway, Is Sensitive to Rottlerin, and Depends on … 303 ENHANCED THERAPY SUCCESS OF RENAL CELL CARCINOMA USING TYROSINE KINASE INHIBITORS COMBINED WITH ROTTLERIN 64PEffects of Rottlerin and genistein through EF2K on proliferation, invasion and cell cycle/death in neuroblastoma cells A polyphenolic compound Rottlerin demonstrates significant in vitro cytotoxicity against human cancer cell lines: isolation and characterization from the fruits of … AB161. Rottlerin-induced autophagy leads to the apoptosis in bladder cancer cells Abstract LB-011: PAK1 inhibitor FRAX1036 sensitizes ovarian cancer cells with amplified 11q13 to cytotoxic effect of rottlerin Activation of BKCa Channels With Rottlerin Greatly Improves Cardiac Functional Improvement Following Surgical Ischemia Associated With Cardioplegic Arrest. Alternative pathways of cancer cell death by rottlerin: apoptosis versus autophagy Anti-allergic actions of Rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models Antiproliferative effect of Rottlerin on SK-MEL-28 melanoma cells Arsenite-Stimulated Glucose Uptake in 3T3-L1 Adipocytes Is Sensitive to Inhibition by Rottlerin and Ro-31-8220 Biosynthesis of promatrix metalloproteinase-9/chondroitin sulphate proteoglycan heteromer involves a Rottlerin-sensitive pathway Coadministration of sorafenib with Rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells Critical appraisal of the MTT assay in the presence of Rottlerin and uncouplers Design, synthesis and functional characterization of Rottlerin analogs Determination of rottlerin, a natural protein kinases C inhibitor, in pancreatic cancer cells and mouse xenografts by RP-HPLC method Development and validation of a RP-HPLC method for quantification of Rottlerin in Kamala (Mallotus philppinensis). Development and validation of a RP-HPLC method for the simultaneous determination of Embelin, Rottlerin and Ellagic acid in Vidangadi churna Down-regulation of caspase-2 by Rottlerin via protein kinase C-δ–independent pathway Down-regulation of Caspase-2 by Rottlerin via Protein Kinase CD–Independent Pathway Effect of rottlerin, a PKC-δ inhibitor, on TLR-4-dependent activation of murine microglia Effects of Rottlerin on in vitro proliferation of and expressions of interleukin-17C, CCL20 and nuclear factor-κB in a human keratinocyte cell line HaCaT Effects of Rottlerin on silica-exacerbated systemic autoimmune disease in New Zealand mixed mice Effects of rottlerin, an inhibitor of calmodulin-dependent protein kinase III, on cellular proliferation, viability, and cell cycle distribution in malignant glioma cells. Effects of Rottlerin, an Inhibitor of Calmodulin-dependent Protein Kinase Ill, on Cellular Proliferation, Viability, and Cell Cycle Distribution in Malignant Glioma … Efficient synthesis of Rottlerin and its two subunits Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor Rottlerin and relative insensitivity towards staurosporine Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor Rottlerin and relative insensitivity towards staurosporine Expression of protein kinase c (pkc) isoforms and the effect of selective pkc-s inhibition by Rottlerin on the induction of apoptosis in acute promyelocytic leukemia Improved synergistic anticancer efficacy of quercetin in combination with PI-103, rottlerin, and G0 6983 against MCF-7 and RAW 264.7
Piperlongumin (Piper longum) Overview of the therapeutic potential of piplartine (piperlongumine) Piperlongumine suppresses proliferation of human oral squamous cell carcinoma through cell cycle arrest, apoptosis and senescence Synthesis, cellular evaluation, and mechanism of action of Piperlongumine analogs Alkaloids of Piper longum Linn—I: Structure and synthesis of Piperlongumine and piperlonguminine Piperlongumine induces autophagy by targeting p38 signaling Drug-repositioning screening identified Piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death Antiplatelet activities of newly synthesized derivatives of piperlongumine Piperlongumine induces inhibition of the ubiquitin–proteasome system in cancer cells Synthesis and molecular structure of piplartine (= piperlongumine) Activation of ERK signaling and induction of colon cancer cell death by piperlongumine Discovery of Piperlongumine as a potential novel lead for the development of senolytic agents Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling Piperlongumine inhibits NF‐κB activity and attenuates aggressive growth characteristics of prostate cancer cells Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation Piperlongumine selectively kills cancer cells and increases cisplatin antitumor activity in head and neck cancer Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A2 receptor antagonist Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer … induces apoptosis by ROS-mediated ER stress and mitochondrial dysfunction and displayed synergistic lethality with Piperlongumine in gastric cancer Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells Inhibition of Aflatoxin B~ 1 Biosynthesis by Piperlongumine Isolated from Piper longum L Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP Piperlongumine induces pancreatic cancer cell death by enhancing reactive oxygen species and DNA damage Synthesis and biological evaluation of Piperlongumine derivatives as potent anti-inflammatory agents Synthesis of Piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways Development and mechanism investigation of a new Piperlongumine derivative as a potent anti-inflammatory agent Design, synthesis and biological activity of Piperlongumine derivatives as selective anticancer agents Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway Piperlongumine for enhancing oral bioavailability and cytotoxicity of docetaxel in triple-negative breast cancer Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: a mechanistic investigation Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways Biosynthesis of piperlongumine Piperlongumine inhibits LMP1/MYC-dependent mouse B-lymphoma cells Design and
Polgala Tenuifolia Anti-Obesity Effect of Water Extracts from Polygala tenuifolia Chemical Constituents of Polygala tenuifolia and Their Inhibitory Activity on Lipopolysaccharide-induced Nitric Oxide Production in BV2 Microglia Current Research Progress of Polygala tenuifolia on Pharmacological Activities in the Central Nervous System Cytogenetic analysis of Polygala tenuifolia wild by different staining techniques and fluorescent In situ hybridization Discrimination of geographical origin of cultivated Polygala tenuifolia based on multi-element fingerprinting by inductively coupled plasma mass spectrometry Effect of Cultivation of Different Regions on the Growth and Yield of 1-year-old Polygala tenuifolia Willdenow Effect of Drying Methods on the OnjisaponinB Contents of Polygala tenuifolia Functional characterization of an oxidosqualene cyclase gene encoded β-amyrin synthase from Polygala tenuifolia Willdeow Germination Characteristics of Polygala tenuifolia Seeds according to Harvest Mathod and Temperature Neuroprotective Effect of Aqueous Extract of Polygala tenuifolia Willdenow on Nitric Oxide-induced Apoptosis in SK-N-MC Cells Occupational asthma and rhinitis induced by a herbal medicine, Wonji (Polygala tenuifolia) Phytochemical screening and antimicrobial activity for plants Dracaena cinnabari, Verbena officinal, Polygala tenuifolia and Linux usitatissimum Polygala tenuifolia Decoction polygalic acid in plasma and gastrointestinal fluid concentration determination and analysis. Polygalasaponin XXXII from Polygala tenuifolia root improves hippocampal-dependent learning and memory Predicting the potential distribution of Polygala tenuifolia Willd. under climate change in China Progress in studies on Polygala tenuifolia Protective effects of Polygala tenuifolia on ischemia-induced 4 vessel occlusion in rats Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass … Sleep Induced By A Herbal Agent Polygala tenuifolia Versus That By Alprazolam: A Review With New Data On EEG And Sleep Duration STUDIES ON ANTIDEPRESSIVE EFFECT OF OLIGOSACCHARIDE ESTERS FROM Polygala tenuifolia WILLD SUGAR COMPONENTS OF THE ROOT OF Polygala tenuifolia. UPLC/Q-TOF MS-based metabolomics and qRT-PCR in enzyme gene screening with key role in triterpenoid saponin biosynthesis of Polygala tenuifolia Xanthones and a cinnamic acid derivatives from Polygala tenuifolia A bioactive compound from Polygala tenuifolia regulates efficiency of chronic stress on hypothalamic-pituitary-adrenal axis A CYP716A enzyme function of oleanane oxidase in biosynthesis of triterpenoid in Polygala tenuifolia willd A new glycoside from Polygala tenuifolia Willd A novel triterpenoid saponin from Polygala tenuifolia Willd. A Study on the Constituents from the Roots of Polygala tenuifolia A water-soluble polysaccharide from the roots of Polygala tenuifolia suppresses ovarian tumor growth and angiogenesis in vivo Absorbable phenylpropenoyl sucroses from Polygala tenuifolia Adventitious Shoot Induction and Plant Regeneration in Polygala tenuifolia Affect of Polygala tenuifolia willd on CaMKⅡ expression in hippocampus of manganese poisoning mice Analysis of alkaloids in Polygala tenuifolia by HPLC Analysis of digital gene expression profiles of the cultivated Polygala tenuifolia in different phenological phases Analysis of Diversify in Matched Pair of Polygala tenuifolia Willd. and Acorus Tatarinowii Schott by HPLC [J] Analysis of Fat-Soluble Components from Drug Matched Pair of Polygala tenuifolia Willd. and Acorus Tatarinowii Schott. by GC-MS [J] Analysis of influencing factors of secondary metabolites contents in cultivated Polygala tenuifolia Analysis of the extract substrates of Polygala tenuifolia Willd. with SFE-CO_2 by GC-MS Analysis
Phloretin Effect of phloretin on the permeability of thin lipid membranes. Bioavailability of phloretin and phloridzin in rats The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport A method using 3-O-methyl-D-glucose and phloretin for the determination of intracellular water space of cells in monolayer culture Hypothesis for the interaction of phlorizin and phloretin with membrane carriers for sugars Interaction of electric dipoles with phospholipid head groups. A deuterium and phosphorus-31 NMR study of phloretin and phloretin analogs in phosphatidylcholine … Enzymatic synthesis of novel phloretin glucosides Apple polyphenols, phloretin and phloridzin: new trapping agents of reactive dicarbonyl species phloretin and phloretin analogs: mode of action in planar lipid bilayers and monolayers Interaction between phloretin and the red blood cell membrane. Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats Stimulation of erythrocyte death by phloretin Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct Effect of phloretin on water and solute movement in the toad bladder phloretin-induced changes in ion transport across lipid bilayer membranes. The efficacy of phloridzin and phloretin on tumor cell growth. Inhibition of urea transport in inner medullary collecting duct by phloretin and urea analogues phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells Enzymic oxidation of phloretin glucoside in model system phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport Variation in concentrations of phloridzin and phloretin in apple foliage Application of directly coupled HPLC− NMR− MS to the identification and confirmation of quercetin glycosides and phloretin glycosides in apple peel Evaluation of the anti-inflammatory effects of phloretin and phlorizin in lipopolysaccharide-stimulated mouse macrophages Is phloretin the sugar transport inhibitor in intestine? phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin Inhibition of glucose transport into brain by phlorizin, phloretin and glucose analogues A Na+-independent, phloretin-sensitive monosaccharide transport system in isolated intestinal epithelial cells Apple flavonoid phloretin inhibits Escherichia coli O157: H7 biofilm formation and ameliorates colon inflammation in rats Asymmetry of the hexose transfer system in human erythrocytes. Comparison of the effects of cytochalasin B, phloretin and maltose as competitive inhibitors. The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets Interaction of phloretin with membranes: on the mode of action of phloretin at the water-lipid interface Asymmetrical binding of phloretin to the glucose transport system of human erythrocytes Anti-inflammatory and immunosuppressive effect of phloretin. Specificity of glucose transport in Trypanosoma brucei Effective inhibition by phloretin and cytochalasin B phloretin differentially inhibits volume‐sensitive and cyclic AMP‐activated, but not Ca‐activated, Cl− channels phloretin-an uncoupler and an inhibitor of mitochondrial oxidative phosphorylation Chloride dependence of frusemide‐and phloretin‐sensitive passive sodium and potassium fluxes in human red cells. Effect of phloretin on monosaccharide transport in erythrocyte ghosts On the
Gambogic Acid (Garcinia hanburyi) Studies on chemical modification and biology of a natural product, gambogic acid (II): Synthesis and bioevaluation of gambogellic acid and its derivatives from gambogic acid as antitumor agents Inducing cell cycle arrest and apoptosis by dimercaptosuccinic acid modified Fe3O4 magnetic nanoparticles combined with nontoxic concentration of bortezomib and gambogic acid in RPMI-8226 cells The Next Generation Non-competitive Active Polyester Nanosystems for Transferrin Receptor-mediated Peroral Transport Utilizing gambogic acid as a Ligand Crystallization of Pseudopolymorphs of Some Gamboge Pigments. Pyridine, Dimethylformamide and Dimethylsulfoxide Solvates of Morellic Acid, gambogic acid and Guttiferic Acid Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid 1213901. Synthesis and anti-tumor activity of NO-donating derivatives of gambogic acid 345. Gamboge. Part I. The constitutions of the acids C 11 H 10 O 4 and C 12 H 10 O 6 derived from gambogic acid 47 gambogic acid delivery using lipid nanoparticles modified with cell-penetrating peptide A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation A novel exploration of a combination of gambogic acid with TiO2 nanofibers: The photodynamic effect for HepG2 cell proliferation A novel redox/pH dual-responsive and hyaluronic acid-decorated multifunctional magnetic complex micelle for targeted gambogic acid delivery for the treatment of … A Probe into mechanism of gambogic acid-induced apoptosis in SPC-A-1 lung adenocarcinoma cells [J] A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid A solvent-assisted active loading technology to prepare gambogic acid and all-trans retinoic acid co-encapsulated liposomes for synergistic anticancer therapy Absolute configuration of (−)-gambogic acid, an antitumor agent Abstract# 4392: Role of transferrin receptor 1 and Src in gambogic acid-induced apoptosis Advance on Mechanisms in Antitumor Effect of gambogic acid and Its Derivates [J] Aminated β-cyclodextrin-grafted Fe 3 O 4-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation Aminated β-cyclodextrin-grafted Fe₃O₄-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation An open-labeled, randomized, multicenter phase IIa study of gambogic acid injection for advanced malignant tumors An open-labeled, randomized, multicentered, phase IIa study for advanced cancer treatment by gambogic acid injection (THS). An oxidative analogue of gambogic acid-induced apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its anticancer activity in vitro Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823 Anticancer effect and apoptosis induction of gambogic acid in human leukemia cell line K562 in vitro Anticancer effect of gambogic acid in gastric cancer line SGC-7901 Anti-CD22-conjugated CdTe QDs co-loaded with doxorubicin and gambogic acid: a novel platform for lymphoma treatment Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal … Anti‑inflammatory effects of gambogic acid in murine collagen‑induced arthritis through PI3K/Akt signaling pathway Anti-invasive effect of gambogic acid in MDA-MB-231 human breast carcinoma cells Antimetastatic Effects of gambogic acid are Mediated via the Actin Cytoskeleton and NF‐κ B Pathways in SK‐HEP 1 Cells Antiproliferative activity