The anti-aging effects of SIRT1 activation include: - Protection against oxidative stress - Regulation of age-related diseases - Increased stress resistance - Potential lifespan elongation - Involvement in the metabolic response to calorie restriction - Extension of lifespan in various organisms - Resistance to oxidative stress and cardiovascular health - Cellular protection and regulation of gene expression - Support for vascular and metabolic health - Impact on age-related diseases and longevity - Correlation with age, cholesterol levels, and eNOS expression - Potential compensatory mechanism against oxidative stress - Induction of antioxidants and contribution to longevity through gene-environment interactions. SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), referring to the fact that its sirtuinhomolog (biological equivalent across species) in yeast (S. cerevisiae) is Sir2. SIRT1 is an enzyme that deacetylates proteins that contribute to cellular regulation (reaction to stressors, longevity).[8] Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family.[6] Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity.[9]Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] In mammals, SIRT1 has been shown to deacetylate and thereby deactivate the p53 protein.[16] SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells and embryonic and neonatal tissues. This function provides a link between sirtuin expression and the cellular response to limited nutrients due to caloric restriction.[17] Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha/ERR-alpha complex, which are essential metabolic regulatory transcription factors.[10][11][12][13][14][15] Human aging is characterized by a chronic, low-grade inflammation level[18] and NF-κB is the main transcriptional regulator of genes related to inflammation.[19] SIRT1 inhibits NF-κB-regulated gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.[20][21] Increased expression of SIRT1 protein extended both the mean and maximal lifespan of mice.[53] In these mice health was also improved as well as bone and muscle mass. Another SIRT1 activator (SRT1720) also extended lifespan and improved the health of mice.[54] A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging
AMP-activated protein kinase (AMPK) is a cellular energy regulator that plays a critical role in maintaining metabolic balance. In obesity, AMPK activity is often impaired, hindering the body's ability to burn fat for energy and regulate blood sugar. Studies have shown that activating AMPK through exercise, calorie restriction, or certain medications can promote fat burning, improve insulin sensitivity, and combat inflammation, all of which contribute to better overall health and potentially aid in weight management. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity AMPK: a nutrient and energy sensor that maintains energy5 homeostasis AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α The AMPK signalling pathway coordinates cell growth, autophagy and metabolism LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 AMPK and PPARδ Agonists Are Exercise Mimetics The LKB1–AMPK pathway: metabolism and growth control in tumour suppression TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms AMPK in Health and Disease PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function Structure of mammalian AMPK and its regulation by ADP Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1 AMPK: a key regulator of energy balance in the single cell and the whole organism Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome Metabolism of inflammation limited by AMPK and pseudo-starvation Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt An AMPK-FOXO
Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring"[1] and κύτος kýtos, meaning "hollow"[2]) is the natural, regulated mechanism of the cell that removes unnecessary or dysfunctional components.[3] It allows the orderly degradation and recycling of cellular components.[4][5] Three forms of autophagy are commonly described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA). In macroautophagy, expendable cytoplasmic constituents are targeted and isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome,[6][7] which, in time, fuses with an available lysosome, bringing its specialty process of waste management and disposal; and eventually the contents of the vesicle (now called an autolysosome) are degraded and recycled. In disease, autophagy has been seen as an adaptive response to stress, promoting survival of the cell; but in other cases it appears to promote cell death and morbidity. In the extreme case of starvation, the breakdown of cellular components promotes cellular survival by maintaining cellular energy levels. The name "autophagy" was in existence and frequently used from the middle of the 19th century[8]. In its present usage, the term autophagy was coined by Belgian biochemist Christian de Duve in 1963 based on his discovery of the functions of lysosome.[3] The identification of autophagy-related genes in yeast in the 1990s allowed researchers to deduce the mechanisms of autophagy,[9][10][11][12][13] which eventually led to the award of the 2016 Nobel Prize in Physiology or Medicine to Japanese researcher Yoshinori Ohsumi.[14] 1000 Scientific Studies all about Autophagy: Autophagy in the pathogenesis of disease Autophagy fights disease through cellular self-digestion Autophagy: process and function Methods in Mammalian Autophagy Research Autophagy regulates lipid metabolism Autophagy and Metabolism Autophagy: Renovation of Cells and Tissues Autophagy as a Regulated Pathway of Cellular Degradation Autophagy in immunity and inflammation Autophagy and Aging Autophagy and the Integrated Stress Response mTOR regulation of Autophagy Regulation Mechanisms and Signaling Pathways of Autophagy Role of Autophagy in cancer Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy Induction of Autophagy and inhibition of tumorigenesis by beclin 1 Autophagy in Health and Disease: A Double-Edged Sword Methods for monitoring Autophagy AMPK and mTOR regulate Autophagy through direct phosphorylation of Ulk1 LC3 and Autophagy The role of Autophagy during the early neonatal starvation period Death by design: apoptosis, necrosis and Autophagy Autophagy in cell death: an innocent convict? TFEB Links Autophagy to Lysosomal Biogenesis Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy Autophagy: cellular and molecular mechanisms A protein conjugation system essential for Autophagy Self-eating and self-killing: crosstalk between Autophagy and apoptosis Autophagy: molecular machinery for self-eating Suppression of basal Autophagy in neural cells causes neurodegenerative disease in mice Autophagy in Human Health and Disease Loss of Autophagy in the central nervous system causes neurodegeneration in mice Parkin is recruited selectively to impaired mitochondria and promotes their Autophagy Potential therapeutic applications of Autophagy Apoptosis, Autophagy, and more Autophagy Suppresses Tumorigenesis through Elimination of p62 Mammalian Autophagy: core molecular machinery and signaling regulation LC3 conjugation system in mammalian Autophagy Endoplasmic Reticulum Stress Triggers Autophagy Autophagy and cancer The Beclin 1 network regulates Autophagy and apoptosis Escape of Intracellular Shigella from Autophagy Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy Autophagy in infection, inflammation and immunity Impairment
SEE WINNERS HERE Summary of the Interstellar 88/8 Extreme Weight Loss Challenge The 88/8 weight loss program promises significant fat loss, with participants reportedly losing up to 30 pounds in just 12 days. The program incorporates a structured regimen combining fasting, hydration, and physical activity, facilitated by the use of specific supplements known as Interstellar Blends. Key Components: 1. Fasting Protocol: Participants undergo an 88-hour dry fast, consuming only a limited amount of espresso and Interstellar Blends, followed by an 8-hour rehydration and feasting period. This cycle is repeated to achieve weight loss goals. 2. Physical Activity: A minimum of 10-15 miles of walking per day is mandatory, emphasizing the importance of consistent cardiovascular exercise in conjunction with fasting. 3. Hydration: Prior to initiating the fast, participants are advised to hydrate extensively to ensure effective body flushing and to facilitate optimal fat loss. 4. Hormonal Regulation: The program outlines the body’s metabolic processes involved in fat breakdown, highlighting the roles of various hormones and enzymes such as PKA and cAMP in lipolysis. 5. Potential Health Issues: The text discusses potential disruptions in metabolic processes and emphasizes the importance of maintaining overall health to achieve the desired results. 6. Behavioral Considerations: The program stresses the importance of preparation, mental discipline, and avoiding impulsive eating, particularly in response to emotional triggers. 7. Incentives: Participants can earn monetary prizes based on their weight loss achievements, with recorded success stories of individuals who have lost substantial weight within the program. In conclusion, the 88/8 weight loss challenge focuses on a disciplined approach to fasting, hydration, and physical activity, with the potential for impressive weight loss results while encouraging a supportive community through sharing progress in a dedicated Facebook group. 30 POUNDS IN 12 DAYS OR LESS FACEBOOK GROUP TO SEE PIX & WINNERS On a budget? Message Gavin! SECRET BLENDS YOU NEED TO DO 88/8 AVAILABLE HERE 16 EASY STEPS OF HOW YOUR BODY TURNS FAT INTO WATER AND AIR 1. Homeostasis : Think of your body as a well-oiled machine that's always trying to keep everything balanced. This balance is called homeostasis. 2. Signal Reception : When something changes in your body, like when you start exercising or haven't eaten in a while, your body sends a signal that it needs more energy. 3. Signal Interpretation : This signal goes to your brain, which acts like a control center, figuring out what needs to be done. 4. Hormone Regulation : Your brain then sends out orders to your body to start making certain hormones. 5. Gland Stimulation : These orders go to specific factories in your body called glands, telling them to start making these hormones. 6. Hormone Production : The glands start making the hormones. 7. Hormone Release and Transport : Once the hormones are made, they're sent out into your bloodstream, like trucks delivering a package. 8. Hormone Binding : These hormones are like keys that fit into specific locks, called receptors, on the surface of cells. 9.
A combined chitosan/nano-size hydroxyapatite system for the controlled release of icariin A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast … A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis A natural flavonoid glucoside, icariin, regulates Th17 and alleviates rheumatoid arthritis in a murine model A new bone repair scaffold combined with chitosan/hydroxyapatite and sustained releasing icariin A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide A novel approach to utilize icariin as icariin-derived ecm on small intestinal submucosa scaffold for bone repair A novel icariin type flavonoid from Epimedium pseudowushanense A sensitive and specific indirect competitive enzyme‑linked immunosorbent assay for the detection of icariin A simultaneous determination of ferulic acid and icariin in the Li'ankang tablet by HPLC A study on PLGA sustained release icariin/titanium dioxide nanotube composite coating A Traditional Chinese Medicine–icariin-Enhances the Effectiveness of Bone Morphogenetic Protein 2 AB045. Therapeutic potential of icariin in combination with PDE5 inhibitor on penile atrophy and erectile dysfunction in a rat model of post-prostatectomy AB117. Efficacy and mechanism of combination therapy using icariin and daily sildenafil citrate for the treatment of erectile dysfunction in a rat model of bilateral … Absorption and metabolism of icariin in different osteoporosis rat models Absorption and metabolism of icariin in the in situ singlepass perfused rat intestinal model Absorption and utilisation of epimedin C and icariin from Epimedii herba, and the regulatory mechanism via the BMP2/Runx2 signalling pathway Absorption kinetics of icariin solid lipid nanoparticles in rat's intestines Absorption mechanism of icariin across Caco-2 monolayer model Activation of endoplasmic reticulum stress is involved in the activity of icariin against human lung adenocarcinoma cells Activation of Nrf2 signaling by icariin protects against 6‐OHDA‐induced neurotoxicity Adsorption and Purification of Total Flavonoids and icariin on Herba Epimedii. by Macroprous Resin [J] Advances in neuroharmacological effects and molecular mechanisms of icariin Advances in study on icariin extraction, separation, and its anti-tumor mechanism. Amelioration of icariin for the epididymis impairment induced by streptozocin (STZ) in rats An Experimental Study of Effects of icariin on Increasing Smad4 mRNA Level in Osteoblast Cells of OVX Rats An experimental study on the use of icariin for improving thickness of thin endometrium An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis An open-label pilot study of icariin for co-morbid bipolar and alcohol use disorder An outline for the pharmacological effect of icariin in the nervous system Analysis of biliary excretion of icariin in rats Analysis of genes expression profiles of icariin in treating osteoporosis of ovariectomized rats Analysis of icariin and epimedin C in cigarette and its smoke particulate matter by LC/ESI/MS. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro Analysis of Uncertainty for Determination of the icariin in Bushen Oral Liquid by HPLC [J] Angiogenic and MMPs modulatory effects of icariin improved
5-DemethylTangeretin Is More Potent Than Tangeretin In Inhibiting Dimethylbenz (A) Anthracene (Dmba)/12-O-Tetradecanoylphorbol-13-Acetate (Tpa)-Induced Skin … A Safety Study Of Oral Tangeretin And Xanthohumol Administration To Laboratory Mice A Tangeretin Derivative Inhibits The Growth Of Human Prostate Cancer Lncap Cells By Epigenetically Restoring P21 Gene Expression And Inhibiting Cancer Stem-Like … Abstract Lb-167: A Novel Metabolite Of Citrus Tangeretin Epigenetically Inhibits The Growth Of Human Prostate Cancer Cells Anti-Inflammatory And Antioxidant Mechanism Of Tangeretin In Activated Microglia Anti-Inflammatory Properties Of Tangeretin, 5-DemethylTangeretin And Their Primary Metabolites Antimicrobial Activity Of Nobiletin And Tangeretin Against Pseudomonas Antioxidant Protection Of Nobiletin, 5-Demethylnobiletin, Tangeretin, And 5-DemethylTangeretin From Citrus Peel In Saccharomyces Cerevisiae Antitumor Efficacy Of Tangeretin By Targeting The Oxidative Stress Mediated On 7, 12-Dimethylbenz (A) Anthracene-Induced Proliferative Breast Cancer In Sprague … Apigenin And Tangeretin Enhance Gap Junctional Intercellular Communication In Rat Liver Epithelial Cells Application Of Emulsion-Based Delivery System To Enhance Bioavailability And Efficacy Of Tangeretin Assessing The In Vitro Bioavailability Of Tangeretin And Its Derivatives In Caco-2 Cell Model Attenuation Of Tert-Butyl Hydroperoxide (T-Bhp)-Induced Oxidative Damage In Hepg2 Cells By Tangeretin: Relevance Of The Nrf2–Are And Mapk Signaling … Biotransformation Of The Citrus Flavone Tangeretin In Rats. Identification Of Metabolites With Intact Flavane Nucleus Blockade Of Stat3 Signaling Contributes To Anticancer Effect Of 5-Acetyloxy-6, 7, 8, 4′-Tetra-Methoxyflavone, A Tangeretin Derivative, On Human Glioblastoma … Cardioprotective Efficiency Of Tangeretin Against Heart Failure Induced By Isoproterenol In Rats Carnosic Acid, Tangeretin, And Ginkgolide-B Anti-Neoplastic Cytotoxicity In Dual Combination With Dexamethasone-[Anti-Egfr] In Pulmonary Adenocarcinoma (A549 … Cellular Metabolic Energy Modulation By Tangeretin In 7, 12-Dimethylbenz (A) Anthracene-Induced Breast Cancer Characterization And Bioaccessibility Of Tangeretin-Loaded Zein Colloidal System Chemotherapeutic Effect Of Tangeretin, A Polymethoxylated Flavone Studied In 7, 12-Dimethylbenz (A) Anthracene Induced Mammary Carcinoma In Experimental Rats Citrus Flavone Tangeretin Inhibits Leukaemic Hl-60 Cell Growth Partially Through Induction Of Apoptosis With Less Cytotoxicity On Normal Lymphocytes Citrus Peel Polymethoxyflavones Nobiletin And Tangeretin Suppress Lps-And Ige-Mediated Activation Of Human Intestinal Mast Cells Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis Via Activating The Ampk-Pgc1-Α Pathway In Vitro And In Vivo: A Possible Mechanism For Its … Citrus Tangeretin Reduces The Oxidative Stress Of The Myocardium, With The Potential For Reducing Fatigue Onset And Myocardial Damage Combination Of Cisplatin And Tangeretin Induces Apoptosis In Cisplatin-Resistant Human Ovarian Cancer Cells Through Modulation Of Phospho-Akt And Its Downstream … Combination Of Tangeretin And 5-Fluorouracil Modulates Cell Cycle And Induce Apoptosis On Widr Cells Combinational Applicaton Of Silybin And Tangeretin Attenuates The Progression Of Non-Alcoholic Steatohepatitis (Nash) In Mice Via Modulating Lipid Metabolism Comparative Binding Studies Of Curcumin And Tangeretin On Up-Stream Elements Of Nf-Kb Cascade: A Combined Molecular Docking Approach Corrigendum To" Tangeretin, A Citrus Pentamethoxyflavone, Antagonizes Abcb1-Mediated Multidrug Resistance By Inhibiting Its Transport Function"[Pharm. Res. 110 … Cytoprotective Effect Of Tangeretin In Hydrogen Peroxyde-Inducedoxydative Stress On Human Umbilical Vein Endothelial Cells (Huvecs) Determination Of Tangeretin In Rat Plasma By Lc-Electrospray-Ion Trap Ms Determination Of Tangeretin In Rat Plasma: Assessment Of Its Clearance And Absolute Oral Bioavailability Dietary Flavonoid Tangeretin Induces