AUTOPHAGY ACTIVATOR 200:1

The Most Powerful Science Based Autophagy Activating Formula on the Planet!

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The ULTIMATE fasting companion.

100g bag = 300 1/8 tsp servings.

Featuring: 2-deoxy-d-glucose (2-DG) • 8-Prenylnaringenin • Albatrellus confluens • Alisol B isolated from Alisma orientale • Allicin • Amorphophallus konjac tubor • Anthocyanin extract from black soybean (Glycine max L.) • Apigenin • Apios americana Medik flowers extract • Areca nut • Artemisia vulgaris (mugwort) • Azuki bean (Vigna angularis) extract • Bacopa monnieri • Benzoin gum (Styrax benzoin) • Berberine • Betanin‐Enriched Red Beetroot (Beta vulgaris L.) • Bitter Melon Extract Saponins30% • Brunfelsia grandiflora • Butea monosperma (Lam.) flowers • Buxus sempervirens • Carnosic acid (CA), a polyphenolic diterpene isolated from Rosemary (Rosemarinus officinalis) • Carnosol • Catechin • Celastrol (tripterine) isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) • Celastrus orbiculatus • Cepharanthine (CEP) a biscoclaurine alkaloid extracted from Stephania cepharantha • Chaihu (Radix bupleuri), • Chebulagic acid from Terminalia chebula • Chuan xiong (Rhizoma chuanxiong) • Cichorium intybus Linn. Extract • Clionamine B Isolated from Cliona celata • convallatoxin isolated from Antiaris toxicaria, • Cordycepin • Corynoxine B , isolated from Uncaria rhynchophylla (Miq.) Jacks (Gouteng in Chinese), • Cucurbita moschata, variety “long of Naples,” • Curcumin • Dandelion root • Dihydromyricetin (Ampelopsin) • Dimethyl cardamonin isolated from Syzygium samarangense • Dioscin • Docosahexaenoic acid (DHA) • Donglingcao (Rabdosia rubesens), • EGb 761 from Ginkgo biloba extract • Emblica officinalis extract • Evodiamine, an alkaloid isolated from Evodia rutaecarpa • Fenugreek • Fisetin • Fragaria vesca leaves • Fucoidan • Fucoxanthin from Laminaria japonica • Galangin • Ganoderma lucidum • Genistein • Ginger (Zingiber officinale Roscoe) • Gingerol • Ginsenoside 20 (S)-Rg3 • Glucosamine • Glutathione • Gynura formosana Kitam. leaves • Hibiscus sabdariffa Leaf • Honokiol from Magnolia officinalis • Hou po (Cortex magnoliae officinalis) • Hu Zhang (Rhizoma polygoni cuspidati), • Huaier extract • Isorhamnetin from sea buckthorn (Hippophae rhamnoides L.) • Isorhynchophylline (IsoRhy) from Uncaria rhynchophylla • Kaempferol • Luteolin • Matrine • Mung bean (Vigna Radiata) • Muscadine grape skin extract • Myrtillin • Naringin • oblongifolin C from Garcinia yunnanensis Hu • Old Man’s Beard (Usnea barbata) • Oleanolic acid • Onjisaponin B derived from Radix Polygalae • Oridonin • Paclitaxel from pacific yew tree • Panax ginseng • Parthenolide from Feverfew • Phellinus Linteus Extract • Pimenta dioica berries (Allspice) • Piperine • Piperlongumine (PL), from fruit of Long pepper (Piper longum) • Pluchea indica root extract • Plumbagin from Plumbago zeylanica L, Juglans regia, J. cinerea, and J. nigra • Polygonatum cyrtonema Hua • Quercetin • Resveratrol • Rhodiola rosea • Rottlerin from Mallotus philippinensis • Safflower extract • Salidroside • Sarsaparilla (Smilax glabra rhizome) extract • Saussurea lappa extract • Schisandrin A. (Schisandra chinensis fructus) • Silibinin • Tanshinone IIA from the root of Salvia miltiorrhiza Bunge, • Theobroma cacao L • Triptolide (TPL) from Tripterygium wilfordii, • Ursolic acid • Vitamin D3 • Vitamin K2 (MK4) • Vitexin • Wogonin from Scutellaria baicalensis

Click on studies below to learn more:

2-deoxy-d-glucose (2-DG)

1. The wonders of 2‐deoxy‐d‐glucose
2. 2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase
3. Mitofusin 2-Deficiency Suppresses Cell Proliferation through Disturbance of autophagy
4. 2-Deoxy-d-glucose enhances TRAIL-induced apoptosis in human gastric cancer cells through downregulating JNK-mediated cytoprotective autophagy
5. Synergy of 2-deoxy-d-glucose combined with berberine in inducing the lysosome/autophagy and transglutaminase activation-facilitated apoptosis
6. Glycolysis inhibition by 2-deoxy-d-glucose reverts the metastatic phenotype in vitro and in vivo
7. Synergistic increase in efficacy of a combination of 2-deoxy-d-glucose and cisplatin in normoxia and hypoxia: switch from autophagy to apoptosis
8. 2‐deoxy‐D‐glucose augments photodynamic therapy induced mitochondrial caspase‐independent apoptosis and energy‐mediated autophagy
9. Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy
10. Differential effects of the glycolysis inhibitor 2‐deoxy‐D‐glucose on the activity of pro‐apoptotic agents in metastatic melanoma cells, and induction of a cytoprotective autophagic response
11. Melatonin-Mediated Intracellular Insulin during 2-Deoxy-d-glucose Treatment Is Reduced through autophagy and EDC3 Protein in Insulinoma INS-1E Cells
12. 2-Deoxy-d-glucose Suppresses the In Vivo Antitumor Efficacy of Erlotinib in Head and Neck Squamous Cell Carcinoma Cells
13. Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death
14. FF when combined with 2-DG lowers ATP levels and inhibits autophagy
15. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
16. Glucosamine induces autophagy via an mtor-independent pathway
17. Chronic ingestion of 2-deoxy-d-glucose induces cardiac vacuolization and increases mortality in rats
18. Deconvoluting the role of reactive oxygen species and autophagy in human diseases
19. Hexokinase-II Positively Regulates Glucose Starvation-Induced autophagy through TORC1 Inhibition
20. Inhibition of autophagy by 3‑MA enhances endoplasmic reticulum stress‑induced apoptosis in human nasopharyngeal carcinoma cells
21. 2-DG led to a higher expression of Beclin-1, a crucial component of the autophagy pathway
22. Glycolysis inhibitor 2-deoxy-D-glucose suppresses carcinogen-induced rat hepatocarcinogenesis by restricting cancer cell metabolism
23. Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC
24. autophagy induced by 2-deoxy-D-glucose suppresses intracellular multiplication of Legionella pneumophila in A/J mouse macrophages
25. The combination of tephrosin with 2-deoxy-D-glucose enhances the cytotoxicity via accelerating ATP depletion and blunting autophagy in human cancer cells
26. Abstract 1044: A combination of cisplatin and 2-deoxy-d-glucose results in synergistic cell death in both normoxia and hypoxia by the attenuation of autophagy
27. Silencing of Elongation Factor-2 Kinase Potentiates the Effect of 2-Deoxy-d-Glucose against Human Glioma Cells through Blunting of autophagy
28. autophagy and reversed 2‐DG‐mediated suppression
29. Adipokinetic hormone-induced lipolysis in the fat body of an insect, Manduca sexta: synthesis of sn-1, 2-diacylglycerols.
30. The differential effects of these stresses on the rise in glycerol as an index of lipolysis implies that the sympathetic circuitry was par- tially disabled vis-a-vis the response to 2-DG,
31. It is concluded that 2-DG-induced thermogenesis and lipolysis are primarily dependent on P-adrenergic stimulation
32. In conclusion, unlike the vertebrate system in which lipolysis is regulated solely by the cAMP system, in the insect fat body, both cAMP and calcium are relevant messengers in the stimulation of sn-1,2-DG production.
33. hyperphagia and in the day-time a low rate of glucose utilization, lipolysis and hypophagia, it might be suspected that 2-DG
34. These data therefore support a defect in glucose sensing as a possible initiator of obesity and type 2 diabetes … 50 For instance, glucagon secretion can be induced by the direct injection of 2-deoxy-D-glucose (2-DG)
35. in as much as mice deficient in either
    protein did not develop obesity (Flier, 2004 … chain fatty acid has been found to inhibit food intake (Obici et al., 2002), whereas central administration of 2-deoxyglucose (2-DG
36. 2–DG-lnduced eating and that serotoninergic and dopaminerglc
    anorectic drugs modulate the eating responses of rats to cerebral glucoprivatlon induced by insulin or by 2–DG differently suggesting that glucose dysmetabollsm in obesity
37. Early response evaluation of therapy with AP23573 (an mtor inhibitor) in sarcoma using [18F]2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan
38. Intrinsically lower AKT, mtor and HIF activity correlates with increased sensitivity to 2-deoxy-D-glucose under hypoxia in lung cancer cell lines
39. Abstract 4081: Sensitivity of gastric cancer cell lines against 2-deoxy-D-glucose is independent of PI3K/mtor inhibition
40. The Relevance of mtor and Hypoxia Inducible Factor to 2-Deoxy-D-Glucose Toxicity in Lung Cancer Cell Lines Under Hypoxia
41. Inhibition of mtor increases cytotoxicity of 2-deoxy-D-glucose in small cell lung cancer under hypoxia
42. Abstract 1422: Dietary 2-deoxy-D-glucose (2-DG) reduces TLR-4 induced acute inflammation and prevents chronic inflammation driven carcinogenesis
43. Contribution of oxidative stress to radiosensitization by a combination of 2-DG and 6-AN in human cancer cell line

8-PRENYLNARINGENIN ( FROM HOPS EXTRACT )

1. Flavonoid-induced autophagy in hormone sensitive breast cancer cells
2. Treatment of PC‐3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase‐independent form of cell death
3. Prenylated chalcones and flavonoids for the prevention and treatment of cancer
4. Effects of natural prenylated flavones in the phenotypical ER (+) MCF-7 and ER (−) MDA-MB-231 human breast cancer cells
5. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells
6. Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo
7. New Insights into the Benefits of Polyphenols in Chronic Diseases
8. Dietary supplementation with shiikuwasha extract attenuates dexamethasone-induced skeletal muscle atrophy in aged rats
9. Pharmaceutical composition
10. Flavones Inhibit LPS-Induced Atrogin-1/MAFbx Expression in Mouse C2C12 Skeletal Myotubes
11. Quercetin and related polyphenols: new insights and implications for their bioactivity and bioavailability
12. Natural Estrogen Receptor Modulators and Their Heterologous Biosynthesis
13. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model
14. Several epidemiologic studies suggest
    that a polyphenol-enriched diet is an important strategy to prevent obesity and related chronic diseases, namely, T2DM. Both xanthohumol (XN) and 8-prenylnaringenin
15. 8-prenylnaringenin from hop) [10, 12, 13 … The prolonged lack of estrogen can cause cardiovascular disease, osteoporosis, os- teoarthritis, degenerative disc disease, obesity,
16. Effect of xanthohumol and 8‐prenylnaringenin on MCF‐7 breast cancer cells oxidative stress and mitochondrial complexes expression
17. Xanthohumol and 8-prenylnaringenin reduce type 2 diabetes–associated oxidative stress by downregulating galectin-3

Albatrellus confluens

1. Grifolin induces autophagic cell death by inhibiting the Akt/mtor/S6K pathway in human ovarian cancer cells
2. The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review)
3. Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets
4. Neoalbaconol induces cell death through necroptosis by regulating RIPK-dependent autocrine TNFα and ROS production
5. Inactivation of Ras and Changes of Mitochondrial Membrane Potential Contribute to Oridonin-Induced autophagy in A431 Cells
6. Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway
7. Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells
8. Elaborating the Role of Natural Products-Induced autophagy in Cancer Treatment: Achievements and Artifacts in the State of the Art
9. Natural products as modulator of autophagy with potential clinical prospects
10. Biosynthesis of Antroquinonol and 4-Acetylantroquinonol B via a Polyketide Pathway Using Orsellinic Acid as a Ring Precursor in Antrodia cinnamomea
11. Relevance of necroptosis in cancer
12. LOW-MOLECULAR-WEIGHT COMPOUNDS WITH ANTICANCER ACTIVITY OF MUSHROOM ORIGIN
13. Grifolic acid induces mitochondrial membrane potential loss and cell death of RAW264.7 macrophages
14. Targeting Cancer Cell Death with Small Molecule Agents for Potential Therapeutics
15. Chinese Herbs Interfering with Cancer Reprogramming Metabolism
16. Natural Compounds Regulate Glycolysis in Hypoxic Tumor Microenvironment
17. Roles of PI3‐K/Akt pathways in nanoparticle realgar powders‐induced apoptosis in U937 cells
18. Expression and Characterization of Protein Latcripin-3, an Antioxidant and Antitumor Molecule from Lentinula edodesC91-3
19. Evaluating DAPK as a therapeutic target
20. NA selectively inhibits proliferation and induces apoptosis and autophagy in cancer cells.
21. Albatrellus ovinus (sheep … Several other activities have been reported including hypoglycaemic effect [14], effect against obesity

Alisol B isolated ( from Alisma orientale )

1. Alisol A 24-Acetate and Alisol B 23-Acetate Induced autophagy Mediates Apoptosis and Nephrotoxicity in Human Renal Proximal Tubular Cells
2. Alisol B 23-acetate induces autophagic-dependent apoptosis in human colon cancer cells via ROS generation and JNK activation
3. Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mtor pathway
4. Alisol B 23-acetate-induced HepG2 hepatoma cell death through mtor signaling-initiated G1 cell cycle arrest and apoptosis: A quantitative proteomic study
5. Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces autophagy, Endoplasmic Reticulum Stress, and Apoptosis
6. Potential Agents for Cancer and obesity Treatment with Herbal Medicines from the Green Garden 1071 cological studies has been conducted using this compound [30,56]. Interestingly, alisol B
7. NAFLD has been associated with obesity, type 2 diabetes mellitus, hyperlipidemia, hypertension, fibrosis, and hepatocellular carcinoma [6 … Ten potential compounds, that is, gallic acid, chrysophanol, rhein, emodin, physcion, alisol C monoacetate, alisol B
8. Alisol B 23-acetate (AB23A) is a natural triterpenoid isolated from Rhizoma alismatis, which is a medicinal plant that has … the gene expression of CPT1α, ACADS and PPARα, which are involved in fatty acid β-oxidation (B). AB23A also increased the lipolysis
9. Alisol B 23‑acetate inhibits the viability and induces apoptosis of non‑small cell lung cancer cells via PI3K/AKT/mtor signal pathway

allicin ( From Garlic Extract )

1. Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3K/Akt/mtor and MAPK/ERK/mtor signaling pathways
2. Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice
3. Therefore the in vivo effects of tolbutamide and insulin on lipolysis and lipid levels may not be similar. Such a difference is also seen in the effect of allicin
4. The aim of the research was to study the mechanism of intermolecular interaction of allicin and lecithin with pancreatic lipase, and developing the composition, contributing to the inactivation process of lipolysis,
5. behavioral modifications for the treatment of
   obesity and likely with more success than caloric restriction alone. Based in part on its spectrum of activity in other cell types, we tested ajoene, a stable derivative of allicin
6. Our data suggest that allicin potentially prevents obesity and associated metabolic disorders such as type 2 diabetes mellitus by enhancing the expression of brown adipocyte-specific genes
7. Allicin ameliorates doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis
8. Allicin Alleviates inflammation of Trinitrobenzenesulfonic Acid-Induced Rats and Suppresses P38 and JNK Pathways in Caco-2 Cells
9. Allicin Attenuates inflammation and Suppresses HLA-B27 Protein Expression in Ankylosing Spondylitis Mice
10. Attenuation of oxidative stress, inflammation, and endothelial dysfunction in hypercholesterolemic rabbits by allicin
11. Diet Supplementation with Allicin Protects against Alcoholic Fatty Liver Disease in Mice by Improving Anti-inflammation and Antioxidative Functions
12. Comparative Study of Alliin and Allicin Inhibit Tumor Necrosis Factor-α Induced inflammation
13. Allicin Attenuates Myocardial Ischemia Reperfusion Injury in Rats by Inhibition of inflammation and oxidative stress
14. The immunomodulatory effects of the garlic organosulfur compounds allicin and Z-ajoene in an in vitro murine model of LPS-induced inflammation
15. The liver-protective effects of allicin against alcoholic fatty liver disease and liver inflammation.
16. Allicin Protects PC12 Cells Against 6-OHDA-Induced oxidative stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics
17. Allicin prevents H2O2-induced apoptosis of HUVECs by inhibiting an oxidative stress pathway
18. Allicin prevents oxidized low-density lipoprotein-induced endothelial cell injury by inhibiting apoptosis and oxidative stress pathway
19. Allicin inhibits oxidative stress-induced mitochondrial dysfunction and apoptosis by promoting PI3K/AKT and CREB/ERK signaling in osteoblast cells
20. Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic
21. Protective effect of allicin on high glucose/hypoxia-induced aortic endothelial cells via reduction of oxidative stress
22. In situ allicin generation using targeted alliinase delivery for inhibition of MIA PaCa-2 cells via epigenetic changes, oxidative stress and cyclin-dependent kinase inhibitor (CDKI) expression
23. Allicin ameliorates cognitive impairment in APP/PS1 mice via Suppressing oxidative stress by Blocking JNK Signaling Pathways
24. Protective effect of allicin against oxidative stress and hepatocyte autophagy in iron-overloaded rats

amorphophallus konjac tubor

1. Suppression of gastric cancer by extract from the tuber of amorphophallus konjac via induction of apoptosis and autophagy
2. Amorphophallus koniac Koch (Araceae), obesity, lipid and glucose metabolism alterations.
3. Amorphophallus konjac … KGM has recently been marketed in capsule form, as a drink mix and in food products (Brown, 2000, Talbott, 2003) and has been touted for its potential in the treatment of obesity
4. obesity has reached alarming levels in the United States … in
   the colon,* Glucomannan is a water-soluble, fermentable dietary fiber extracted from the tuber or root ofthe elephant yam, also known as konjac {Amorphophallus
5. Therefore using natural products that contain glucomannan
   to reduce obesity and LDL-C is good choise. Glucomannan in the global market derived from Amorphophallus konjac.
6. Amorphophallus Konjac … When stored body fat is broken down and used, lipase enzymes hydrolyze triglycerides into glycerol and free fatty acids during the breakdown of fat, called lipolysis

The tuber of amorphophallus konjac (TuAK) is an antitumor herb used in traditional Chinese medicine. The present study investigated the inhibitory effect of TuAK against gastric cancer and the underlying mechanisms associated with two programmed cell death pathways, apoptosis and autophagy. TuAK was extracted by organic solvents including ethanol and ligarine. The extract of TuAK, shortened as TuAKe, significantly inhibited the growth of cultured gastric cancer cell lines SGC-7901 and AGS, with IC50 of 35-45 µg/ml. TuAKe could increase cell apoptosis and induce cell cycle arrest. For the apoptosis-associated proteins, expressions of survivin and Bcl-2 were decreased by treatment of TuAKe, and the expression of Bax and caspase-9 was increased. Furthermore, TuAKe could promote autophagy, and the antitumor efficacy of TuAKe was significantly hampered by targeted suppression of autophagy, suggesting that autophagy contributed to TuAKe-induced cell death. Furthermore, patients with gastric cancer who received TuAK-based medicinal decoction achieved improved scores in assessment of life quality compared with those without TuAK treatment. This study demonstrated the antitumor activity of TuAKe against gastric cancer, and is the first report to show that the underlying mechanism is associated with induction of autophagy. Our data provided support of the clinical use of amorphophallus konjac-based medication in combination with classical chemotherapy to achieve optimized outcome for gastric cancer.

Anthocyanin extract ( from black soybean Glycine max L.)

1. [Study on Mulberry Anthocyanins Induced autophagy and Apoptosis of Human Gastric Cancer SGC-7901 Cell autophagy].
2. Anthocyanins Regulate NAFLD by Promoting autophagy Pathway
3. Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death
4. Mulberry Anthocyanins Induce Leukemia WEHI-3 Cells Apoptosis, autophagy, Differentiation and prolong leukemic mice survival.
5. MdATG18a overexpression improves tolerance to nitrogen deficiency and regulates anthocyanin accumulation through increased autophagy in transgenic apple
6. Protective effect of anthocyanin on alcohol-induced liver fibrosis is due to the regulation on AMPK/mtor/autophagy pathway and energy status
7. Protective Effect of Purple Tomato Anthocyanidin on Chromium(VI)-Induced autophagy in LMH Cells by Inhibiting Endoplasmic Reticulum Stress
8. autophagy is required for tolerance of drought and salt stress in plants
9. Apoptosis and rotator cuff tears: scientificevidence from basic science to clinical findings
10. We investigated the effects of anthocyanins on cell growth, differentiation, and lipolysis in 3T3-L1 cells to test our hypothesis that anthocyanins could reduce adipose tissue mass by acting directly on adipocytes.
11. These observation provides the first evidence that anthocyanin directly inhibits lipolysis in adipocytes during hyperglycemia, suggesting that this could be a potential mechanism involved in the insulin-sensitizing properties of anthocyanins
12. it is possible that the effects of anthocyanins on TG accumulation may not only be achieved by the down-regulation of lipogenic transcription factors, but also by regulating lipolysis pathway(s)
13. Effects of Anthocyanin-rich Extract from Black Rice on Rats with High Fat Diets-induced obesity
14. Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism
15. The main beneficial effect of roselle (Hibiscus sabdariffa) on obesity is not only related to its anthocyanin content
16. Anthocyanin-rich Black Elderberry Extract improves Inflammatory Markers and Insulin Resistance in a High-Fat Diet-Induced obesity Model of Mice
17. Dietary anthocyanin prevents obesity and ameliorates hyperglycemia in mice: PO0790
18. Vision preservation during retinal inflammation by anthocyanin-rich bilberry extract: cellular and molecular mechanism
19. Anthocyanin-rich fractions from red raspberries attenuate inflammation in both RAW264.7 macrophages and a mouse model of colitis
20. Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet‐induced obese mice
21. Inhibitory effect of anthocyanin-rich black soybean testa (Glycine max (L.) Merr.) on the inflammation-induced adipogenesis in a DIO mouse model
22. Signatures of anthocyanin metabolites identified in humans inhibit biomarkers of vascular inflammation in human endothelial cells
23. Anthocyanin-rich Riceberry bran extract attenuates gentamicin-induced hepatotoxicity by reducing oxidative stress, inflammation and apoptosis in rats
24. Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular inflammation in Endothelial Cells and Apo E−/− Mice
25. Cyanidin 3-Rutinoside, an Anthocyanin Pigment of Schisandra chinensis Baill, Inhibits Allergic inflammation
26. Elongator mediates ABA responses, oxidative stress resistance and anthocyanin biosynthesis in Arabidopsis
27. A Randomized Clinical Trial Evaluating the Efficacy of an Anthocyanin–Maqui Berry Extract (Delphinol®) on oxidative stress Biomarkers
28. An anthocyanin-rich strawberry extract protects against oxidative stress damage and improves mitochondrial functionality in human dermal fibroblasts exposed to an oxidizing agent
29. Anthocyanin‐rich red cabbage (Brassica oleracea L.) extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet
30. Overexpression of R2R3-MYB gene leads to accumulation of anthocyanin and enhanced resistance to chilling and oxidative stress
31. Anthocyanin-Rich Juice Lowers Serum Cholesterol, leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats

Apigenin ( From Celery Extract )

1. Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and autophagy
2. Apigenin Alleviates Endotoxin-Induced Myocardial Toxicity by Modulating inflammation, oxidative stress, and autophagy
3. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells
4. Inhibition of PI3K/Akt/mtor pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells
5. Oral Efficacy of Apigenin against Cutaneous Leishmaniasis: Involvement of Reactive Oxygen Species and autophagy as a Mechanism of Action
6. Inhibition of autophagy ameliorates atherogenic inflammation by augmenting apigenin-induced macrophage apoptosis
7. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
8. α-Mangostin and apigenin induced the necrotic death of BT474 breast cancer cells with autophagy and inflammation
9. Apigenin restores impairment of autophagy and downregulation of unfolded protein response regulatory proteins in keratinocytes exposed to ultraviolet B radiation
10. Apigenin Combined With Gefitinib Blocks autophagy Flux and Induces Apoptotic Cell Death Through Inhibition of HIF-1α, c-Myc, p-EGFR, and Glucose Metabolism in EGFR L858R+T790M-Mutated H1975 Cells
11. The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
12. Apigenin Ameliorates the obesity‐Induced Skeletal Muscle Atrophy by Attenuating Mitochondrial Dysfunction in the Muscle of obese Mice
13. Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates obesity-Related inflammation Via Regulation of Macrophage Polarization
14. Several in vitro and in vivo studies have reported the anti-inflammatory, anti-diabetic and anti-obesity effects of the flavonoid apigenin.
15. Background and purpose Apigenin can exert beneficial actions in the prevention of obesity. However, its putative action on obesity-associated bowel motor dysfunctions is unknown.
16. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mtor Pathway
17. Apigenin reduces the Toll-like receptor-4-dependent activation of NF-κB by suppressing the Akt, mtor, JNK, and p38-MAPK
18. Apigenin inhibits proliferation and migratory properties of Barrett’s esophageal adenocarcinoma cells by targeting PI3K/Akt/mtor pathway
19. The antidepressant effects of apigenin are associated with the promotion of autophagy via the mtor/AMPK/ULK1 pathway
20. Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects
21. Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells
22. Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
23. Protective role of apigenin on rotenone induced rat model of Parkinson’s disease: Suppression of neuroinflammation and oxidative stress mediated apoptosis
24. Apigenin attenuates oxidative stress and neuronal apoptosis in early brain injury following subarachnoid hemorrhage
25. Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling
26. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression
27. Effect on oxidative stress, glucose uptake level and lipid droplet content by Apigenin 7, 4′-dimethyl ether isolated from Piper longum L
28. Topical Apigenin Alleviates Cutaneous inflammation in Murine Models
29. Apigenin Protects Endothelial Cells from Lipopolysaccharide (LPS)-Induced inflammation by Decreasing Caspase-3 Activation and Modulating Mitochondrial Function
30. Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK‐3β/NF‐κB signaling cascade
31. Apigenin Attenuates inflammation in Experimentally Induced Acute Pancreatitis-Associated Lung Injury
32. Apigenin-7-O-β-d-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock
33. Apigenin attenuates hippocampal oxidative events, inflammation and pathological alterations in rats fed high fat, fructose diet
34. Anti-inflammation and anti-fibrosis with PEGylated, apigenin loaded PLGA nanoparticles in chronic pancreatitis disease
35. Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
36. Apigenin Retards Atherogenesis by Promoting ABCA1-Mediated Cholesterol Efflux and Suppressing inflammation
37. Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway
38. Apigenin affects leptin/leptin receptor pathway and induces cell apoptosis in lung adenocarcinoma cell line
39. Counteracting effects of apigenin and leptin on lung adenocarcinoma cells.
40. leptin and Apigenin: Antagonists in the Apoptotic Pathway of Lung Adenocarcinoma Cell Line

Apios americana Medik flowers extract

1. Apios americana Medik flowers extract protects PC12 cells against H2O2 induced neurotoxicity via regulating autophagy
2. Apios americana Medikus tuber polysaccharide exerts anti-inflammatory effects by activating autophagy
3. Apios americana Medik flowers polysaccharide (AFP-2) attenuates H2O2 induced neurotoxicity in PC12 cells
4. Effects of C-Glycosides from Apios americana against oxidative stress during Hyperglycemia through Regulating Mitogen-Activated Protein Kinases and Nuclear Factor Erythroid 2-Related Factor 2
5. Anti-Visceral obesity Effect of Apios americana Medikus in Diet-Induced obese Mice
6. Apios americana Medik (hereinafter Apios) has been reported to treat diseases, including cancer, hypertension, obesity, and diabetes
7. Apios could inhibit the proliferation of cancer cells and alleviate obesity, hypertension and diabetes
8. There is some evidence that Apios may cure chronic
   constipation and exert positive effects on hypertension, disorders before and after childbirth, obesity, and diabetes.
9. Apios americana Medik extract alleviates lung inflammation in influenza virus H1N1-and endotoxin-induced acute lung injury
10. Effects of C-Glycosides from Apios americana Leaves against oxidative stress during Hyperglycemia through Regulating Mitogen-Activated Protein Kinases and Nuclear Factor Erythroid 2-Related Factor 2

Areca nut

1. autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling
2. Mechanistic and compositional studies of the autophagy-inducing areca nut ingredient
3. Impacts of autophagy-Inducing Ingredient of Areca Nut on Tumor Cells
4. autophagy induction by a natural ingredient of areca nut
5. autophagy induction by the 30–100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species
6. Arecoline and the 30–100 kDa fraction of areca nut extract differentially regulate mtor and respectively induce apoptosis and autophagy: a pilot study
7. autophagy Induced by Areca Nut Extract Contributes to Decreasing Cisplatin Toxicity in Oral Squamous Cell Carcinoma Cells: Roles of Reactive Oxygen Species/AMPK Signaling
8. Molecular and cellular cues of diet‐associated oral carcinogenesis—with an emphasis on areca‐nut‐induced oral cancer development
9. Long‐term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity
10. Impacts of autophagy-Inducing Ingredient of Areca Nut on Tumor Cells
11. Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3β: An Implication for Cytopathic Effects in Betel Quid Chewers
12. Ionizing radiation induces autophagy in human oral squamous cell carcinoma.
13. autophagy mediates oral submucous fibrosis
14. Role of autophagy in head and neck cancer and therapeutic resistance
15. autophagy and its implication in human oral diseases
16. Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma
17. autophagy and Apoptosis Play Opposing Roles in Overall Survival of Esophageal Squamous Cell Carcinoma
18. Tetrandrine induces cell death in SAS human oral cancer cells through caspase activation-dependent apoptosis and LC3-I and LC3-II activation-dependent autophagy
19. Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut‐induced carcinogenesis
20. Clathrin‐mediated endocytosis is required for ANE 30‐100K‐induced autophagy
21. Chapter 16 – Erufosine Induces autophagy and Apoptosis in Oral Squamous Cell Carcinoma: Role of the Akt–mtor Signaling Pathway
22. Thiamine Deficiency and Neurodegeneration: the Interplay Among oxidative stress, Endoplasmic Reticulum Stress, and autophagy
23. Pattern of Areca (betel) Nut Chewing and Obesity Measures in Guam and Saipan, Mariana Islands.
24. Betel nut (Areca catechu) consumption and induction
    glucose intolerance in adult CD1 mice and their F1 and F2 offspring … Betel nut chewing is strongly associated with general and central obesity in Chinese male middle-aged adults
25. It is also used in socio-religious practices, in ayurvedic medicines against leucoderma, leprosy, cough, fits, worms anaemia and obesity. Areca tannins from areca nut are found to have inhibitory activities on reverse transcriptase enzyme
26. Areca nut chewing is the fourth most popular substance abuse habit in the world [4]. Previous studies have found that chewing areca nut is associated with obesity, metabolic syndrome, hypertension (HTN),
27. The present invention provides a lipolysis stimulator and a slimming agent, containing as an active ingredient any form of a plant or an extract thereof, the plant being selected from among common juniper, togenashi, rosehip, areca.
28. Prevalence of type II diabetes, hyperlipidemia,
    hypertriglyceridemia and metabolic syndromes are more common in areca nut chewers as its metabolite, arecoline, inhibits adipogenic differentiation, induces lipolysis
29. Areca nut affecting metabolic processes is that arecoline may inhibit the differentiation of adipose tissue, induce adenylyl-cyclase-dependent lipolysis
30. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E 2 , interleukin-6 and TNF-α production of oral epithelial cells by areca nut extract and arecoline
31. Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice
32. inflammation.biomedcentral.com/articles/10.1186/1476-9255-9-22″>Areca nut chewing and systemic inflammation: evidence of a common pathway for systemic diseases
33. Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract
34. Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress
35. Role of tumor necrosis factor-α, leptin, and white blood cell count in betel nut chewing–related metabolic derangements

Artemisia vulgaris (mugwort)

1. Herbal extract of Artemisia vulgaris (mugwort) induces antitumor effects in HCT-15 human colon cancer cells via autophagy induction, cell migration suppression and loss of mitochondrial membrane potential.
2. Therapeutic efficacy of Artemisia absinthium against Hymenolepis nana: in vitro and in vivo studies in comparison with the anthelmintic praziquantel
3. The Extracts of Artemisia absinthium L. Suppress the Growth of Hepatocellular Carcinoma Cells through Induction of Apoptosis via Endoplasmic Reticulum Stress and Mitochondrial-Dependent Pathway
4. iTRAQ-Based Proteomics Analysis of autophagy-Mediated Responses against MeJA in Laticifers of Euphorbia kansui L.
5. Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review
6. Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice
7. PROMISING BIOLOGICAL ACTIVITIES OF SESQUITERPENE LACTONES
8. SIRT2 Exacerbates MG132-induced Protein Accumulation and Cytotoxicity by Inhibition of autophagy Turnover
9. Accumulation of Indolyl-3-Acetic and Abscisic Acids by “Hairy” Roots of Artemisia vulgaris
10. Antilipogenic and Hypolipidemic Effects of Ethanol Extracts from Two Variants of Artemisia in obese Diabetic Mice
11. Antioxidant and apoptosis modulating effects of Artemisia Vulgaris leaf extracts on in vitro systems subjected to oxidative stress
12. Immunotherapy Of Mugwort Pollen Extract Decreases Airway Hyperresponsiveness And Lung inflammation In A Recombinant Art V1-induced Rat Model Of Allergy
13. 126 Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-specificT-Cell Receptor and HLA-DR1

Ashitaba (Angelica keiskei koidzumi)

1. Soluble fraction of A. keiskei (AK) extracts and its …
   LC3B-I, LC3B-II, and SQSTM1/p62 were gradually reduced as evidence of autophagic flux
2. Ashitaba (Angelica Keiskei) Exudate Prevents Increases in Plasminogen Activator Inhibitor-1 Induced by Obesity in Tsumura Suzuki Obese Diabetic Mice
3. Daily Supplementation with Fresh Angelica keiskei Juice Alleviates High‐Fat Diet‐Induced Obesity in Mice by Modulating Gut Microbiota Composition
4. Antidiabetic Activities of Chalcones Isolated from a Japanese Herb, Angelica keiskei
5. [Effects of angelica keiskei chalcone on expression of glucose transporter proteins in liver and skeletal muscle cells of type 2 diabetic rats].
6. Phytonutrient and anti-diabetic functional properties of flavonoid-rich ethanol extract from Angelica Keiskei leaves
7. Effects of Angelica Keiskei Chalcone on Insulin Resistance of SkeletalMuscle Cells of Type 2 Diabetic Rats
8. Anti – diabetic Activities of Ashitaba (Angelica keiskei) : Induction of Adipocyte Differentiation and Enhancement of Glucose Uptake in Adipocyte

Azuki bean (Vigna angularis) extract

1. Azuki bean (Vigna angularis) extract reduces oxidative stress and stimulates autophagy in the kidneys of streptozotocin-induced early diabetic rats
2. Saponins and Flavonoids from Adzuki Bean (Vigna angularis L.) Ameliorate High-Fat Diet-Induced obesity in ICR Mice
3. Suppression of obesity by Black Adzuki Beans (Vigna angularis) in High-fat Diet Fed obese Mouse Model
4. Effects of azuki beans on oxidative stress, hypertriacylglycerolaemia, hypertension, obesity, and diabetes
5. Polyphenol-enriched azuki bean (Vina angularis) extract reduces the oxidative stress and prevents DNA oxidation in the hearts of streptozotocin-induced early diabetic rats
6. Studies on the changes of oxidative stress and autophagy in the hearts of streptozotocin-induced early diabetes rats, andthe improvement effects by azuki bean (Vigna angularis) extract [an abstract of dissertation and a summary ofdissertation review

Bacopa monnieri

1. Bacopa monnieri‐Induced Protective autophagy Inhibits Benzo[a]pyrene‐Mediated Apoptosis
2. The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis
3. cPKCγ-Modulated autophagy in Neurons Alleviates Ischemic Injury in Brain of Mice with Ischemic Stroke Through Akt-mtor Pathway
4. Bacopa monnieri-induced protective autophagy inhibits benzo[a]pyrene-mediated apoptosis
5. Bacopa monnieri (Brahmi) induced autophagy Inhibit Benzo[a]pyrene mediated cytotoxicity
6. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy
7. Phytochemicals Bridging autophagy Induction and Alpha-Synuclein Degradation in Parkinsonism
8. Plant Extracts Stimulate the autophagy-lysosomal Protein Clearance Pathway and Improve Brain Synapse Markers in an Explant Model of Age-related Protein Accumulation Stress (FS05-04-19)
9. Pharmaceutical composition and drug effect of synthetic Bacopa monnieri L.health promoting agentfrom the perspective of resistance fatigue
10. The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis
11. Virtual Screening of Peptidyl Arginine Deiminase Type 4 Inhibiting Potential of Chosen Flavonoids
12. In vitro cytotoxicity studies of silver nanoparticles with activated folic acid on cancer cell lines.
13. Bacopa monnieri as an Antioxidant Therapy to Reduce oxidative stress in the Aging Brain
14. Renoprotective effect of Bacopa monnieri via inhibition of advanced glycation end products and oxidative stress in STZ-nicotinamide-induced diabetic nephropathy
15. Alterations in Hippocampal oxidative stress, Expression of AMPA Receptor GluR2 Subunit and Associated Spatial Memory Loss by Bacopa monnieri Extract (CDRI-08) in Streptozotocin-Induced Diabetes Mellitus Type 2 Mice
16. Pretreatment with Bacopa monnieri extract offsets 3-nitropropionic acid induced mitochondrial oxidative stress and dysfunctions in the striatum of prepubertal mouse brain
17. Neuromodulatory role of Bacopa monnieri on oxidative stress induced by postnatal exposure to decabromodiphenyl ether (PBDE -209) in neonate and young female mice
18. Role of Bacopa monnieri in the temporal regulation of oxidative stress in clock mutant (cryb) of Drosophila melanogaster
19. Microbial interference mitigates Meloidogyne incognita mediated oxidative stress and augments bacoside content in Bacopa monnieri L.
20. Extracts of Bacopa monnieri (L) Pennell Down-Regulate the Expression of Leukotriene C4 Synthase mRNA in HL-60 Cells and Suppress OVAInduced inflammation in BALB/c Mice

benzoin gum (Styrax benzoin) ( From Benzoin Tree Bark )

1. Antibacterial, anti-biofilm and anticancer potentials of green synthesized silver nanoparticles using benzoin gum (Styrax benzoin) extract
2. Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy
3. Styrax benzoin D. (SB) on Brain Physiological Activities Monitored in Real-time
4. Benzoin-like compounds (Figure [1]) have showed high activity towards inhibiting the 11βHSD1 receptor related to diseases such as diabetes, obesity

Berberine ( From Berberis vulgaris )

1. Berberine alleviates cardiac ischemia/reperfusion injury by inhibiting excessive autophagy in cardiomyocytes
2. Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mtor signaling pathway
3. Berberine enhances the AMPK activation and autophagy and mitigates high glucose-induced apoptosis of mouse podocytes
4. Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage
5. Berberine induces autophagy in glioblastoma by targeting the AMPK/mtor/ULK1-pathway
6. Berberine attenuates hepatic steatosis and enhances energy expenditure in mice by inducing autophagy and fibroblast growth factor 21
7. Berberine protects against ischemia/reperfusion injury after orthotopic liver transplantation via activating Sirt1/FoxO3α induced autophagy
8. Pharmacologic preconditioning with berberine attenuating ischemia-induced apoptosis and promoting autophagy in neuron
9. Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement
10. Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis
11. Berberine reduces adipogenic and inflammatory molecules 603 adipocyte reducing effects are caused by lipolysis
12. This result is quite consistent with the previous report that berberine could exhibit significant lipolysis effects in Hep G2 cells
13. TG is the main component of very low-density lipoprotein and increased extracellular TG suggested insulin-mediated inhibition of lipolysis was attenuated. We also observed that berberine reduced extracellular TG accumulation after the stimulation of palmitate
14. However, we previously found that berberine decreased insulin secretion and lipolysis via cAMP/ protein kinase A (PKA) pathway independent of AMPK activation in pancreatic β-cells and adipocytes
15. Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of obesity and Insulin Resistance in High-Fat Diet-Fed Rats
16. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats
17. Effects and Action Mechanisms of Berberine and Rhizoma coptidis on Gut Microbes and obesity in High-Fat Diet-Fed C57BL/6J Mice
18. Berberine Ameliorates Hepatic Steatosis and Suppresses Liver and Adipose Tissue inflammation in Mice with Diet-induced obesity
19. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels
20. Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes
21. ERK-dependent mTOR pathway is involved in berberine-induced autophagy in hepatic steatosis.
22. Berberine decelerates glucose metabolism via suppression of mtor‑dependent HIF‑1α protein synthesis in colon cancer cells
23. Berberine attenuates apoptosis in rat retinal Müller cells stimulated with high glucose via enhancing autophagy and the AMPK/mtor signaling
24. Protection of berberine on intestinal mucosa following autologous orthotropic liver transplantation and its correlationship with p-AMPK activation and p-mtor inactivation
25. GW24-e1352 Berberine mitigated cardiac hypoxiareoxygenation injury by Suppressed Autophagy and Reduced Cell Death via inhibition of the activation of AMPK-mtor signalling pathway in rat H9c2 cells
26. Berberine preconditioning protects against hepatic cold ischemia reperfusion injury through the modulation of PI3K/Akt/mtor signaling pathway
27. Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway
28. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
29. Berberine ameliorates inflammation in patients with acute coronary syndrome following percutaneous coronary intervention
30. Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation
31. Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and inflammation in Rats
32. Berberine Protects against Neuronal Damage via Suppression of Glia-Mediated inflammation in Traumatic Brain Injury
33. Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling
34. Relative Inhibitory Activity of Berberine-Type Alkaloids against 12-ο-Tetradecanoylphorbol-13-acetate-Induced inflammation in Mice
35. Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction
36. Anti-Inflammatory Activities of Pentaherbs Formula, Berberine, Gallic Acid and Chlorogenic Acid in Atopic Dermatitis-Like Skin inflammation
37. Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans
38. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose
39. Berberine Ameliorate oxidative stress and Astrogliosis in the Hippocampus of STZ-Induced Diabetic Rats
40. Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing oxidative stress and inflammation Response: Role of Silent Information Regulator 1
41. Effects of Berberine on Amelioration of Hyperglycemia and oxidative stress in High Glucose and High Fat Diet-Induced Diabetic Hamsters In Vivo
43. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats
44. Resolution of Liver Fibrosis by Isoquinoline Alkaloid Berberine in CCl4-Intoxicated Mice Is Mediated by Suppression of oxidative stress and Upregulation of MMP-2 Expression
45. Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat
46. The inhibition of inflammatory molecule expression on 3T3-L1 adipocytes by berberine is not mediated by leptin signaling

Betanin‐Enriched Red Beetroot (Beta vulgaris L.)

1. Abstract 10893: Dietary Nitrate Supplementation With Beetroot Juice Enhances Cardiac autophagy Markers AMBRA-1 (Activating Molecule in Beclin-1-regulated autophagy) and ATG-5 (autophagy-related Gene 5): Protective Role Against Doxorubicin Cardiotoxicity
2. Betanin‐Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF‐7 Cells
3. POTENTIAL APPLICATION OF BEETROOT IN THERAPY OF obesity
4. Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat
5. Betanin, isolated from fruits of Opuntia elatior Mill attenuates renal fibrosis in diabetic rats through regulating oxidative stress and TGF-β pathway
6. Betanin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress-myeloperoxidase/low-density lipoprotein in rat
7. Short-Term Betanin Intake Reduces oxidative stress in Wistar Rats
8. Protective Effects of Betanin against oxidative stress in a Peripheral Artery Vasospasm Model in Rat

bitter melon

1. Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death
2. Methanolic Extracts of Bitter Melon Inhibit Colon Cancer Stem Cells by Affecting Energy Homeostasis and autophagy
3. Bitter melon juice targets molecular mechanisms underlying gemcitabine resistance in pancreatic cancer cells
4. Bitter melon: a panacea for inflammation and cancer
5. Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation
6. Altered White Adipose Tissue Protein Profile in C57BL/6J Mice Displaying Delipidative, Inflammatory, and Browning Characteristics after Bitter Melon Seed Oil Treatment
7. Roles of Peroxisome Proliferator-Activated Receptor α in Bitter Melon Seed Oil-Corrected Lipid Disorders and Conversion of α-Eleostearic Acid into Rumenic Acid in C57BL/6J Mice
8. BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells
9. Bitter Melon as a Therapy for Diabetes, inflammation, and Cancer: a Panacea?
10. Bitter gourd (Momordica charantia) as a rich source of bioactive components to combat cancer naturally: Are we on the right track to fully unlock its potential as inhibitor of deregulated signaling pathways
11. Bitter Melon Powder Protects against obesity-associatedFatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced obesity
12. Increased lipolysis in primary human adipocytes, with a concomitant reduction in PPARγ, SREBP-1c, perilipin, and resistin genes expression. These studies are critical as they lay the foundation to identify molecular targets and anti-obesity effects of bitter melon
13. Beneficial Role of Bitter Melon Supplementation in obesity and Related Complications in Metabolic Syndrome
14. Momordica charantia (Bitter Melon) Reduces obesity-Associated Macrophage and Mast Cell Infiltration as well as Inflammatory Cytokine Expression in Adipose Tissues
15. Bitter Melon Powder Protects against obesity-associatedFatty Liver Disease by Improving Colonic Microenvironment in Rats with High-fat Diet-induced obesity
16. Anti-obesity effect of bitter melon (Momordica charantia).
17. Momordica charantia (Bitter Melon) Improves Glucose and Lipid Metabolism Disturbance through Reducing obesity-associated inflammation in Mice
18. The Mechanism of Bitter Melon Power Preventing obesity-related inflammation
19. Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats
20. Bitter Melon (Momordica charantia) Reduces Adiposity, Lowers Serum Insulin and Normalizes Glucose Tolerance in Rats Fed a High Fat Diet
21. Bitter melon seed oil may reduce the adiposity through the hypothalamus mtor signaling in mice fed a high fat diet
22. Strawberry, loquat, mulberry, and bitter melon juices exhibit prophylactic effects on LPS-induced inflammation using murine peritoneal macrophages
23. Bitter melon: a panacea for inflammation and cancer
24. Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation
25. Inhibitory effects of wild bitter melon leaf extract on Propionibacterium acnes-induced skin inflammation in mice and cytokine production in vitro
26. Bitter Melon as a Therapy for Diabetes, inflammation, and Cancer: a Panacea?
27. Wild Bitter Melon Leaf Extract Inhibits Porphyromonas gingivalis-Induced inflammation: Identification of Active Compounds through Bioassay-Guided Isolation
28. Bitter melon (Momordica charantia) attenuates atherosclerosis in apo-E knock-out mice possibly through reducing triglyceride and anti-inflammation
29. Bitter Melon Improves Glycemic Control and inflammation in Adipose Tissue of Obese and Diabetic Rats
30. Organ inflammation and oxidative damages in fructose-fed adult offspring born of fructose-fed dams: modulation by maternal bitter melon supplementation (1033.6)
31. Regulation of Sphingosine Kinase 1 and Adipose inflammation by Momordica charantia (Bitter Melon) in High-Fat Diet-Fed Mice
32. Supplementation of Bitter Melon to Rats Fed a High-Fructose Diet During Gestation and Lactation Ameliorates Fructose-Induced Dyslipidemia and Hepatic oxidative stress in Male Offspring
33. Supplementation of Bitter Melon to Rats Fed a High-Fructose Diet During Gestation and Lactation Ameliorates Fructose-Induced Dyslipidemia and Hepatic oxidative stress in Male Offspring
34. The Butanol Fraction of Bitter Melon (Momordica charantia) Scavenges Free Radicals and Attenuates oxidative stress
35. Testicular oxidative stress in Sprague-Dawley rats treated with bitter melon (<i>Momordica charantia</i>): the effect of antioxidant supplementation
36. Fresh Bitter Melon Fruit (Momordica charantia) Attenuated oxidative stress, Fibrosis and Renal Injury in Carbon Tetrachloride Treated Rats
37. Maternal bitter melon supplementation reduces the risk for metabolic defects later in life: effects on lipidhandling, oxidative stress and inflammation in offspring born to damsfed a high fructose diet
38. Bitter Melon (Momordica charantia) Protects from oxidative stress-Induced Premature Senescence in WI-38 Human Lung Fibroblast Cell
39. The Effect of Bitter Melon Extract (Momordica charantia)in Inhibition of NFkB Activation in leptin treated HUVECS

Brunfelsia grandiflora

1. The Effect of Brunfelsia grandiflora Ethanol Extract on the Induction of autophagy in Human Lung Fibroblasts
2. Inhibition of Cell Proliferation and Induction of Apoptosis by Ethanolic Extract of Lespedeza cuneata G. Don in Human Colorectal Cancer HT-29 cells