July 30, 2019

Klotho

Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be […]
January 4, 2020

P53

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence Senescence and tumour clearance is triggered […]
January 6, 2020

HSP90

Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation. It also stabilizes a number of proteins […]
January 7, 2020

TELOMERE SHORTENING & PREMATURE AGING

A branching process model of telomere shortening A continuous correlation between oxidative stress and telomere shortening in fibroblasts A Critical Role for Pin2/TRF1 in ATM-dependent Regulation […]
January 7, 2020

PREMATURE SENESCENCE

Premature Senescence ”Senescence is more than merely a cell division clock that regulates the proliferative lifespan of normal cells. “Premature” senescence is an active cytostaticprogram that […]
January 7, 2020

JAK INHIBITION ALLEVIATES SASP

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age A hallmark of aging is chronic sterile inflammation, which is closely associated with […]
January 8, 2020

Oncogene Activation

… : VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (oncogene,(2018), 37, 41,(5585 … … and functional interaction between polyoma […]
January 10, 2020

JNK PREVENTS PREMATURE SENESCENCE

Prevention of premature senescence requires JNK activation Premature senescence is considered as a cellular defense mechanism to prevent tumorigenesis. Although recent evidences show that c-Jun N-terminal […]
January 10, 2020

MDM2

MDM2 antagonists attenuate the senescence-associated secretory phenotype Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells […]